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Nanoparticles take on tooth infections in kids: a new hope?

NCT ID NCT06926322

Disease control Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a new nano-based paste (chitosan-coated silver nanoparticles) works better than a standard antibiotic paste for treating infected baby molars in children aged 4-8. The goal is to reduce pain, swelling, and infection, and to see which paste kills bacteria best. The trial involves 108 children and compares three different pastes placed inside the tooth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
chitosan-coated silver nanoparticles and double antibiotic paste (metronidazole and ciprofloxacin)
What this could lead to
If it works, this could offer a simpler, more effective treatment for infected baby teeth, reducing pain and the need for extractions.
What could go wrong
This is a small, early-stage trial (108 children) testing a new nano-formulation. The nanoparticles may not work better than the standard paste, and long-term safety in young children is unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 108 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2025

An estimate. Start dates often move.

Expected to finish

Aug 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

4 to 8 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy cooperative children of both sexes in the age range of 4-8 years old. * Children with consenting parents who accept to participate in the study and sign the consent forms. * Children with mandibular primary molars with clinical and radiographic signs of pulpal necrosis. Exclusion Criteria: * Children with hypersensitivity to any of the used medicaments. * Non-restorable teeth without sufficient coronal structure for placement of rubber dam isolation and restoration with stainless steel crowns * Non-restorable teeth with perforated pulpal floor

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis Pain, Postoperative Persistent Infection root resorption

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Necrotic pulp Pain, postoperative Persistent infection Root resorption

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of dentistry Ain shams university

    Cairo, Egypt

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