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Mouthwash may speed up gum healing after wisdom tooth surgery

NCT ID NCT05414253

Disease control Sponsor: University of Pisa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a mouthwash containing chlorhexidine and hyaluronic acid helps gums heal better after wisdom tooth removal. Fifty-four healthy adults who need wisdom tooth surgery will use the mouthwash, and doctors will check their healing over two weeks. The goal is to see if this combination reduces wound problems and improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Chlorhexidine and hyaluronic acid mouthwash
What this could lead to
If it works, this could point toward a better way to help gums heal faster and more completely after wisdom tooth surgery.
What could go wrong
This is a small, early-stage trial with only 54 people, so results may not apply to everyone. The improvement in healing might be small or not noticeable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 54 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2022

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * males or females of age range between 18 and 70 years, * good health status, * indication to perform third molar surgery, * patients willing to give informed consent, * compliance to the study follow-up, Exclusion Criteria: * pregnancy or breast-feeding, * indication to antibiotic therapy prior to surgical treatment, * chronic infections, * systemic diseases (including cardiovascular, pulmonary, cerebral, and metabolic diseases), * previous therapy with the mouth rinses employed in the present study, and * smoking habit (\>20 cigarettes per day, and/or pipe or cigar smoking).

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Conditions

The condition(s) this trial relates to.

injury mouth disorder Surgical Wound

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Impacted third molar tooth Surgical wound Wound heal

Contacts and locations

Locations

  • University Hospital of Pisa

    Pisa, 56126, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.