Could a blood clot and a skin filler fix receding gums?
NCT ID NCT07662447
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding hyaluronic acid to a platelet-rich fibrin membrane improves the treatment of receding gums. Thirty adults with a specific type of gum recession will receive either the PRF membrane alone or with hyaluronic acid, alongside a surgical flap procedure. The main goal is to see how much of the exposed tooth root is covered, and secondary goals include measuring pain after the procedure.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- platelet-rich fibrin and hyaluronic acid
- What this could lead to
- If successful, this could offer a more effective, less painful treatment for receding gums using the body's own healing factors.
- What could go wrong
- This is a small, early-stage trial with only 30 participants, so results may not apply to everyone. The added benefit of hyaluronic acid over PRF alone is uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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30 people
The number who actually took part.
- Started
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Jul 2025
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 70 years
- Sex
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Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Systemically healthy patients aged 18-50 years presenting with Cairo RT1 gingival recession defects were included in the study. Patients were selected if the recession defect was present on a vital tooth with an identifiable cementoenamel junction and no interproximal clinical attachment loss. The selected tooth was required to be free from caries, cervical restorations, non-carious cervical lesions interfering with measurement, pulpal pathology, and pathological mobility. Patients with acceptable oral hygiene after initial periodontal therapy, preferably with Plaque Index ≤1, were included. Patients willing to participate in the study, sign informed consent, and report for all follow-up visits were included. -Exclusion Criteria Patients were excluded if they were smokers or tobacco users, including smokeless tobacco users. Patients with systemic conditions that could affect periodontal wound healing, such as uncontrolled diabetes mellitus, immunosuppressive disorders, bleeding disorders, connective tissue disorders, or any serious systemic illness, were not included. Pregnant or lactating women were excluded from the study. Patients taking medications known to influence gingival healing, including corticosteroids, immunosuppressants, bisphosphonates, anticoagulants, or long-term anti-inflammatory drugs, were excluded. Patients with poor oral hygiene, untreated gingival inflammation, active periodontal disease, or recession defects classified as Cairo RT2 or RT3 were not included. Teeth with cervical caries, cervical restorations, deep abrasion, erosion, non-carious cervical lesions interfering with CEJ identification, endodontic pathology, periapical lesions, non-vital pulp, traumatic occlusion that could not be corrected before surgery, or previous periodontal plastic surgery at the selected site within the past 12 months were excluded. Patients undergoing orthodontic treatment or those who had recently completed orthodontic treatment were also excluded if tooth movement could affect gingival margin stability. Patients unwilling to provide consent or unable to attend the follow-up schedule were not included.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Gulf Medical University
Ajman, Ajman Emirate, 00000, United Arab Emirates
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Boosting gum grafts: do blood or gel Add-Ons reduce shrinkage?
- Can a new flap technique better cover receding gums?
- A new twist on gum surgery could better cover exposed roots
- Sugar water vs. steroids: a new battle against back pain
- Gum graft boost: growth factors may strengthen receding gum repair