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Cold rinse after root canal may ease pain, study tests best technique

NCT ID NCT07500870

Symptom relief Sponsor: All India Institute of Medical Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at two ways to clean root canals (rotary vs. reciprocating files) and whether rinsing with very cold saline (cryotherapy) reduces pain after the procedure. Sixty adults with infected but painless teeth will be randomly assigned to one of four groups. Patients will rate their pain at different times, and X-rays after six months will check healing. The goal is to find which method causes less discomfort and better recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cryotherapy (cold saline rinse)
What this could lead to
If successful, this could help dentists choose techniques that reduce pain after root canal treatment and improve healing, potentially lowering the need for painkillers.
What could go wrong
This is a small, early-stage study with only 60 participants, so results may not apply to all patients. The benefits of cryotherapy or one instrumentation method may be minimal or not statistically significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Systemically healthy (ASA (American Society of Anesthesiologists)-I,II )(22) participants between 18 - 60 years of age with diagnosis of pulp necrosis and AAP in single rooted lower anteriors and premolars Tooth will be diagnosed as AAP if it shows no clinical symptoms (no pain on percussion or palpation). 2. Radiographic evidence of periapical pathology with PAI score between 2 - 5. Exclusion Criteria: The patients with the following clinical and radiographic features will be excluded from the study: Clinical features: 1. Teeth with previous history of root canal treatment. 2. Teeth requiring severe prosthetic rehabilitation. 3. Pregnant or nursing mothers. 4. Periodontally compromised teeth. 5. Analgesic consumption for at least 12hrs before the visit. Radiographic features: 1. Immature/ Open apex 2. Non-patent apical foramen 3. Root resorption 4. External resorption 5. Calcified pulp canals.

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis dental pulp necrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periapical healing Post endodontic pain

Contacts and locations

Locations

  • All India Institute of Medical Sciences

    Nagpur, Maharashtra, 441108, India

More trials for these conditions

Other studies related to the condition(s) this trial covers.