New nutrition strategy aims to speed recovery after abdominal surgery

NCT ID NCT05127109

Disease control Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a structured nutrition plan for 300 ICU patients who had abdominal surgery and cannot eat normally. The plan includes IV nutrition, oral supplements, and a device to measure calorie needs. Researchers will track infections, ICU stay length, and muscle loss to see if this approach improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Nutrition Ecosystem pathway (IV nutrition, oral supplements, and calorie measurement devices)
What this could lead to: If successful, this nutrition plan could reduce infections and shorten ICU stays for patients recovering from major abdominal surgery.
What could go wrong: This is a single-site Phase 4 study with 300 participants, so results may not apply to all hospitals or patient groups. The nutrition plan is complex and may not be easy to implement everywhere.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2022

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age \>= 18 years 2. ICU admission with major abdominal trauma, intra-abdominal sepsis, ischemic bowel/vascular emergencies, or penetrating trauma 3. Not expected to receive oral or enteral nutrition for \> 72 hours 4. Primary team approval of PN 4\. \< 72 hours post-operative intervention Exclusion Criteria: 1. Expected death or withdrawal of life-sustaining treatment within the first 72 hours of ICU admission 2. Patients admitted with * Diabetic ketoacidosis or non-ketotic hyperosmolar coma * MELD \> 20 or acute fulminant hepatic failure 3. Patients allergic to any component of parenteral nutrition or lipid solution 4. Pregnant or breastfeeding patients 5. Incarcerated or prisoner prior to admission

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Conditions

The condition(s) this trial relates to.

Abdominal Injuries acute intestinal ischemia infectious disease with sepsis Intraabdominal Infections ischemic bowel disorder mouth disorder nutritional disorder Sepsis vascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Abdominal trauma Diet, healthy Enteral feeding FOOD Intensive care Intra-abdominal infection Ischemic bowel Nutrition ORAL Penetrating abdominal trauma Sepsis Surgery Vascular

New nutrition strategy aims to speed recovery after abdominal surgery

What the study statuses mean