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Gum fluid may reveal secrets of toothache

NCT ID NCT07592455

First seen May 18, 2026 · Last updated Jun 21, 2026 · Updated 7 times

Summary

This completed study looked at 36 patients with severe toothache (irreversible pulpitis) to see if pain and tissue inflammation are linked to certain biological markers in gum fluid. Researchers collected gum fluid samples before and after root canal treatment and measured markers like TNF-alpha and substance P. The goal was to better understand the connection between symptoms and underlying biology, not to test a new treatment.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AinShams University

    Cairo, Cairo Governorate, 12611, Egypt

Conditions

The condition(s) this trial relates to.

pulpitis Toothache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.