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Root canal pain study: which sealer hurts less?

NCT ID NCT06726837

Symptom relief Sponsor: Dicle University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at pain after root canal treatment using two types of sealers: bioceramic and resin. 72 adults with no pain before treatment had a single-root tooth filled. They rated their pain at 6, 24, 48, and 72 hours, and 7 days after. The goal was to see if the sealer type affects how much pain people feel.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
root canal sealers (bioceramic and epoxy resin-based)
What this could lead to
If one sealer causes less pain, dentists may use it to make root canals more comfortable.
What could go wrong
This is a small, completed study with only 72 patients. Results may not apply to all teeth or people. Pain is subjective and varies widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

72 people

The number who actually took part.

Started

Dec 2024

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18-65 years * Patients who agreed to participate in this study * Patients with single-rooted, single-canal maxillary or mandibular teeth diagnosed with asymptomatic irreversible pulpitis * Patients with asymptomatic teeth * Patients who have not used any analgesic, anti-inflammatory, or antibiotic drugs in the last 7 days * Patients with good oral hygiene * Patients with a sustained positive response to cold test and electric pulp test * Patients with healthy periapical tissues (to be confirmed by periapical radiography) Exclusion Criteria: * Patients who refused to participate in this study * Patients with medical problems (patients with immunosuppressive/systemic diseases, patients on medication) * Patients with negative responses to thermal and electrical pulp tests * Patients with advanced periodontal disease (probing depth \>4 mm) * Patients with preoperative percussion and palpation of the involved tooth * Open apex, presence of calcification, presence of resorption * Patients requiring endodontic treatment of more than one tooth * Patients with allergic sensitivity to materials and agents to be used during root canal treatment * Patients with allergic sensitivity to local anesthetics * Patients with systemic or allergic sensitivity to NSAIDs * Pregnant and lactating patients * Teeth that cannot be restored due to excessive material loss in the coronal structure

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asymptomatic irreversible pulpitis Postoperative dental pain Root canal sealers

Contacts and locations

Locations

  • Dicle University, Faculty of Dentistry, Department of Endodontics

    Diyarbakır, 21010, Turkey (Türkiye)

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