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Could a dab of antibiotic gel replace pills after wisdom tooth removal?

NCT ID NCT07573033

Symptom relief Sponsor: Liaquat College of Medicine and Dentistry Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether applying antibiotics directly into the tooth socket after wisdom tooth removal works as well as taking antibiotic pills. 90 adults having their lower wisdom teeth taken out were split into two groups: one got antibiotic gel at the surgery site, the other took pills for 5 days. Researchers tracked infections, dry socket, pain, and swelling for 14 days to see which method was safer and more effective.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

90 people

The number who actually took part.

Started

Feb 2024

Finished

Jul 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Individuals aged 18-40 years. * Patients scheduled for surgical extraction of impacted mandibular third molars. * Presence of pain, infection, or impaction requiring extraction. * Fully or partially impacted mandibular third molars. * Pell and Gregory Class II or Class III impaction. * Medically fit for surgical procedures and antibiotic therapy. * Provided written informed consent. Exclusion Criteria * Known allergy to antibiotics. * Known allergy to local anesthetic agents. * Previous surgery in the same anatomical area. * Poor oral hygiene. * Active oral infections. * Presence of systemic illness contraindicating surgery or antibiotic use. * Pregnant women. * Breastfeeding women. * Inability to attend follow-up visits.

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Conditions

The condition(s) this trial relates to.

alveolar periostitis facial neuralgia Facial Pain impacted teeth, multiple Surgical Wound Infection Tooth, Impacted

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Facial pain Impacted mandibular third molar postoperative surgical site infection postoperative pain postoperative inflammation dry socket (alveolar osteitis) Impacted tooth Postoperative complications in maxillofacial surgery Surgical wound infection

Contacts and locations

Locations

  • Liaquat College of Medicine and Dentistry

    Karachi, Sindh, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.