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Can special toothpaste stop kids' cavities? new study tests fluoride vs. probiotics

NCT ID NCT07579403

Prevention Sponsor: The Affiliated Hospital of Qingdao University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether fluoride or probiotic toothpaste can prevent cavities in 508 children aged 4-5. Kids brushed twice daily for 12 months with either fluoride, probiotic, or plain toothpaste. Researchers also surveyed eating and brushing habits to find risk factors for cavities.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Fluoride toothpaste and probiotic toothpaste
What this could lead to
If successful, this could point toward better toothpaste options for preventing cavities in young children.
What could go wrong
This is a completed Phase 4 study in one city, so results may not apply to all children. Toothpastes only reduce risk, not eliminate cavities entirely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

508 people

The number who actually took part.

Started

Jan 2023

Finished

Sep 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

48 months to 59 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 4-5 years (48-59 months) * Informed consent obtained from parents or guardians, with permanent residence in Pingdu City and willingness to actively cooperate throughout the study * No long-term medication use * Absence of systemic diseases and mental health disorders Exclusion Criteria: * Not meeting any of the inclusion criteria * Children whose parents or guardians did not provide informed consent * Presence of systemic diseases or mental health disorders * Long-term medication use

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Conditions

The condition(s) this trial relates to.

Child Behavior dental caries prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Child behavior Dental caries

Contacts and locations

Locations

  • The Affiliated Hospital of Qingdao University

    Qingdao, Shandong, 266003, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.