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Could a silver gel halt cavities without the drill?

NCT ID NCT05395065

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 17, 2026 · Last updated Aug 18, 2026 · Updated 1 time

Summary

This study is testing whether applying a silver diamine fluoride gel followed by a fluoride varnish can stop cavities in children's baby teeth. Researchers will follow 237 children for a year to see how many cavities become inactive and whether parents are satisfied with the treatment. The goal is to find a simple, non-invasive way to manage tooth decay in young children.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Silver diamine fluoride gel and sodium fluoride varnish
What this could lead to
If effective, this could offer a simple, non-invasive way to stop cavities in children's baby teeth, potentially reducing the need for drilling or fillings.
What could go wrong
This is an observational study without a comparison group, so results may be less conclusive. The gel may cause tooth staining, and long-term effectiveness is still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

237 people

The number who actually took part.

Started

Jul 2022

Finished

Jan 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The children will be recruited from five schools (Centro Educativo Inicial) in Puno, Peru

Ages

3 to 4 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * At least one active caries lesion Good general health by parent report Exclusion Criteria: * Unable to cooperate with exam or procedure

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • UGEL Manazo

    Puno, Puno, Peru

  • UGEL Puno 210001 Las Torres

    Puno, Puno, Peru

  • UGEL Puno Magisterial

    Puno, Puno, Peru

  • UGEL San Jose

    Puno, Puno, Peru

  • UGEL Villa del Lago

    Puno, Puno, Peru

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