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Dental stress study: saliva test reveals hidden anxiety in kids with weak enamel

NCT ID NCT07389148

Knowledge-focused Sponsor: Lokman Hekim University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 01, 2026 · Updated 2 times

Summary

This study looks at whether children with a condition called molar incisor hypomineralization (MIH), which causes weak enamel on molars and front teeth, experience more stress during dental checkups. Researchers will measure stress by testing saliva for cortisol and checking heart rate and oxygen levels in 90 kids aged 8 to 12—half with MIH and half without. No treatments are given; the goal is simply to understand stress responses better so dentists can provide more comfortable care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help dentists better understand and manage anxiety in children with MIH, leading to more personalized and less stressful dental care.
What could go wrong
This is a small observational study with no treatment, so it won't directly improve health. Results may not apply to all children or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

91 people

The number who actually took part.

Started

Jan 2026

Finished

Apr 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of children aged 8 to 12 years attending the Department of Pediatric Dentistry. Participants include children diagnosed with molar incisor hypomineralization and age-matched healthy control children without MIH.

Ages

8 to 12 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children aged between 8 and 12 years. * Children diagnosed with molar incisor hypomineralization (MIH) according to the European Academy of Paediatric Dentistry (EAPD) criteria or healthy children without MIH. * Ability to cooperate sufficiently to complete the clinical dental examination and study procedures. * Written informed consent obtained from a parent or legal guardian. Exclusion Criteria: * Presence of systemic, hormonal, or metabolic diseases. * Regular use of medications known to affect salivary cortisol levels or cardiovascular parameters (e.g., corticosteroids, beta-blockers). * History of systemic conditions that may influence stress response. * Refusal of participation by the child or parent/legal guardian.

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Conditions

The condition(s) this trial relates to.

amelogenesis imperfecta, type 3A Molar Hypomineralization

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Molar incisor hypomineralization

Contacts and locations

Locations

  • Lokman Hekim University, Faculty of Dentistry

    Ankara, Ankara, 06510, Turkey (Türkiye)

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