Mouth proteins may hold clues to gum disease severity
NCT ID NCT07751393
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This study investigates whether specific proteins involved in inflammation are present at different levels in people with healthy gums, gingivitis, or periodontitis. Researchers will collect saliva, gum fluid, and gum tissue samples from 75 adults and measure the levels of these proteins. The goal is to see if these proteins are linked to the severity of gum disease, which could help explain how it develops and potentially lead to new detection or treatment strategies.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If certain proteins are found at different levels in people with gum disease, this could point toward new ways to detect or treat periodontitis in the future.
- What could go wrong
- This is an early observational study, so it may not prove that these proteins cause gum disease. Results may not lead directly to new treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
75 people
The number who actually took part.
- Started
-
May 2024
- Finished
-
Dec 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adults aged 18 to 60 years attending the periodontology clinic were enrolled and classified into three groups based on clinical periodontal parameters according to the 2017 World Workshop classification: periodontal health, gingivitis, and periodontitis (Stage III). Exclusion criteria included any systemic disease, regular medication use, smoking, pregnancy or lactation, periodontal treatment within the past 6 months, antibiotic use within the past 6 months, and presence of prosthetic restorations on the teeth to be sampled. A total of 75 participants (25 per group; 38 male, 37 female) were included.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Inclusion criteria for the Healthy Control group were: presence of ≥ 20 teeth in the mouth, probing pocket depth (PPD) ≤ 3 mm, the percentage of bleeding sites for the whole mouth \< 10%, and, on radiographic examination, a distance of ≤ 3 mm between the cemento-enamel junction and the alveolar bone crest in 95% of all teeth. Inclusion criteria for the Gingivitis group were: presence of ≥ 20 teeth in the mouth, PPD ≤ 3 mm, % of bleeding sites for the whole mouth ≥ 10%, and, on radiographic examination, a distance of ≤ 3 mm between the cemento-enamel junction and the alveolar bone crest in 95% of all teeth. Inclusion criteria for the Stage 3 Periodontitis group were: presence of ≥ 15 teeth in the mouth, more than 30% of teeth affected by periodontal disease, affected teeth exhibiting probing depths of 6 mm or more and clinical attachment loss (CAL) of ≥ 5 mm, vertical bone loss of 3 mm or more, class 2 or 3 furcation involvement, and radiographic evidence of alveolar bone loss extending to the middle third and beyond (33%) in the relevant teeth Exclusion Criteria: Exclusion criteria for all groups were defined as: presence of any systemic disease, regular use of any medication, smoking, pregnancy or lactation, periodontal treatment within the last 6 months, antibiotic use within the last 6 months, and the presence of prosthetic restorations on the teeth to be sampled.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Gingivitis are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Kubra Aral , Phd Ext. 422 341 01 06 [email protected]
Malatya, 44100, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a pill replace an IV for gum surgery pain relief?
- Can everyday supplements boost gum disease therapy?
- Seeing your gums in 3D: can personalized images spark better brushing?
- Can pulling a loose tooth and putting it back save it?
- Gum fluid proteins eyed as link between smoking and periodontitis
- Gum fluid holds clues to Behçet's disease puzzle