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Vitamin injections may shorten time in braces, early study suggests

NCT ID NCT06847880

Symptom relief Sponsor: University of Baghdad Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 4 times

Summary

This study tested whether injecting vitamins C or E into the gums could help teeth move faster during braces treatment. 51 patients received either vitamin C, vitamin E, or a placebo injection every two weeks to a month for six months. Researchers measured tooth movement, pain, and root health to see if these antioxidants improve orthodontic outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
vitamins C and E
What this could lead to
If it works, this could point toward a way to make orthodontic treatment faster and less painful.
What could go wrong
This is a small, early-phase study with only 51 participants, so results may not apply to everyone. The vitamins are injected locally, which may cause discomfort or side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

56 people

The number who actually took part.

Started

Feb 2025

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients aged 12 years and above, who are indicated for fixed appliance orthodontic treatment. 2. Patients with moderate to very severe crowding of the mandibular anterior teeth as per the Little's Irregularity Index (LII). 3. Treatment with or without two mandibular first premolars extraction. Presence of all the mandibular permanent teeth, except the third molars. 5\. The overbite and overjet should not impede bracket placement on the mandibular anterior teeth. Exclusion Criteria: 1. History of previous orthodontic intervention. 2. History of trauma or root resorption in the mandibular anterior teeth. 3. Presence of mandibular anterior teeth crowding of less than 4 mm (LII). 4. Existence of blocked-out teeth precluding engagement with the aligning archwire. 5. History of systemic diseases, especially diabetes and bone diseases. 6. Patients with periodontitis and obvious loss of tooth attachment according to Plaque and Bleeding on Probing indices. 7. Pregnant and lactating mothers. 8. Mouth breathing patients and smokers. 9. Healthy patients who have not used any medications (such as anti-inflammatory or antimicrobial drugs) or supplements (such as vitamins)

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Conditions

The condition(s) this trial relates to.

root resorption

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Biomarkers Pain perception Rate of orthodontic tooth movement Root resorption

Contacts and locations

Locations

  • Baghdad Al-Karkh Health Directorate, Baghdad, Iraq

    Baghdad, Baghdad Governorate, 10013, Iraq

  • Baghdad Al-Rusafa Health Directorate

    Baghdad, Baghdad Governorate, 10061, Iraq

  • College of Dentistry, University of Baghdad, Baghdad, Iraq

    Baghdad, Baghdad Governorate, 10071, Iraq

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