Gum surgery recovery boosted by Platelet-Rich fibrin and hyaluronic acid?
NCT ID NCT06865092
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether injectable platelet-rich fibrin (i-PRF), titanium platelet-rich fibrin (t-PRF), or hyaluronic acid gel can improve wound healing after gum surgery for overgrown gums. Sixty healthy adults were randomly assigned to one of four groups. Researchers measured pain, burning, and healing at several time points over 28 days. The goal is to find a way to help gums heal faster and more comfortably.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- injectable platelet-rich fibrin (i-PRF), titanium platelet-rich fibrin (t-PRF), and 0.8% hyaluronic acid gel
- What this could lead to
- If successful, these treatments could speed up gum healing and reduce pain after gum surgery.
- What could go wrong
- This is a small, completed study with 60 participants. Results may not apply to everyone, and the treatments are not yet proven to be better than standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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60 people
The number who actually took part.
- Started
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May 2023
- Finished
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Nov 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. ≥18-65 years of age 2. Being systemically healthy 3. Having chronic inflammatory gingival overgrowth in the mandibular and maxillary anterior region, with no attachment and bone loss 4. Not to have used any medication in the last three months 5. Not smoking 6. At least 20 natural teeth Exclusion Criteria: 1. Patients with orthodontic appliances 2. Patients with removable (partial) prostheses 3. Patients with immunosuppressive agents, systemic corticosteroids, chemotherapy, and/or radiotherapy drugs and/or drugs that may cause gingival enlargement use in the last 6 months 4. Patients with oral and/or peri-oral pain 5. Patients with significant oral lesions 6. Patients with antibiotic use in the last 3 months, pregnancy and breastfeeding 7. Patients who have undergone periodontal treatment within the last 6 months 8. Patients with poor communication skills 9. Smokers and alcohol users
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Sağlık Bilimleri Üniversitesi Gülhane Diş Hekimliği Fakültesi
Ankara, 06010, Turkey (Türkiye)
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