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Could a saliva test spot gum disease? new study investigates

NCT ID NCT07669233

Knowledge-focused Sponsor: Zhang, Yuwei Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether certain amino acids in saliva differ between people with healthy gums, gingivitis, and periodontitis. Researchers also tracked how these amino acids changed after standard non-surgical gum treatment in 32 periodontitis patients. The goal is to see if saliva tests could help diagnose or monitor gum disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Non-surgical periodontal therapy (scaling and root planing)
What this could lead to
If successful, this could lead to a simple saliva test to help diagnose and monitor gum disease.
What could go wrong
This is a small, early-stage study with only 77 participants. The results may not apply to everyone, and the saliva test may not prove reliable in larger, more diverse groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

77 people

The number who actually took part.

Started

Nov 2023

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 20 and 50 years old at the time of enrollment. * Body mass index (BMI) between 18.5 and 24.0 kg/m². * No special dietary habits (e.g., long-term vegetarian diet, extreme dieting) and no food allergies. * Body weight fluctuation less than 3 kg in the past 6 months before enrollment. * At least 20 natural teeth remaining in the oral cavity (excluding third molars). * Able to understand and sign the written informed consent form voluntarily. * Able to attend all scheduled follow-up visits as required. * For participants in the interventional arm: diagnosed with periodontitis according to the 2018 International Classification of Periodontal and Peri-Implant Diseases and Conditions. Exclusion Criteria: * Systemic diseases such as diabetes mellitus, rheumatoid arthritis, or immunodeficiency disorders. * Use of antibiotics, anti-inflammatory drugs, or antioxidant medications within 3 months before enrollment. * Received any form of periodontal treatment (e.g., scaling, root planing, periodontal surgery) within 6 months before enrollment. * Long-term use of medications known to affect gingival health, including calcium channel blockers, phenytoin, cyclosporine, or hormone replacement therapy drugs. * History of smoking (current or former smokers) or use of tobacco products within the past 5 years. * Pregnant or lactating women. * Presence of severe oral mucosal diseases or active dental caries requiring immediate treatment. * Participation in other interventional clinical trials within the past 30 days. * Mental or cognitive disorders that may affect the ability to comply with study procedures.

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Conditions

The condition(s) this trial relates to.

gingivitis Periodontal Attachment Loss periodontal disorder Periodontal Pocket periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingivitis and periodontal diseases Periodontal attachment loss Periodontal debridement Periodontal pocket Periodontitis

Contacts and locations

Locations

  • West China Hospital of Stomatology, Sichuan University

    Chengdu, Sichuan, 610041, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.