Reproductive system disorder

This early-stage trial tested whether a new herpes vaccine called HSV529 is safe for people. Researchers gave the vaccine or a placebo to 69 healthy adults aged 18 to 40, some of whom had herpes and some who did not. Participants received three shots over six months and were moni…

This study tests an experimental vaccine called GBS-NN/NN2 against Group B Streptococcus (GBS), a bacteria that can cause serious infections in newborns. The trial includes pregnant women both with and without HIV, giving two doses between 26 and 30 weeks of pregnancy. Researcher…

This study tests an RSV vaccine in pregnant women living with HIV. The goal is to see if the vaccine is safe and helps mothers pass protective antibodies to their babies, potentially preventing severe RSV lung infections in infants. The trial involves about 681 pregnant participa…

This study tested an experimental gonorrhea vaccine in healthy adults aged 18 to 50. The goal was to see if the vaccine is safe and can prevent gonorrhea infections. Over 1,000 participants received either the vaccine or a placebo (salt water shot) and were monitored for side eff…

This study tested a new two-step vaccine approach to protect HIV-infected adults from pneumococcal infections, a common cause of serious illness in this group. The standard vaccine often doesn't work well in people with lower immune cell counts. The study involved 212 participant…

This phase 3 study tested the 9-valent HPV vaccine (Gardasil 9) in over 1,000 Japanese males aged 16 to 26. The goal was to see if the vaccine could prevent persistent HPV infections that can lead to genital warts and anal cancers. Participants received either the vaccine or a pl…

This Phase 1 trial tested a new HIV vaccine in 68 healthy adults to see if it is safe and triggers an immune response. The vaccine uses a DNA-based approach combined with an HIV protein to train the body to fight the virus. While early results are encouraging, this is just the fi…

This study tests an experimental vaginal insert (ABI-2280) to see if it can safely clear persistent high-risk human papillomavirus (HPV) infection in women aged 25 to 55. Participants must have had HPV for at least a year with no serious cervical changes. The study compares diffe…

This trial asks men with advanced prostate cancer which of two oral medications they prefer: the experimental drug ODM-201 or the approved drug enzalutamide. Both work by blocking male hormones that fuel cancer growth. Participants will take each drug for a period and then answer…

This study tests whether two lab-made antibodies can safely control HIV in people who stop their regular antiretroviral therapy for a short time. Thirty-two adults in Sub-Saharan Africa who are currently on HIV treatment will receive either the antibodies or a placebo. The goal i…

This early-phase trial tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, a drug that blocks blood vessel growth in tumors, in 18 adults with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the …

This trial tests whether using 3D on-board imaging before each radiation session improves accuracy and outcomes for men with prostate cancer compared to standard imaging. The study tracks disease-free survival, side effects, and costs over 2 to 5 years. It aims to find the best i…

This study looks at whether a traditional Chinese herbal formula, Guishen Yijing, can help women with diminished ovarian reserve (DOR) — a condition where the ovaries have fewer eggs than expected for a woman's age. Researchers will review medical records of 126 women who took th…

This trial tests whether offering small cash payments to people living with HIV, when they attend counseling sessions and clinic visits, can help them stay engaged in care and achieve viral suppression. Participants are adults identified as high risk for dropping out of care at t…

This phase II trial is testing whether argon plasma coagulation (APC) can safely and effectively treat high-grade anal lesions (AIN 2/3) in HIV-positive men who have sex with men. APC uses ionized argon gas to deliver a controlled electrical current that destroys abnormal cells. …

This early-stage trial is testing an experimental HIV drug called ACC017 in adults with HIV-1 who have never taken HIV medication. The study aims to see if the drug is safe, tolerable, and effective at lowering the amount of virus in the blood, both when used alone and when combi…

This phase 3 trial is testing an investigational drug called DKF-MA102 (leuprorelin acetate) in men with advanced prostate cancer. The goal is to see if two injections, given 12 weeks apart, can safely lower testosterone levels to a target range, which may help control the cancer…

This trial tests whether elagolix, a hormone-blocking drug, can shrink endometriomas (ovarian cysts caused by endometriosis) and ease severe period pain better than the combined birth control pill. Women aged 18-40 with symptomatic endometriomas (2-5 cm) will take either elagolix…

This trial is testing a procedure called HIPEC, where a heated chemotherapy drug (cisplatin) is delivered directly into the abdomen after surgery to remove visible cancer. The goal is to find the safest dose that can be used in patients with advanced ovarian, fallopian tube, or p…

This trial compares two surgical strategies for managing placenta accreta, a condition where the placenta grows too deeply into the uterine wall and can cause severe bleeding during delivery. One approach is a caesarean hysterectomy, which removes the uterus after the baby is bor…

This trial tests whether giving a fluorescent dye called indocyanine green during endoscopic surgery helps surgeons remove non-functioning pituitary macroadenomas more completely. About 34 adults with these tumors will be randomly assigned to receive the dye or not during surgery…

This virtual trial tests whether a daily prebiotic and probiotic supplement can relieve symptoms of bacterial vaginosis and yeast infections, such as itching, odor, and abnormal discharge. Women aged 25 and older with these concerns will take two capsules daily for 30 days. The s…

This study looked at whether taking 12 mg of estradiol daily is better than 8 mg for preparing the uterus lining in women undergoing frozen embryo transfer. 850 women aged 18-40 were randomly assigned to one of the two doses. The goal was to see if the higher dose leads to more p…

This phase 1 trial is testing whether adding the antiviral drug Vistide (cidofovir) to the standard combination of radiation and chemotherapy can improve outcomes for people with HPV-positive cervical cancer. The idea is that Vistide may make cancer cells more sensitive to radiat…

This trial tests whether a dye called indocyanine green, viewed with near-infrared imaging, can help surgeons spot pelvic lymph nodes during robot-assisted prostate removal in men with stage II prostate cancer. The dye is injected into the prostate, and the imaging system is used…

This trial tests whether microscopic surgery to repair varicoceles (enlarged veins in the scrotum) works better than antioxidant medication for men with cryptozoospermia—a condition where very few sperm are present in semen. About 69 men with clinical varicoceles will be randomly…

This early-phase study tested an experimental drug called COM902, alone or with other drugs, in 94 people with advanced cancers like ovarian, lung, and colon cancer. The main goal was to check safety and find the right dose. Researchers also looked for early signs that the drug m…

This trial tests whether injecting platelet-rich plasma (PRP) into the penis, taking a daily oral erectile dysfunction medication (tadalafil 5 mg), or using both together can better improve erectile function in men with organic erectile dysfunction. About 75 men who have had the …

This study tests whether giving an anti-inflammatory drug (anti-TNFα) a few days before a frozen embryo transfer can help women with endometriosis who have had a failed IVF cycle get pregnant. The trial involves 145 participants and compares the clinical pregnancy rate to standar…

This study compares three treatments for early HIV infection: zidovudine (AZT) alone, alpha-interferon alone, or both together. It aims to see which best lowers viral load, protects the immune system, and delays the first serious infection. About 180 adults with early HIV and hea…

This study in Zambia is testing whether community-based and streamlined models of antiretroviral therapy (ART) care can help people living with HIV stay in treatment. It involves about 3,100 HIV-positive adolescents and adults who are not acutely ill. Participants may receive car…

This early-stage trial is testing whether combining two experimental immunotherapy drugs, zalifrelimab and balstilimab, can help shrink or control advanced solid tumors, including cervical cancer. The drugs are designed to block different 'brakes' on the immune system, potentiall…

This Phase 2 trial tests whether drinking three cups of ArtemiCoffee (made from the Artemisia annua plant) daily for 24 weeks can lower PSA levels in 20 men whose prostate cancer has returned after initial treatment. The goal is to see if at least half of the men experience a 50%…

This trial tests whether a structured, pharmacist-led medication management program can help HIV patients at high risk of drug-related problems take their medications more consistently. Participants are randomly assigned to usual care, a basic program, or an enhanced program with…

This study looked at whether giving heated chemotherapy directly into the abdomen during a second-look surgery is possible for people with ovarian, fallopian tube, or peritoneal cancer. Ten participants who had already received standard treatment were enrolled. The goal was to se…

This trial tests whether adding platelet-rich plasma (PRP) to standard surgery for pelvic organ prolapse improves pelvic floor muscle strength and reduces the chance of prolapse returning. Forty women with stage II or higher prolapse will be randomly assigned to receive either PR…

This phase 3 trial is testing a drug called setmelanotide in people with obesity linked to certain gene variants (POMC, PCSK1, LEPR, NCOA1, or SH2B1). About 296 participants, aged 6 to 65, will receive either the drug or a placebo to see if it helps reduce body weight. The study …

This trial tests a community-based program called VINA STEAM, designed to help gay and bisexual men in Ho Chi Minh City cope with stress and HIV-related stigma. Participants join small peer-led groups to build skills that may reduce minority stress and stigma. The study measures …

This phase II trial is testing whether the chemotherapy drug eribulin, given alone or combined with the immunotherapy pembrolizumab, can help people with ovarian or uterine carcinosarcoma that has returned or progressed. The study aims to see if these treatments can shrink tumors…

This study looked at whether adding metformin, a diabetes drug, to standard tuberculosis (TB) treatment is safe and tolerable for people also living with HIV. 112 adults with TB and HIV took either standard TB medicines alone or with metformin for 11 weeks. Researchers monitored …

This study in Zambia evaluates whether dedicated 'viremic clinics'—where people with HIV who have high viral loads receive extra support from a team of healthcare providers—can improve viral suppression. The trial includes 548 participants aged 15 and older who have been on first…

This phase II trial tested two immunotherapy drugs, durvalumab and tremelimumab, in 100 women with ovarian, fallopian tube, or peritoneal cancer that had come back or stopped responding to platinum-based chemotherapy. The study compared giving the drugs together versus one after …

This trial tests two approved antibiotics—azithromycin (a single dose) and doxycycline (twice daily for a week)—to see which is more effective at curing genital chlamydia in young people aged 12-21 living in youth correctional facilities. Participants provide urine samples over a…

This early-stage trial tests the safety and tolerability of two experimental injectable drugs (capsid inhibitors) in 85 healthy adults. Participants receive a single dose or multiple doses of the drug or a placebo. The goal is to see if these drugs are safe enough to study furthe…

This study tested a drug called trametinib in 260 people with low-grade ovarian or peritoneal cancer that returned or worsened. Trametinib works by blocking certain enzymes that help cancer cells grow. The goal was to see if it works better than standard treatments like hormone t…

This study tested a drug called leuprorelin to control central precocious puberty, a condition where children start puberty too early. About 80 children received an injection every 12 weeks for 6 months. The goal was to suppress hormones that drive early puberty, helping children…

This trial investigates whether combining two laparoscopic procedures—resection rectopexy and sacrocolpopexy—can safely and effectively treat women who have both pelvic organ prolapse and obstructive defecation syndrome (a type of chronic constipation). The study will enroll 35 w…

This trial tests whether injecting platelet-rich plasma (PRP) — a concentrate made from a person's own blood — into the penile plaque can reduce curvature and ease symptoms in men with Peyronie's disease. Half the participants receive PRP injections and half receive a placebo (sa…

This trial tests whether portable thermal ablation devices, designed for low-resource settings, can treat cervical precancer as effectively as standard cryotherapy. Women aged 18 and older with high-grade cervical precancer will receive either cryotherapy or thermal ablation with…

This pilot study tested whether women with kidney infections could safely stop antibiotics once their symptoms resolved, instead of taking a full 10-day course. 35 women were randomly assigned to either standard treatment or a patient-directed approach. The main goal was to see i…

This trial tests whether a 7-day antibiotic course—starting with an intravenous dose of ceftriaxone followed by oral cefixime—can effectively treat acute uncomplicated pyelonephritis (a kidney infection) in women aged 18 to 65. The goal is to see if this shorter regimen works as …

This study tested a shorter course of a chemotherapy combination called EPOCH-R in 68 people with HIV and a type of lymphoma. The goal was to see if reducing the amount of chemotherapy could still control the cancer while causing less damage to the immune system. Participants rec…

This phase 3 trial asks whether a dolutegravir-based HIV regimen works as well as or better than an efavirenz-based regimen in pregnant women living with HIV-1. The study compares how well each treatment suppresses the virus at delivery and checks safety for both mothers and thei…

This trial tests whether a daily supplement called WeNatal For Him can improve markers of male fertility, including sperm quality, testosterone levels, energy, and libido. Forty men aged 30 and older who report low energy and low libido will take three capsules each morning for t…

This phase 2 trial tests the drug cabozantinib in women with advanced or metastatic cervical cancer that has worsened after platinum-based chemotherapy. The study aims to see if cabozantinib can control the disease and how safe it is, particularly regarding risks like fistulas. P…

This trial compares two surgical procedures—bipolar enucleation of the prostate (BEEP) and bipolar TURP (bTURP)—for treating benign prostatic hyperplasia (BPH) in men with prostates larger than 80 grams. Researchers measure how much prostate tissue remains after surgery, changes …

This trial tests whether a daily dietary supplement called WeNatal For Her can improve markers of female fertility in women who are trying to conceive. Forty women aged 18-45 will take three capsules each morning for three menstrual cycles. Researchers will measure blood levels o…

This trial compares an oral antibiotic called linezolid to the standard penicillin injection for treating early syphilis. Linezolid can reach the brain, which may help prevent neurosyphilis. About 224 adults with primary, secondary, or early latent syphilis will be randomly assig…

This study looked at whether inositol, a natural supplement, can improve ovulation in women with polycystic ovary syndrome (PCOS) who did not respond to the fertility drug letrozole. 36 women aged 18-35 took part. The researchers compared inositol to metformin, another common tre…

This study tested a program called SYV (The Voice of Youth) to see if supporting mental health helps young people with HIV take their medication regularly. 690 youth aged 10-24 in Tanzania took part. The goal was to improve viral suppression by addressing mental health challenges…

This trial tests whether a web-based app called Game Plan can help men who have sex with men reduce heavy drinking and sexually transmitted infections. Participants receive home HIV/STI self-testing kits and are randomly assigned to either a 24-hour helpline alone or the helpline…

This trial compares two ways to make the first incision for laparoscopic surgery in women with endometrial cancer: the standard umbilical entry versus entry through the Lee-Huang point, a spot on the upper left abdomen. The goal is to see which approach leads to fewer complicatio…

This trial tests whether taking a specific probiotic supplement (Lactobacillus crispatus Lc-G22) alongside standard antifungal treatment can help prevent repeat vaginal yeast infections. One hundred women with a history of frequent yeast infections will receive either the probiot…

This trial tests whether a soft balloon (Cook's balloon) placed in the cervix is better than a vaginal medication (dinoprostone) for starting labor in full-term pregnancies where the baby is growing slowly. The main goal is to see which method leads to more vaginal deliveries and…

This trial tests whether a personalized ventilation strategy, guided by electrical impedance tomography (EIT), can reduce lung complications in men undergoing robot-assisted prostate removal. During this surgery, the abdomen is inflated with gas and the patient is tilted head-dow…

This trial tests an experimental drug, RSO-021, given directly into the chest cavity of people with malignant pleural effusion—a buildup of fluid around the lungs caused by advanced solid tumors or mesothelioma. The study aims to find a safe dose and check for early signs that th…

This study monitors the safety and effectiveness of the drug olaparib (Lynparza) in people with ovarian, breast, prostate, or pancreatic cancer who are prescribed it as part of routine care in South Korea. Researchers will track side effects and how long the cancer stays under co…

This trial tests whether giving small cash payments to HIV-positive pregnant women in Nigeria can encourage them to stay in care and reduce the chance of passing HIV to their babies. Women who register their pregnancy, pick up their medication, deliver at a clinic, and get their …

This study tested a new strategy: giving TB prevention medicine at the same time as TB testing to people with HIV starting or restarting antiretroviral therapy. The goal was to see if this approach gets more people on TB prevention quickly without missing active TB cases. The tri…

This trial investigates whether a single injection of platelet-rich plasma (PRP), made from a person's own blood, can reduce pain and improve function in chronic patellar tendinopathy (knee tendon pain). The study includes 29 adults aged 18–65 who have had tendon pain for over th…

This trial compares two surgical methods for repairing distal hypospadias, a birth defect where the urethral opening is on the underside of the penis. One technique is called glandular urethral disassembly (GUD), and the other is the tubularized incised plate (TIP) method. The st…

This trial investigates an experimental oral drug, LY3143921 hydrate, which blocks a protein called Cdc7 that cancer cells need to divide. It is being tested in adults with advanced solid tumours, including colorectal, ovarian, lung, and pancreatic cancers, that have not responde…

This trial evaluates the Bitrack robotic system, designed to assist surgeons during laparoscopic kidney removal (partial or total) and prostate removal. The study includes 15 adults scheduled for these surgeries. The goal is to check if the robot works safely and effectively, as …

This clinical trial investigates whether different dosing schedules of tadalafil or tamsulosin, when combined with a 5-alpha reductase inhibitor, can better manage urinary symptoms and preserve sexual function in men with benign prostatic hyperplasia (BPH). The study includes 240…

This study surveys HIV-positive adults who switch from taking two or three pills to a single pill containing the same three medicines (tenofovir, emtricitabine, and efavirenz). Researchers want to know if the simpler regimen improves how well patients take their medication, how t…

This phase II trial tests whether combining two hormone-blocking drugs — onapristone and anastrozole — can shrink tumors or slow cancer growth in women with hormone-receptor-positive endometrial cancer that has not responded to prior chemotherapy. Onapristone blocks progesterone …

This study tests two approaches to help people recently involved with the justice system start HIV prevention or treatment and substance use care. One group gets standard patient navigation; the other can choose from a menu of services including in-person clinics, a mobile health…

This trial tests an experimental drug called enfortumab vedotin, which is designed to seek out and destroy cancer cells that have a specific protein called Nectin-4 on their surface. The study includes people with metastatic urothelial cancer (a type of bladder cancer) and other …

This study tests whether a virtual environment (VE) can help minority men who have sex with men and are living with HIV adopt healthier behaviors to prevent cardiovascular disease. Participants use a computer-based virtual world to access educational quests and other features. Th…

This study tests whether extremely low birth weight infants (born before 29 weeks) who receive donor human milk during their hospital stay have better brain development than those given preterm formula. Infants whose mothers cannot or choose not to breastfeed are randomly assigne…

This phase 3 trial investigates whether the antibiotic linezolid can cure yaws, a bacterial skin infection that causes ulcers, as effectively as the standard treatment azithromycin. The study involves 384 children aged 5 to 18 with confirmed yaws. Participants receive either line…

This trial compares two surgical methods—carbon dioxide laser ablation and electrocoagulation—for removing genital warts in women. The main goal is to see which technique gives a better cosmetic result six weeks after treatment. Researchers also track operation time, complication…

This early-phase trial tests whether injecting tiny particles called extracellular vesicles, derived from bone marrow stem cells, directly into the ovary is safe for women with premature ovarian failure. The study includes 10 women aged 20–38 who have had no menstrual period for …

This study compares two surgical approaches for laparoscopic hysterectomy in women with benign or premalignant uterine conditions. One method uses a single incision through the belly button, while the other uses three to four small abdominal cuts. The goal is to see which techniq…

This phase 4 trial tests whether a daily combination of myo-inositol and D-chiro-inositol (with folic acid) can improve menstrual regularity and hormone levels in women with polycystic ovary syndrome (PCOS). Sixty women aged 18–45 with PCOS will receive either the inositol combin…

This study looks at whether CABENUVA, a long-acting injectable HIV medication, is safe and effective for people with HIV who also have severe kidney impairment, including those on dialysis. Participants receive the drug as monthly or every-2-month injections. The goal is to see h…

This study tests a care model where hospitalized adults with opioid use disorder and a serious infection receive long-acting injectable buprenorphine from their infectious disease doctors, alongside infection treatment. The goal is to keep patients on effective medication for opi…

This phase 3 trial investigates whether the drug tolvaptan can safely and effectively correct low sodium levels in patients with hyponatremia, a condition where the body's sodium-water balance is off. The study enrolls adults with mild to moderate hyponatremia who are either euvo…

This study tests whether the drug tolvaptan can safely bring sodium and water levels back to normal in people with low blood sodium (hyponatremia). Participants take a daily tablet or a placebo for a set period. The trial focuses on patients whose hyponatremia is due to excess bo…

This study is testing whether men can safely use tadalafil 5 mg (Cialis) for erectile dysfunction without a prescription. Participants will use a digital health survey to check if the drug is right for them before buying it. The goal is to see if people follow dosing instructions…

This clinical trial tests an investigational drug called tunodafil hydrochloride, taken as a tablet about one hour before sexual activity. The study enrolls men aged 18 to 65 with erectile dysfunction who have a stable female partner. Over 12 weeks, researchers measure changes in…

This study tests a new drug called pegilodecakin, a lab-made version of a natural immune protein (interleukin-10), in people with advanced solid tumors such as melanoma, lung, breast, prostate, ovarian, kidney, colorectal, and pancreatic cancers. The drug is given as a daily shot…

This clinical trial tests whether adding the immunotherapy drug pembrolizumab (Keytruda) to the standard hormone therapy enzalutamide (Xtandi) helps men with a type of advanced prostate cancer called metastatic castration-resistant prostate cancer (mCRPC). The study includes men …

This study tests a new long-acting growth hormone called ACP-001, given as a once-weekly injection, in children with growth hormone deficiency. It compares the safety and effectiveness of this weekly shot to the standard daily growth hormone injections over six months. The goal i…

This phase II trial investigates whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy (carboplatin and paclitaxel) improves outcomes for people with advanced stage III-IV ovarian, fallopian tube, or primary peritoneal cancer. The study aims to s…

This trial investigates whether taking a postbiotic supplement daily for four weeks can help ease symptoms of vaginal yeast infections in women. Participants are sexually active women with a confirmed yeast infection. The study compares the postbiotic to a placebo to see if it im…

This phase 3 trial tests a long-acting growth hormone called TransCon hGH, given as a once-weekly injection, in about 150 children with growth hormone deficiency. The study aims to see if the weekly shot is safe and helps children grow at a normal rate. All participants receive t…

This phase 3 trial tests whether a once-weekly injection of TransCon hGH works as well as daily growth hormone injections in prepubertal children with growth hormone deficiency. About 150 children who have not received growth hormone treatment before will receive either the weekl…

This study tests a long-acting growth hormone called TransCon hGH, given as a once-weekly injection, in children with growth hormone deficiency who have already completed a prior TransCon trial. The goal is to see if the weekly shot remains safe and effective over the long term. …

This phase 3 trial investigates whether a once-weekly injection of lonapegsomatropin, a long-acting growth hormone, can safely and effectively treat adults with growth hormone deficiency. The study compares the weekly drug against a placebo and a standard daily growth hormone pro…

This phase 2 trial tests an experimental drug called LDP, an anti-PD-L1 monoclonal antibody that helps the immune system attack cancer cells. It enrolls adults with muscle-invasive bladder cancer, non-clear cell kidney cancer, or advanced penile cancer. Participants receive LDP i…

This study tests whether combining the immunotherapy drug ipilimumab with the hormone therapy degarelix, given before and after prostate removal surgery, can control advanced prostate cancer. It includes two groups: men with newly diagnosed cancer that has spread to a few other s…

This early-stage trial is testing a combination of two lab-made antibodies in people with advanced solid tumors that have not responded to standard treatments. One antibody (LDP) aims to reactivate the immune system against cancer, while the other (CDP1) blocks a growth signal on…

This phase II trial tests whether the drug RAD001 can shrink or slow the growth of tumors in people with recurrent endometrial cancer. Participants take RAD001 daily by mouth. The study measures how many patients have their tumors shrink or stay stable, and also tracks side effec…

This study tests different ways to help people with HIV take their medication regularly. Researchers will enroll 534 people starting HIV treatment in Cape Town. They will use a device to track pill-taking and try different outreach methods, like calls or texts, to support adheren…

This study tests a program called Maisha (Swahili for 'life') that aims to reduce HIV stigma among pregnant women and their male partners entering antenatal care in Tanzania. The program includes a video and counseling session before HIV testing, plus extra support for those who …

This trial tests a community-based approach to HIV prevention for young people aged 15-30 in rural KwaZulu-Natal, South Africa. Peer navigators guide participants to mobile clinics that offer sexual health services, including HIV testing, PrEP, and contraception. The goal is to r…

This trial compares two types of hormone injections given before prostate brachytherapy (internal radiation) for early-stage prostate cancer. One injection lasts one month, the other three months, and both are used to lower testosterone to make radiation more effective. The study…

This study tests whether a secure website with educational sessions, goal-setting, and tracking tools can help survivors of several cancers (including breast, prostate, colorectal, and others) improve their diet, increase physical activity, and manage weight. Participants are age…

This study tests a mobile app designed specifically for Black adults living with HIV who smoke daily. The app includes culturally tailored content and anxiety-reduction techniques to support quitting. Participants are randomly assigned to use either the tailored app or a standard…

This trial tests whether combining a hormone-releasing IUD with an anchoring IUD can prevent the device from slipping out of place in women with adenomyosis, a condition that causes pelvic pain and heavy bleeding. The study includes 270 women with different uterine cavity depths,…

This trial compares three modern radiotherapy techniques—helical tomotherapy and two types of dynamic arc therapy (RapidArc and VMAT)—for treating prostate, cervical, and anal canal cancers that require pelvic lymph node irradiation. The goal is to determine which method is most …

This study tests a combination of three chemotherapy drugs—gemcitabine, oxaliplatin, and paclitaxel—in people with advanced testicular cancer that has not responded to standard cisplatin-based treatment or has returned after treatment. The goal is to see if this drug combination …

This study tests whether using continuous positive airway pressure (CPAP) or positive end-expiratory pressure (PEEP) during resuscitation helps extremely low birth weight infants (born before 28 weeks) breathe better and avoid lung damage. Half of the babies receive standard care…

This study tests a new way to help vulnerable people with HIV get diagnosed and start treatment right away using a mobile screening unit. Participants receive the once-daily pill Biktarvy on the same day they are enrolled. The goal is to see if this approach helps them stay in ca…

This study investigates whether having a full bladder during intrauterine insemination (IUI) can improve pregnancy rates. The idea is that a full bladder straightens the uterus, making it easier to place sperm correctly using ultrasound guidance. The trial compares this approach …

This study tests whether adding darolutamide to standard hormone therapy (ADT) helps Chinese men with a high-risk form of prostate cancer that has not spread but is no longer responding to hormone therapy alone. Darolutamide blocks the effects of male hormones on cancer cells, po…

This study tested whether letrozole (a drug that lowers estrogen) and L-carnitine (a natural supplement) could improve sperm quality in 90 men with unexplained infertility. Participants took one of the treatments or a combination for three months. The goal was to see changes in s…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This small, completed Phase 1 study tested a single injection of a radioactive drug called Lutetium-177 BQ7876 in 7 men with prostate cancer. The main goals were to see how the drug spreads in the body, how much radiation reaches tumors, and whether it is safe. Because it is very…

This early-stage trial tested a DNA vaccine called NWRD08 in 9 women with high-grade cervical lesions caused by HPV types 16 or 18. The vaccine was given as a shot followed by a mild electrical pulse to help cells take it up. The main goal was to check safety and see if the vacci…

This phase 3 trial tested whether adding bevacizumab (Avastin) to standard chemotherapy (gemcitabine and cisplatin) helps people with advanced urinary tract cancer live longer. 506 patients with cancer that had spread or could not be removed by surgery took part. The study compar…

This phase 2 trial tested a combination of two drugs—paclitaxel (given intravenously and directly into the abdomen) and oral nilotinib—in 21 adults with cancers that had spread to the lining of the abdomen and could not be surgically removed. The goal was to see if the treatment …

This phase 2 trial tested phenelzine sulfate (Nardil), an antidepressant, in 26 men with prostate cancer that returned after initial treatment but hadn't spread. The goal was to see if the drug could lower PSA levels, a marker of cancer activity. Researchers measured how many pat…

This study tested the drug pembrolizumab (Keytruda) as a follow-up treatment for one patient with a rare type of ovarian cancer called small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). The goal was to see if the drug could help keep the cancer from coming back. Beca…

This study tested the drug delamanid in 37 children with multidrug-resistant tuberculosis (MDR-TB), some of whom also had HIV. The goal was to see how the drug works in the body, check for side effects, and find the right dose. Children took delamanid along with their regular TB …

This study tested the safety and effectiveness of enzalutamide (Xtandi) in 52 Indian men with metastatic castration-resistant prostate cancer that had worsened after chemotherapy. Participants took enzalutamide daily while continuing hormone therapy. The main goal was to see how …

This study tested a herbal extract from a Himalayan plant (Nepeta adenophyta) in 116 women with PCOS. Participants took either the herb, the standard drug metformin, or both for 4 months. The goal was to see if the herb could help restore regular menstrual cycles and improve meta…

This study tested whether giving a higher dose of radiation specifically to the visible tumor inside the prostate could improve cancer control in men with localized prostate cancer. Eighty-five men either received a standard radiation plan with an extra boost to the tumor or a co…

This study tested a new type of PET/MRI scan that uses a special tracer to find small spots of prostate cancer that standard scans miss. Men with a rising PSA after prostate surgery and radiation received targeted radiation to those spots. The goal was to see if this approach can…

This pilot study tested whether waiting 30-45 seconds before clamping the umbilical cord, instead of clamping immediately, is feasible and might improve blood health in extremely low birth weight premature infants (24-27 weeks gestation). 54 infants were enrolled. The goal was to…

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This study tests an oral medication called LUM-201 in children with growth hormone deficiency who have not yet received treatment. The goal is to see if taking a pill daily can improve growth as effectively as standard daily injections. The trial also looks for a way to identify …

This study tests a combination of three HIV drugs (amprenavir, lopinavir, and ritonavir) in patients whose current treatments are no longer working. The goal is to see if this new mix can lower the amount of HIV in the blood over 26 weeks. Participants are HIV-positive adults who…

This study looked at when to start giving a drug called rhTPO to cervical cancer patients whose platelet levels drop during chemoradiation. The goal was to see if starting treatment earlier could prevent severe low platelet counts. Researchers studied 75 patients and compared two…

This trial compares a once-daily combination of three HIV drugs (emtricitabine, didanosine, and efavirenz) to the standard multi-pill regimen containing a protease inhibitor. The goal is to see if the simpler daily pill works just as well at keeping the virus undetectable, while …

This study tested a once-daily combination of three HIV drugs (FTC, ddI, efavirenz) in 39 adults who had never taken HIV medication before. The goal was to see if this simpler, once-a-day pill routine worked well and had fewer side effects than older treatments. Participants had …

This study compares a new formulation of the chemotherapy drug doxorubicin (Doxopeg) to the standard version (Caelyx) in people with advanced ovarian cancer or metastatic breast cancer. The goal is to see if the two drugs are absorbed and processed by the body in the same way. Pa…

This completed phase 2 trial tested whether the drug cediranib, given with chemotherapy, is safe for women with advanced ovarian cancer who are at risk of bowel obstruction. 30 participants received the combination. The study focused on whether the treatment caused serious bowel …

This completed Phase 3 study compared the risk of major heart problems between two hormone therapies—relugolix (a pill) and leuprolide (an injection)—in 387 men with prostate cancer. The trial was stopped early by the sponsor, but enrolled patients could continue treatment for up…

This study tested a new immunotherapy called Olvi-Vec, which uses a modified virus to attack cancer cells, in 46 patients with ovarian cancer that had come back or stopped responding to standard treatments. The goal was to see if the treatment was safe and could slow tumor growth…

This Phase 3 trial tested whether taking Elagolix (a hormone-blocking pill) for two months before IVF could improve live birth rates in women with endometriosis. 103 women participated, and the main goal was to see if more babies were born after this pre-treatment. The study comp…

This study compares two ways of injecting BOTOX into the prostate for men with benign prostatic hyperplasia (BPH) who still have bothersome urinary symptoms despite medication. One group receives BOTOX only in the prostate gland, while the other gets injections in the prostate, b…

This early-phase trial tested a new type of vaccine made from a patient's own immune cells (dendritic cells) that are engineered to target a protein called WT1 found in many cancers. Ten people with advanced esophageal, pancreatic, ovarian, or liver cancer received six vaccines o…

This study tested a natural product called FPT-20 in 16 men with sperm production problems due to testicular inflammation. Participants took one tablet daily for 6 to 12 months. The goal was to see if the supplement could increase sperm count and improve semen quality.

This study tested a new type of radiation therapy that adjusts the treatment plan daily based on the patient's anatomy. It included 15 women with endometrial or cervical cancer who had surgery and needed radiation. The goal was to see if smaller treatment margins could be used sa…

This early-phase study tested whether adding indomethacin, a common anti-inflammatory drug, to standard platinum-based chemotherapy is safe for people with colorectal, esophageal, or ovarian cancers. The 13 participants received escalating doses of indomethacin alongside their ch…

This completed Phase 4 trial tested the HIV drug Biktarvy in 202 people who were newly diagnosed with HIV and had low CD4 counts (under 200), meaning they started treatment late. Participants received either Biktarvy or a standard three-drug combination. The main goal was to see …

This study compared two surgical approaches for early-stage cervical cancer: laparoscopic-assisted (minimally invasive) and open abdominal hysterectomy. Sixty women with stage IA1 to IB1 cervical cancer were randomly assigned to one of the two surgeries. Researchers measured surg…

This study tested whether personalized text message reminders can help young people with HIV take their medication consistently. 210 participants from 12 clinics received either standard care or tailored text reminders for 6 months. The goal was to see if the texts improved medic…

This study tested the drug pravastatin in 21 HIV-positive people with high cholesterol who were already on HIV medications. The goal was to see if pravastatin could safely lower their cholesterol without affecting their HIV treatment. Participants received either pravastatin or a…

This study tested whether daily cassava root and sesame seed granules, along with nutrition education, could improve the nutritional health of adults with HIV. Sixty-four participants took part, receiving either the granules plus education or education alone for 16 weeks. The goa…

This study tested three different ways to help people living with HIV stop smoking. Over 670 patients from 13 HIV clinics in Hanoi took part. Nurses either referred patients to a quitline, provided counseling, or offered counseling plus nicotine gum. The goal was to see which met…

This phase 2 trial tested two immunotherapy drugs, nivolumab and ipilimumab, in 10 patients with aggressive pituitary tumors that worsened after surgery and radiation. The goal was to see if the combination could shrink tumors or slow their growth. Researchers also monitored side…

This study tested a device called NanoKnife to treat prostate cancer in 121 men with intermediate-risk disease. The goal was to safely destroy cancer tissue while avoiding major side effects. Researchers checked if the treated area was cancer-free after 12 months and tracked any …

This early-stage trial tested a new drug called PF-07257876 in 29 people with advanced lung, head/neck, or ovarian cancers that had stopped responding to other treatments. The drug is a bispecific antibody designed to help the immune system attack cancer cells. The main goals wer…

This large Phase III trial tested whether adding the drug bevacizumab to chemotherapy works better when the chemo is given into a vein (IV) or directly into the belly (IP). It involved 1560 people with advanced ovarian, fallopian tube, or peritoneal cancers. The goal was to see w…

This study tested a stepped-care program where trained non-specialists provided mental health support and HIV medication adherence help to 280 people in rural Zimbabwe. Participants had both depression and high HIV viral loads. The goal was to see if this approach could improve v…

This study tested a new drug called XTX202 in 95 people with advanced solid tumors that had not responded to standard treatments. The goal was to check safety, find the right dose, and see if the drug could shrink tumors. The trial is now complete.

This study tested whether taking a probiotic called Lactobacillus crispatus LCr86 by mouth could improve vaginal health in women with an intermediate vaginal microbiome. 80 women participated, taking either the probiotic or a placebo for 8 weeks. Researchers measured changes in v…

This phase II trial tested a combination of three drugs—carboplatin, cabazitaxel, and abiraterone—in 61 men with high-volume metastatic prostate cancer that still responds to hormone therapy. The goal was to see how many men had no cancer growth after one year. The study also tra…

This study tested a new technique to help women with primary ovarian insufficiency (early ovarian failure) become pregnant. Doctors removed one ovary, treated small pieces of it with drugs to wake up dormant eggs, and then transplanted the tissue back into the patient. After moni…

This study looked at 156 men with mild to mild-moderate erectile dysfunction who had not responded well to previous treatments. Half received platelet-rich plasma (PRP) injections into the penis plus a daily 5 mg tadalafil pill, while the other half got PRP injections alone. The …

This early-phase trial tested whether combining shockwave therapy with platelet-rich plasma (PRP) injections can improve erectile function in men with microvascular erectile dysfunction. Fifty-nine men received either the combination treatment or a sham procedure. The main goal w…

This study looked at whether adding a drug called epirubicin to the standard two-drug chemotherapy (paclitaxel and carboplatin) helps people with advanced endometrial cancer. Sixty patients were enrolled to see if the three-drug combo is better at controlling the disease before s…

This study followed 354 men with low- to intermediate-risk prostate cancer who chose to freeze only the cancerous half of their prostate (hemi-gland cryoablation). Researchers tracked how well the treatment controlled the cancer and how it affected urinary function and quality of…

This study tested the safety and how the body processes the HIV drug dolutegravir in newborns whose mothers have HIV. A total of 48 mother-infant pairs from four countries participated. Infants received either a liquid or tablet form of the drug during their first weeks of life, …

This early study tested a lab-made antibody called 3BNC117-LS in 43 people, some with HIV and some without. The goal was to see if it is safe and how long it stays in the body. If it works, this antibody might one day help control HIV with less frequent dosing.

This study tested a new X-ray monitoring technique (KIM) during prostate cancer radiation therapy. The goal was to see if it helps doctors aim more precisely at the tumor while reducing harm to healthy tissue. 49 men with low- or intermediate-risk prostate cancer took part. The a…

This phase 2 trial tested whether the immunotherapy drug pembrolizumab (Keytruda) could help keep cancer from growing in people with platinum-resistant ovarian, fallopian tube, or peritoneal cancer. After initial chemotherapy with paclitaxel, 20 participants received pembrolizuma…

This study looked at 80 children with a type of hypospadias (a birth defect where the urine opening is not at the tip of the penis) who had a narrow urethral plate. The researchers compared two different surgical repair methods to see which had fewer complications and better cosm…

This phase I trial tested a new type of radiation therapy for low- and intermediate-risk prostate cancer that delivers a higher dose each day, completing treatment in just 5 sessions over 2 weeks instead of the usual 45-48. The study enrolled 120 participants to check the safety …

This study tested whether a combination of two chemotherapy drugs, gemcitabine and cisplatin, can shrink tumors in people with advanced or metastatic penile cancer. Fifty adults with inoperable or spreading disease took part. The main goal was to see how many patients responded t…

This pilot study tested a new, shorter radiation schedule (ultra-hypofractionation) in 13 men with early-stage prostate cancer. The goal was to see if this approach causes fewer urinary side effects while still controlling the cancer. Participants had low- to intermediate-risk pr…

This study tested whether adding a prostate cancer vaccine (PROSTVAC) and chemotherapy (docetaxel) to standard hormone therapy works better than hormone therapy alone for men whose prostate cancer has spread. 74 men with metastatic castration-sensitive prostate cancer took part. …

This study tested whether people with HIV who have high immune cell counts (CD4 above 500) can safely take antiretroviral drugs in 6-month cycles—6 months on treatment, then 6 months off—instead of taking them every day. The goal was to see if this approach could keep their immun…

This trial tests whether a vaginal self-sampling device can accurately detect high-risk human papillomavirus (HPV) compared to samples collected by a clinician. About 1,000 women aged 30-64, either regular screening attendees or those who haven't been screened in 3+ years, will p…

This study evaluates a disposable, at-home PCR test that detects chlamydia and gonorrhea from a urine sample. Men aged 14 and older collect their own sample and use the test with app or written instructions. The goal is to see if the test works accurately outside a clinic, potent…

This trial tests whether a new PET/CT tracer, 64Cu-SAR-bisPSMA, can find more sites of prostate cancer recurrence than the standard 68Ga PSMA-11 scan in men whose PSA rises after prostate removal. Fifty men will receive both scans, and researchers will compare how many lesions ea…

This trial is testing whether 3D ultrasound can diagnose placenta accreta spectrum more accurately than the standard 2D ultrasound with color Doppler. Placenta accreta is a serious pregnancy condition where the placenta grows too deeply into the uterine wall, which can cause seve…

This study tests a special dye that makes prostate cancer cells glow during surgery. About 22 men with aggressive prostate cancer will receive the dye before their prostate removal surgery. Surgeons will use a special camera to see the glowing cancer, helping them remove more of …

This study is testing whether a simple blood test can help doctors tell apart two main causes of intrauterine growth restriction (IUGR) — a condition where a baby grows slower than expected in the womb. The test measures the ratio of two proteins, sFlt-1 and PlGF, which are linke…

This trial explores whether specially trained dogs can identify high-risk prostate cancer by smelling urine samples. Men with suspected prostate cancer will provide urine samples, which six dogs will sniff. The study will compare the dogs' accuracy against MRI results and biopsy …

This study looks at which tests work best to find early signs of HPV-related cancer in the cervix or anus of people living with HIV. About 1,586 participants from Mexico and Puerto Rico will be tested using different methods, including HPV tests and cell samples. The goal is to c…

This trial tests whether a green dye, injected during keyhole surgery to remove benign ovarian cysts, can show how well the ovary is still getting blood flow. The idea is that better blood flow might mean the ovary is healthier and more likely to support a future pregnancy. Women…

This trial tests whether a new hybrid tracer, ICG-99mTc-nanoscan, can replace the standard tracer for sentinel node biopsy in people with penile cancer, melanoma, or oral cancer. The hybrid tracer combines a fluorescent dye with a radioactive marker, potentially allowing surgeons…

This large registry study is testing whether a special type of PET scan, called PSMA-PET, can better detect where prostate cancer has returned after initial treatment. Thousands of men with suspected recurrent prostate cancer across Ontario will receive this scan. The goal is to …

This study compares a new rapid point-of-care test for chlamydia, gonorrhea, and mycoplasma genitalium to standard lab testing. The goal is to see if the faster test helps doctors give the right antibiotics on the same day, reducing unnecessary or missed treatments. Participants …

This completed phase 1 trial tested a radioactive imaging agent called [99mTc]Tc-DB8 in 10 people with prostate or breast cancer. The goal was to see how the agent spreads in the body and whether it can help detect tumors using SPECT scans. Researchers also checked for safety and…

This completed phase 1 study tested a new radioactive imaging agent called 99mTc-RM26 in 10 people with prostate or breast cancer. The goal was to see how the agent spreads in the body and whether it can help spot tumors using SPECT scans. Researchers also checked for safety and …

This completed Phase 1 study tested a new radioactive imaging agent called [123I]I-DARPIN-Ec1 in 10 people with lung or ovarian cancer. The goal was to see how the agent spreads in the body and whether it can help spot tumors on SPECT scans. Researchers compared the new scan resu…

This completed Phase 1 study tested a new radioactive tracer called [99mTc]Tc-BQ0413 in 10 men with prostate cancer. The tracer was injected once, and SPECT scans were taken over 24 hours to see where it goes in the body and how safe it is. The goal is to develop a better imaging…

This study tested two new technologies—optical genome mapping and long-read DNA sequencing—against standard chromosome tests in 350 people with infertility, intellectual disability, birth defects, or miscarriage. The goal was to see if these newer methods can find more chromosome…

This study tests a special SPECT imaging agent that seeks out a protein called LRRC15, found on many aggressive cancers like pancreatic, breast, lung, and brain tumors. The goal is to see if this scan can help doctors diagnose and stage these cancers more accurately. Healthy volu…

This study tested a new blood test called EPISPOT to find prostate cancer cells in the blood of 361 men with localized prostate cancer before they received any treatment. The goal was to see if this test could predict remission better than an existing test called CellSearch. The …

This study tested whether a special MRI technique called susceptibility weighted imaging (SWI) can better detect endometriosis lesions before surgery. Endometriosis spots often contain old blood, which SWI is good at seeing. Researchers compared SWI-MRI findings with what surgeon…

This study looked at whether women would be willing to collect their own urine sample for cervical cancer screening instead of a traditional swab. 173 women aged 31-49 at a French hospital tried it and answered questions about their experience. The goal was to see how acceptable …

This study tested a new MRI method that measures temperature changes in the prostate. The goal is to help doctors find cancer more accurately and guide laser treatments. Researchers scanned 70 men who already needed an MRI for prostate cancer diagnosis. The focus was on checking …

This study tested an AI software called Quantib Prostate to see if it can detect prostate cancer on MRI scans as accurately as expert radiologists. Researchers looked at 200 men who had prostate MRIs and biopsies. The AI's readings were compared to the radiologist's readings, usi…

This completed study looked at 251 women with infertility who had a hysterosalpingography (HSG) — an X-ray test that checks if the fallopian tubes are open. The researchers compared three different ways of doing the test: using a metal cannula, an active balloon, or a passive bal…

This study tested whether specially trained dogs can identify breast, lung, prostate, or colorectal cancer by sniffing breath samples collected on masks. Over 1,300 people provided breath samples before their regular cancer screening or biopsy. The dogs' results were compared to …

This study tested two different radioactive tracers (68Ga-RM2 and 68Ga-PSMA-617) used in PET/CT scans to see which one better detects prostate cancer in men scheduled for prostate removal surgery. Twenty-two men with low, intermediate, or high-risk prostate cancer received both s…

This study in Addis Ababa, Ethiopia, tests whether giving protein supplements only to pregnant women who are undernourished can prevent problems like low birth weight and stillbirth. Over 6,700 pregnant women are randomly assigned to receive supplements either universally or only…

This study looks at whether US women at risk for HIV can and will take Truvada, a daily pill that prevents HIV infection. Researchers will measure how well women stick to the pill regimen over 24 weeks and explore their attitudes toward this prevention method. The goal is to see …

This study followed 40 women at high genetic risk for ovarian cancer due to BRCA mutations or strong family history. One group chose to have their ovaries and fallopian tubes removed to prevent cancer, while the other group opted for regular CA-125 blood tests every 3 months to c…

This study tests a program called Tu'Washindi, designed by and for young women in Kenya. It combines support clubs and community sessions to help girls ages 15-24 reduce intimate partner violence and consistently use HIV prevention pills (PrEP). About 1,562 participants will be f…

This study tests two ways to prevent HIV: a rectal gel used before sex and daily pills. About 150 men will try each method for 8 weeks to see which is safer, easier to use, and more acceptable. The goal is to give people more choices for on-demand HIV prevention.

This study tested a program where trained peer navigators (women with similar experiences) helped women in the criminal justice system access HIV prevention services like PrEP. The goal was to reduce stigma and improve linkage to care. Thirty women participated, and the study mea…

This trial tests a program designed for Latino fathers to help them reduce risky sexual behaviors, substance abuse, and domestic violence, and improve communication with their sons. The program combines two behavioral interventions: one that teaches fathers about HIV prevention a…

This study tests a program called 'Health is Wealth: A Cervical Health Program' designed to encourage cervical cancer screening among African American and Sub-Saharan African immigrant women. Participants attend a two-hour educational session and receive an HPV self-sampling kit …

This trial tests a tablet-based decision support tool designed to help women learn about their HIV risk and prevention options, including PrEP. Women aged 18-45 who are not living with HIV will be randomly assigned to use the tool before a clinic visit or to receive standard coun…

This study tests a culturally tailored program to prevent chronic diseases like diabetes, high blood pressure, and obesity in Latino men over 50 living with HIV. Participants meet with a community health worker, join group walking sessions three times a week, and discuss pleasant…

This study tests whether training influential members of social networks to talk about PrEP can encourage more African-American men who have sex with men to use it. Half of the recruited networks will have their leaders trained to share accurate PrEP information and counter misco…

This study tests whether limiting daily eating to an 8–10 hour window can improve metabolic health and potentially lower the risk of endometrial cancer. Overweight or obese Native Hawaiian/Pacific Islander women at elevated risk will follow a time-restricted eating schedule for s…

This study compares different ways of screening pregnant women for three common sexually transmitted infections (chlamydia, gonorrhea, and trichomonas) to see if treating these infections can reduce the risk of preterm birth and low birth weight. Over 2,200 pregnant women in Sout…

This study tests a program called Start the Conversation, designed to help Black cisgender women learn about and start taking PrEP—a daily pill that prevents HIV. The program includes training for gynecology residents to discuss PrEP with patients, plus a social media campaign. R…

This study tests a counseling program called ACTPrEP, designed to help young Black men who have sex with men (ages 18-34) start and continue taking PrEP, a daily pill that prevents HIV. The program uses acceptance and commitment therapy to address thoughts and feelings that might…

This study looked at 363 women with a history of three or more miscarriages who carry a specific gene mutation (MTHFR C677T). Researchers compared two treatments during pregnancy: aspirin plus folic acid, or the same plus a blood thinner (enoxaparin). The goal was to see which ap…

This study looks at how often cisgender women in Kenya need to take the HIV prevention pill Truvada (TDF-FTC) to keep protective drug levels in their blood. Participants are randomly assigned to take 2, 4, or 7 doses per week for up to 16 weeks, and their drug levels are measured…

This study tests whether a proven HIV prevention education program can be delivered through Facebook to reach high-risk rural women in Appalachia. Participants are women leaving jail who have a history of drug use and risky sexual behavior. The goal is to see if social media can …

This study tested whether a couples-focused counseling and testing program could help prevent HIV and improve care. 544 couples from rural South Africa took part. The goal was to see if this approach increases viral suppression and engagement in HIV care.

This study looked at whether an extract from banana flower stamens could help prevent benign prostatic hyperplasia (BPH), a non-cancerous enlargement of the prostate that can cause urinary problems. Fifty men aged 40 to 80 with mild to moderate symptoms took part. Researchers mea…

This study tested whether taking the tuberculosis prevention drug isoniazid for 36 months instead of the usual 6 months could better prevent TB in adults with HIV. Nearly 2,000 participants in Botswana were randomly assigned to either short or long treatment. The goal was to see …

This study evaluated a program called PALMS that uses live movement and sound to teach HIV prevention to high-risk minority male teens aged 12-18 in juvenile justice or drug treatment centers. The goal was to see if the program reduces risky sexual behaviors and encourages HIV te…

This study tests whether a non-ablative radiofrequency treatment can improve vaginal tissue health and reduce symptoms of Genitourinary Syndrome of Menopause (GSM), such as dryness and discomfort, in postmenopausal women. Participants will be randomly assigned to receive either t…

This study tested whether a medication reminder app on smartphones helps women undergoing IVF remember to take their injections. Researchers compared 387 patients who used the app with those who did not, tracking how often they forgot doses, their satisfaction, and the number and…

This study tested a fractional carbon dioxide laser treatment for women with vaginal and urinary symptoms like dryness, burning, pain during sex, and incontinence. One hundred women received three laser sessions about six weeks apart. The main goal was to see if symptoms improved…

This study tested a daily dietary supplement (DITTO Cycle Supplement) in 40 women aged 18-45 who regularly experience period symptoms like cramps, bloating, fatigue, and mood swings. Over three menstrual cycles, researchers tracked changes in symptom severity and quality of life …

This trial tests whether removing the urinary catheter and vaginal pack about 6 hours after pelvic organ prolapse surgery—instead of the usual 1-2 days—helps women recover faster. Researchers will compare time to first urination, walking ability, hospital stay length, and patient…

This early-stage trial is testing whether a topical solution containing calcitriol, a form of vitamin D, can safely reduce hair loss in adults receiving taxane-based chemotherapy for breast, gynecologic, or other solid tumors. Participants apply the solution to their scalp twice …

This study looks at whether cooling the mouth with popsicles during chemotherapy can reduce taste changes in prostate cancer patients. About 60 people starting a type of chemo called taxane will be asked to suck on popsicles during their infusion. The goal is to see if this simpl…

This study compared two types of ultrasound-guided nerve blocks (caudal block and dorsal penile block) to control pain after hypospadias repair in 62 boys aged 1-6 years. The main goal was to see how long it took before children needed extra pain medicine. The results could help …

This trial tests whether a 12-week structured physiotherapy program—including stretching, aerobic jogging, Kegel exercises, and relaxation—can reduce the severity of period pain in 360 female physical therapy students with primary dysmenorrhea. Participants are randomly assigned …

This study tests four different vaginal treatments (estrogen, DHEA, estrogen with probiotics, and a moisturizer) in 160 breast cancer patients who have vaginal atrophy due to hormone therapy. The goal is to see which treatment best relieves symptoms like dryness and pain, and imp…

This study tests whether placing ice inside the rectum before a prostate biopsy can lower pain, anxiety, stress hormone levels, and complications like bleeding. About 84 men having their first prostate biopsy will either receive standard care or ice application. The goal is to se…

This trial tests whether using a virtual reality headset can reduce pain, improve comfort, and ease psychological symptoms in boys aged 6-12 after hypospadias surgery. Half the children will play a car racing game in VR for 15 minutes shortly after surgery, while the other half r…

This trial tests whether combining breathing exercises with core stabilization exercises relieves menstrual pain better than core exercises alone. It enrolls 48 women aged 18–25 with primary dysmenorrhea, who will attend supervised sessions three times a week for eight weeks. Res…

This study tests a type of brain stimulation called accelerated theta burst stimulation (a form of TMS) to see if it can lower cravings for methamphetamine in people living with HIV. Thirty adults aged 18-65 with HIV and a history of meth use will receive the treatment. The goal …

This study tests a psychosocial program called Conquer Fear Support (CFS) for people with stage III or IV lung or gynecologic cancer who are experiencing fear of cancer progression. The program includes psychoeducation, attention training, worry management, and detached mindfulne…

This trial tests whether an ultrasound-guided erector spinae plane block can reduce pain and the need for opioids during and after cesarean sections in women with placenta accreta, a condition where the placenta grows too deeply into the uterine wall. Participants will receive th…

This study looks at whether a program called prehabilitation—which helps patients get stronger and healthier before surgery—can lower the chance of problems after surgery for advanced ovarian cancer. About 146 women having surgery for ovarian cancer will take part. The goal is to…

This study tested whether a mobile app that teaches patients about prostate surgery can improve their experience. 68 patients were split into two groups: one used the app, the other received standard care. Researchers measured anxiety, fear, pain, and satisfaction before and afte…

This study tested whether a TENS unit, a small device that sends mild electrical pulses through the skin, can reduce pain during endometriosis flares. Forty women with surgically confirmed endometriosis tracked their pain for three months without the device, then for three months…

This study looks at whether giving a local anesthetic to the abdominal wall at the start of robotic prostate surgery, rather than at the end, can reduce the amount of strong painkillers (opioids) needed during the operation. About 50 adults with prostate cancer or benign prostate…

This trial tests whether drinking lavender herbal tea twice daily for nine days around each menstrual cycle can reduce the emotional and physical symptoms of premenstrual syndrome (PMS), such as anxiety, depression, stress, and pain. Sixty women with PMS will be randomly assigned…

This trial investigates whether adding electroacupuncture to a daily nutritional supplement can reduce the severity of premenstrual syndrome (PMS) in young women aged 20 to 29. Participants receive either the supplement alone or the supplement plus 21 sessions of electroacupunctu…

This trial tests whether Ningmitai, a traditional Chinese medicine used for urinary issues, can reduce pelvic pain in men with chronic prostatitis. About 240 men aged 18-60 with long-term pelvic discomfort will receive either Ningmitai alone, the painkiller celecoxib alone, or bo…

This trial tests whether adding two surgical steps—suspending the urethra and rebuilding pelvic fascia—during robot-assisted prostate removal can help men regain urinary continence sooner. About 60 prostate cancer patients will receive the modified procedure and be followed for t…

This trial investigates whether a 20-minute warm-water footbath containing magnesium sulfate can reduce pain in women with primary dysmenorrhea (painful periods). Around 120 women aged 18–35 are randomly assigned to receive the magnesium footbath, a plain warm-water footbath, or …

This phase 2 trial tests whether giving the sedative dexmedetomidine during pituitary tumor surgery can dampen the body's stress response and improve early recovery. About 64 adults with non-functioning pituitary adenomas undergoing endoscopic transsphenoidal surgery will be rand…

This phase II trial tests whether flibanserin, a drug approved for low sexual desire in women, can increase sexual interest in men with prostate cancer who are receiving androgen deprivation therapy (hormone therapy). About 44 men will be randomly assigned to take flibanserin or …

This pilot study tests a digital decision aid designed for people who have experienced sexual assault and are considering HIV post-exposure prophylaxis (PEP). The tool helps patients and providers weigh risk, effectiveness, side effects, and personal priorities together. Research…

This study investigates whether performing progressive muscle relaxation exercises before an endometrial biopsy can help reduce pain, lower anxiety, and improve comfort in premenopausal women. Participants will be women aged 40 or older with irregular cycles who need this biopsy.…

This study explores whether combining mindfulness meditation with transcutaneous nerve stimulation (TENS) can reduce foot pain in people living with HIV who have peripheral neuropathy. Participants use a home TENS device and practice guided meditation over several weeks. The goal…

This study investigates whether a 12-week program of tai chi and qigong (called Body Mind Training) can reduce fatigue in male cancer survivors aged 55 and older. Participants are randomly assigned to the mind-body training, a light exercise-only group, or a usual-care group. Res…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can reduce menstrual pain, depression, and anxiety in young women with primary dysmenorrhea (painful periods without an underlying condition). Participants receive either real or sham stimula…

This study investigates whether an extract from snakehead fish (Ophiocephalus striatus) can reduce menstrual pain in teenage girls with primary dysmenorrhea—cramps without an underlying disease. The trial gives participants either the fish extract or a placebo for 14 days before …

This study tested whether ear acupressure (small pellets on specific ear points) plus basic breast care can reduce pain and blocked milk ducts in women after cesarean delivery. 72 new mothers with blocked ducts received either real ear acupressure or a sham version for 3 days, al…

This pilot study tests a new way to treat urinary symptoms caused by an enlarged prostate. Using 3D ultrasound guidance, doctors insert a thin needle through the skin between the scrotum and anus to deliver microwave heat directly to the overgrown prostate tissue. The approach ai…

This study investigates whether a 60-minute web-based education program can reduce infertility-related distress and improve fertility readiness in women undergoing intrauterine insemination (IUI) treatment. The program covers fertility basics, diagnostic methods, medications, and…

This study compared two surgical techniques for treating benign prostatic hyperplasia (BPH): bipolar enucleation and thulium laser enucleation. Sixty men with large prostates (80 grams or more) were randomly assigned to one of the two procedures. Researchers measured operation ti…

This study tested a drug called M701, given directly into the belly, combined with standard cancer therapy, for people with malignant ascites (fluid buildup) from stomach, colon, or ovarian cancer. The goal was to see if M701 could delay the need for fluid drainage and improve su…

This study tests whether high-intensity laser therapy (HILT) can reduce pain during intercourse for women with provoked vestibulodynia, a condition causing severe pain at the vaginal opening. About 145 women with moderate to severe pain will receive either real or sham laser trea…

This trial investigates whether daily seed cycling capsules can reduce common PMS symptoms like cramps, bloating, fatigue, and mood swings. Forty women aged 18 to 45 with a history of menstrual symptoms will take the capsules for two menstrual cycles and report changes through qu…

This study tests whether a podcast-based education program can reduce the severity of premenstrual syndrome (PMS) symptoms and improve quality of life in female university students. Participants listen to eight podcast episodes over four weeks that cover topics like understanding…

This study tested two non-surgical treatments for pelvic organ prolapse (POP) in 28 women: a special electromagnetic chair (HIFEM) and pelvic floor exercises with biofeedback. Both were compared to usual care (lifestyle advice). The goal was to see which approach better eases sym…

This trial tests whether a shorter-acting spinal anesthetic (prilocaine) helps pregnant women recover feeling and movement faster after a cervical stitch procedure compared to the standard drug (bupivacaine). About 129 healthy pregnant women at risk of preterm loss will receive o…

This study looked at whether watching a video through virtual reality goggles with music can reduce pain and improve sleep quality in women with period pain (dysmenorrhea). 77 women aged 15-49 with moderate to severe pain used either VR with music or just music alone for 3 days. …

This study tested whether auricular acupressure (pressing points on the ear) can reduce symptoms of premenstrual syndrome (PMS) in female college students. 66 participants received either real or sham acupressure over 8 weeks. Researchers measured changes in PMS symptoms and qual…

This study tested whether pelvic floor muscle training combined with patient education can improve genital and urinary symptoms in postmenopausal women. Fifty women participated in an 8-week program that included progressive exercises and information sessions. Researchers measure…

This pilot study tested a 6-session therapy called Goal-Focused Emotion Regulation Therapy (GET) in 35 young Latino testicular cancer survivors aged 18-39. The therapy helps participants set goals, manage emotions, and find meaning after cancer. Researchers measured anxiety, depr…

This study tested whether a special nursing plan (called ERAS) could help women recover after surgery for cervical cancer. 160 women were split into two groups: one got the ERAS nursing plan, the other got standard care. The goal was to see if the ERAS plan could lower the risk o…

This study looked at whether high-intensity interval training (short bursts of hard exercise) can improve physical function and reduce fatigue in adults aged 50-80 living with HIV who are sedentary and tired. Participants were randomly assigned to either high-intensity training o…

This completed study tested hyaluronic acid fillers injected into the penis to increase width and girth in 20 healthy men aged 21 to 65. The main goal was to see if size increased after one year using 3D imaging. The treatment is a temporary cosmetic procedure, not a cure for any…

This study tested three behavioral approaches—sleep restriction, stimulus control, and systematic light exposure—to help gynecologic cancer survivors who have trouble sleeping. 78 participants completed the program, and researchers measured changes in sleep quality and daytime im…

This study tested whether combining motor imagery (mentally practicing movements) with gentle exercise can reduce menstrual pain and improve coordination. Forty-eight women with moderate to severe period pain were split into three groups: one did motor imagery plus exercise, one …

This study compared two treatments for an enlarged prostate (BPH): a newer steam-based procedure called Rezum and a standard surgery called TUEP. Researchers measured how well each improved urinary symptoms, urine flow, and sexual function in 70 men over age 50. The goal was to s…

This study tested whether laughter yoga and sleep hygiene training could help university students with premenstrual syndrome (PMS). 45 female students took part in 4 weekly 45-minute laughter yoga sessions plus sleep hygiene advice. Researchers measured changes in PMS symptoms, s…

This study tested whether a structured cognitive behavioral therapy (CBT) program could reduce psychological distress and improve problem-solving skills in women with vaginismus. Sixty women were randomly assigned to either CBT sessions over three months or routine care. The resu…

This study looked at whether a one-hour hypnosis session, done 5 to 15 days before a hysterectomy for pelvic gynecological cancer, could lower anxiety around the time of surgery. Twenty-nine women participated, and the hypnosis was guided by a trained nurse. The main goal was to …

This study tested whether one-on-one sessions with a trained nurse could help people with resistant hypertension better handle side effects like sexual problems and bladder control issues caused by their blood pressure medications. The goal was to see if this education helps pati…

This study looked at whether acupuncture can reduce pain and improve daily life for women with painful periods (primary dysmenorrhea). 64 women aged 18-35 with regular cycles and moderate to severe pain took part. Researchers measured pain levels and quality of life before and af…

This study tested a 3-month treatment with a combination of vitamin D, green tea extract (EGCG), vitamin B6, and D-Chiro-inositol in 108 women with uterine fibroids who were planning surgery. The goal was to see if the supplement could ease symptoms and possibly help some women a…

This study looked at whether lifestyle changes can help reduce period pain in obese women aged 18 to 25. 67 women with moderate to severe pain took part. Researchers measured pain levels, severity, and other factors before and after the program.

This study explores whether a virtual robot assistant can help Black men recently diagnosed with prostate cancer get the support and information they need. Researchers will ask about 50 participants to use the app and give feedback on how easy and helpful it is. The goal is to se…

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This study asks whether common antacids or multivitamins change how the body absorbs raltegravir, an HIV medication. Healthy adult volunteers will take raltegravir alone and alongside different antacids or a multivitamin, with blood samples measuring drug levels over 12 hours. Th…

This study looks at how often women develop intrauterine adhesions (scar tissue inside the uterus) after having fibroids removed through laparoscopic or open surgery. Researchers will check for adhesions using a small camera inserted into the uterus three months after surgery. Th…

This completed study from the National Institute of Mental Health looked at over 1,500 women to better understand the symptoms of premenstrual syndrome (PMS) and a severe form called PMDD. Researchers used interviews, rating scales, and hormone tests to track mood and behavior ch…

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This study looked at nearly 1,400 people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. The goal was to find the genetic causes and link them to specific symptoms. Researchers used clinical exams and genetic testing to better understand how these dis…

This study looked at 78 women to understand why chronic pelvic pain happens in endometriosis. Researchers examined hormones, immune chemicals, and genes, and how nerves and muscles are involved. Participants included women with endometriosis and pain, those with pain but no endom…

This study followed 1,377 people living with HIV in Liberia over three years to track how the disease progresses and affects their health. Researchers collected blood and urine samples, conducted physical exams, and asked about medications and risk behaviors. The goal was to gath…

This study looked at 460 people with HIV to see what types of cancer they have and why some choose to join cancer clinical trials. Researchers tracked cancers like Kaposi sarcoma, lymphoma, and HPV-related tumors. They also used surveys to learn how HIV and cancer treatments affe…

This study looks at whether a web-based virtual genetics board helps doctors discuss and manage prostate cancer genetics. About 118 healthcare providers, including oncologists and genetic counselors, will use the board and then give feedback through surveys and interviews. The go…

This study looks at genes in men with advanced prostate cancer that has spread and is no longer responding to hormone therapy. Researchers will analyze tissue, blood, and urine samples from 92 patients receiving a drug called abiraterone. The goal is to find genetic changes that …

This study looked at 190 HIV-positive women starting HIV medicines to see how often herpes virus symptoms appear or get worse. Researchers collected blood, urine, and vaginal samples over a year to track virus activity. The goal was to understand why some women have herpes flare-…

This study will give 100 migrant women in Turkey three structured training sessions on sexually transmitted infections, self-efficacy, and reproductive autonomy. Researchers will measure changes in knowledge, confidence, and decision-making compared to a control group. The goal i…

This study aims to understand why testicular cancer sometimes runs in families. Researchers will collect DNA samples and medical information from about 750 people in families with multiple cases of testicular cancer. No treatment is given; the goal is to find genes that increase …

This study looked at 200 people living with HIV in Liberia to compare two tests for latent tuberculosis (TB) infection: a blood test (IGRA) and a skin test (TST). The goal was to see which test works better in this population. Participants had a skin test and their results were c…

This study follows nearly 600 people with Smith-Magenis syndrome (SMS), a rare genetic condition, to track how their health, behavior, and development change over time. Researchers will perform detailed medical exams, genetic tests, and surveys to better understand the syndrome's…

This study collected tissue samples from the tonsils, lymph nodes, bowel, and lungs of HIV patients and healthy volunteers. The goal was to measure the amount of virus and certain immune cells in these tissues during treatment. By comparing samples, researchers hoped to learn mor…

This study aims to develop a program to help people living with HIV in Zambia re-engage with care after they have missed appointments or stopped taking their medication. Many people cycle in and out of HIV care, and returning is a critical moment to prevent future lapses. Researc…

This study tests whether a family-centered developmental care program, called NIDCAP, can improve brain and behavior outcomes in preterm infants born with severe intrauterine growth restriction. The intervention involves weekly observations of each infant's behavior, with persona…

This trial asks whether a single tablet combining three HIV medications (ACC017, emtricitabine, and tenofovir alafenamide) is absorbed by the body just as well as taking the same drugs separately. Healthy adult volunteers will receive both versions in a random order under fasting…

This completed study examined 217 Hispanic people living with HIV in California, Mexico, and Puerto Rico to see if the types of bacteria in the anus are linked to high-risk HPV infection and pre-cancerous lesions. Researchers collected anal swabs and questionnaires to compare mic…

This study examines whether placentas from pregnancies with intrauterine growth restriction (IUGR) have different levels of certain progesterone receptors compared to healthy pregnancies. Researchers will analyze placental tissue collected after delivery from 90 women. The goal i…

This study looks at proteins in the blood of women with ovarian, peritoneal, or fallopian tube cancer who are in remission. The goal is to find a protein pattern, or 'fingerprint,' that signals when the cancer might come back. Researchers followed 119 women with stage III or IV c…

This study tested a document called Voicing My CHOiCES, designed to help young adults (ages 18-39) with serious illnesses like cancer or HIV discuss their care preferences. Participants filled out questionnaires about anxiety, social support, and communication, then reviewed the …

This study looks at how psychological and social factors might help people living with HIV resist self-stigma—the negative feelings and beliefs they may hold about themselves due to their condition. Researchers will survey both patients and their healthcare providers to understan…

This study looked at markers of inflammation, blood clotting, and blood vessel function in 310 HIV-infected adults and healthy volunteers. Researchers collected blood samples to understand how these markers relate to HIV and risks like heart disease or stroke. The goal was to gat…

This study looked at liver fibrosis (scarring) in 127 HIV patients who had high liver enzymes while on antiretroviral therapy. Participants underwent tests like liver biopsy, ultrasound, and CT scans to measure liver damage. The goal was to understand how common and severe liver …

This study investigates whether lymph nodes in the lower abdomen, called the inferior epigastric lymph node basin, might be an early stop for ovarian cancer spreading from the peritoneum. Researchers will biopsy these nodes in 20 patients undergoing surgery for ovarian peritoneal…

This study looks at whether levels of a protein called zonulin, found in blood and semen, differ between infertile men with and without varicocele (enlarged veins in the scrotum). Researchers will measure zonulin in 119 men and compare it with standard semen quality measures like…

This study aimed to develop and test two new questionnaires for people with recurrent urinary tract infections (UTIs). The Recurrent UTI Symptom Scale measures symptom severity, while the Recurrent UTI Impact Questionnaire looks at how the condition affects daily life, work, and …

This study follows about 1,000 adults in South Africa and Uganda who are switching to a common HIV treatment called TLD, which combines three drugs into one pill. The goal is to see how effective TLD is in everyday conditions, not just in controlled trials. If the treatment stops…

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This study tests whether a specially designed play can help reduce stigma around PrEP (pills that prevent HIV) for young women in Kenya. About 160 people, including young women who use PrEP and community members, will watch the play and share their thoughts. The goal is to see if…

This study looks at whether the virus that causes COVID-19 can be found in the semen of men with cancer who are storing sperm before treatment. Researchers will test both the fluid and the sperm cells for the virus and compare results with nasal swabs and blood tests. The goal is…

This study looks at women who have had one cesarean section and are now deciding how to give birth again: trying a vaginal delivery (TOLAC) or scheduling another C-section (ERCD). The goal is to compare the safety of both options for the baby and the mother. Researchers will foll…

This study looked at 14 men with intermediate-risk prostate cancer who were scheduled for prostate removal surgery. Each man received two different types of PET scans to see which one better highlights cancer cells. The goal was to compare the scans' ability to detect and measure…

This trial compares spinal anesthesia (using bupivacaine) with general anesthesia in men undergoing transurethral resection of the prostate (TURP) for benign prostatic hyperplasia. Researchers measure blood clotting and breakdown markers before surgery and at 1 and 24 hours after…

This trial investigates how a single injection of degarelix, a drug that lowers testosterone, affects prostate cancer cells when given just days before prostate removal surgery. Researchers aim to measure changes in cell growth (Ki-67 levels) by comparing biopsy and surgical tiss…

This study tests whether a five-day education program, based on a health promotion model, can improve fertility awareness and preconception knowledge in women aged 18–35 who plan to get pregnant within a year. Participants attend daily 60-minute group sessions for five days. Rese…

This study looks at how cumulative stress and trauma influence alcohol use and HIV self-management in young people living with HIV, ages 18 to 29. Researchers will track drinking patterns and viral load to identify modifiable targets for future interventions. The goal is to find …

Women who become pregnant after weight-loss (bariatric) surgery have a higher chance of delivering smaller-than-expected babies. This study tests whether tracking blood sugar fluctuations with a continuous glucose monitor during each trimester can help predict which babies will b…

This trial investigates whether women with endometriosis have different blood pressure, pain, and platelet responses compared to healthy women. Participants take aspirin or a placebo and undergo handgrip exercise, cold pressor tests, and blood draws. The goal is to understand how…

This observational study tracks patients in Korea who have been prescribed Somavert (pegvisomant) for acromegaly, a condition caused by too much growth hormone. Researchers will monitor side effects and whether patients show clinical improvement during routine treatment. The goal…

This study looks at whether self-compassion—treating yourself with kindness during tough times—helps explain the link between PMS symptom severity and quality of life. Researchers will survey female nursing students aged 18 to 25 who have PMS, measuring their symptoms, self-compa…

This study investigates whether telling others about an HIV diagnosis affects how consistently people take their HIV medications. Researchers believe that disclosure might lead to social support, which could improve adherence. The study follows 120 people with HIV who are already…

This study examines how consistently pregnant women with HIV take their antiretroviral medication during pregnancy and after childbirth. Using electronic monitoring devices, pill counts, and interviews, researchers track changes in adherence and record the barriers and facilitato…

This study looks at whether a woman's expectations before endometriosis surgery influence her pain, disability, and well-being afterward. Researchers follow about 300 women for a year, tracking their symptoms and psychological factors. The goal is to understand why some women sti…

This study looks at what factors increase the risk of a serious complication called anastomotic leakage after ovarian cancer surgery. Researchers will analyze data from 401 patients to build a prediction model. The goal is to help surgeons identify high-risk patients early and ta…

This study looks at two ways to examine the uterine cavity after women have had hysteroscopic surgery for conditions like polyps, fibroids, or a uterine septum. One method is a non-invasive 3D ultrasound; the other is an office hysteroscopy, which involves inserting a small camer…

This study tests a digital education program designed to help newly diagnosed women with gynecological cancer learn about egg freezing (oocyte cryopreservation). The program uses videos, images, WhatsApp, and online meetings to teach about fertility preservation options. Research…

This study follows 67 women with cervical cancer for one year after they finish radiation therapy. Researchers want to see how their quality of life, including physical and emotional well-being, changes over time. Participants fill out questionnaires about symptoms like fatigue, …

This study looks at how proteins in the blood change in women with ovarian cancer as they go through standard treatment. Researchers collected blood samples before surgery, after surgery, and after chemotherapy to see if these protein shifts could give a fuller picture of how the…

This study follows adults in Zambia who have both HIV and chronic hepatitis B to track liver health over up to 10 years. Researchers aim to understand how current HIV treatments affect hepatitis B and liver damage, and to identify factors that lead to serious outcomes like liver …

This study looks at cerebral small vessel disease (CSVD) — damage to tiny blood vessels in the brain that can cause memory loss and disability — in people with HIV over age 50. Researchers want to see if CSVD is linked to blood vessel problems in the eyes and kidneys, which could…

This study looks at how sleep length and quality may affect the success of in vitro fertilization (IVF) in women. Participants will wear a ring-shaped device that tracks sleep patterns before and after a frozen embryo transfer. The goal is to see if sleep parameters like total sl…

This study examines whether two specific ultrasound measurements—the ratio of the transverse cerebellar diameter to abdominal circumference and the ratio of mid-thigh circumference to femur length—can more accurately estimate gestational age in both healthy and growth-restricted …

This study looks at how the womb lining heals after different types of womb-sparing surgery for placenta accreta, a serious pregnancy condition where the placenta grows too deeply into the womb wall. Researchers will use a small camera (hysteroscopy) three months after surgery to…

This study looked at how certain enzymes called matrix metalloproteinases (MMPs) and their inhibitors relate to human papillomavirus (HPV) in cervical dysplasia and cancer. Researchers collected tissue and cell samples from 216 women with different stages of cervical lesions. The…

This completed study looked at whether a simple blood test (liquid biopsy) can help track breast, ovarian, and endometrial cancers. Researchers analyzed circulating tumor cells in 150 women to see if these cells could predict the risk of cancer spreading or how well treatment wor…

This study tested whether Pluvicto, a radioactive drug for prostate cancer, can be safely given through a permanently implanted port (TIVAP) instead of a standard IV. Researchers measured if any drug got stuck in the port in 107 patients. The goal was to see if using the port is …

This completed study looked at a new antibody called anti-SIRPα as a potential immunotherapy for liver cancer. Researchers used blood and tissue samples from 30 liver cancer patients to see how the antibody affects immune cells. The goal was to understand whether blocking the SIR…

This study looked at whether it is safe to skip antibiotics before a prostate biopsy. Researchers followed 1753 men who had a biopsy through the perineum (the area between the scrotum and anus). They compared infection rates in those who did not get antibiotics to existing data f…

This study looked at two ways to help breast and ovarian cancer survivors get genetic counseling: a mailed brochure or a phone call with a health coach. About 668 women took part. The goal was to see which method led more people to actually get genetic counseling or testing. The …

This study looks at whether a score called KELIM can predict how well ovarian cancer patients respond to maintenance treatment with PARP inhibitors after initial chemotherapy. Researchers will analyze data from 243 patients who took part in the PAOLA-1 trial. If KELIM proves usef…

This completed study looked at 80 patients with advanced prostate cancer that had stopped responding to chemotherapy. All patients received a radioactive drug called 177Lu-PSMA-617. Researchers compared two types of scans—PET and SPECT—to see which better tracks changes in tumor …

This study tested two peer education programs to see which better improves nursing students' knowledge, attitudes, and behaviors about sexually transmitted infections (STIs). Thirty-six first-year nursing students were split into two groups: one received a program based on a beha…

This study looked at 294 women with deep endometriosis affecting the rectum. Researchers compared how patients felt after conservative surgery versus more radical bowel removal. The goal was to see which approach leads to fewer bowel and bladder problems and to find factors that …

This study looked at how two types of exercise—high-intensity interval training (HIIT) and continuous moderate exercise—affect sleep and inflammation in 52 older adults with HIV. Participants exercised three times a week for 16 weeks. Researchers measured sleep quality through su…

This study looks at whether a special type of PET scan, using two different tracers, can help predict how aggressive a person's prostate cancer is before surgery. Researchers will use computer models to analyze the scan images and compare the results with standard biopsy and surg…

This study looked at 50 women aged 30–50 who had a cervical conization (a cone-shaped biopsy) to treat abnormal cervical cells. Researchers measured blood flow in the uterine artery before and one month after surgery using Doppler ultrasound. The goal was to see if the surgery ch…

This study tested whether injecting a fluorescent dye called indocyanine green (ICG) into the ureters helps surgeons see them more clearly during laparoscopic surgery for deep infiltrating endometriosis. 51 women with suspected or confirmed deep endometriosis took part. The goal …

This study tested a device called the Alife Hera System, which uses a computer algorithm to score embryos based on images and patient information. The goal was to see if using this score alongside standard methods helps doctors choose the embryo most likely to result in a pregnan…

This study reviewed 1251 intrauterine insemination (IUI) cycles at one hospital to see if the type of fertility drug used or the cause of infertility affected pregnancy rates. Participants were women aged 20-44 with normal ovulation and their partners with adequate sperm. The res…

This study looks at whether the types of bacteria living in the vagina influence how well women recover after surgery for pelvic organ prolapse using a vaginal mesh. Researchers will analyze stored samples from 41 women who had this surgery, comparing those who had complications …

This study looked at 107 women having a first-time cervical procedure (LEEP) for abnormal cells. Researchers compared how local anesthesia (cervical block) versus general or spinal anesthesia affected the size of the removed tissue. The goal was to see if the anesthesia method in…

This study looked at 777 people with HIV in Brazil who failed their first treatment with tenofovir, lamivudine, and dolutegravir. Researchers wanted to understand what types of drug resistance and virus subtypes were involved. The goal is to improve treatment choices for people i…

This study followed 40 women with cervical, uterine, or ovarian cancer to see how their relationship and sexual communication changed from diagnosis to 3 months after treatment. Participants filled out questionnaires about their sexual activity, desire, and discomfort. The goal w…

This study looks at why certain immune cells (CD4 and CD8 T cells) remain activated in people with HIV whose viral load has been undetectable on antiretroviral therapy for at least two years. Researchers are investigating whether a common virus called cytomegalovirus (CMV) or an …

This study tested a new software tool called ACRODAT that helps doctors track disease activity in people with acromegaly. The tool looks at five key factors like hormone levels, symptoms, and quality of life. Researchers compared patients whose doctors used ACRODAT to those recei…

This early-stage trial tested a single injection of JL18008, a lab-made protein designed to boost immune cells, in 40 healthy adults. The main goal was to check safety and how the body handles the drug. Researchers also measured changes in immune cell counts over 56 days. This is…

This study looked at how often thyroid problems (specifically an underactive thyroid) occur in people with HIV. Researchers reviewed medical records of 154 HIV-positive adults who were treated at a French hospital between 2001 and 2012. The goal was to get a clearer picture of th…

This study looked at 49 people with masses in the sellar region of the brain (near the pituitary gland). Researchers compared MRI scans before surgery with the final diagnosis after surgery to see how well imaging predicts the type of tumor. The goal was to improve diagnosis and …

This completed study looked at 59 men who have sex with men and use methamphetamine. Researchers used a program that gives rewards for drug-free urine samples to help them cut back. They measured inflammation in the rectum and tracked STI/HIV risk behaviors over 8 weeks. The goal…

This study looked at 200 men with sperm abnormalities to see if vacuoles (tiny holes) in the sperm head are linked to DNA damage. Researchers used high-powered microscopes and genetic tests to measure vacuole size and chromosome errors. The goal is to help doctors pick healthier …

This study tested whether a nurse navigation program—including education, counseling, and WhatsApp follow-up—could encourage more women aged 30-65 to get screened for cervical cancer. 80 women who were not regularly screened took part. The program aimed to improve their understan…

This study looked at a protein called osteopontin in the blood of pregnant women whose water broke too early (PPROM). Researchers compared 71 women with early rupture to those with normal-term rupture to see if protein levels differ. The goal was to learn more about the biology b…

This study created a massive, secure database of over 14,000 prostate MRI scans from men with or suspected of having prostate cancer. Researchers used this data to train artificial intelligence (AI) models to better tell apart slow-growing from aggressive cancers, predict if canc…

This study looked at how an experimental drug called SHR3680 affects the way the body processes three other common drugs: digoxin, rosuvastatin, and metformin. Thirty-six men with prostate cancer took SHR3680 along with these drugs to see if there were any interactions. The goal …

This study looked at how people living with HIV in rural Uganda experience stigma, including feelings of shame, loss of self-respect, and mistreatment by others. Researchers surveyed 180 adults to understand these experiences better. The goal was to gather information, not to pro…

This study tested a device called Seedchrony that measures a natural chemical in the uterus to see if it can predict whether an embryo transfer will lead to pregnancy. The study involved 92 women undergoing their first IVF cycle. The goal is to find a way to improve the low succe…

This study looked at how not having enough healthy food (food insecurity) can lead to insulin resistance in people living with HIV. Researchers tested a community-based "food as medicine" program that provided healthy food and taught cooking and self-care skills. The goal was to …

This study looked at whether measuring the stiffness of uterine fibroids can help predict how well they respond to a non-invasive treatment called MR-HIFU. Forty women with symptomatic fibroids were enrolled. The goal was to improve patient selection so that only those likely to …

This early-phase trial tested a fluorescent antibody that attaches to prostate cancer cells. Seven men with moderate- to high-risk prostate cancer received the antibody before robotic prostate removal surgery. The goal was to see if the glowing antibody could help surgeons identi…

This study tested a more concentrated version of the long-acting HIV drug cabotegravir in 138 healthy adults. Researchers gave the injection in different ways (into muscle or under the skin) to see how the body processes it and to check for side effects. The goal was to gather sa…

This study tested whether a two-hour, peer-led workshop with religious messages could encourage Muslim women in North East England and Scotland to get screened for breast, bowel, and cervical cancer. 169 women aged 25-74 who were not up-to-date with all eligible screenings took p…

This study collected ultrasound and MRI images from 100 women with endometriosis who were scheduled for surgery. The goal was to create a database that helps doctors better identify and stage the disease using these scans. Participants were aged 18-40, had a clinical diagnosis, a…

This study looked at two ways of giving anesthesia during robotic prostate removal surgery. One method used a low flow of gas (1 liter per minute) and the other used a normal flow (3 liters per minute). The goal was to see which one is better for breathing, heart function, and co…

This study looked at how doctors in Russia treat a specific type of ovarian cancer called HRD-positive. Researchers collected information from 414 patients to understand what treatments they received and how they fared. The goal was to describe real-world practice, not to test a …

This study looked at 384 women having their first C-section to compare two methods of closing the uterus: one layer of stitches vs. two layers. The goal was to see which method leads to better scar healing and fewer problems like pain or irregular bleeding. Researchers used ultra…

Researchers at Stanford University tested a new micro-ultrasound device to see if it can more accurately find and outline prostate cancer. The study involved 95 men scheduled for biopsy or prostate removal. The ultrasound images were compared with standard pathology results to he…

This study looked at genetic changes in prostate cancer samples from 84 men who had surgery. The goal was to find DNA markers that could predict if the cancer would come back or spread. By identifying these markers, doctors may one day better tailor follow-up care and treatment f…

This completed study looked at ways to increase diversity in cancer clinical trials, focusing on breast, liver, and prostate cancers. Researchers worked with communities, doctors, and scientists in New York City to find better ways to include people of color and underserved group…

This study looked at whether a special PET/CT scan, done within two months after treatment, helps doctors make better decisions for patients with advanced cervical cancer. Researchers compared what doctors would decide without the scan versus with it. The study involved 40 patien…

This completed study examined levels of certain proteins and growth factors in the placentas of 48 women with placenta previa or placenta percreta during the third trimester. Researchers measured substances like decorin, laminin, and collagen in placental tissue and blood samples…

This early-phase trial studied how compounds from black raspberries are absorbed and processed in 60 men with prostate cancer who were scheduled for surgery. Participants ate a black raspberry confection and followed a special diet before surgery. The goal was not to treat cancer…

This study looked at how lifestyle factors like diet and health habits affect a couple's ability to conceive. Researchers followed 266 couples planning their first pregnancy, tracking how long it took to get pregnant and any early pregnancy losses. The goal was to better understa…

This study tested a digital health platform to help people with a hereditary risk of breast and ovarian cancer share their genetic test results with family members. Researchers worked with 128 participants in Switzerland and Korea to see if the tool reduced distress and improved …

This study looks at how radiation therapy for brain tumors like meningioma or pituitary adenoma might affect autobiographical memory—the memories of your life events. Researchers will ask 17 patients to complete memory tests one and two years after treatment. The goal is to see i…

This study looked back at 388 women with advanced ovarian, fallopian tube, or peritoneal cancer who were taking the drug niraparib as maintenance therapy. Researchers wanted to see how often serious side effects happened and how patients used the drug in real-life UK clinics. No …

This study looked at 30 women with PCOS who had trouble ovulating. Researchers measured a hormone called AMH while giving low doses of FSH to see if a drop in AMH happens when an egg follicle starts to grow. The goal was to better understand why ovulation fails in PCOS, not to te…

This study looked at 40 women with symptomatic uterine fibroids to understand why MR-guided focused ultrasound (HIFU) works better for some than others. Researchers used MRI and contrast-enhanced ultrasound to measure fibroid blood flow, stiffness, and other features before treat…

This study compared penile length in 200 adult men undergoing cystoscopy under spinal anesthesia versus general anesthesia. Researchers measured length and asked surgeons to rate satisfaction with access. The goal was to see if anesthesia choice affects penile size during the pro…

This study surveyed 385 women aged 35 or younger with early-stage breast cancer to learn their attitudes about the risk of infertility from adjuvant therapy. The goal was to understand how concerns about having children might influence their treatment choices. The results could h…

This study reviewed over 11,000 patients with advanced ovarian cancer to see if hospitals that follow ten specific quality standards for surgery have better outcomes. The research looked at how long patients lived without their cancer getting worse and overall survival. The goal …

This study tested whether an AI tool can help health providers write medical summaries that are easier for patients to understand. 120 providers were split into two groups: one used the AI tool, the other did not. The goal was to see if AI could improve readability and save time,…