Can a hormone drug shrink painful ovarian cysts better than the pill?

NCT ID NCT07763847

Completed Disease control Sponsor: Mst.Sumyara Khatun Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This trial tests whether elagolix, a hormone-blocking drug, can shrink endometriomas (ovarian cysts caused by endometriosis) and ease severe period pain better than the combined birth control pill. Women aged 18-40 with symptomatic endometriomas (2-5 cm) will take either elagolix 150 mg or a birth control pill daily for three months. Researchers will measure changes in cyst size via ultrasound and pain scores using a visual analog scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: elagolix (a hormone-blocking drug) compared with a combined oral contraceptive pill (ethinyl estradiol and desogestrel)
What this could lead to: If elagolix works better than the pill, it could offer a new non-surgical option for shrinking endometriomas and reducing severe period pain.
What could go wrong: This is a small, short-term trial (60 women, 3 months), so results may not last or apply broadly. Elagolix can have side effects like bone thinning and liver issues.

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Conditions

The condition(s) this trial relates to.

endometriosis ovarian endometriosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIOMA

Contacts and locations

Locations

Bangladesh Medical University

Dhaka, Shahbag, 1000, Bangladesh

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