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Which endometrioma treatment best protects fertility?

NCT ID NCT05637073

Terminated Disease control Sponsor: University of Valencia Source: ClinicalTrials.gov ↗

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study compares three common approaches for managing endometriomas (ovarian cysts caused by endometriosis): surgical removal, daily hormone therapy with dienogest, or regular ultrasound monitoring. Researchers will measure how each option affects ovarian reserve—a key marker of fertility—by tracking levels of anti-Mullerian hormone over one year. The study includes premenopausal women aged 18–39 with small to moderate-sized cysts.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Dienogest
What this could lead to
If successful, this study could help women with endometrioma choose a treatment that better preserves their fertility potential.
What could go wrong
This is an observational study, not a randomized trial, so results may be influenced by patient choice. The sample size is small and follow-up is only one year.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endometriosis ovarian endometriosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIOMA

Contacts and locations

Locations

  • Hosp Clinico Universitario-INCLIVA

    Valencia, Valencia, 46010, Spain

  • University Hospital Poznan

    Poznan, Poznan, 60-355, Poland

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