Could an arthritis drug boost IVF success in endometriosis patients?

NCT ID NCT07509411

Completed Disease control Sponsor: Benha University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 12, 2026 · Updated 3 times

Summary

This study tests whether giving an anti-inflammatory drug (anti-TNFα) a few days before a frozen embryo transfer can help women with endometriosis who have had a failed IVF cycle get pregnant. The trial involves 145 participants and compares the clinical pregnancy rate to standard care. The goal is to see if reducing inflammation improves the womb's ability to accept an embryo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TNF-α inhibitor (a drug that blocks inflammation)
What this could lead to: If it works, this could offer a new treatment option to improve pregnancy chances for women with endometriosis who have failed previous IVF attempts.
What could go wrong: This is a small, early-phase trial (145 participants) and results may not apply to all endometriosis patients. The drug may not improve pregnancy rates and could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endometriosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIOSIS

Contacts and locations

Locations

Benha university

Banhā, El Qalyoubia, 13511, Egypt

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