Can aspirin uncover hidden vascular differences in endometriosis?

NCT ID NCT05962034

Completed Knowledge-focused Sponsor: Penn State University Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This trial investigates whether women with endometriosis have different blood pressure, pain, and platelet responses compared to healthy women. Participants take aspirin or a placebo and undergo handgrip exercise, cold pressor tests, and blood draws. The goal is to understand how blood vessel regulation differs in endometriosis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: aspirin (acetylsalicylic acid) and placebo
What this could lead to: If differences in vascular regulation are found, this could point toward new ways to manage pain and cardiovascular risk in endometriosis.
What could go wrong: This is a small, early-stage study with only 21 participants, so results may not apply broadly. Aspirin is generally safe but can cause stomach upset or bleeding risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endometriosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIOSIS

Contacts and locations

Locations

Noll Laboratory

University Park, Pennsylvania, 16802, United States

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