Weekly shot could replace daily needles for kids with growth hormone deficiency

NCT ID NCT02781727

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether a once-weekly injection of TransCon hGH works as well as daily growth hormone injections in prepubertal children with growth hormone deficiency. About 150 children who have not received growth hormone treatment before will receive either the weekly shot or daily injections for 52 weeks. The main goal is to compare how much the children grow over the year. If successful, this could mean fewer injections for children and their families.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
TransCon hGH (lonapegsomatropin)
What this could lead to
If successful, children with growth hormone deficiency could switch from daily injections to a single weekly shot, reducing treatment burden.
What could go wrong
This is a phase 3 trial, but results may not confirm non-inferiority or better safety versus daily hGH. Long-term effects beyond 52 weeks are not yet known.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Ascendis Pharma Investigational Site

    Birmingham, Alabama, 35233, United States

  • Ascendis Pharma Investigational Site

    Little Rock, Arkansas, 72202, United States

  • Ascendis Pharma Investigational Site

    Los Angeles, California, 90048, United States

  • Ascendis Pharma Investigational Site

    Orange, California, 92868, United States

  • Ascendis Pharma Investigational Site

    Centennial, Colorado, 80112, United States

  • Ascendis Pharma Investigational Site

    Jacksonville, Florida, 32207, United States

  • Ascendis Pharma Investigational Site

    Orlando, Florida, 32806, United States

  • Ascendis Pharma Investigational Site

    Saint Paul, Minnesota, 55102, United States

  • Ascendis Pharma Investigational Site

    Jackson, Mississippi, 39216, United States

  • Ascendis Pharma Investigational Site

    Lebanon, New Hampshire, 03756, United States

  • Ascendis Pharma Investigational Site

    Mineola, New York, 11501, United States

  • Ascendis Pharma Investigational Site

    Oklahoma City, Oklahoma, 73104, United States

  • Ascendis Pharma Investigational Site

    Portland, Oregon, 97239, United States

  • Ascendis Pharma Investigational Site

    Dallas, Texas, 75235, United States

  • Ascendis Pharma Investigational Site

    Fort Worth, Texas, 76104, United States

  • Ascendis Pharma Investigational Site

    Tacoma, Washington, 98405, United States

  • Ascendis Pharma Investigational Site

    Yerevan, 0075, Armenia

  • Ascendis Pharma Investigational Site

    Clayton, 3168, Australia

  • Ascendis Pharma Investigational Site

    Minsk, 220020, Belarus

  • Ascendis Pharma Investigational Site

    Varna, 9010, Bulgaria

  • Ascendis Pharma Investigational Site

    Tbilisi, 0144, Georgia

  • Ascendis Pharma Investigational Site

    Tbilisi, 0159, Georgia

  • Ascendis Pharma Investigational Site

    Tbilisi, 0162, Georgia

  • Ascendis Pharma Investigational Site

    Athens, 11527, Greece

  • Ascendis Pharma Investigational Site

    Milan, 20157, Italy

  • Ascendis Pharma Investigational Site

    Roma, 00165, Italy

  • Ascendis Pharma Investigational Site

    Grafton, 1023, New Zealand

  • Ascendis Pharma Investigational Site

    Warsaw, 02-691, Poland

  • Ascendis Pharma Investigational Site

    Iași, 700111, Romania

  • Ascendis Pharma Investigational Site

    Izhevsk, 426009, Russia

  • Ascendis Pharma Investigational Site

    Kazan', 420138, Russia

  • Ascendis Pharma Investigational Site

    Krasnoyarsk, 620022, Russia

  • Ascendis Pharma Investigational Site

    Moscow, 125373, Russia

  • Ascendis Pharma Investigational Site

    Moscow, 127994, Russia

  • Ascendis Pharma Investigational Site

    Nizhny Novgorod, 603136, Russia

  • Ascendis Pharma Investigational Site

    Novosibirsk, 630048, Russia

  • Ascendis Pharma Investigational Site

    Omsk, 644001, Russia

  • Ascendis Pharma Investigational Site

    Saint Petersburg, 191144, Russia

  • Ascendis Pharma Investigational Site

    Saint Petersburg, 194100, Russia

  • Ascendis Pharma Investigational Site

    Samara, 443079, Russia

  • Ascendis Pharma Investigational Site

    Saratov, 410054, Russia

  • Ascendis Pharma Investigational Site

    Tomsk, 634050, Russia

  • Ascendis Pharma Investigational Site

    Ufa, 450008, Russia

  • Ascendis Pharma Investigational Site

    Vologda, 160022, Russia

  • Ascendis Pharma Investigational Site

    Voronezh, 394024, Russia

  • Ascendis Pharma Investigational Site

    Izmir, 35100, Turkey (Türkiye)

  • Ascendis Pharma Investigational Site

    Melikgazi, 38039, Turkey (Türkiye)

  • Ascendis Pharma Investigational Site

    Trabzon, 61080, Turkey (Türkiye)

  • Ascendis Pharma Investigational Site

    Kharkiv, 61093, Ukraine

  • Ascendis Pharma Investigational Site

    Kyiv, 01021, Ukraine

  • Ascendis Pharma Investigational Site

    Kyiv, 04114, Ukraine

  • Ascendis Pharma Investigational Site

    Odesa, 65031, Ukraine

  • Ascendis Pharma Investigatonal Site

    Gdansk, 80-952, Poland

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