Cure My Disease

Don't miss your cure!

 Log in / Sign up

Weekly shot could replace daily needles for kids with growth hormone deficiency

NCT ID NCT03344458

Completed Disease control Sponsor: Ascendis Pharma A/S Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This study tests a long-acting growth hormone called TransCon hGH, given as a once-weekly injection, in children with growth hormone deficiency who have already completed a prior TransCon trial. The goal is to see if the weekly shot remains safe and effective over the long term. About 300 children from several countries are taking part, and all receive the active drug. The main focus is on safety, with growth rate and hormone levels also tracked.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
TransCon hGH (lonapegsomatropin), a once-weekly injection of long-acting growth hormone
What this could lead to
If successful, this could offer children with growth hormone deficiency a more convenient once-weekly treatment instead of daily injections, potentially improving adherence and growth outcomes.
What could go wrong
This is an extension trial, so participants already know the drug is safe and effective in the short term. However, long-term risks are still being studied, and not all children may respond equally.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ENDOCRINE SYSTEM DISEASES are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

endocrine system disorder Failure to Thrive isolated congenital growth hormone deficiency pituitary dwarfism pituitary gland disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOCRINE SYSTEM DISEASES GROWTH HORMONE DEFICIENCY, PEDIATRIC HORMONE DEFICIENCY PITUITARY DISEASES

Contacts and locations

Locations

  • Ascendis Pharma Investigational Site

    Birmingham, Alabama, 35233, United States

  • Ascendis Pharma Investigational Site

    Los Angeles, California, 90048, United States

  • Ascendis Pharma Investigational Site

    Orange, California, 92868, United States

  • Ascendis Pharma Investigational Site

    Sacramento, California, 95821, United States

  • Ascendis Pharma Investigational Site

    Centennial, Colorado, 80112, United States

  • Ascendis Pharma Investigational Site

    Jacksonville, Florida, 32207, United States

  • Ascendis Pharma Investigational Site

    Orlando, Florida, 32806, United States

  • Ascendis Pharma Investigational Site

    Tallahassee, Florida, 32308, United States

  • Ascendis Pharma Investigational Site

    Saint Paul, Minnesota, 55102, United States

  • Ascendis Pharma Investigational Site

    Jackson, Mississippi, 39216, United States

  • Ascendis Pharma Investigational Site

    Lebanon, New Hampshire, 03756, United States

  • Ascendis Pharma Investigational Site

    Mineola, New York, 11501, United States

  • Ascendis Pharma Investigational Site

    New York, New York, 10029, United States

  • Ascendis Pharma Investigational Site

    Cleveland, Ohio, 44195, United States

  • Ascendis Pharma Investigational Site

    Oklahoma City, Oklahoma, 73104, United States

  • Ascendis Pharma Investigational Site

    Portland, Oregon, 97227, United States

  • Ascendis Pharma Investigational Site

    Portland, Oregon, 97239, United States

  • Ascendis Pharma Investigational Site

    Dallas, Texas, 75390, United States

  • Ascendis Pharma Investigational Site

    Fort Worth, Texas, 76104, United States

  • Ascendis Pharma Investigational Site

    Charlottesville, Virginia, 22908, United States

  • Ascendis Pharma Investigational Site

    Norfolk, Virginia, 23507, United States

  • Ascendis Pharma Investigational Site

    Tacoma, Washington, 98405, United States

  • Ascendis Pharma Investigational Site

    Yerevan, 0075, Armenia

  • Ascendis Pharma Investigational Site

    Clayton, Victoria, 3168, Australia

  • Ascendis Pharma Investigational Site

    Minsk, 220020, Belarus

  • Ascendis Pharma Investigational Site

    Varna, 9010, Bulgaria

  • Ascendis Pharma Investigational Site

    Tbilisi, 0159, Georgia

  • Ascendis Pharma Investigational Site

    Athens, 11527, Greece

  • Ascendis Pharma Investigational Site

    Auckland, 1010, New Zealand

  • Ascendis Pharma Investigational Site

    Gdansk, 80-952, Poland

  • Ascendis Pharma Investigational Site

    Warsaw, 02-691, Poland

  • Ascendis Pharma Investigational Site

    Izhevsk, 426009, Russia

  • Ascendis Pharma Investigational Site

    Krasnoyarsk, 660022, Russia

  • Ascendis Pharma Investigational Site

    Moscow, 117036, Russia

  • Ascendis Pharma Investigational Site

    Saint Petersburg, 194100, Russia

  • Ascendis Pharma Investigational Site

    Saratov, 410054, Russia

  • Ascendis Pharma Investigational Site

    Ufa, 450008, Russia

  • Ascendis Pharma Investigational Site

    Vologda, 160022, Russia

  • Ascendis Pharma Investigational Site

    Voronezh, 394024, Russia

  • Ascendis Pharma Investigational Site

    Kharkiv, 61093, Ukraine

  • Ascendis Pharma Investigational Site

    Kyiv, 01021, Ukraine

  • Ascendis Pharma Investigational Site

    Odesa, 65031, Ukraine

More trials for these conditions

Other studies related to the condition(s) this trial covers.