Weekly shot could replace daily growth hormone injections for children

NCT ID NCT03305016

Completed Disease control Sponsor: Ascendis Pharma Endocrinology Division A/S Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This phase 3 trial tests a long-acting growth hormone called TransCon hGH, given as a once-weekly injection, in about 150 children with growth hormone deficiency. The study aims to see if the weekly shot is safe and helps children grow at a normal rate. All participants receive the drug, and the trial lasts 26 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TransCon hGH (a long-acting growth hormone injection)
What this could lead to: If successful, this could offer children with growth hormone deficiency a more convenient once-weekly injection instead of daily shots, potentially improving adherence and quality of life.
What could go wrong: This is a phase 3 trial, but it is open-label (everyone knows they get the drug) and relatively short (26 weeks). Long-term safety and effectiveness are not yet established, and individual results may vary.

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Conditions

The condition(s) this trial relates to.

endocrine system disorder Failure to Thrive isolated congenital growth hormone deficiency pituitary dwarfism pituitary gland disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOCRINE SYSTEM DISEASES GROWTH HORMONE DEFICIENCY, PEDIATRIC HORMONE DEFICIENCY PITUITARY DISEASES

Contacts and locations

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Locations

Center of Excellence in Diabetes and Endocrinology

Sacramento, California, 95821, United States
Children's Diabetes and Endocrine Center

Portland, Oregon, 97227, United States
Children's Hospital of The King's Daughters

Norfolk, Virginia, 23507, United States
Children's Medical Center

Dallas, Texas, 75235, United States
Children's Minnesota

Saint Paul, Minnesota, 55102, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Cook Children's Medical Center

Fort Worth, Texas, 76104, United States
Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Monash Children's Hospital

Clayton, Victoria, 3168, Australia
NYU Winthrop Hospital

Mineola, New York, 11501, United States
Nemours Children's Health System

Jacksonville, Florida, 32207, United States
Neufeld Medical Group Inc.

Los Angeles, California, 90048, United States
Oregon Health & Science University

Portland, Oregon, 97239, United States
Orlando Health Inc.

Orlando, Florida, 32806, United States
Rocky Mountain Pediatric Endocrinology

Centennial, Colorado, 80112, United States
Stollery Children's Hospital

Edmonton, Alberta, T6G 2B7, Canada
Tallahassee Memorial Hospital

Tallahassee, Florida, 32308, United States
The Liggins Institute, The University of Auckland

Grafton, Auckland, 1023, New Zealand
University of Alabama

Birmingham, Alabama, 35233, United States
University of Iowa

Iowa City, Iowa, 52242, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Virginia Children's Hospital

Charlottesville, Virginia, 22903, United States

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