Could a weekly shot replace daily growth hormone for kids?

NCT ID NCT01947907

Completed Disease control Sponsor: Ascendis Pharma A/S Source: ClinicalTrials.gov ↗

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study tests a new long-acting growth hormone called ACP-001, given as a once-weekly injection, in children with growth hormone deficiency. It compares the safety and effectiveness of this weekly shot to the standard daily growth hormone injections over six months. The goal is to see if the weekly option can provide similar growth benefits with fewer injections.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ACP-001 (long-acting growth hormone)
What this could lead to: If successful, this could allow children with growth hormone deficiency to receive treatment with just one injection per week instead of daily shots, improving convenience and quality of life.
What could go wrong: This is an early-phase trial with only 53 participants, so results may not apply to all children. The weekly injection may not work as well as daily therapy, and there could be unknown side effects.

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Conditions

The condition(s) this trial relates to.

isolated congenital growth hormone deficiency pituitary dwarfism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GROWTH HORMONE DEFICIENCY (GHD)

Contacts and locations

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Locations

2nd Children City Clinic

Minsk, Belarus
Ain Shams University Hospital

Cairo, Egypt
Ankara University School of Medicine

Ankara, Turkey (Türkiye)
Bashkir State Medical University

Ufa, Russia
Buda Children's Hospital

Budapest, Hungary
Cairo University Hospital

Cairo, Egypt
Children's Hospital of Athens "P. A. Kyriakou"

Athens, Greece
Children's Memorial Health Institute Warsaw

Warsaw, Poland
Children's University Hospital

Ljubljana, Slovenia
Donetsk Regional Children Clinical Hospital

Donetsk, Ukraine
Ege Üniversity

Izmir, Turkey (Türkiye)
El Mansoura University Hospital

El Mansoura, Egypt
El Shatby University Hospital

Alexandria, Egypt
Emergency Clinical Hospital Cluj-Napoca

Cluj-Napoca, Romania
Federal State Budgetary Institution

Moscow, Russia
Heim Pal Children's Hospital

Budapest, Hungary
Hôpital Femme-Mère-Enfant

Lyon, France
Hôpital Jeanne de Flandre

Lille, France
Hôpital des enfants Pellegrin

Bordeaux, France
Institute of Endocrinology and Metabolism

Kiev, Ukraine
Kharkiv National Medical University

Kharkiv, Ukraine
Louis Turcanu Emergency Hospital for Children Timisoara

Timișoara, Romania
Masaryk´s Hospital

Ústí nad Labem, Czechia
Medical University of Lublin

Lublin, Poland
Odessa National Medical University

Odesa, Ukraine
Regional Hospital N°2 Rzeszow

Rzeszów, Poland
Samara State Medical University

Samara, Russia
St. Petersburg State Pediatric Medical Academy

Saint Petersburg, Russia
St. Spiridon County Clinic Emergency Hospital

Iași, Romania
Ukrainian Children Specialized Clinical Hospital

Kiev, Ukraine
University Children's Hospital Magdeburg

Magdeburg, Germany
University Hospital Leipzig

Leipzig, Germany
University Medical Hospital

Katowice, Poland
University Multiprofile Hospital for Active Treatment (UMHAT) "Sv. Marina"

Varna, Bulgaria
University of Pecs

Pécs, Hungary
University of Szeged

Szeged, Hungary

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