New IUD combo aims to stop displacement in adenomyosis
NCT ID NCT07680985
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This trial tests whether combining a hormone-releasing IUD with an anchoring IUD can prevent the device from slipping out of place in women with adenomyosis, a condition that causes pelvic pain and heavy bleeding. The study includes 270 women with different uterine cavity depths, comparing the combined device to standard IUDs or hormone therapy alone. Participants are followed for 6 months to check device stability and symptom improvement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Levonorgestrel-releasing intrauterine system (LNG-IUS) combined with Indomethacin-GyneFix IUD
What this could lead to
If successful, this approach could reduce IUD expulsion rates, making hormone therapy more reliable for managing adenomyosis symptoms like pain and heavy bleeding.
What could go wrong
This is a single-center study with a 6-month follow-up, so long-term benefits and risks are unknown. The device combination may still fail or cause complications.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Ice Pack for Pain After vNOTES Hysterectomy NCT07626684
- Blood Loss in Laparoscopic Hysterectomy – NCT06875518
- Nociception-Guided Analgesia for Endometriosis S NCT06732050
- Vaginal Repair with Leuprorelin for CSD (NCT05206682)
- Uterine Artery Embolization & Fertility Study (NCT05271981)
- L-PGDS as a Diagnostic Marker for Adenomyosis (NCT06864494)
Contacts and locations
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Locations
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Wenzhou People's Hospital
Wenzhou, Zhejiang, 325000, China