New IUD combo aims to stop displacement in adenomyosis

NCT ID NCT07680985

Completed Disease control Sponsor: Wenzhou People's Hospital Source: ClinicalTrials.gov ↗

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This trial tests whether combining a hormone-releasing IUD with an anchoring IUD can prevent the device from slipping out of place in women with adenomyosis, a condition that causes pelvic pain and heavy bleeding. The study includes 270 women with different uterine cavity depths, comparing the combined device to standard IUDs or hormone therapy alone. Participants are followed for 6 months to check device stability and symptom improvement.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Levonorgestrel-releasing intrauterine system (LNG-IUS) combined with Indomethacin-GyneFix IUD
What this could lead to: If successful, this approach could reduce IUD expulsion rates, making hormone therapy more reliable for managing adenomyosis symptoms like pain and heavy bleeding.
What could go wrong: This is a single-center study with a 6-month follow-up, so long-term benefits and risks are unknown. The device combination may still fail or cause complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adenomyosis Dysmenorrhea Menorrhagia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADENOMYOSIS

Contacts and locations

Locations

Wenzhou People's Hospital

Wenzhou, Zhejiang, 325000, China

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