ADENOMYOSIS

This study tests whether a two-month hormone pretreatment (GnRH agonist plus letrozole) before standard frozen embryo transfer can improve live birth rates in women with adenomyosis. About 222 participants will be randomly assigned to either the new regimen or standard care. The …

This study compares vaginal repair surgery alone versus surgery followed by leuprorelin, a drug that temporarily stops menstruation. The goal is to see if delaying periods helps the scar defect heal better. The trial includes 94 women with cesarean scar defects and adenomyosis wh…

This study looks at whether giving a GnRH agonist before a frozen embryo transfer can help women with endometriosis or adenomyosis get pregnant. About 180 women aged 18 to 36 will be randomly assigned to receive either standard hormone support or standard support plus one or two …

This study is looking at whether a protein called L-PGDS can be used to diagnose adenomyosis, a condition where uterine tissue grows into the muscle wall, causing pain and heavy bleeding. Researchers will measure L-PGDS levels in vaginal swabs, blood, and urine from 60 women with…

This study tests whether a specific ultrasound measurement can reliably detect superficial endometriosis on the uterosacral ligaments. Researchers will compare ultrasound findings with laparoscopic surgery results in 64 women undergoing gynecological surgery. If a clear cutoff th…

This study tests whether injecting the local anesthetic bupivacaine into the small surgical cuts and the vaginal cuff at the end of a laparoscopic hysterectomy can lower postoperative pain. 120 women having the surgery for non-cancer reasons will be randomly assigned to receive t…

This study tests whether a special pain consultation and education session can help women with endometriosis feel more in control of their pain and improve their quality of life. About 110 women will either receive the new consultation plus usual care, or usual care alone. They w…

This study compares robot-assisted hysterectomy to standard laparoscopic surgery for women with deep endometriosis and adenomyosis. The goal is to see which approach leads to fewer complications and better quality of life. 224 participants will be randomly assigned to one of the …

This study is looking at 60 women who are getting a hormone-releasing IUD (LNG-IUD) to see if the timing of insertion during their menstrual cycle affects whether they develop ovarian cysts. Researchers will use ultrasound to check for cysts at 0, 3, 6, and 12 months after insert…

This study follows 5,300 women aged 18-42 with endometriosis or adenomyosis to see if these conditions get worse over time. Researchers track pain, bleeding, fertility, and use imaging to monitor changes. They also explore immune system and gut bacteria links. No new treatment is…

This observational study is recruiting 530 women to better understand endometriosis and adenomyosis. Researchers will analyze genetic, epigenetic, and imaging data, using artificial intelligence to develop better diagnostic tools. The goal is to enable earlier detection and more …