Weekly shot could replace daily hormone injections for growth hormone deficiency

NCT ID NCT04615273

Completed Disease control Sponsor: Ascendis Pharma Endocrinology Division A/S Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This phase 3 trial investigates whether a once-weekly injection of lonapegsomatropin, a long-acting growth hormone, can safely and effectively treat adults with growth hormone deficiency. The study compares the weekly drug against a placebo and a standard daily growth hormone product. Researchers measure changes in body fat and lean muscle mass over 38 weeks to assess the treatment's impact.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lonapegsomatropin (a long-acting growth hormone)
What this could lead to: If successful, this could offer adults with growth hormone deficiency a more convenient once-weekly injection instead of daily shots, potentially improving treatment adherence and quality of life.
What could go wrong: This is a phase 3 trial, so while promising, the long-acting hormone may not prove as effective or safe as daily therapy. Side effects from growth hormone treatment, such as joint pain or fluid retention, remain possible.

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Conditions

The condition(s) this trial relates to.

endocrine system disorder Failure to Thrive isolated congenital growth hormone deficiency pituitary dwarfism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOCRINE SYSTEM DISEASES GROWTH HORMONE DEFICIENCY HORMONE DEFICIENCY

Contacts and locations

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Locations

Ascendis Pharma Investigational Site

Birmingham, Alabama, 35205, United States
Ascendis Pharma Investigational Site

Phoenix, Arizona, 85048, United States
Ascendis Pharma Investigational Site

Fresno, California, 93720, United States
Ascendis Pharma Investigational Site

Los Angeles, California, 90048, United States
Ascendis Pharma Investigational Site

Los Angeles, California, 90095, United States
Ascendis Pharma Investigational Site

Palo Alto, California, 94304, United States
Ascendis Pharma Investigational Site

Torrance, California, 90509, United States
Ascendis Pharma Investigational Site

Chicago, Illinois, 60611, United States
Ascendis Pharma Investigational Site

Indianapolis, Indiana, 46202, United States
Ascendis Pharma Investigational Site

Boston, Massachusetts, 02114, United States
Ascendis Pharma Investigational Site

Dearborn, Michigan, 48126, United States
Ascendis Pharma Investigational Site

Rochester, Minnesota, 55905, United States
Ascendis Pharma Investigational Site

St Louis, Missouri, 63110, United States
Ascendis Pharma Investigational Site

Las Vegas, Nevada, 89148, United States
Ascendis Pharma Investigational Site

Reno, Nevada, 89511, United States
Ascendis Pharma Investigational Site

New York, New York, 10017, United States
Ascendis Pharma Investigational Site

New York, New York, 10021, United States
Ascendis Pharma Investigational Site

Morehead City, North Carolina, 28557, United States
Ascendis Pharma Investigational Site

Portland, Oregon, 97239, United States
Ascendis Pharma Investigational Site

Pittsburgh, Pennsylvania, 15212, United States
Ascendis Pharma Investigational Site

Dallas, Texas, 75390, United States
Ascendis Pharma Investigational Site

San Antonio, Texas, 78232, United States
Ascendis Pharma Investigational Site

Seattle, Washington, 98108, United States
Ascendis Pharma Investigational Site

Yerevan, 0075, Armenia
Ascendis Pharma Investigational Site

Saint Leonards, New South Wales, 2065, Australia
Ascendis Pharma Investigational Site

Sydney, New South Wales, 2109, Australia
Ascendis Pharma Investigational Site

Box Hill, Victoria, 3128, Australia
Ascendis Pharma Investigational Site

Fitzroy, Victoria, 3065, Australia
Ascendis Pharma Investigational Site

Parkville, Victoria, 3050, Australia
Ascendis Pharma Investigational Site

Perth, Western Australia, 6009, Australia
Ascendis Pharma Investigational Site

Vancouver, British Columbia, V6Z 1Y6, Canada
Ascendis Pharma Investigational Site

Halifax, Nova Scotia, B3H 1V7, Canada
Ascendis Pharma Investigational Site

Copenhagen, 2100, Denmark
Ascendis Pharma Investigational Site

Lyon, 69677, France
Ascendis Pharma Investigational Site

Marseille, 13385, France
Ascendis Pharma Investigational Site

Nantes, 44093, France
Ascendis Pharma Investigational Site

Paris, 75013, France
Ascendis Pharma Investigational Site

Tbilisi, 0144, Georgia
Ascendis Pharma Investigational Site

Tbilisi, 0159, Georgia
Ascendis Pharma Investigational Site

München, Bavaria, 80336, Germany
Ascendis Pharma Investigational Site

Athens, Attica, 10676, Greece
Ascendis Pharma Investigational Site

Athens, Attica, 11527, Greece
Ascendis Pharma Investigational Site

Thessaloniki, Central Macedonia, 54636, Greece
Ascendis Pharma Investigational Site

Thessaloniki, 546 42, Greece
Ascendis Pharma Investigational Site

Beersheba, 8410100, Israel
Ascendis Pharma Investigational Site

Haifa, 31048, Israel
Ascendis Pharma Investigational Site

Petah Tikva, 4941480, Israel
Ascendis Pharma Investigational Site

Tel Aviv, 6423906, Israel
Ascendis Pharma Investigational Site

Genova, 16132, Italy
Ascendis Pharma Investigational Site

Rome, 00161, Italy
Ascendis Pharma Investigational Site

Rome, 00168, Italy
Ascendis Pharma Investigational Site

Rozzano, 20089, Italy
Ascendis Pharma Investigational Site

Kobe, Hyōgo, 650-0047, Japan
Ascendis Pharma Investigational Site

Kawasaki, Kanagawa, 211-8533, Japan
Ascendis Pharma Investigational Site

Yokohama, Kanagawa, 222-0036, Japan
Ascendis Pharma Investigational Site

Yokohama, Kanagawa, 236-004, Japan
Ascendis Pharma Investigational Site

Matsumoto, Nagano, Japan, Japan
Ascendis Pharma Investigational Site

Kashihara, Nara, 634-8522, Japan
Ascendis Pharma Investigational Site

Ishikawa, Okinawa, 920-0293, Japan
Ascendis Pharma Investigational Site

Suita, Osaka, 565-0871, Japan
Ascendis Pharma Investigational Site

Chiba, 260-8677, Japan
Ascendis Pharma Investigational Site

Fukuoka, 812-8582, Japan
Ascendis Pharma Investigational Site

Kagoshima, 890-8520, Japan
Ascendis Pharma Investigational Site

Kawasaki, 216-8511, Japan
Ascendis Pharma Investigational Site

Nagakute, 480-1195, Japan
Ascendis Pharma Investigational Site

Okayama, 700-8558, Japan
Ascendis Pharma Investigational Site

Osaka, 550-0006, Japan
Ascendis Pharma Investigational Site

Tokyo, 108-8329, Japan
Ascendis Pharma Investigational Site

Yamagata, 990-9585, Japan
Ascendis Pharma Investigational Site

George Town, 10450, Malaysia
Ascendis Pharma Investigational Site

Kota Bharu, 16150, Malaysia
Ascendis Pharma Investigational Site

Malacca, 75400, Malaysia
Ascendis Pharma Investigational Site

Putrajaya, 62250, Malaysia
Ascendis Pharma Investigational Site

Leiden, 2300, Netherlands
Ascendis Pharma Investigational Site

Palmerston North, Manawatu-Wanganui, 4440, New Zealand
Ascendis Pharma Investigational Site

Wellington, 6021, New Zealand
Ascendis Pharma Investigational Site

Krakow, 31-501, Poland
Ascendis Pharma Investigational Site

Lodz, 93-338, Poland
Ascendis Pharma Investigational Site

Poznan, 60-355, Poland
Ascendis Pharma Investigational Site

Warsaw, 03-242, Poland
Ascendis Pharma Investigational Site

Wroclaw, 50-367, Poland
Ascendis Pharma Investigational Site

Bucharest, 11868, Romania
Ascendis Pharma Investigational Site

Iași, 700106, Romania
Ascendis Pharma Investigational Site

Timișoara, 300723, Romania
Ascendis Pharma Investigational Site

Belgrade, 11000, Serbia
Ascendis Pharma Investigational Site

Kragujevac, 34000, Serbia
Ascendis Pharma Investigational Site

Bratislava, 82606, Slovakia
Ascendis Pharma Investigational Site

Ľubochňa, 3491, Slovakia
Ascendis Pharma Investigational Site

Seoul, 03722, South Korea
Ascendis Pharma Investigational Site

Seoul, 05278, South Korea
Ascendis Pharma Investigational Site

Seoul, 06591, South Korea
Ascendis Pharma Investigational Site

Suwon, 443-721, South Korea
Ascendis Pharma Investigational Site

Alicante, 3010, Spain
Ascendis Pharma Investigational Site

Barcelona, 8035, Spain
Ascendis Pharma Investigational Site

Barcelona, 8041, Spain
Ascendis Pharma Investigational Site

Madrid, 28006, Spain
Ascendis Pharma Investigational Site

Santiago de Compostela, 15706, Spain
Ascendis Pharma Investigational Site

Seville, 41013, Spain
Ascendis Pharma Investigational Site

Ankara, 06560, Turkey (Türkiye)
Ascendis Pharma Investigational Site

Antalya, 07070, Turkey (Türkiye)
Ascendis Pharma Investigational Site

Aydin, 09010, Turkey (Türkiye)
Ascendis Pharma Investigational Site

Izmir, 35100, Turkey (Türkiye)
Ascendis Pharma Investigational Site

İzmit, 41001, Turkey (Türkiye)
Ascendis Pharma Investigational Site

Kayseri, 38039, Turkey (Türkiye)
Ascendis Pharma Investigational Site

Ivano-Frankivsk, 76008, Ukraine
Ascendis Pharma Investigational Site

Kharkiv, 61103, Ukraine
Ascendis Pharma Investigational Site

Kyiv, 03115, Ukraine
Ascendis Pharma Investigational Site

Kyiv, 04001, Ukraine
Ascendis Pharma Investigational Site

Kyiv, 04114, Ukraine
Ascendis Pharma Investigational Site

Vinnytsia, 21010, Ukraine
Ascendis Pharma Investigational Site

Cardiff, CF14 4XW, United Kingdom
Ascendis Pharma Investigational Site

Coventry, CV2 2DX, United Kingdom
Ascendis Pharma Investigational Site

Leeds, LS9 7TF, United Kingdom

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