Reproductive system disorder

This trial tests whether combining two drugs—pucotenlimab, which helps the immune system attack cancer, and becotatug vedotin, which delivers a toxin directly to tumor cells—can eliminate advanced penile cancer before surgery. Men with high-risk, locally advanced penile squamous …

This trial is testing an experimental oral drug, LG00313112, in people with advanced solid tumors that carry a specific genetic change called TP53 Y220C. The drug aims to restore the function of the p53 protein, which normally helps stop cancer growth. The study includes adults w…

This trial tests whether a single, outpatient treatment using low-thermal argon plasma can clear grade 2 cervical intraepithelial neoplasia (CIN2), a precancerous condition. Participants receive either the plasma treatment, a sham procedure, or standard active surveillance. The m…

This phase 2 trial is testing whether the immunotherapy drug sintilimab can eliminate early-stage (I-II) MSI-H/dMMR endometrial cancer without the need for surgery. About 48 participants will receive sintilimab alone every three weeks. The goal is to see if the drug can produce a…

This trial is testing whether a personalized cell therapy can help women with ovarian cancer that has returned. Doctors will remove a tumor, extract immune cells called tumor-infiltrating lymphocytes (TILs), and boost them in the lab before infusing them back into the patient. Af…

This study investigates whether combining two immune checkpoint inhibitors—one targeting GARP:TGF-β1 and another targeting PD-1—can better reactivate and eliminate dormant HIV-infected cells. Using blood samples from people with HIV-1 on suppressive antiretroviral therapy, resear…

This early-stage trial is testing whether experimental HIV vaccines can safely teach the immune system to recognize and fight the virus. Healthy adults without HIV will receive a protein nanoparticle vaccine, followed by a booster—either another protein nanoparticle or an mRNA va…

This study tests an experimental RNA-based vaccine called BNT168 in adults both with and without HIV. The goal is to see if the vaccine is safe, triggers an immune response, and can help control the amount of virus in the body. Participants receive either the vaccine or a placebo…

This study tests a two-part HIV vaccine in healthy adults who do not have HIV. The vaccine uses a DNA 'prime' followed by a protein 'boost' to train the immune system against multiple HIV strains. Researchers are checking if the vaccine is safe and whether it triggers a strong im…

This phase II trial is testing an investigational drug called BL-M09D1 in people with advanced gynecological cancers (such as ovarian, cervical, or endometrial cancer) and other solid tumors that have progressed despite standard treatment. The drug is given by intravenous infusio…

This study tests an experimental drug called ATX-898 in people with advanced solid tumors that have spread or cannot be removed by surgery. The trial has two parts: first, ATX-898 is given alone to find the safest dose; second, it is combined with other anti-cancer drugs to see i…

This trial tests whether a 7-day course of doxycycline can effectively cure asymptomatic anal lymphogranuloma venereum (LGV), a sexually transmitted infection caused by Chlamydia trachomatis. Currently, treatment lasts 21 days, but recent studies suggest a shorter course may work…

This trial tests whether the LapBox Manual Containment System, a double-wall bag used during laparoscopic surgery, can prevent leaks when removing uterine fibroids. About 30 women having laparoscopic hysterectomy or myomectomy will use the device, and surgeons will check for any …

This Phase II trial tests whether an immune-boosting drug (N-803) alone or combined with a vaccine (ETBX-071) can lower PSA levels in men whose prostate cancer has returned after targeted radiation therapy. Participants receive up to eight cycles of treatment and are followed for…

This study offers continued access to tucatinib, an oral targeted therapy, for people with HER2-positive cancers (including breast, cervical, and lung) who were already benefiting from the drug in a previous Pfizer-sponsored trial. The main goal is to monitor long-term safety and…

This trial is testing a new way to deliver radiation therapy for prostate cancer. Instead of standard radiation, it uses MRI to precisely target the tumor, potentially sparing healthy tissue and reducing side effects. The study will include about 20 adults with early-stage prosta…

This Phase 3 trial tests a new biologic drug (PF-08634404) plus chemotherapy against the approved drug Keytruda plus chemotherapy in 600 women with advanced or recurrent pMMR endometrial cancer. The goal is to see if the new combination helps patients live longer without their ca…

This trial tests whether a supervised strength and conditioning program can protect the heart and reduce inflammation in men with prostate cancer who are receiving radiation and hormone therapy. Participants will follow a structured exercise routine, and researchers will measure …

This study tests whether baricitinib, an FDA-approved drug for other conditions, can keep HIV under control after participants stop their usual antiretroviral therapy (ART). Twenty people with well-controlled HIV will take baricitinib alongside ART for 26 weeks, then continue bar…

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …

This phase 2 trial tests a combination of a vaccine (TriAdeno) and an immune-boosting drug (N-803) in 52 men with early-stage, low- or medium-risk prostate cancer who are currently on active surveillance. The vaccine targets three proteins found in prostate cancer cells, while N-…

This trial tests whether transcutaneous tibial nerve stimulation (TTNS), a non-invasive nerve stimulation technique, can improve sexual function and pelvic alignment in women aged 25–35 who have both low back pain and female sexual dysfunction. Participants will receive TTNS alon…

This phase 2 trial is testing an experimental drug called xaluritamig in men with metastatic castrate-resistant prostate cancer who had only a partial or stable response to lutetium-177 therapy. The goal is to see if xaluritamig can shrink tumors or lower PSA levels. About 30 par…

This trial tests a six-session peer-led program called Gwan Enjoy Life for sexual minority men living with HIV in Jamaica. The program aims to reduce depression, anxiety, and loneliness while helping participants stay engaged in HIV care and take their medications. Sixty men will…

This phase 2 trial is testing whether adding relacorilant—a drug that blocks a stress-related hormone—to the chemotherapy nab-paclitaxel can shrink tumors in people with recurrent or metastatic cervical cancer. Participants have already tried platinum-based chemo and immunotherap…

This trial tests whether a new device called Prolieve, which uses microwave heat and balloon dilation, can relieve moderate-to-severe urinary symptoms from an enlarged prostate as effectively as the established UroLift implant procedure. Men aged 50-80 who haven't found relief fr…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This pilot study tests whether adding extra doses of the antibiotic azithromycin to standard care can improve outcomes for pregnant people whose water breaks very early (between 22 and 28 weeks). Thirty participants will be randomly assigned to receive either the standard antibio…

This study tests a device called Vanquish that uses water vapor (steam) to destroy prostate cancer tissue in men with Grade Group 3 intermediate-risk prostate cancer. Fifty participants will receive the treatment and be followed for two years to see if the cancer is reduced and t…

This trial tests whether applying a platelet-rich fibrin (PRF) membrane during hypospadias repair surgery improves healing and reduces complications like fistulas. PRF is made from the patient's own blood and is thought to support tissue repair. The study will include 80 boys wit…

This trial explores whether a single dose of psilocybin, combined with motivational support therapy, can help people with HIV who have moderate-to-severe methamphetamine use disorder reduce or stop their meth use. Participants will be randomly assigned to receive either a higher …

This trial compares HHK001, an investigational version of leuprorelin acetate, to Enantone, an approved treatment for endometriosis. Both contain the same active ingredient, but HHK001 uses an updated formulation. The study will enroll 30 women aged 18-45 with endometriosis, who …

This trial is testing whether a new drug called raludotatug deruxtecan (R-DXd), given alone or with bevacizumab, can help people with advanced ovarian cancer live longer and delay cancer growth compared to standard chemotherapy. The study includes adults with high-grade serous or…

This early-phase trial is testing whether combining two immune-based treatments—Sipuleucel-T, a vaccine made from a patient's own immune cells, and N-803, a drug that boosts immune activity—is safe and tolerable for men with metastatic prostate cancer that has stopped responding …

This trial tests whether adding a chemical injection to microwave ablation improves treatment for uterine fibroids, common non-cancerous tumors that can cause heavy bleeding and pain. Microwave ablation uses heat to destroy fibroid tissue, but blood flow can cool the area and red…

This trial is testing an experimental therapy called CRG-150, which uses a patient's own immune cells that have been gene-edited to potentially fight cancer. The study includes adults with advanced HR-positive/HER2-negative breast cancer, triple-negative breast cancer, or prostat…

This phase 3 trial is testing whether giving men with metastatic prostate cancer half the standard dose of certain hormone therapies (called ARPIs) can be just as effective as the full dose, while causing less fatigue and fewer treatment stoppages. About 1,500 men with prostate c…

This study tests whether adding a radioactive drug called 177Lu-PSMA-617 to standard radiation therapy can allow men with high-risk localized prostate cancer to take hormone therapy for only 6 months instead of the usual 24 months. The goal is to see if this approach is as effect…

This study tests a program called Light Inside, designed to reduce stigma for women living with HIV who use drugs. The program involves five small-group sessions that teach coping skills and communication strategies to help participants stay engaged in HIV care and adhere to thei…

This phase 3 trial tests whether the experimental drug mocertatug rezetecan (Mo-Rez), given alone or with bevacizumab, can delay cancer progression better than standard observation or bevacizumab alone in people with newly diagnosed advanced ovarian cancer that does not have a ho…

This early study tests a new drug (177Lu-DTPA-SC16.56) that delivers radiation directly to cancer cells in people with small-cell lung cancer or neuroendocrine prostate cancer that has come back after standard chemotherapy. The main goal is to find the safest dose and see if the …

This trial tests whether injecting a fluid mixture around the prostate before surgery can make the procedure easier and reduce bleeding. Men with enlarged prostates and moderate-to-severe urinary symptoms will be randomly assigned to either the new hydrodissection-assisted techni…

This trial tests the drug mercaptopurine in people with hereditary leiomyomatosis and renal cell carcinoma (HLRCC), a rare genetic condition that raises the risk of skin, uterine, and kidney tumors. The study aims to find the safest dose and see if the drug can shrink kidney canc…

This early-stage trial is testing an experimental drug called JNJ-98768111 in people with advanced prostate cancer that has spread to other parts of the body. The drug is designed to seek out and attach to a protein called KLK2 on prostate cancer cells, delivering a toxic agent d…

This trial tests whether injecting a diluted solution of terlipressin, a drug that narrows blood vessels, under the outer layer of a uterine fibroid before removal can reduce blood loss during myomectomy surgery. Women scheduled for myomectomy will be randomly assigned to receive…

This study offers continued access to an experimental combination of two oral drugs—avutometinib and defactinib—for people with recurrent low-grade serous ovarian cancer (LGSOC) who have already been benefiting from this treatment in a prior study. The goal is to allow uninterrup…

This study tests an experimental drug called TUB-040 in people with recurrent or progressive endometrial cancer that has not responded to platinum-based chemotherapy and immunotherapy. TUB-040 is an antibody-drug conjugate designed to bind to a protein called NaPi2B on cancer cel…

This study tests whether injecting poly-L-lactic acid (PLLA), a substance already used in cosmetic treatments, into the vaginal wall can safely and effectively treat cystocele (a type of pelvic organ prolapse). Twenty women with stage 2 cystocele will receive either PLLA or a pla…

This study compares two surgical methods to repair a short (up to 2 cm) narrowing in the bulbar urethra. One technique removes the scarred section and reconnects healthy ends; the other uses a graft from the lining of the testicle to widen the stricture. 94 men aged 18-50 with no…

This trial tests whether testosterone therapy can help men with spinal cord injury who have low testosterone and difficulty walking. The goal is to see if it increases muscle and bone in the legs, reduces body fat, and improves strength. Some participants also receive finasteride…

This study compares a robotic water-jet procedure called Aquablation to active surveillance (close monitoring) in 333 men with low- or intermediate-risk localized prostate cancer. The goal is to see if Aquablation can better prevent cancer from progressing to a more serious grade…

This trial tests a new device called Vivifi that aims to reduce symptoms of an enlarged prostate (BPH) by gently altering the blood supply to the prostate through a small scrotal procedure. The study involves 20 men aged 45–80 with moderate-to-severe urinary symptoms. Researchers…

This trial is testing whether a 10-week course of fluconazole works as well as the standard 24-week course for people with HIV who have a cryptococcal infection in their blood (antigenemia) but no symptoms. It also compares starting HIV medications right away versus waiting 14 da…

This early-stage trial tests an experimental medicine called BI 3822971 in adults with advanced or metastatic solid cancers, such as lung, head and neck, breast, esophageal, bladder, vulvar, or cervical cancer, who have no standard treatment options left. The goal is to find out …

This trial tests a single-use surgical tool called the Aulea Veloxion™ resectoscope for treating enlarged prostate (BPH). The device is designed to shorten surgery time and reduce costs compared to standard reusable scopes. Twenty men aged 30–70 with symptomatic BPH will undergo …

This trial tests whether an oral medication called linzagolix can replace daily injections used to prevent premature ovulation during in vitro fertilization (IVF). The study compares the number of mature eggs retrieved in women taking the pill versus those receiving standard inje…

This phase 2 trial is testing whether combining two drugs—mirvetuximab soravtansine and suvemcitug—can help people with a type of ovarian cancer that has stopped responding to platinum-based chemotherapy. The study will enroll 20 adults with FRα-positive, platinum-resistant recur…

This trial compares two prostate medications, tamsulosin and silodosin, to see how each affects the iris—the colored part of the eye—in men with benign prostatic hyperplasia (BPH). Both drugs can make the iris floppy and the pupil small, which complicates cataract surgery. The st…

This trial is testing whether adding elemene liposomes—a compound derived from a traditional Chinese medicinal plant—to standard chemotherapy (carboplatin and paclitaxel) can help people with advanced or recurrent endometrial cancer. Participants will receive either the combinati…

This pilot trial tests whether a daily drospirenone pill can replace standard daily injections during ovarian stimulation for women with poor ovarian reserve undergoing IVF. Participants take either drospirenone or the usual injection alongside their fertility hormones, then have…

This phase 2 trial is testing whether adding an experimental drug called OK-1 to the standard chemotherapy paclitaxel can shrink tumors in people with advanced or recurrent endometrial cancer. Participants take OK-1 capsules twice daily along with weekly intravenous paclitaxel. T…

This early-stage trial is testing an experimental drug called SHR-6914 in men with prostate cancer that has spread to other parts of the body. The main goal is to see if the drug is safe and tolerable, and to find the right dose for future studies. Participants must have a confir…

This trial is testing whether using microultrasound to guide a radiation boost to cancerous spots inside the prostate can reduce side effects compared to standard radiation therapy. Men with intermediate-risk prostate cancer will receive stereotactic body radiation therapy (SBRT)…

This phase 3 trial investigates whether taking progesterone during the luteal phase of the menstrual cycle can increase the chance of a live birth for couples with unexplained infertility. Participants take either progesterone or a placebo twice daily for up to six months while t…

This trial tests whether a cold knife hysteroscopy technique (Yiwu procedure) can remove multiple endometrial polyps as effectively as standard electrocision, but with less damage to the uterine lining. About 850 women aged 20 to 48 with multiple polyps will be randomly assigned …

This phase 2 trial tests whether a single injection of teverelix DP, a hormone-blocking drug, can shrink the prostate and improve urinary function in men who recently experienced a first episode of acute urinary retention due to an enlarged prostate. About 126 men aged 45 and old…

This trial tests whether adding darolutamide to standard chemotherapy and hormone therapy before prostate removal can improve long-term outcomes for men with locally advanced prostate cancer. Participants receive either the triple combination or the standard two-drug regimen for …

This trial tests an experimental drug called ASP388B, given alone or alongside standard cancer therapies, in people with advanced solid tumors that have spread or cannot be removed by surgery. The study has two parts: the first finds a safe dose, and the second tests that dose in…

This trial is investigating whether an experimental drug called XNW5004, when combined with standard anti-tumor therapies, can help control advanced prostate cancer. The study involves men with prostate cancer that has spread. Researchers are looking at how safe the combination i…

This trial is testing whether a new formulation of a drug for benign prostatic hyperplasia (enlarged prostate) works the same as the existing version. Healthy adult male volunteers receive a single dose of each formulation after a meal, and researchers compare how much drug gets …

This trial explores whether semaglutide, a drug approved for weight management, can affect tumor biology when given for 3 to 6 months before prostate removal surgery. About 20 men with intermediate-risk localized prostate cancer and a BMI over 35 will receive weekly injections. R…

This study looks at a surgical technique called total lower segmentectomy with cervico-corporeal anastomosis (TLS-CCA) combined with mechanical towel compression for women with placenta accreta spectrum (PAS). The goal is to see if this approach can reduce blood loss during deliv…

This study tracks the safety and effectiveness of mirvetuximab soravtansine (MIRV), a drug that targets a protein called folate receptor alpha on cancer cells, in patients with advanced ovarian, fallopian tube, or primary peritoneal cancer. Researchers will observe 400 patients r…

This trial tests whether a simple urine test can help adolescent girls and young women in Kenya stay on track with their daily HIV prevention pills (PrEP). Participants who get the test will receive immediate feedback on their drug levels during counseling sessions. Researchers w…

This early-phase trial explores whether PSMA PET scans can help doctors adjust radiation therapy for men with prostate cancer that has spread to 4 to 20 spots in the body. Participants receive standard hormone therapy plus a special PET scan, then targeted radiation to all visibl…

This study tests a new drug combination (BL-B01D1 plus other treatments) in 180 men with metastatic castration-resistant prostate cancer that has spread and stopped responding to hormone therapy. The goal is to see if the combination can delay cancer growth or shrink tumors. Part…

This trial tests whether a package of support from a community health worker can help adults hospitalized with advanced HIV in Lusaka, Zambia, stay in care and survive longer. Participants are randomly assigned to receive the ARC intervention or standard care and are followed for…

Hormone therapy for prostate cancer often causes muscle loss, which may weaken the immune system by reducing a key signalling protein called IL-7. This trial tests whether a 12-week supervised strength training programme can prevent muscle loss and raise IL-7 levels in men receiv…

This trial tests whether an online, personalized lifestyle program can help rural postmenopausal breast and endometrial cancer survivors lose weight and improve their health. Participants follow a tailored diet and aerobic exercise plan, with mobile health tools to track progress…

This study tests whether giving the antibiotic azithromycin before a cervical stitch (cerclage) can help high-risk pregnancies last longer. About 80 pregnant women with a weak cervix will receive either azithromycin or a placebo, plus standard care. The goal is to see if the anti…

This trial tests whether a single injection of carbetocin, a longer-acting relative of oxytocin, can reduce blood loss in women undergoing open abdominal surgery to remove uterine fibroids. About 900 participants will be randomly assigned to receive carbetocin or a placebo, and d…

This early-phase trial is testing whether a personalized mRNA vaccine called NeoOVSV, given alongside standard chemotherapy and an immunotherapy drug, can safely help prevent ovarian cancer from returning after surgery. The vaccine is designed to train the immune system to recogn…

This early-stage trial is testing an experimental drug called GS-0415 in people with HIV who already have the virus well-controlled by standard antiretroviral therapy. The study will give single and multiple doses of GS-0415 to evaluate its safety, tolerability, and how the body …

This phase 2 trial is testing whether a targeted antibody-drug conjugate called sacituzumab tirumotecan, given alone or together with the immunotherapy pembrolizumab, can shrink tumors in people with ovarian clear cell carcinoma that has returned after prior immunotherapy. The st…

This study looks at how effective the drug Pluvicto (177Lu-PSMA-617) is in treating men with a type of advanced prostate cancer that no longer responds to hormone therapy and has spread to other parts of the body. Researchers will analyze medical records from over 1,000 patients …

This phase II pilot trial is testing a three-drug combination—radium-223, darolutamide, and standard hormone therapy—in men with high-volume metastatic hormone-sensitive prostate cancer. The goal is to see if adding radium-223 as maintenance therapy after initial treatment can im…

This study tests whether sending patients home on the same day of surgery, with follow-up care via phone calls, home visits, and a mobile app, is as safe and less costly than keeping them in the hospital overnight. The trial includes adults in Uganda having low-risk procedures su…

This phase 1 trial tests an experimental drug called TJ037130 in adults with advanced solid tumors, including ovarian, gastric, and endometrial cancers that have spread. The main goal is to check the drug's safety and find the best dose for future studies. Participants receive TJ…

This trial compares a new formulation (AD-116A) of a drug used for benign prostatic hyperplasia to the original version (AD-1161) in healthy adult male volunteers. The goal is to see if the two formulations are bioequivalent—meaning they work the same way in the body. Participant…

This phase II trial tests an experimental drug called SYS6041, alone or combined with chemotherapy and other agents, in women whose ovarian cancer has returned. The study evaluates safety, the best dose, and how well the treatments shrink tumors. Participants must have a specific…

This study tests an experimental injection called BBM-C101 in 200 people with persistent HPV16 or HPV18 infection and low-grade precancerous lesions of the cervix, vulva, vagina, or anus. Participants receive four shots under the skin over three weeks. The trial monitors safety a…

This trial tests whether cleaning the vagina with a betadine solution for 30 seconds just before a cesarean section can lower the chance of wound infections, fever, and uterine infection after surgery. About 600 women having either planned or emergency C-sections will take part. …

This trial tests whether adding orlistat, a weight-loss drug that blocks fat absorption, to standard progestin therapy can improve treatment response in young women (45 or younger) with early-stage endometrial cancer or atypical endometrial hyperplasia who have low progesterone r…

People living with HIV have twice the risk of heart attacks and stroke compared to the general population. This trial tests whether integrating clinical pharmacists into HIV care can improve blood pressure control and reduce cardiovascular disease risk. The study enrolls 450 adul…

This study tests an experimental biologic, NWRD09, in women aged 18 to 65 with HPV16-positive cervical high-grade squamous intraepithelial lesions (HSIL), a precancerous condition. Participants receive four intramuscular injections over 12 weeks. The main goal is to see if the tr…

This study tests whether adding the experimental drug saruparib to standard hormone therapy can slow the growth of metastatic hormone-sensitive prostate cancer. It includes men whose cancer has not progressed after prior chemotherapy or a specific type of radiation therapy. Parti…

This study explores whether a simple blood test that measures tumor DNA (ctDNA) can help doctors decide when to stop a targeted radiation therapy called 177Lu-PSMA-617 in men with advanced prostate cancer that has spread and is no longer responding to hormone therapy. The goal is…

This trial tests a streamlined approach for men at high risk of clinically significant prostate cancer. Under one anesthesia session, doctors perform an MRI-guided biopsy, analyze the tissue immediately with rapid lab tests, and if cancer is confirmed, proceed directly to laparos…

This trial tests a 24-week virtual care program called BRIDGE NET for people with serious mental illness who are starting cancer treatment. The program brings together oncology and mental health teams to plan care, provide early psychiatric support, and regularly check in with pa…

This phase III trial compares a shorter course of radiation therapy (hypofractionated) against the standard longer course for people with cervical cancer. Both groups also receive chemotherapy and brachytherapy. The goal is to see if the shorter schedule controls the cancer just …

This phase 3 trial tests an experimental drug called SYS6043 against standard chemotherapy in people with platinum-resistant ovarian, primary peritoneal, or fallopian tube cancer. Participants are randomly assigned to receive either SYS6043 or one of three standard chemotherapies…

This trial tests two experimental treatments for erectile dysfunction in men who have had robotic prostate surgery for prostate cancer. One group receives an injection of urine-derived exosomes into the penis, while the other gets ozone gas delivered through the rectum. Researche…

This study follows 600 men in South Korea with moderate to severe enlarged prostate symptoms that tamsulosin alone didn't control well. Researchers will track side effects and symptom improvement over 24 weeks of treatment with Vesomni, a combination tablet. The goal is to see ho…

This phase 3 trial tests whether a new drug called mocertatug rezetecan (Mo-Rez) combined with bevacizumab works better than standard chemotherapy plus bevacizumab for women with platinum-sensitive ovarian cancer. The study includes about 690 participants whose cancer has returne…

This phase 3 trial tests whether adding an experimental drug (GSK5733584) to standard immunotherapy can help keep advanced or recurrent endometrial cancer from growing. About 610 adults who have already completed initial chemotherapy with immunotherapy will receive either the new…

This trial tests an experimental vaccine called SYS6026 in people with high-grade cervical lesions caused by HPV type 16 or 18. The goal is to see if the vaccine can help the body clear the virus and reverse the lesions, potentially avoiding the need for surgery. Participants are…

This study tests whether a 12-week virtual cooking and nutrition program is practical and helpful for Hispanic prostate cancer survivors and their caregivers. Participants attend nutrition education, cooking classes, and health coaching sessions online. The goal is to see if the …

This study tests whether a vaginal ovule device, used alongside standard antibiotics or antifungals, improves vaginal health in women with bacterial vaginosis or yeast infections. Eighty women aged 18 to 60 receive either the active device or a placebo ovule over three treatment …

This study tests whether blue LED light therapy can improve symptoms of common vaginal conditions like menopause-related dryness, bacterial vaginosis, and yeast infections. About 150 women aged 18 to 75 will receive the treatment either at home or in a clinic. Researchers will ch…

This study tests whether a daily oral supplement containing green tea extract (EGCG), folic acid, vitamin B12, and hyaluronic acid can help women clear a persistent human papillomavirus (HPV) infection. HPV is a common virus that can cause cervical cancer if it stays in the body …

This study tests whether taking linzagolix (Yselty) for 3 to 6 months before an embryo transfer can improve live birth rates in women with adenomyosis who have experienced repeated implantation failure. Adenomyosis can make the womb lining less receptive to embryos, even when the…

This study tests whether adding Qiling Yiqi tablets, a Chinese herbal medicine, to standard HIV therapy can improve immune function in people whose CD4 counts remain low despite successful viral suppression. The trial involves 240 adults with HIV who have been on antiretroviral t…

This early-phase trial tests a digital program called CONNECT, designed to help women who have survived sex trafficking access care for HIV, substance use, and mental health. Delivered through a street medicine team that serves unhoused women, the program pairs participants with …

This study tests whether adding Fuyang Jiedu Granules, a traditional Chinese herbal mixture, to standard antiretroviral therapy can improve immune function in people with HIV who have persistently low CD4 counts despite viral suppression. The trial includes 240 adults aged 18–60 …

This trial investigates whether a minimally invasive procedure using a special dye can better detect cancer spread in men with early-stage testicular cancer. About 20-30% of these patients have cancer cells in lymph nodes that standard scans miss. Participants are randomly assign…

This study tests a new biologic drug called XYA02 in 190 adults with advanced solid tumors (including lung, ovarian, and pancreatic cancers) that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see if the drug can shrink tumo…

This study looks at how well the chemotherapy drug temozolomide works for people with aggressive pituitary tumors or pituitary cancer that hasn't responded to standard treatments like surgery or radiation. Researchers are collecting data from medical records across multiple hospi…

This study tests a new drug, ubamatamab, combined with standard chemotherapy drugs (carboplatin, paclitaxel, and bevacizumab) in 43 people with advanced ovarian cancer that did not respond well to initial treatment. The goal is to see if the combination is safe and can shrink tum…

This study looks at whether the RSV vaccine given in late pregnancy can help protect babies born to mothers with HIV. RSV is a leading cause of infant hospitalization, and babies exposed to HIV are at higher risk. Researchers will measure antibody levels in mothers and infants to…

This study tests whether a program that helps incarcerated men with HIV notify their sex and drug-use partners about possible HIV exposure can increase testing and treatment. Participants can choose to tell partners themselves or have a trained notifier do it anonymously. The goa…

This study tests a new approach for treating high-grade cervical precancer (HSIL) using a cream called HAL that is activated by a special light, instead of standard surgery. About 230 women will be randomly assigned to receive either the light therapy or surgery. The main goal is…

This trial tests whether a single infusion of granulocyte colony-stimulating factor (G-CSF) into the uterus can improve pregnancy outcomes in women with thin endometrium (uterine lining) undergoing frozen embryo transfer. Thin endometrium can reduce the chance of pregnancy. The s…

This study evaluates the long-term safety of an oral medication called LUM-201 for children with growth hormone deficiency (GHD). Children who completed a prior 12-month trial can receive LUM-201 daily for up to 36 additional months. The goal is to see if the pill is safe and tol…

This trial tests two different daily doses of fertility hormones (follitropin-delta and menotropin) during ovarian stimulation for IVF in women aged 35 and older. The goal is to see which dosing strategy leads to more good-quality embryos. The study involves 240 women with normal…

This study tests whether pelvic floor muscle training (PFMT) with a handheld biofeedback device can improve erectile function and sexual quality of life in men with functional hypogonadism (low testosterone) and erectile dysfunction. Participants are randomly assigned to PFMT wit…

This study monitors the safety and effectiveness of mirvetuximab soravtansine (MIRV) in people with a specific type of ovarian, fallopian tube, or primary peritoneal cancer that has stopped responding to platinum-based chemotherapy and tests positive for the folate receptor-alpha…

This study looks at whether switching to a daily pill containing bictegravir, emtricitabine, and tenofovir alafenamide (BIC/FTC/TAF) can help people with HIV who previously did not respond to a long-acting injectable treatment (CAB/RPV LAI). The study includes 30 adults and will …

This trial investigates whether giving obese women with polycystic ovary syndrome (PCOS) a GLP-1 receptor agonist (a drug that helps control appetite and blood sugar) along with healthy lifestyle education for 12 weeks before starting fertility treatment can improve their chances…

This study tests an experimental drug, TAX2, in adults with advanced or metastatic solid tumors that have not responded to standard treatments. The trial has two parts: first, finding a safe dose, and then testing that dose in more people. Researchers will monitor side effects, h…

This phase II trial tests a combination of two drugs—SYS6026 and Enlonstobart—in people with advanced solid tumors that have spread and are linked to HPV types 16 or 18. The study aims to see if the combination is safe and shows signs of shrinking tumors. Participants must be at …

This trial tests whether a special mesh-like suture (Duramesh) can prevent incisional hernias better than a standard slowly-absorbable suture (PDS loop) in women having abdominal surgery for gynecological cancers. About 300 participants will be randomly assigned to one of the two…

This study looks at how surgery to fix varicocele—enlarged veins in the scrotum—affects the number of immature sperm cells in semen. Infertile men aged 20 to 45 with varicocele will have a microsurgical procedure to tie off the abnormal veins. Their semen will be tested before su…

This phase 1 trial tests whether giving a higher first dose of the radioactive drug Lu-177-PSMA-617 can improve treatment for men with metastatic castration-resistant prostate cancer. The drug targets a protein on prostate cancer cells and delivers radiation to kill them. Researc…

This early-stage trial tests whether adding CP-PCA07 (a form of niclosamide, a drug used for tapeworm infections) to the standard drug enzalutamide can safely help men with castration-resistant prostate cancer that has stopped responding to treatment. The study involves 18 men an…

This trial tests whether combining an immune-boosting cream (imiquimod) with a low dose of an immunotherapy drug (nivolumab) can shrink vulvar squamous cell carcinoma tumors before surgery. About 50 women with resectable, early-to-moderate stage vulvar cancer will receive the dru…

This trial investigates whether combining a targeted radioactive drug (177Lu-PSMA-617) with a hormone therapy (darolutamide) before surgery can improve outcomes for men with high-risk localized prostate cancer. Participants receive two doses of the radioactive drug and daily horm…

This study tests whether offering rapid HIV testing during a dental visit leads more people to get tested than simply referring them to a lab. About 6,700 adult dental patients at four community health centers will be offered either a quick oral swab test on-site or a referral fo…

This trial explores whether a new type of radiotherapy called CT online-adaptive radiotherapy can safely deliver treatment for endometrial cancer in just 5 sessions over a week and a half, instead of the usual 25 sessions over 5 weeks. The study includes 30 adults who have had su…

This trial tests a drug called sacituzumab govitecan in people with advanced or recurrent ovarian, fallopian tube, or primary peritoneal cancer that has high levels of a protein called TROP-2. Participants must have already tried standard treatments without success. The drug is g…

This trial tests a personalized mRNA vaccine called NeoOVIV in people with stage II or III ovarian cancer who have had surgery. The vaccine is designed to teach the immune system to recognize and attack cancer cells. Participants receive the vaccine alongside standard chemotherap…

This phase 2 trial tests a drug called tisotumab vedotin in people with advanced squamous cell carcinoma of the vulva that has returned or spread. The drug is an antibody-drug conjugate designed to seek out and destroy cancer cells. The study aims to see how many participants' tu…

This phase 2 trial tests whether combining two immunotherapy drugs (iparomlimab and tuvonralimab) with standard chemotherapy before surgery can improve outcomes for people with advanced ovarian cancer. Participants receive 3-4 cycles of the combination, followed by surgery to rem…

This study looks at whether people with HIV who need a liver transplant can safely receive a liver from a donor who also had HIV. Researchers will compare infections and cancer rates between those who get an HIV-positive donor liver and those who get an HIV-negative donor liver. …

This early-stage trial tests an injection called BBM-C101 in 60 women with high-grade cervical precancer linked to HPV16 or HPV18. The goal is to see if the drug is safe and can shrink or eliminate abnormal cells, potentially offering a non-surgical alternative. Participants rece…

This study tests whether a combination of two immunotherapy drugs (QL1706), a targeted therapy (bevacizumab), and standard chemotherapy can shrink advanced ovarian cancer before surgery. About 36 women with stage III-IV ovarian cancer will receive the treatment every 3 weeks, the…

This study tests a new oral drug called DAT-2645 in up to 30 people with advanced or metastatic ovarian cancer that has a BRCA1/2 mutation or is HRD-positive. Participants take the drug daily in 21-day cycles. The main goal is to see if the drug shrinks tumors, and researchers wi…

This study compares two surgical techniques for ovarian endometrioma—standard cyst removal (cystectomy) versus a newer method using argon plasma coagulation (APC) to vaporize the cyst lining. The goal is to see which better preserves ovarian reserve, measured by antral follicle c…

This study tests whether using MRI and AI to guide steam therapy can improve treatment for an enlarged prostate (BPH). Men aged 30-80 with moderate symptoms and a prostate size between 30-80 mL are eligible. All participants receive the standard steam procedure, but with added MR…

This study will test a doula support program for 15 pregnant women with HIV in South Florida. The doula will provide education, adherence support, and lactation counseling from pregnancy through 12 weeks after birth. The goal is to see if this program is feasible and acceptable, …

This early-phase trial tests a one-time treatment called OPB-201, where a patient's own immune cells are modified in a lab to better recognize and attack cancer cells that carry a protein called PRAME. The study will enroll 30 adults with recurrent endometrial cancer or platinum-…

This study tests whether a type of abdominal massage called visceral osteopathic manual therapy can improve sperm quality and blood flow in men with varicocele, a condition where veins in the scrotum become enlarged and can cause infertility. Thirty-two men aged 18-45 will either…

This study tests a new drug called GenSci142, given as a vaginal capsule, for treating bacterial vaginosis (BV). About 30 women with BV will receive either GenSci142 or a standard antibiotic cream to compare safety and how well each works. The goal is to see if the new capsule is…

This phase 3 trial compares a single intravenous dose of temocillin to the standard ceftriaxone shot for treating gonorrhea. The goal is to see if temocillin works just as well while having less impact on the gut's healthy bacteria, which can help prevent the rise of drug-resista…

This study tests whether a combined approach—offering HIV PrEP (pills or injections) and STI prevention (doxycycline after sex) along with smartphone tools—helps young men at high risk stay protected. About 400 men aged 18-29 who have sex with men will be followed for a year to s…

This pilot study tests a program called Kisoboka Amaka for men living with HIV who drink heavily and have pregnant partners. The program combines counseling, financial training, and mobile savings to help men drink less and take their HIV medication consistently. Researchers will…

This study tests a new drug called DEC003M, which is designed to seek out and destroy prostate cancer cells by targeting a protein called PSMA. The trial enrolls adults with advanced prostate cancer that has stopped responding to standard hormone therapy. Researchers aim to find …

This trial tests whether adding a lab-made antibody (ePGT121v1-LS) to standard HIV medication can help infants under one year old achieve better viral suppression. About 87 infants in South Africa will receive either the antibody or a placebo injection every 12 weeks for 48 weeks…

This study tests a personalized approach to hormone therapy for men with metastatic hormone-sensitive prostate cancer. The goal is to reduce treatment intensity for lower-risk patients to minimize side effects while still controlling the cancer. About 108 participants will receiv…

This early-phase trial tests a new cell therapy called NK521 for people with advanced liver cancer (hepatocellular carcinoma) or ovarian cancer that has not responded to standard treatments. NK521 are natural killer (NK) cells that have been gene-edited to remove three proteins t…

This study looks at how well a combination of two drugs, iparomlimab and tuvonralimab (called QL1706), works for people with recurrent or metastatic cervical cancer that has worsened after platinum-based chemotherapy. Researchers will compare outcomes of those receiving QL1706 to…

This trial tests whether adding two lab-made antibodies (ePGT121v1-LS and VRC07-523-LS) to standard antiretroviral therapy can help infants living with HIV achieve viral suppression. Infants up to one year old in Mozambique and Cameroon receive four injections of the antibodies o…

This phase II trial tests whether adding a targeted radiation drug (177Lu-PSMA-617) to standard hormone therapy, with or without additional hormone-blocking pills, can better control low-volume metastatic hormone-sensitive prostate cancer. The study enrolls men whose cancer has s…

This study tests the safety of the immunotherapy drug dostarlimab when given together with standard chemotherapy (carboplatin and paclitaxel) as a first treatment for adults in India with advanced or recurrent endometrial cancer. Participants receive the drug combination initiall…

This study tests whether adding precisely targeted radiation to standard hormone therapy helps men with metastatic hormone-sensitive prostate cancer. All participants first receive six months of darolutamide plus androgen deprivation therapy. Those whose cancer has not progressed…

This trial tests whether fluzoparib plus bevacizumab works as well as the standard olaparib plus bevacizumab for maintenance therapy in women with HRD-positive advanced ovarian cancer after initial chemotherapy. The study enrolls about 120 participants and tracks how long they st…

This Phase II trial tests whether adding the immunotherapy drug cadonilimab to chemotherapy before surgery helps people with locally advanced cervical cancer live longer without the disease coming back. About 134 participants will be randomly assigned to receive either the drug c…

This study tests whether the drug elranatamab can help keep plasmablastic lymphoma, a rare and aggressive blood cancer, from returning after initial chemotherapy. About 17 adults with or without HIV who have already responded to first treatment will receive elranatamab injections…

This study tests whether a single, powerful dose of MRI-guided radiation can safely treat prostate cancer that has come back in a few lymph nodes after initial treatment. Forty-eight men will receive one 24 Gy radiation session aimed precisely at the affected nodes. The main goal…

This study tests a light-activated drug (HAL-PDT) to treat cervical precancer (CIN2) in 500 women aged 18-50. The treatment is guided by how the cervix responds, with up to 4 sessions. The main goal is to see if the abnormal cells shrink or disappear within 6 months, avoiding the…

This study looks at whether giving a GnRH agonist hormone treatment before a frozen embryo transfer can improve pregnancy and live birth rates in women with persistent chronic endometritis (a uterine infection that doesn't clear with antibiotics). About 150 women aged 20-40 will …

This study tests whether giving radiotherapy to the prostate and to cancer spots seen on PET scans can help men with metastatic prostate cancer whose PSA levels remain high after six months of hormone therapy. Participants continue their hormone treatment and receive three PSMA-P…

This Phase 2 trial tests a new drug called MAR002 in 72 adults with acromegaly, a condition caused by a pituitary tumor that leads to too much growth hormone. Participants will receive either MAR002 or a placebo as injections under the skin. The study will check if the drug is sa…

This study looks at how long-acting injectable HIV drugs (cabotegravir and rilpivirine) work in the body during pregnancy and after childbirth. About 40 pregnant women with HIV will receive the shots every 4 weeks. The goal is to measure drug levels and see if they stay effective…

This phase 2 trial tests a drug called sacituzumab tirumotecan in people with neuroendocrine prostate cancer, a rare and aggressive form that has progressed after platinum-based chemotherapy. The drug is given by IV infusion three times per 42-day cycle. The study measures how ma…

This early-stage trial will compare a new drug called AJU-G721 to an existing reference drug, G721R, in 36 healthy adult men. The goal is to see if the two drugs produce similar levels in the blood and have comparable safety. Both drugs contain tamsulosin, which is used to treat …

This study will test a Spanish-language program called Healthy Choices for 45 young adults (ages 18-29) living with HIV in the Dominican Republic who also struggle with alcohol use and stigma. The program is designed to help them better manage their health and reduce the impact o…

This study tests whether Sanghe Jianghuo Granules, a traditional Chinese herbal medicine, can safely slow down early puberty in girls aged 5 to 8.5 years. The trial will involve 200 participants who will take the granules or a placebo twice daily for 3 months. The main goal is to…

This study follows 100 adults with congenital adrenal hyperplasia (CAH) who switch from standard steroids to a timed-release hydrocortisone (Efmody). The goal is to see if better mimicking the body's natural cortisol rhythm improves hormone levels, metabolic health, and quality o…

This study compares myo-inositol alone versus myo-inositol plus alpha-lactalbumin in 82 women with PCOS who want to conceive. Over 12 weeks, researchers will track pregnancy rates, menstrual regularity, and metabolic changes. The goal is to see if adding alpha-lactalbumin improve…

This phase 2 trial is testing a new, intensive treatment plan for 28 people with advanced ovarian cancer. The approach combines chemotherapy given into the abdomen and vein, a special vaccine made from the patient's own immune cells, and the immunotherapy drug Keytruda. The goal …

This phase II trial tests whether combining elacestrant, a drug that lowers estrogen, with everolimus, which stops cancer cells from growing and cuts their blood supply, can control advanced or recurrent ER+ endometrial cancer. About 50 adults whose cancer has returned or spread …

This study tests a new drug (GV20-0251) combined with an immunotherapy (anti-PD-1) in people with advanced solid tumors that have not responded to or cannot tolerate standard treatments. About 227 adults with various cancers, including lung, breast, and colorectal, will participa…

This early-phase study tests a drug called zanidatamab in 10 adults with advanced HER2-positive solid tumors (like endometrial, bladder, or pancreatic cancer) that have worsened after at least one prior treatment. Participants receive the drug by IV every two weeks. The main goal…

This Phase 3 trial compares an experimental drug, QLC5508, against the standard chemotherapy docetaxel in 700 men with metastatic castration-resistant prostate cancer that has worsened after hormone therapy. The main goal is to see if QLC5508 delays cancer growth better than doce…

This study tests a drug called Trastuzumab Rezetecan in 15 adults with advanced solid tumors that have the HER2 protein. The goal is to see if the drug can shrink tumors. Participants get the drug by IV every 3 weeks. This is for people whose cancer has worsened after other treat…

This study tests a program that combines group counseling, financial literacy training, and savings accounts to help Ugandan teens with HIV manage depression and stick to their medication. About 588 adolescents aged 15-19 will take part. The goal is to see if this approach can re…

This early-stage trial tests a new drug, QLF4113, in about 140 men with metastatic castration-resistant prostate cancer that has spread and no longer responds to standard hormone therapy. The main goals are to find a safe dose and check for side effects, while also looking for si…

This study will compare two different HIV medication combinations in 60 people who also have active tuberculosis. Participants will receive either a newer drug (Ainuovirine) or a standard one (Efavirenz), along with their TB meds. The goal is to see which regimen better suppresse…

This early-stage trial tests whether combining two drugs—ibalizumab and chidamide—can safely reduce the hidden HIV reservoir in people living with HIV. The study will enroll up to 29 adults on stable antiretroviral therapy. Researchers will monitor side effects and measure change…

This study will test a mobile app called MindBodyU designed to help young people (ages 16-25) living with HIV in South Carolina stay connected to their care and take their HIV medication regularly. The goal is to see if the app is easy to use, liked by users, and helps improve me…

This Phase 2 trial tests a combination of three drugs—camrelizumab, famitinib, and standard chemotherapy—in 54 women with recurrent or metastatic cervical cancer that cannot be treated with surgery or radiation. The goal is to see if the combo shrinks tumors and controls the dise…

This trial investigates whether giving a thyroid hormone (levothyroxine) to very small preterm infants with mildly low thyroid function can improve their physical growth and brain development by age two. The study includes infants born weighing under 1500 grams who are small for …

This study tests a daily pill called zanzalintinib in men with advanced prostate cancer that has stopped responding to hormone therapy and has already been treated with Pluvicto. The goal is to see if the drug can delay cancer growth or shrinkage. About 30 participants will take …

This study will test a two-drug HIV pill (Dolutegravir/Lamivudine) in 210 pregnant women who have never taken HIV medication. The goal is to see if it controls the virus and prevents passing HIV to their babies. Participants will be compared to those on standard three-drug therap…

This study looks at whether giving women living with HIV the option to collect their own HPV test samples at home or in their community, with help from health workers, increases how many get screened for cervical cancer. About 17,700 women will take part across multiple clinics. …

This phase 3 trial tests a new long-acting octreotide injection (SYHX2008) in 154 adults with active acromegaly, a condition where the body makes too much growth hormone. The main goal is to see if the drug can bring hormone levels back to normal. Participants will receive the in…

This phase II trial is testing whether adding an immunotherapy drug (QL1706) to standard chemotherapy before surgery can help shrink tumors in women with early-stage cervical cancer (stages IB1-IB3). About 50 participants will receive the combination, then undergo conservative su…

This study tests a program called iSYV that combines peer-led group sessions with a gamified text-message game to support mental health and HIV care for 5,000 youth aged 15-24 in Tanzania. The goal is to see if it helps them keep their virus under control and stay in care. The pr…

This study looks at whether a long-acting injectable HIV prevention drug (cabotegravir) can be delivered fairly and effectively in NHS sexual health clinics. Researchers will follow 200 people taking the drug for 12 months, along with 20 healthcare professionals, to see how well …

This study tests whether letrozole, a drug that lowers estrogen, can treat early ectopic pregnancy as effectively as the standard drug methotrexate. The trial will enroll 70 women with confirmed ectopic pregnancy and low hormone levels. Participants will receive one of the two dr…

This long-term extension study offers continued access to several cancer drugs—including cabozantinib, atezolizumab, and nivolumab—for up to 5,000 patients who benefited from them in earlier Exelixis-sponsored trials. The study focuses on monitoring safety and ongoing clinical be…

This early-stage study tests a new drug called HH160 in about 56 adults with advanced solid tumors (cancers that have spread). The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. Participants will receive HH160 alone or with other cancer tr…

This study tests whether adding two immunotherapy drugs (iparomlimab and tuvonralimab) to chemotherapy before standard chemoradiation can help people with locally advanced cervical cancer live longer without the disease getting worse. About 486 adults aged 18-75 with stage III-IV…

This study tests whether mixing a woman's own platelet-rich plasma (PRP) with her partner's sperm before intrauterine insemination (IUI) can increase pregnancy rates. About 288 women with infertility will be randomly assigned to receive either standard IUI or IUI with PRP-treated…

This study tests a new drug called zanzalitinib in people with a type of advanced prostate cancer that no longer responds to hormone therapy and has spread to soft tissues or organs. The goal is to see if the drug can slow or stop cancer growth. About 19 participants will receive…

This study tests whether a shorter, 5-month combination of TB drugs works as well as the standard 6-month treatment for people with both HIV and drug-susceptible tuberculosis. It involves 148 participants with very weak immune systems (CD4 count under 100). The goal is to see if …

This study tests a new device that sorts sperm without spinning them, which may reduce DNA damage often seen in older men. It involves 378 couples where the male partner is 40 or older and the female partner has at least 5 mature eggs. The goal is to see if this device leads to m…

This trial is testing an experimental imaging agent called [⁶⁴Cu]Cu-RAX301, which is designed to bind to prostate cancer cells and show up on PET/CT scans. The study includes men with prostate cancer who are either about to have surgery to remove the prostate or who may have a re…

This pilot study investigates whether a PSMA PET scan, using an injected radiotracer, can detect clinically significant prostate cancer recurrence one year after focal HIFU treatment, compared with the standard MRI. About 30 men with prostate cancer who meet specific criteria wil…

This trial investigates whether Posluma, a PSMA-targeted PET scan, can accurately detect any remaining or returning prostate cancer about 12 months after focal therapy. Researchers will compare the scan results with MRI and biopsy data in 22 men with intermediate-risk, organ-conf…

This study is looking at whether a blood test called Galleri can help detect ovarian cancer early in people with BRCA1 or BRCA2 gene changes, who are at higher risk. Participants will give a blood sample and answer questionnaires about their experience. The study will also check …

This trial evaluates a new ultra-thin flexible penile monitoring system designed to diagnose erectile dysfunction (ED) by measuring nighttime erections. The current standard device, RigiScan, uses mechanical rings that can be uncomfortable and disrupt sleep, potentially skewing r…

This study tests a new AI framework called Cad-MMFF that combines clinical information, ultrasound, and MRI images to better detect clinically significant prostate cancer. The goal is to see if this approach can reduce unnecessary biopsies and safely limit the use of MRI. The stu…

This trial is testing whether a new ultrasound scoring system can accurately predict the severity of placenta accreta spectrum (PAS), a condition where the placenta grows too deeply into the uterine wall. The study will enroll 50 pregnant women with placenta previa and a history …

This study is testing whether a new scoring system, called the Fusion CEMEP score, can safely guide prostate biopsy decisions. The goal is to see if men with suspected prostate cancer can skip the extra systematic biopsies and only have targeted biopsies based on MRI findings. Th…

This pilot study is testing whether a special PET/MRI scan using a radioactive tracer called 68Ga-PSMA-11 can better identify all areas of significant prostate cancer in men with localized disease. The goal is to improve selection for focal therapy, a treatment that targets only …

This study tests a community-based screening strategy for tuberculosis (TB) in migrant communities in New York City. A mobile van offers digital chest X-rays with AI interpretation, along with TB symptom checks, blood tests for latent TB, and HIV testing. The goal is to see wheth…

This trial tests whether a fluorescent dye called zopocianine can make prostate cancer cells glow under near-infrared light during surgery. Men with prostate cancer scheduled for prostatectomy receive a single dose of the dye before surgery. The goal is to see if the dye helps su…

This trial is testing whether a breath analysis device can detect unique chemical patterns—called volatile organic compounds—that may signal the presence of cancer. Researchers will collect breath samples from 1,000 people with various cancers and 1,000 healthy volunteers, then u…

This trial is testing whether the GeneXpert system, a portable device that can run multiple tests, can accurately detect HIV, chlamydia, gonorrhea, hepatitis C, and HPV in community health centers and clinics. Researchers will compare its results to standard lab tests and track w…

This study tests whether a new eye-tracking device called SONDA can accurately measure visual field loss in people with pituitary tumors. Standard visual field tests require patients to press a button when they see lights, which can be tiring and unreliable. The SONDA test instea…

This trial is testing whether a special PET scan (FTT-PET) and a blood test that looks for tumor DNA (ctDNA) can predict how well men with metastatic prostate cancer will respond to PARP inhibitor therapy. The study will enroll about 75 men whose cancers have certain genetic muta…

This study explores whether measuring radioactive counts from PSMA PET/CT-guided biopsy samples can instantly tell if a tissue core contains cancer. Researchers aim to find a cutoff value that reliably distinguishes cancerous from non-cancerous tissue, using standard pathology as…

This study tests a new imaging tracer called [18F]FAPI-74, which attaches to a protein found on cells in tumors and scarred or inflamed tissue. Researchers want to see if it can show these areas more clearly than current scans. About 770 adults with various cancers or non-cancer …

This study tests a new imaging technique that could help surgeons see if cancer has spread to lymph nodes during surgery for gynecologic cancers like ovarian, endometrial, cervical, and vulvar cancer. The method uses a special microscope to examine lymph node tissue right after i…

This study evaluates several experimental blood tests designed to detect ovarian cancer earlier. Researchers compare results from people with ovarian cancer to those without cancer to see how well the tests distinguish between the two. The tests look for specific changes in the b…

This study compares two ways to spot early warning signs of cervical cancer: a simple vinegar test (VIA) and a magnified exam (colposcopy). Researchers will check how well each method finds pre-cancerous changes in women aged 25 to 65 who have symptoms or abnormal Pap smears. The…

This study tests a new infrared fluorescence staining technique that could help doctors diagnose prostate cancer faster during a biopsy. The method is compared to the standard frozen section analysis and the gold-standard paraffin section. If successful, it may offer a quicker, m…

This study compares an AI algorithm to radiologists in reading prostate MRI scans to detect clinically significant prostate cancer. About 500 men with suspected prostate cancer will have their MRI read by both AI and a radiologist, and results will be compared. If the AI performs…

This study looks at whether a specialized blood test can detect tiny bits of cancer DNA in the blood of women with advanced ovarian cancer after they finish initial treatment. Researchers will follow 300 women for up to 3 years, taking blood samples at key times. The goal is to s…

This study tests a new robotic bronchoscopy system that uses real-time 3D imaging to help doctors biopsy lung nodules in people with HIV. The goal is to see if this robot-guided approach is more accurate and safer than current navigation methods. One hundred participants will be …

This study tests a new PET/CT imaging agent called 68Ga-NYM032 in 232 men with suspected prostate cancer recurrence after initial treatment. Participants have rising PSA levels, and the scan aims to accurately locate any remaining cancer. The goal is to see how well the scan dete…

This study tests a new radioactive tracer called 68Ga-FAPI-PSMA for PET/CT scans to see if it can find and stage solid tumors (like prostate, liver, and ovarian cancers) better than current tracers. About 20 adults with suspected or confirmed tumors will receive the tracer and ha…

This phase 2 trial tests whether a new radioactive imaging agent, 61Cu-NU101, can detect prostate cancer spread as well as or better than the current standard, Pylarify. 34 men with confirmed prostate cancer and visible disease on a prior Pylarify scan will receive one dose of 61…

This study tests a workshop led by peers and a Black GP to encourage Black men aged 45 and over to talk to their doctor about prostate cancer risk and get a PSA test. About 300 men from three UK regions will take part. Half attend the workshop right away, the other half wait six …

This study aims to develop a blood test that can accurately detect serious cervical lesions in women infected with HPV16 or HPV18, the high-risk types linked to cervical cancer. Researchers will collect blood samples and medical data from about 1,465 women across three hospitals …

This study will test whether analyzing stool and urine samples using a technique called metagenomics can find infections in people with weakened immune systems (due to HIV, chemotherapy, or immunosuppressive drugs). Currently, doctors often need to take invasive samples like bloo…

This phase 2 trial will test whether a special PET scan using Flotufolastat F18 can accurately detect any remaining prostate cancer after focal therapy (like cryotherapy or HIFU). About 60 men with prostate cancer who haven't had prior treatment will get the scan before and after…

This trial tests whether teaching families to wash children's hands and faces with soap can lower the rate of active trachoma, a bacterial eye infection that can lead to blindness. About 990 children aged 1-9 in central Ethiopia will take part, with some households receiving a st…

This study tests whether practicing deep breathing exercises before surgery can lower the chance of postoperative delirium—a state of confusion and disorientation—in men undergoing robot-assisted prostate removal for prostate cancer. Half of the 50 participants will be taught a s…

This study tests a group-based HIV prevention program designed specifically for Black women aged 50 and older living in subsidized housing. The program aims to improve HIV knowledge, condom use, and testing. Participants will be randomly assigned to start the program right away o…

This study tests whether it is practical and safe to remove the fallopian tubes during planned weight-loss (bariatric) surgery as a way to lower the risk of ovarian cancer. Many ovarian cancers are thought to start in the fallopian tubes, and removing them can reduce risk by abou…

This trial asks whether taking 50 mL of extra virgin olive oil every day can reduce the chance of heart attacks, strokes, and related deaths in people living with HIV. About 1,300 adults aged 50–75 with well-controlled HIV and at least one heart risk factor will be randomly assig…

This study tests whether taking low-dose aspirin can lower inflammation in the womb lining and help prevent endometrial cancer. It involves 25 postmenopausal women who have non-atrophic endometrial changes and pain. Participants will be randomly assigned to take aspirin or not, a…

This pilot study aims to see if offering self-collection kits for cervical cancer screening and HPV vaccination in emergency departments can reach women who have limited healthcare access. Researchers will enroll 100 women aged 18-65 and track how many participate and complete th…

This study compares monitoring by nurses versus physicians for people taking HIV pre-exposure prophylaxis (PrEP). It looks at how well patients follow their PrEP schedule, their satisfaction with care, and the cost of each approach. The goal is to see if nurse-led care can be a s…

This study is developing a prediction model to identify pregnancies at increased risk of stillbirth or fetal growth restriction, often caused by placental problems. Researchers will follow 7,000 pregnant individuals, collecting data from early pregnancy through delivery and postp…

This trial tests whether a self-administered vaginal swab, analyzed with advanced molecular technology, can detect and treat bacterial imbalances early in pregnancy. Pregnant women at high risk of preterm birth will either receive this screening plus targeted antibiotics or stand…

This trial tests whether a prenatal exercise program that combines Liuzijue qigong with traditional Kegel exercises, guided by a mobile app, can prevent postpartum urinary incontinence and pelvic organ prolapse. Pregnant women in their third trimester will be randomly assigned to…

This pilot trial tests a mobile app called Bandi, designed to support HIV prevention among young men who have sex with men in South Korea. Participants are randomly assigned to either the full app, which includes interactive health content, peer forums, a sexual health log, and a…

This pilot study tests whether training popular opinion leaders in rural South Africa can increase uptake of HIV prevention tools. Researchers will select and train young adults to share sexual health information and distribute HIV self-tests to their peers. The study will assess…

This trial tests whether giving students accurate information about their peers' actual behavior can reduce heavy drinking and risky sexual activity. About 1,350 adolescents in three Ugandan schools will complete surveys and receive personalized feedback comparing their own estim…

This study explores whether offering HIV prevention medication (PrEP) through pharmacies can help more young women aged 18-24 in Tanzania access and consistently use it. Researchers compare four different pharmacy-based service models to standard care, and later test cost-sharing…

This trial tests whether taking a single dose of the antibiotic doxycycline within 24 hours of condomless sex can prevent bacterial sexually transmitted infections (STIs) like chlamydia, gonorrhea, and syphilis in women aged 18–35 at increased risk. Participants are randomly assi…

This study tests a mobile health app called mSYNC designed to help prevent HIV in people who use drugs and visit the emergency department. The app provides counseling and support for risk behaviors, mental health, and access to care. Researchers want to see if the app is acceptab…

This study tests a 5-month text-messaging program called #TranscendentHealth, created specifically for transgender boys and gender-diverse youth assigned female at birth, ages 14 to 18. The program aims to improve condom use, birth control use, and HIV/STI testing by addressing t…

This study tests a simpler way to give TB preventive therapy to household contacts of TB patients and people living with HIV. Instead of monthly clinic visits, some participants get the full course of pills at once in their community. Researchers want to see if this approach help…

This study adapts a program called CARES to help 2,100 adolescent girls and young women (ages 16-24) in South Africa and Zimbabwe consistently use HIV prevention methods like pills, rings, or injections. The program includes counseling, text reminders, and peer support. Researche…

This study tests a mobile app called LOTUS designed to help people who use drugs engage with HIV prevention services like testing and PrEP. The app provides tips, reminders, peer support, and a way to ask healthcare professionals questions. The trial will enroll 40 participants t…

This study tests whether electroacupuncture (using mild electric pulses on needles) plus tiny thumbtack needles can prevent nerve damage caused by chemotherapy in people with early-stage cancer. About 278 patients with breast, stomach, bowel, lung, or ovarian cancer will receive …

This study will test if using two heat probes instead of one can better prevent cervical cancer in 300 women with HIV in Zimbabwe. The standard single-probe treatment often fails in these women. The goal is to see if the two-probe method is safe, acceptable, and more effective at…

This study will compare two enhanced flu vaccines—one with an adjuvant (MF59) and one with a higher dose—in 350 adults living with HIV. The goal is to see which vaccine triggers a stronger immune response. Participants will receive one shot and have their antibody levels checked …

This study tests whether using two probes during a heat-based treatment (thermal ablation) works better than the usual one-probe method to prevent cervical cancer in women living with HIV. About 200 women aged 25-49 with HIV and cervical precancer will be enrolled. The goal is to…

This study tests whether electroacupuncture (acupuncture with mild electrical pulses) combined with tiny thumbtack needles can prevent peripheral neuropathy—numbness, tingling, or pain—caused by chemotherapy in people with advanced cancer. The trial enrolls adults with stage IV b…

This study tests whether removing the fallopian tubes at the same time as gallbladder surgery is safe and practical. Ovarian cancer often starts in the fallopian tubes, so removing them may prevent it. The trial will enroll 240 women aged 35 and older to see if the extra procedur…

This pilot study will test a program called INSPIRE, designed to reduce stigma and increase HIV testing among Chinese immigrant women who work in massage parlors in Queens, NYC. The program involves four one-on-one conversations with a peer advocate over six weeks, plus weekly te…

This trial tests whether an artificial intelligence chatbot can help men with prostate cancer better understand radiation therapy. Participants will use a plain-language chatbot alongside standard education from their care team. Researchers will measure changes in patients' confi…

This trial tests whether adding a structured yoga therapy program to standard surgery for endometriosis can reduce chronic pain and improve quality of life. About 188 women scheduled for endometriosis surgery will either receive standard care alone or standard care plus 32 guided…

This study tests whether adding an injection of Xeomin (a type of botulinum toxin) to the erectile dysfunction pill tadalafil can improve erections better than the pill alone. About 30 men with mild-to-moderate ED will receive both treatments in a crossover design. The goal is to…

This study tests whether adding estrogen to standard prostate cancer treatment can improve quality of life for 60 men with metastatic hormone-sensitive prostate cancer. Standard therapy often causes hot flashes and other side effects by lowering estrogen. The study compares estro…

This phase 2 trial tests whether a low dose of naltrexone (LDN) can reduce fatigue in men with prostate cancer who are on hormone therapy (ADT). The study will enroll 60 participants and measure fatigue, quality of life, and safety. It is not yet recruiting.

This study tests whether a digital serious game, Endoexpedition, can improve how people with endometriosis receive information about their condition and treatment options. Participants will be randomly assigned to either play the game or read standard written materials. The trial…

This study tests whether high-intensity focused ultrasound (HIFU) can safely and effectively treat urinary symptoms caused by an enlarged prostate. Seventeen men aged 45 to 80 with moderate to severe symptoms will receive a single HIFU treatment using a probe placed in the rectum…

This trial tests whether an 8-week program of coordinated breathing and pelvic floor exercises can reduce pain and improve quality of life in university women aged 18-24 with primary dysmenorrhea (painful periods without underlying disease). Participants will either do the exerci…

This study tests whether adding telehealth sex therapy to standard pelvic floor physical therapy helps men recover urinary and sexual function after prostate cancer treatment. All participants receive pelvic floor therapy and education on using a vacuum erection device. Half are …

This pilot study tests whether high-intensity interval training (HIIT) before prostate removal surgery can improve recovery and reduce anxiety. Men scheduled for radical prostatectomy will do vigorous exercise for about 60 minutes per week for at least four weeks before their ope…

This study tests whether an AI-powered program can help older adults with serious illnesses like cancer or heart disease manage emotional distress. Participants receive short videos and daily check-ins from a chatbot that teaches practical coping skills, all from their own phone.…

This trial tests whether a single virtual reality exposure session, added to standard care, can help women with vaginismus—a condition causing involuntary pelvic muscle tightening due to fear of vaginal penetration. Participants will experience a virtual environment designed to g…

This trial tests a supportive care program called E-MOTE, delivered by an AI-assisted robot during hospital stays and a mobile app after discharge, for women newly diagnosed with gynecologic cancer who are undergoing surgery. The program includes emotional assessments, empathetic…

This trial tests whether mind-body practices like breathwork, meditation, and gentle yoga can improve quality of life, stress, and sleep in people who have recently finished cancer treatment. Participants will practice these techniques weekly for six weeks while wearing an activi…

This trial investigates whether adding a hands-on technique called abdominopelvic fascial release to stretching exercises can reduce menstrual pain and improve scar mobility in women who have had a cesarean section. The study enrolls women aged 20 to 35 with moderate to severe pe…

This study tests a mobile health app called OPUCARE designed to support women with infertility who are about to undergo egg retrieval. The app provides medication reminders, treatment information, side-effect tips, and motivational messages. Researchers want to see if using the a…

This trial investigates whether early electroacupuncture can reduce persistent lower urinary tract symptoms—like frequent or painful urination—in men recovering from benign prostatic hyperplasia surgery. Participants receive three sessions of electroacupuncture starting two days …

This trial tests an 8-week eHealth program called eMindExCare that combines mindfulness practices with home-based aerobic and resistance exercises for prostate cancer patients undergoing active treatment. The study aims to see if the program is feasible and acceptable, and whethe…

This early-stage trial tests a new fixed-dose combination pill called Viaca, which contains sildenafil and cabergoline, for erectile dysfunction. The study enrolls 30 healthy adult male volunteers to compare the safety, tolerability, and drug levels of the combination against eac…

This study tests whether watching storytelling videos and writing or talking about personal experiences can reduce stigma and improve quality of life for women living with both cervical cancer and HIV in Zambia. Participants are randomly assigned to different combinations of stor…

This trial tests whether a wearable device that delivers a cooling sensation on the wrist can reduce the burden of hot flashes in men with prostate cancer who are on androgen deprivation therapy (ADT). About 66 participants will be randomly assigned to use the device right away o…

This pilot study tests whether a Patient Empowerment Project (PEP) can improve the experience of people seeking fertility treatment. Patients complete a brief questionnaire about their sensitivities and preferences before their first visit, and clinic staff use the responses to t…

This trial tests whether coloring mandalas for 20 minutes can lower anxiety, pain, and improve vital signs and satisfaction in men undergoing transurethral resection of the prostate (TURP). Half of the 64 participants will color a mandala before surgery; the other half will recei…

This study tests whether a small, wearable patch that stimulates a nerve in the leg can help men who still have bladder symptoms after prostate surgery. Participants will either receive behavioral therapy alone or behavioral therapy plus the patch for 12 weeks. The goal is to see…

This trial investigates whether acupuncture can help women who have trouble urinating after a radical hysterectomy for cervical cancer. Participants receive either real acupuncture or a sham version (using non-penetrating needles) alongside standard care with a catheter and medic…

This phase 2 trial tests whether nemolizumab, an injectable biologic, can reduce severe itching in women with vulvar lichen sclerosus, a chronic inflammatory skin condition. Participants receive weight-based doses of the drug and track their itch scores daily. The study focuses o…

This trial tests F-GYN, a single-use injectable gel made of non-crosslinked hyaluronic acid, for women with moderate to severe vaginal dryness and atrophy. Participants either receive the injection right away or continue standard non-hormonal care for 4 weeks before getting the i…

This study compares two non-drug approaches—aerobic exercise and a specific neck massage technique—to see if they can improve memory in women with premenstrual syndrome (PMS). Researchers will enroll 40 women aged 18 to 30 who have PMS and memory complaints. Participants will be …

This trial investigates whether a supervised program of aerobic and strength training can improve quality of life, heart function, and body composition in men with prostate cancer who are receiving androgen deprivation therapy (hormone therapy). The study involves 46 men aged 40 …

This pilot study tests a communication skills training program called Starting the Conversation for prostate cancer patients who are bothered by sexual problems. About 100 men will either receive the training or a general health education program. The goal is to see if the traini…

This study will compare two treatments for moderate to severe urinary symptoms caused by an enlarged prostate. One group takes a standard drug (alfalitic) plus a natural supplement (Serenoa repens, or saw palmetto), while the other takes the same drug plus another standard medica…

This study tests whether Pilates or gym exercises better relieve pain from primary dysmenorrhea (period pain) in young women aged 17-25. Fifty-two participants will do either Pilates or gym workouts three times a week for three months. Researchers will measure pain intensity, sym…

This pilot study tests whether a device called Flyte can help improve urinary incontinence in women who had radiation therapy for endometrial or cervical cancer. The Flyte device is used at home and delivers gentle vibrations while the user does Kegel exercises. The study will ch…

This study tests whether adding cyclobenzaprine, a muscle relaxant, to standard pain medicines (ibuprofen, acetaminophen, and short-term narcotics) improves pain control and reduces narcotic use after minimally invasive hysterectomy. About 36 women undergoing laparoscopic hystere…

This study tests a web-based program designed to help caregivers of prostate cancer patients deal with uncertainty and reduce the burden of caregiving. The program is based on a theory about how people handle uncertainty in illness. Researchers will measure changes in caregivers'…

This study tests whether taking high doses of vitamin E and CoQ10 daily for 90 days can reduce chronic side effects from pelvic radiation in people treated for prostate, uterine, cervical, or anal cancer. Researchers will monitor safety, side effects, and quality of life in 200 a…

This study tests whether Emotional Freedom Techniques (EFT), a therapy that combines tapping on acupressure points with focused thoughts, can reduce pain intensity, pain-related worrying, and emotional distress in nursing students who suffer from painful periods. Participants are…

This study tests whether gentle belly massage can reduce period pain and improve quality of life in women with painful periods, with or without endometriosis. About 80 women will be randomly assigned to receive either real massage or a light touch (sham) over three menstrual cycl…

This study looks at whether a prehabilitation program—including physical therapy, dietary advice, and emotional support—given before major cancer surgery can reduce deaths and serious complications within 30 days after the operation. About 180 adults with cancers of the pancreas,…

This study tests a procedure called irreversible electroporation (IRE) to treat urinary symptoms caused by an enlarged prostate. About 40 men aged 50 and older with moderate to severe symptoms will receive the treatment. The goal is to see if IRE safely improves urine flow and re…

This study tests whether adding Eroxon gel to the standard pill tadalafil can improve erections in men aged 18 to 40 with type 2 diabetes. Thirty men who already take tadalafil will use the gel before sex and report changes in erectile function. The goal is to see if the combinat…

This study tests a 5-day online Theta Healing program—including meditation, visualization, and self-compassion exercises—in 142 women with PCOS. The goal is to see if it reduces fertility anxiety and improves body image compared to usual care alone. Results will be measured 6 wee…

This study tests whether a 12-week exercise program, delivered via Zoom, is practical and helpful for older adults (65+) with cancer who live in rural areas. Participants will do two supervised exercise sessions per week. The goal is to see if the program improves quality of life…

This study tests whether suzetrigine, a new painkiller that works on nerves without affecting the brain, can control pain after pelvic surgery as well as standard opioids. 120 women will receive either suzetrigine or opioids, along with common pain relievers. The goal is to see i…

This study tests whether a single hypnosis session during chemotherapy can reduce anxiety and other side effects like nausea in young people with cancer. It includes 70 participants aged 15-49 with sarcoma, germ cell tumors, or breast cancer. Researchers will compare anxiety leve…

This study looks at whether an 8-week supervised weightlifting program can help active women with functional hypothalamic amenorrhea (a condition where periods stop due to stress and low calorie intake) safely regain their menstrual cycles. Researchers will compare 28 women—some …

This trial tests if leaving out vaginal gauze packing after prolapse surgery helps women recover faster. 360 women having surgery for pelvic organ prolapse will be randomly assigned to either receive standard packing for two hours or no packing at all. The goal is to see if skipp…

This study looks at whether teaching pelvic floor muscle exercises before and after prostate removal surgery can help men control urine leakage and feel better day-to-day. Ten men who have surgery for prostate cancer will learn these exercises from nurses. The goal is to see if t…

This study tests whether cauterizing the uterine artery at its origin before removing the uterus via laparoscopy reduces blood loss and surgery time compared to the standard technique. It will involve 44 women over 35 with non-cancerous conditions like fibroids or abnormal bleedi…

This study tests if a newer, shorter course of radiation therapy (MH-ART) is as good as the standard longer course (CF-IMRT) for women who have had surgery for cervical or endometrial cancer. The goal is to see if the new approach causes fewer side effects and improves quality of…

This study looks at how HIV and substance use disorder (SUD) affect the sense of smell and decision-making. Researchers will test 120 adults aged 18–65, including people with HIV, SUD, both, or neither. Participants will complete smell tests and computer tasks over two visits, an…

This study will give a single dose of oral methamphetamine to 20 people with HIV who are on effective antiretroviral therapy and have undetectable virus levels. The goal is to see if the drug can temporarily wake up dormant HIV hiding in cells, which could help researchers find n…

This study tests a program called HOLA that teaches oncologists special communication skills to build better relationships with their Latino patients who have advanced cancer. Researchers will compare how strong the bond is between doctors who take the training and those who don'…

This study tests a quality improvement method called SAIA to help emergency departments in Kenya offer more HIV tests to people who often miss out, like men, teens, and key populations. Researchers will compare hospitals that use SAIA with those that don't, measuring how many pat…

This study aims to create new laboratory models of ovarian cancer that no longer respond to standard platinum-based chemotherapy or PARP inhibitors. Researchers will take tumor tissue from patients with resistant disease and grow it in mice and in the lab to mimic real clinical c…

This study looks at how the body processes doxycycline, an antibiotic, when taken in different ways—either as a single dose or repeated doses (daily or every three days). Healthy adults without any sexually transmitted infections will be randomly assigned to one of these schedule…

This study aims to understand how migration history and social factors affect the quality of life of Black immigrant men from Sub-Saharan Africa and the Caribbean who have been diagnosed with prostate cancer. Researchers will interview 40 men to learn about their experiences and …

This study looks at how anticipated stigma and illness identity affect quality of life in men with hypogonadism (low testosterone). It compares these men to those with other chronic endocrine conditions like diabetes, hypothyroidism, or hypertension. The goal is to see if these p…

This study uses an online questionnaire to gather information from 15,000 Spanish-speaking adults about their sexual health, behaviors, and any experiences of altered consciousness during orgasm. The goal is to better understand the range of sexual function and pleasure, and to e…

This study looks at whether the mobility of a cesarean scar is related to the severity of menstrual pain in women who have had a C-section. Researchers will measure scar mobility, pain levels, and pressure sensitivity in 34 women aged 20–35 with regular cycles and period pain. Th…

This early-stage study looks at how a common tuberculosis drug, rifampin, affects levels of a new HIV prevention medicine called MK-8527. Fourteen adults with latent TB (no active symptoms) will take MK-8527 with and without rifampin. The goal is to see if the two drugs can be us…

This study looks at the long-term urinary, sexual, and bowel health of people aged 7 to 25 who had surgery for Hirschsprung disease as young children. Hirschsprung disease is a rare birth defect where part of the large intestine lacks nerve cells, causing blockages. Surgery remov…

This study compares two common prostate medications, tamsulosin and silodosin, to see how they affect pupil size and the thickness of a layer at the back of the eye called the choroid. Men aged 50 and older with benign prostatic hyperplasia (BPH) who have not used these drugs bef…

This study aims to develop an online educational tool for women diagnosed with endometrial cancer. Participants will use a website to access educational content, complete surveys, and provide feedback on its usability. The goal is to create a resource that can be made widely avai…

This study tests whether ShouTai Pills, a traditional Chinese herbal remedy, can improve egg quality in women with diminished ovarian reserve (DOR) who are undergoing IVF. Researchers will analyze follicular fluid to identify biological markers that predict who might benefit. The…

This study examines the most common symptoms of genitourinary syndrome of menopause (GSM) in postmenopausal women and how these symptoms impact quality of life. Researchers will also look at whether using a non-hormonal topical gel called XCM INTIM for at least 8 weeks is linked …

This study asks whether visual signs seen during a hysteroscopy — a camera exam of the uterus — can reliably detect chronic endometritis, a long-term inflammation of the uterine lining. About 100 women already scheduled for hysteroscopy as part of their fertility care will take p…

This pilot trial tests whether a risk calculator designed for Nigerian men can help primary care providers better identify those with clinically significant prostate cancer. Researchers will train healthcare workers at community hospitals and then support them in using the tool f…

This trial explores whether a whole-body bone scan (SPECT/CT) taken in the treatment position can help doctors plan stereotactic radiotherapy more precisely for prostate cancer that has spread to the bones. Thirty patients will receive the scan in addition to standard imaging, an…

This study looks at how a special program, called the Geriatric Surgery Verification Program, works at the James Cancer Hospital. The program helps doctors and nurses better care for patients aged 65 and older who need cancer surgery. It includes checking for age-related issues l…

This study looks at whether artificial intelligence and detailed molecular analysis can help predict how high-grade serous ovarian cancer will behave after surgery. Researchers will analyze tumor images, genetic data, and patient records from 1,300 women to build a model that for…

This study investigates whether erectile dysfunction (ED) in men being treated for high blood pressure is linked to a hidden heart condition called subendocardial ischemia, where the heart muscle doesn't get enough oxygen. Researchers will compare a noninvasive heart test called …

This study explores whether at-home saliva samples can reliably measure key steroid hormones in people with congenital adrenal hyperplasia (CAH), a condition requiring lifelong hormone therapy. Currently, monitoring involves morning blood tests that miss daily hormone fluctuation…

This study follows women aged 70 and older with ovarian cancer to understand why some experience cognitive decline or delirium during treatment. Researchers will track memory, thinking skills, frailty, and quality of life over 12 months, and analyze blood samples for markers of b…

This study follows babies and young children (up to age 5) who have a genetic diagnosis of ataxia telangiectasia (A-T), a rare disease that affects movement and immunity. Researchers use brain and lung scans, blood tests, and movement analysis to spot early signs of disease progr…

This study tests whether a low-cost visual aid called B-OK bottles can help people in South Africa better understand HIV and antiretroviral therapy (ART). The bottles use beads to show how HIV affects health and how ART can make the virus undetectable and untransmittable. About 6…

This study tests whether a behavioral education program can help men with low sperm quality reduce their exposure to endocrine disrupting chemicals (EDCs) found in everyday products. Participants complete 14 online modules over 8 weeks, and researchers measure changes in environm…

This study looks at whether primary dysmenorrhea (painful periods) is linked to changes in the biomechanics of the lower back and pelvis. Researchers will compare female university students aged 18-24 who have moderate to severe menstrual pain with those who have little or no pai…

This study tests a new, non-invasive method to check embryos for chromosome problems before IVF transfer. Instead of taking a cell sample, researchers analyze fluid the embryo grows in. The goal is to see if this test can predict which embryos will lead to a healthy pregnancy. Th…

This study follows men aged 45 and older who are scheduled for surgery that removes only the middle part of an enlarged prostate (the median lobe). The goal is to see which factors before surgery—like symptoms, urine flow, and prostate shape—are linked to success one year later. …

This study looks at how certain cancers develop in people with HIV and what factors might increase their risk. Researchers will analyze medical data from 1,000 HIV-positive adults to track which types of cancer occur most often and why. The goal is to improve early detection and …

This study looks at postmenopausal women who have a thickened uterine lining (endometrium) found by chance but have no symptoms like bleeding. Researchers will use a tiny camera (hysteroscopy) to view the lining and take tissue samples to compare the camera findings with lab resu…

This study brings together data from multiple previous trials to investigate a rare group of people with HIV who can keep the virus under control even after stopping antiretroviral therapy. Researchers will analyze stored blood samples and clinical records to look for biological …

This study looks at how a person's migration history and social situation affect how well HIV treatment works. Researchers will compare the health outcomes of 150 migrants living with HIV in France, based on their social and administrative status. The goal is to understand whethe…

This study explores whether ovulation can be detected using non-invasive methods like saliva, hair samples, and smartwatch data instead of standard blood tests. Researchers will monitor 30 women with regular menstrual cycles over three cycles, collecting saliva and hair for proge…

This study examines how often patients have a difficult time placing a breathing tube during prostate surgery called HoLEP. Researchers look back at medical records of 300 patients to find out which factors, such as weight, prostate size, or certain medications, may increase the …

This study looks at men with localized prostate cancer who had robot-assisted surgery to remove the prostate. The goal is to find which factors—like PSA levels, tumor grade, or MRI results—best predict whether the cancer will come back (called biochemical recurrence). Researchers…

This study will include about 2,748 people with breast, gynecologic, or pancreatic cancer. Researchers want to see if adding patient-reported outcomes—like symptoms, preferences, and travel distance—to tumor board discussions helps doctors make better treatment decisions. The goa…

This study looks at men with an enlarged prostate who previously used the ProVee urethral expander device. Researchers want to see if these men needed any additional surgical treatments after the device was removed. The goal is to understand how well the device works over the lon…

This study looks at 200 people with pneumonia to find out how many actually have an infection caused by Chlamydia pneumoniae, a type of bacteria. Researchers will use PCR tests to check for the germ and compare results with standard care. The goal is to see if this infection is o…

This study explores whether artificial intelligence can help perform high-field whole-body MRI scans faster while keeping image quality high. Researchers will compare standard MRI sequences with AI-accelerated versions in 600 adults undergoing screening for prostate, lung, or vas…

This study will recruit 100 sexual partners of people diagnosed with gonorrhea. Researchers will take an extra throat swab to analyze all the bacteria and their genes using a technique called metagenomics. The goal is to find hidden infections, antibiotic resistance, and see how …

This study looks at blood flow in a part of the fetal heart called the aortic isthmus in pregnancies where the baby is not growing well (fetal growth restriction). Researchers will compare Doppler measurements between affected fetuses and healthy ones to see if these patterns can…

This study looks at whether pieces of tumor DNA and HPV DNA circulating in the blood can predict if cervical cancer will return after successful first-line treatment. Researchers will collect blood samples over time from 60 patients whose cancer has gone into complete remission. …

This study observes how well a combination of two drugs, olaparib and abiraterone, works as a first treatment for men with metastatic castration-resistant prostate cancer who have already tried other hormone therapies. Researchers will track how long patients stay on the treatmen…

This study looks at sleep health in people with HIV who are on different antiretroviral therapies. Some participants switch from a dolutegravir-based regimen to a doravirine-based one, while others stay on dolutegravir. Sleep is measured using questionnaires, wrist-worn activity …

This study will follow 5,500 first-time pregnant women to see if blood tests and eye scans can predict complications like preeclampsia, fetal growth restriction, and gestational diabetes. Researchers will collect samples and images at different points during pregnancy and compare…

This early-stage trial in 18 healthy adults compares a new octreotide tablet (T25) with an existing capsule (MYCAPSSA) to see how much drug gets into the blood. It also checks whether a high-fat meal changes absorption of the tablet. Participants take single doses under fasting o…

This study looks at how feeling anxious or scared before prostate surgery affects recovery and satisfaction in men with an enlarged prostate. Researchers will follow 80 men who are having either laser or standard surgery. They will use questionnaires to measure anxiety, depressio…

This study will look back at records from 92 IVF patients whose embryos came from abnormally fertilized eggs. Researchers want to see how often these embryos lead to pregnancy and live birth. The goal is to help fertility doctors make better decisions about whether to use such em…

This study investigates whether a simple coronary CT scan can detect early signs of heart disease in people with HIV. Researchers will measure calcium buildup in the heart arteries of 384 Mexican adults with HIV who have undetectable viral loads. The goal is to better understand …

This study looks at how common stigma is for breast and cervical cancer patients, caregivers, and community health workers in Rwanda. It also tests a program called RISE that includes resilience training, support groups, and videos of cancer survivors to see if it can reduce stig…

This study looks at women with diminished ovarian reserve (DOR) — a condition where the ovaries have fewer eggs, making IVF harder. Researchers are examining specific RNA molecules in the fluid around eggs to see how they relate to egg quality and embryo development. The goal is …

This study looks at how to safely place a breathing tube in people with acromegaly, a condition that can cause changes in the face and airway. It compares two methods: direct laryngoscopy and video laryngoscopy. The goal is to find which method gives a better view of the airway a…

This study looks at how HIV-1 hides in immune cells in the gut of people on effective antiretroviral therapy. Researchers will collect blood and colon tissue from 30 HIV-positive volunteers and healthy controls during routine colonoscopies. The goal is to understand why these gut…

This study compares immune cells, specifically natural killer cells, in women with deep endometriosis and those without the condition. Researchers will collect blood, tissue, and vaginal samples from 50 participants to look for differences that might explain the disease. The goal…

This study will send different types of WhatsApp messages to 235,000 people in Chile who are due for cancer or chronic disease screenings. Researchers want to see if the way a message is worded (basic, risk-focused, or peace-of-mind) and whether it mentions one test or both tests…

This study tests whether injecting a radioactive tracer directly into the prostate artery improves imaging compared to standard arm injection in 10 men with high-risk prostate cancer. The goal is to see if this method gives clearer pictures and helps predict the right radiation d…

This study tests whether a safe dose of ivermectin, a common deworming drug, can make human feces deadly to flies that spread trachoma. Trachoma is a leading cause of blindness, and these flies carry the bacteria from person to person. Twelve healthy adults will take ivermectin, …

This study tests a method to help clinics prescribe long-acting injectable PrEP, a shot that prevents HIV. Researchers will work with 20 healthcare providers and staff to improve how they offer this option. The goal is to see if a simple, flexible strategy can increase the number…

This study will look at over 12,000 adults in the Basque Country to compare how common multiple health conditions, taking many medications, and getting risky prescriptions are among people with HIV versus the general population. Researchers will use electronic health records to g…

This study will look at whether SPECT scans taken after Lu-PSMA therapy can help predict how well patients with metastatic castration-resistant prostate cancer (mCRPC) are doing. Researchers will measure tumor activity and volume on the scans and compare them to standard PET-base…

This study will develop and test a free, cloud-based platform to educate women aged 18-45 with early-stage gynecologic cancer about fertility preservation options. Researchers will compare awareness, knowledge, and attitudes between a group using the platform and a group receivin…

This study looks at how HIV might change the way the body handles fats in the liver, leading to fatty liver disease. Researchers will collect one blood sample from 120 adults: people with HIV and fatty liver, people without HIV but with fatty liver, and healthy controls. By analy…

This study will check if menstrual blood can give the same health information as regular blood tests, uterine biopsies, and vaginal swabs. One hundred menstruating women aged 18 and over will provide samples during their period. The goal is to see if menstrual blood is a useful, …

This study looks at how doctors in tumor board meetings work together when discussing ovarian and uterine cancer cases. About 400 physicians will fill out surveys after each meeting to measure things like communication, teamwork, and decision-making. The goal is to understand wha…

This pilot study investigates how well a dual-wavelength diode laser can destroy endometriotic tissue inside ovarian cysts (endometriomas). Researchers will apply the laser to cyst walls removed during surgery and examine the tissue under a microscope to see if all abnormal cells…

This study looks at how Black and Hispanic adults in the U.S. feel about online information on prostate cancer. Participants will view a video or text post about the disease and then fill out a short survey. The goal is to understand trust and emotional reactions to online health…

This study looks at how two types of birth control devices—copper IUDs and hormonal IUDs—affect the bacteria in the vagina and the risk of infections. About 120 HIV-negative women aged 18-40 will be randomly assigned to one device and followed for a year. Researchers will collect…

This study will follow over 1,000 women in Spain who are having vaginal surgery for pelvic organ prolapse. The goal is to see how often bladder control problems (like stress or urge incontinence) develop or improve after surgery. Researchers hope to find risk factors that can hel…

This study will follow about 484 couples undergoing a type of IVF called ICSI to see if sperm DNA damage affects their chances of having a baby. Researchers will measure DNA breaks in sperm before and after a washing step, then track pregnancy and live birth rates. The goal is to…

This large observational study will follow 4,000 young cancer survivors (ages 15-39) across Europe to understand how different cancer treatments impact fertility, hormone function, and pregnancy outcomes. Researchers will also evaluate the safety and success of fertility preserva…

This study will analyze data from 2,000 men who had prostate surgery for an enlarged prostate (BPH). Researchers want to build a scoring system using MRI scans, urine flow tests, and symptom scores to predict who will have a good outcome. The goal is to help doctors and patients …

This study will follow 3,000 young women (ages 15-39) with cancer to understand how treatments like chemotherapy and immunotherapy impact their fertility, pregnancy outcomes, and quality of life. Researchers will also look at the safety and success of fertility preservation metho…

This study looks at the best way to help prostate cancer survivors learn about and get genetic testing for inherited cancer risks. About 500 participants will be randomly assigned to a digital guide, a printed guide, or standard care. Researchers will track who requests testing a…

This study looks at whether hairdressers in the East of England can become sexual health champions for Black African women. The goal is to see if it's possible and acceptable for hairdressers to share information about HIV prevention and local sexual health services with their cl…

This study looks at whether a web-based education program can improve women's attitudes and beliefs about HPV testing, which is key for preventing cervical cancer. About 120 women aged 18-60 will take part, with half receiving the online education and the other half getting stand…

This study looks at whether giving patients clear, standardized instructions before and after pituitary surgery can improve their recovery. Researchers will compare hospital stay length, complication rates, and unplanned readmissions in 102 adults having elective surgery. The goa…

This study follows 1,000 young men (ages 15-39) diagnosed with cancer to understand how treatments affect their fertility and hormone levels over time. Researchers will collect medical history, semen samples, and blood tests before and after therapy to identify who is at risk for…

Denys-Drash syndrome is a rare genetic condition that causes kidney failure in early childhood, often requiring a transplant. Past research suggests these children have a much higher chance of developing a type of lymphoma after transplant compared to other kids. This study will …

This study is a registry that will collect health information from up to 5,000 women experiencing perimenopause, menopause, or premature ovarian insufficiency. Researchers will gather data from medical records and ongoing visits to a specialized clinic, tracking symptoms, treatme…

This study will compare two types of robot-assisted surgery for prostate or kidney cancer: single-port (one small incision) and multi-port (several incisions). Researchers will track 376 adults to see which approach leads to a shorter hospital stay and better recovery. The study …

This study looks at whether a testosterone lotion applied to men's skin can transfer to women through casual contact. Researchers will measure testosterone levels in the blood of female partners after skin-to-skin contact. The goal is to understand if the lotion is safe for use a…

This study aims to better understand and treat myofascial pelvic pain, a common cause of long-term pelvic pain in women. Researchers will use a noninvasive imaging technique to measure pelvic floor muscle function before and after three different treatments: education with relaxa…