Could a stool sample replace a spinal tap? new study tests Non-Invasive infection detection
NCT ID NCT07603453
First seen Jun 13, 2026 · Last updated Jun 21, 2026 · Updated 2 times
Summary
This study will test whether analyzing stool and urine samples using a technique called metagenomics can find infections in people with weakened immune systems (due to HIV, chemotherapy, or immunosuppressive drugs). Currently, doctors often need to take invasive samples like blood, spinal fluid, or tissue biopsies to find the cause of an infection. If stool and urine work as well, it could make diagnosis easier and safer. The study will enroll 120 participants and compare results from non-invasive samples with those from standard invasive tests.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Hôpital Necker - Enfants Malades
Paris, Île-de-France Region, 75015, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Metagenomic sequencing (mNGS) of stool and urine samples
What this could lead to
If successful, this could allow doctors to diagnose infections in immunocompromised patients using simple stool or urine samples instead of invasive procedures like spinal taps or tissue biopsies.
What could go wrong
This is an early-stage study with only 120 participants, so results may not apply to all patients. The technique may not detect all pathogens, and false positives or negatives are possible.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.