Scientists hunt for genetic clues to mysterious immune diseases

NCT ID NCT00246857

Recruiting now Knowledge-focused Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 11 times

Summary

This study aims to find the genetic causes of inherited immune problems that affect white blood cells called lymphocytes. Researchers will review medical records and collect blood samples from up to 5,000 people with suspected immune disorders, as well as their relatives. The goal is to understand why some people have enlarged lymph nodes, autoimmune issues, or frequent infections due to problems with cell growth and death.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to better understanding of genetic immune diseases and potentially point toward future treatments.
What could go wrong: This is an observational screening study, not a treatment trial. It may not directly benefit participants and could take years to yield meaningful results.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autoimmune disease hereditary disease immunodeficiency disease immunodysregulation with variable immunodeficiency and autoimmunity inborn error of immunity Primary Immunodeficiency Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY IMMUNE DEFICIENCY

Contacts and locations

Locations

Ankara Medical University
RECRUITING

Ankara, Turkey (Türkiye)
Gazi University
RECRUITING

Ankara, Turkey (Türkiye)
Hacettepe University
RECRUITING

Ankara, Turkey (Türkiye)
Marmara University
RECRUITING

Istanbul, Turkey (Türkiye)
National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States
Necemttin Erbakan University
RECRUITING

Konya, Turkey (Türkiye)
Sureyyapasa Chest Diseases and Chest Surgery Training and Research Hospital
RECRUITING

Istanbul, Turkey (Türkiye)
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109-0624, United States

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