Water jet surgery could offer new option for prostate cancer patients
NCT ID NCT07650448
First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 2 times
Summary
This study compares a robotic water-jet procedure called Aquablation to active surveillance (close monitoring) in 333 men with low- or intermediate-risk localized prostate cancer. The goal is to see if Aquablation can better prevent cancer from progressing to a more serious grade. Participants will be followed for several years to track cancer outcomes and the need for additional treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Aquablation therapy (water-jet tissue removal using the AquaBeam or HYDROS Robotic System)
- What this could lead to
- If successful, this could offer men with localized prostate cancer a minimally invasive option that lowers the chance of cancer worsening compared to just watching and waiting.
- What could go wrong
- This is an early-stage trial with no results yet, and the procedure carries surgical risks like bleeding, infection, or urinary problems. It may not prove better than active surveillance.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Adult & Pediatric Urology
Omaha, Nebraska, 68114, United States
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Advanced Research
Delray Beach, Florida, 33484, United States
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Advocate Aurora Research Institute
Sheboygan, Wisconsin, 53081, United States
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Albany Medical College
Albany, New York, 12208, United States
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Arizona Clinical Trials
Chandler, Arizona, 85224, United States
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Boulder Medical Center
Boulder, Colorado, 80304, United States
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Chinese University of Hong Kong
Shatin, Hong Kong
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Endeavor Health
Glenview, Illinois, 60026, United States
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Georgia Urology
Atlanta, Georgia, 30328, United States
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Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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Integrated Medical Professionals, PLLC
New York, New York, 10016, United States
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Johns Hopkins University
Baltimore, Maryland, 21287, United States
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Kansas City Urology Care
North Kansas City, Missouri, 64116, United States
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Kearney Urology Center
Kearney, Nebraska, 68847, United States
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MUSC Hollings Cancer Center
Charleston, South Carolina, 29425, United States
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Mountain View Hospital
Idaho Falls, Idaho, 83401, United States
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Tidelands Health Urology
Murrells Inlet, South Carolina, 29576, United States
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Tri Valley Urology
Murrieta, California, 92562, United States
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University of Chicago
Chicago, Illinois, 60637, United States
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University of Miami
Miami, Florida, 33146, United States
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University of Rochester Medical Center
Rochester, New York, 14642, United States
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University of Southern California
Los Angeles, California, 90089, United States
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Urology Austin
Austin, Texas, 78745, United States
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Urology Clinics of North Texas
Dallas, Texas, 75231, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can sound waves offer a lasting fix for prostate problems?
- A sharper eye on prostate cancer: could new imaging spare healthy tissue?
- Could a smartwatch and remote coaching cut incontinence after prostate surgery?
- Could a placental wrap help men recover erections faster after prostate cancer surgery?
- AI model may forecast prostate cancer recurrence after surgery
- Hormone shot timing may affect recovery after prostate cancer treatment