LOCALIZED PROSTATE CANCER

This study is testing whether adding a focused radiation boost after standard short-course radiotherapy improves outcomes for men with localized prostate cancer. About 1,200 men will be randomly assigned to receive either standard SBRT alone or SBRT plus one of three boost method…

This study tests whether a 16-week home-based high-intensity interval training (HIIT) program can slow prostate cancer in Black men who are on active surveillance (monitoring the cancer without immediate treatment). The trial involves 68 participants who will use a stationary bik…

This study tests whether stem cells from donated fat tissue can help men recover erectile function after surgery for localized prostate cancer. Forty men aged 40 to 70 will receive either stem cells or a placebo during or after their prostate removal. The goal is to see if the tr…

This study tests a new robot-assisted surgery for localized prostate cancer that leaves the full length of the urethra intact. The goal is to help men regain urinary continence faster after prostate removal. About 60 men with early-stage prostate cancer will undergo the procedure…

This phase 2 trial is testing whether the immunotherapy drug atezolizumab, alone or combined with etrumadenant or tocilizumab, can boost immune cell activity in prostate tumors before surgical removal. About 68 men with localized prostate cancer will receive treatment before radi…

This study tests a new way to deliver radiation therapy for early-stage prostate cancer. Instead of two separate sessions days apart, both radiation doses are given just three hours apart on the same day. The goal is to see if this is safe and could make treatment more convenient…

This study is testing a new, shorter radiation treatment for men with early-stage prostate cancer. Instead of the usual 5 sessions, doctors will give 3 high-dose radiation treatments. The goal is to see if this approach is safe and causes fewer side effects while still controllin…

This study is testing ablative therapies—treatments that destroy cancer cells with heat or cold—for men with localized prostate cancer. Researchers want to see how well these treatments control cancer and affect quality of life, including urinary and sexual function. The study wi…

This phase 2 trial tests whether taking simvastatin, a common cholesterol drug, for 8 weeks before prostate surgery can improve the immune system's ability to fight prostate cancer. Half of the 36 men with localized prostate cancer will receive the drug, while the other half will…

This early-phase trial is testing whether giving epigenetic therapy before prostate removal can make the cancer more visible to the immune system. About 20 men with high-risk prostate cancer will receive the drugs before their scheduled prostatectomy. The main goals are to check …

This early-phase trial is testing a new way to deliver radiation for low-to-intermediate risk prostate cancer. Instead of many sessions, it uses just two high-dose treatments, with an extra boost to the main tumor. The goal is to see if this approach is safe and feasible for abou…

This study is testing a new way to deliver radiation for prostate cancer that adapts to daily changes in the body. It involves 100 men with low- or intermediate-risk prostate cancer. The goal is to see if this approach can better protect nearby organs and improve quality of life.

This study is testing whether giving only 3 doses of high-precision radiation (SBRT) over 3 days is as safe and effective as the usual 5-dose schedule for men with low or intermediate risk prostate cancer. The radiation is guided by a special catheter that acts like a GPS, tracki…

This study tests a new type of radiation therapy for prostate cancer that uses an MRI machine to guide the beam in real time. The goal is to deliver high doses of radiation more precisely to the tumor while sparing healthy tissue. The trial will enroll 50 men with localized or li…

This phase 2 trial is testing whether a special PET scan tracer called 18F-DCFPyL can accurately show how prostate cancer responds to standard radiation therapy. About 130 adults with newly diagnosed, localized prostate cancer will receive the tracer and undergo PET/CT scans at s…

This phase 2 trial tests whether a radioactive tracer called 64Cu-DOTA-AE105 can accurately show the aggressiveness of prostate cancer on a PET scan. About 168 men with low- to intermediate-risk prostate cancer will receive the tracer and undergo imaging. The goal is to see if th…

This study will test whether a special type of scan called PSMA PET/MRI can find prostate cancer that comes back after a treatment called High-Intensity Focused Ultrasound (HIFU) better than a standard MRI. About 60 men who had HIFU for prostate cancer will get both scans one yea…

This trial tests whether a structured telemedicine program — including wearable activity monitors, breathing exercises, and remote physiotherapy — can reduce urinary incontinence after radical prostatectomy for localized prostate cancer. Two hundred men scheduled for surgery will…

This early study tests whether a gel called Barrigel can stay unfrozen and protect the rectum during prostate cancer cryoablation (freezing treatment). About 20 men with localized or recurrent prostate cancer will receive the gel before the procedure. The main goal is to see if t…

This study looks at whether a special low-field MRI scanner can give clearer images for prostate cancer radiation therapy in people who have both hips replaced. Standard MRI often creates blurry images around metal implants, making it hard to aim the radiation precisely. The rese…

This study tests if a newer, more precise type of radiation (adaptive SBRT) can cause fewer urinary problems than standard radiation for men with localized prostate cancer. About 320 men will be randomly assigned to one of the two radiation methods. The goal is to see if the newe…

This study tests whether oxybutynin, a medication used for overactive bladder, can help men recover urinary control sooner after robotic prostate removal for prostate cancer. About 135 participants will take either the drug or a placebo daily for up to 3 months. Researchers will …

This trial compares two types of radiation therapy for low-risk prostate cancer: SBRT (a precise, high-dose external beam treatment) and low-dose rate brachytherapy (implanting radioactive seeds). The goal is to see which causes fewer urinary and bowel side effects and leads to a…

This research project tracks men treated with a technology called High-Intensity Focused Ultrasound (HIFU) for prostate cancer or an enlarged prostate. The goal is to see how well this treatment controls disease and affects urinary and sexual function over 10 to 20 years. By coll…

This study follows men with low-risk prostate cancer who have chosen active surveillance—monitoring the cancer over time rather than treating it right away. Researchers will collect data for years to learn which signs predict that the cancer may become aggressive. The goal is to …

This study is developing and testing an educational tool to help men aged 65 and older with prostate cancer decide with their doctors whether to reduce the frequency of follow-up tests like biopsies. The tool is being tested with 45 participants, including patients, caregivers, a…

This study follows 64 men with localized prostate cancer who undergo laparoscopic radical prostatectomy (keyhole surgery to remove the prostate). The goal is to track any complications that occur from the day of surgery up to 30 days later. By understanding how often problems hap…

This study compares regular MRI scans to standard care for men with low- to medium-risk prostate cancer who choose active surveillance (monitoring instead of immediate treatment). The goal is to see if MRIs can detect cancer progression earlier and more accurately, potentially re…

This study looks at anxiety levels in men with low-risk prostate cancer who are closely monitored instead of receiving immediate treatment, and also checks how their partners are doing. Researchers will use questionnaires to measure anxiety and find out what factors might predict…

This study is testing whether removing fewer lymph nodes during prostate cancer surgery is as safe and effective as removing more. Researchers will compare two groups of 800 men with prostate cancer who are having their prostate removed. One group will have a limited lymph node r…

This study tests whether showing surgeons a visual decision-support tool before they meet with patients improves how they discuss risks and benefits of surgery. Up to 20 urologists and 200 patients with prostate or kidney cancer will take part. Researchers will compare conversati…

This study is testing a blood test that looks for tiny pieces of prostate cancer cells floating in the bloodstream. The goal is to see if the number of these cells can tell doctors how advanced the cancer is and if it comes back after surgery. About 200 men with early-stage prost…