LOCALIZED PROSTATE CANCER

This phase 2 trial tests a combination of a vaccine (TriAdeno) and an immune-boosting drug (N-803) in 52 men with early-stage, low- or medium-risk prostate cancer who are currently on active surveillance. The vaccine targets three proteins found in prostate cancer cells, while N-…

This study compares a robotic water-jet procedure called Aquablation to active surveillance (close monitoring) in 333 men with low- or intermediate-risk localized prostate cancer. The goal is to see if Aquablation can better prevent cancer from progressing to a more serious grade…

This early-phase study tests a shorter, more intense form of carbon-ion radiation for men with low- or intermediate-risk prostate cancer. Instead of the usual 12 sessions, patients receive just 6. The main goal is to check safety and side effects within 90 days. Up to 20 men will…

This pilot study will test a new device that uses pulsed field ablation (PFA) to treat localized prostate cancer in 50 men aged 45 or older. The goal is to see if the procedure is safe and effective at destroying cancer cells while minimizing damage to surrounding tissue. Partici…

This study tests whether stem cells from donated fat tissue can help men recover erectile function after surgery for localized prostate cancer. Forty men aged 40 to 70 will receive either stem cells or a placebo during or after their prostate removal. The goal is to see if the tr…

This study tests a drug called darolutamide, with or without hormone therapy (ADT), given before surgery for high-risk localized prostate cancer. Sixty men will be split into two groups: one gets darolutamide alone, the other gets darolutamide plus ADT for 3-6 months before robot…

This study looks at whether a blood test, called the RILA assay, can predict which prostate cancer patients will have late side effects from a precise type of radiation therapy (SBRT). About 220 men with low- or intermediate-risk prostate cancer will give a blood sample before tr…

This study will test whether a focal microwave ablation procedure for localized prostate cancer can be performed under local anesthesia instead of general anesthesia or deep sedation. Twenty eligible patients will undergo the treatment while awake, and researchers will measure ho…

This early study tests whether a gel called Barrigel can stay unfrozen and protect the rectum during prostate cancer cryoablation (freezing treatment). About 20 men with localized or recurrent prostate cancer will receive the gel before the procedure. The main goal is to see if t…

This study looks at whether a special low-field MRI scanner can give clearer images for prostate cancer radiation therapy in people who have both hips replaced. Standard MRI often creates blurry images around metal implants, making it hard to aim the radiation precisely. The rese…

This study tests whether a more targeted (focal) radiation boost can better preserve urinary quality of life compared to standard whole gland treatment in men with intermediate- or high-risk prostate cancer. About 58 participants will receive either focal or whole gland high dose…

This study tests a web-based program called SCIPI that provides men with localized prostate cancer easy-to-understand information, communication tools, and social support. About 200 newly diagnosed patients will be randomly assigned to use SCIPI or receive usual care. Researchers…

This study tests whether early electroacupuncture (a type of acupuncture with mild electric pulses) can help men regain bladder control after prostate cancer surgery. About 216 men aged 18 to 80 will receive either real or fake electroacupuncture three times a week for six weeks,…

This study will test whether ChatGPT, an artificial intelligence chatbot, can help men better understand their prostate cancer diagnosis. Fifty men who recently had a prostate biopsy will use the chatbot to review their pathology results. Researchers will measure how accurately p…

This study looks at how a short, home-based high-intensity workout affects steroid hormones in men with low-grade prostate cancer who are on active surveillance. About 49 men will do one supervised bodyweight HIIT session and provide saliva samples. The goal is to see if the exer…