Could a simple antibiotic dosing schedule be key to STI prevention?

NCT ID NCT07755618

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This study looks at how the body processes doxycycline, an antibiotic, when taken in different ways—either as a single dose or repeated doses (daily or every three days). Healthy adults without any sexually transmitted infections will be randomly assigned to one of these schedules, and researchers will measure drug levels in the blood over time. The goal is to understand how well each schedule maintains effective drug concentrations, which could inform future strategies for using doxycycline to prevent STIs. The study also tracks any stomach-related side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
doxycycline hyclate (an antibiotic) in immediate-release or delayed-release tablet form
What this could lead to
If successful, this could help optimize doxycycline dosing for preventing sexually transmitted infections, potentially making prevention more effective and easier to follow.
What could go wrong
This is a small, early-phase study focused on drug levels and side effects, not on whether doxycycline actually prevents STIs. Results may not translate to real-world prevention, and gastrointestinal side effects are possible.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27599, United States

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