Could a simple antibiotic dosing schedule be key to STI prevention?
NCT ID NCT07755618
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This study looks at how the body processes doxycycline, an antibiotic, when taken in different ways—either as a single dose or repeated doses (daily or every three days). Healthy adults without any sexually transmitted infections will be randomly assigned to one of these schedules, and researchers will measure drug levels in the blood over time. The goal is to understand how well each schedule maintains effective drug concentrations, which could inform future strategies for using doxycycline to prevent STIs. The study also tracks any stomach-related side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- doxycycline hyclate (an antibiotic) in immediate-release or delayed-release tablet form
- What this could lead to
- If successful, this could help optimize doxycycline dosing for preventing sexually transmitted infections, potentially making prevention more effective and easier to follow.
- What could go wrong
- This is a small, early-phase study focused on drug levels and side effects, not on whether doxycycline actually prevents STIs. Results may not translate to real-world prevention, and gastrointestinal side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for SEXUALLY TRANSMITTED INFECTION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could routine STI screening during pregnancy prevent preterm births?
- New trial combines HIV PrEP and STI prevention in one package for young men
- Daily doxycycline levels measured to fight STIs
- Could hidden infections harm fertility? new study investigates
- Massive infection database aims to unlock secrets of deadly diseases
- Meningitis b vaccine tested as gonorrhea shield in men