Autoimmune disorder of endocrine system

This study compares a new insulin pump system, Omnipod 6, to the current Omnipod 5 in 200 people with type 1 or type 2 diabetes who have poor blood sugar control. Participants will use both pumps for a set time to see which one helps keep blood sugar in a healthy range more effec…

This study looks at how well the Omnipod 5 Automated Insulin Delivery System works in real-world settings for people with type 1 diabetes. About 152 participants aged 2 and older will use the system for the first time. The goal is to see if it helps keep blood sugar levels in a h…

This study tests a new drug, CNP-103, in people aged 12 to 35 who were diagnosed with stage 3 type 1 diabetes within the last 6 months. The goal is to see if the drug is safe and can help control the disease. Participants will receive either the drug or a placebo, and researchers…

This study tests whether teplizumab, a drug already approved in the US, can safely delay the start of full-blown type 1 diabetes in Japanese people aged 8 to 34 who are at high risk (Stage 2). Participants will receive a 14-day IV treatment and be monitored for side effects and h…

This study will follow 2,200 children and adults with type 1 diabetes who are using the Omnipod 5 system, a tubeless insulin pump that automatically adjusts insulin based on continuous glucose monitor readings. Over 12 months, researchers will track how often severe low or high b…

This early-stage trial tests a new biologic drug called MER511 in 100 adults with Graves' disease. The main goal is to check safety and side effects, and to see how the body handles the drug when given by IV or injection. Participants must be on stable thyroid medication. The stu…

This study tests whether BHV-1300 can help adults with Graves' disease achieve normal thyroid function without antithyroid drugs. Participants receive either BHV-1300 or a placebo via injection. The main goal is to see if more people on BHV-1300 have normal thyroid hormone levels…

This study looks at whether adding GLP-1 receptor agonists or SGLT inhibitors to insulin helps adults with type 1 diabetes manage their blood sugar better. Researchers will track 300 participants for one year, measuring changes in HbA1c and other health markers. The goal is to se…

This early-stage trial tests whether TIX100, a daily oral pill, is safe and tolerable in healthy adults who are overweight or obese. Over 28 days, participants receive either TIX100 or a placebo, and researchers monitor for side effects and how the drug moves through the body. Th…

This study tests a new smartphone-based system that automatically delivers insulin for people with type 1 diabetes. Six adults who already use insulin pumps will try the system for a short time under close supervision. The goal is to see if the technology works safely and reliabl…

This study tests a treatment called VX-880 for people with type 1 diabetes who have dangerous low blood sugar episodes. The therapy uses donor cells that can produce insulin, aiming to let participants stop taking insulin shots and avoid severe hypoglycemia. About 52 adults with …

This study tests whether montelukast, a common allergy medication, can lower protein levels in urine and improve kidney and blood vessel function in people with type 1 diabetes who have early signs of kidney disease. Inflammation is thought to play a role in diabetic kidney damag…

This study follows 630 people with type 1 diabetes in Japan who are already prescribed Awiqli, a once-weekly injection. Researchers will track side effects and blood sugar control over one year to see how the drug works in everyday life. The goal is to manage diabetes, not cure i…

This study compares a new insulin that is injected once a week (insulin icodec) to a standard daily insulin (insulin glargine) in about 877 adults with type 1 diabetes. The goal is to see if the weekly insulin controls blood sugar just as well as the daily one. Participants will …

This study tests a new care model for 80 young adults with type 1 diabetes who are moving from pediatric to adult healthcare. The program includes a nurse educator, psychologist, and transition navigator working together to provide support over six months. The goal is to see if t…

This study tests whether baricitinib, a pill, can help preserve the body's ability to make insulin in people newly diagnosed with type 1 diabetes. About 300 children and young adults (ages 1 to under 36) will take either baricitinib or a placebo for 60 weeks. The goal is to see i…

This early-phase study tests whether combining mesenchymal stem cells (MSCs) with specially engineered immune cells (CAR-T cells) is safe and can help control autoimmune diseases. About 30 adults with established autoimmune conditions will receive the treatment and be monitored f…

This trial tests a new drug called IMVT-1402 for adults with Graves' disease, a condition where the thyroid is overactive. The study will include 210 participants who still have high thyroid levels despite taking standard medications. Participants will receive either one of two d…

This study looks at whether a second islet transplant can safely improve blood sugar control in adults with type 1 diabetes whose first transplant stopped working. Researchers will follow 20 patients for up to 5 years, checking graft function, insulin use, and severe low blood su…

This study tests whether specially engineered immune cells, called CAR-T cells, can safely treat autoimmune diseases. The cells are designed to target and suppress B cells, which play a key role in many autoimmune conditions. The trial involves 30 adults and focuses on safety and…

This study is testing a new blood filter called the Plasma Filter PX2. It is used in a procedure called therapeutic plasma exchange, which removes harmful substances from the blood of people with autoimmune diseases. About 46 adults will take part, and the study will check if the…

This study is testing a mobile app called Adhera Caring Digital Program for Obesity (ACDP-O) in 280 families. The app provides personalized education, mental health monitoring, and wearable device integration to support weight management and well-being in adolescents and young ad…

This phase 2 trial tests whether ruxolitinib, a drug already approved for certain blood disorders, can help regrow hair in people with APECED, a rare immune condition that often causes severe alopecia areata. About 70 participants aged 12 to 75 will take the pill twice daily for …

This Phase 2 trial tests a drug called rezpegaldesleukin in people recently diagnosed with type 1 diabetes (within 100 days). The goal is to see if it can help the body keep producing some insulin, reducing the need for injected insulin. 66 participants will receive either the dr…

This study tests a new approach for teens (ages 10-17) recently diagnosed with type 1 diabetes. They will use an inhaled insulin called Afrezza along with a long-acting injected insulin. The goal is to see if this combination helps keep blood sugar in a healthy range and is safe …

This study compares a continuous glucose monitor (CGM) to standard fingerstick testing in 270 adults with type 1 or type 2 diabetes who use insulin injections. Participants wear the Accu-Chek SmartGuide sensor to track blood sugar levels continuously. The goal is to see if the CG…

This study tests whether a 12-week sleep-focused behavioral program can help adults with type 1 diabetes improve their sleep and blood sugar control. Participants learn sleep hygiene, stress management, and routines to target 7-9 hours of quality sleep. The study tracks sleep wit…

This study looks at whether a plant-based (vegan) diet can help children with autoimmune hepatitis achieve disease remission. Researchers will compare a vegan diet to a standard high-protein diet over 180 days in 40 newly diagnosed children. The goal is to see if diet changes can…

This study compares the iLet Bionic Pancreas, an automated insulin delivery system, to standard care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the device for 13 weeks or continue their usual routine. The goal is to see if the devic…

This study tests a drug called teplizumab in people aged 1 to 25 who were recently diagnosed with type 1 diabetes. The goal is to see if teplizumab can help control blood sugar and reduce the need for insulin at mealtimes. Participants will receive either teplizumab or a placebo …

This study tests a digital tool that helps children under 12 with type 1 diabetes calculate their insulin doses. The tool considers factors like carbs, blood sugar levels, and trends. Researchers will compare blood sugar control (HbA1c) over 6 months between kids using the tool p…

This study is checking if a new insulin pump (NMX8) and continuous glucose monitor (DS5/Simplera Sync) are safe for people with type 1 or type 2 diabetes. About 400 participants, ages 7 to 85, will first wear the sensor for up to 40 days, then use the pump for about 90 days while…

This early-phase study tests whether dichloroacetate (DCA), a drug used safely for decades in a rare metabolic disorder, can improve brain function during low blood sugar (hypoglycemia) in people with type 1 diabetes. Sixteen participants with a history of severe hypoglycemia or …

This early-stage study is testing a new insulin pill (SCD0503) in 16 men with type 1 diabetes. The goal is to see how well the pill works compared to standard injected insulin and whether it is safe. Participants will have their blood sugar carefully controlled during the study t…

This early-stage trial tests a new drug called NNC0497-0040 in healthy people, those with overweight or obesity, and people with type 1 diabetes who are also overweight. The goal is to see if the drug is safe and tolerable when given as a weekly injection. About 146 participants …

This study tests an experimental pill called cadisegliatin taken alongside insulin in adults with type 1 diabetes. The goal is to see if it can lower the number of dangerously low blood sugar events (hypoglycemia) without worsening overall blood sugar control. About 150 participa…

This study is testing a new tool called MODI, which is a smart algorithm that helps people with diabetes figure out the right amount of insulin to take. About 100 adults with type 1 or type 2 diabetes will use the MODI system along with a continuous glucose monitor for 13 weeks. …

This study tests whether giving a low dose of anti-thymocyte globulin (ATG) followed by either adalimumab or verapamil can help preserve the body's ability to make insulin in people aged 9 to under 21 who were recently diagnosed with type 1 diabetes. The main goal is to see if th…

This study is testing whether semaglutide, a drug already used for type 2 diabetes, can reduce kidney damage in people with type 1 diabetes and diabetic kidney disease. About 60 adults will receive either semaglutide or a placebo for 26 weeks. Researchers will measure changes in …

This study tests a bone marrow transplant from a family donor for children under 21 with severe non-cancer blood disorders like sickle cell disease, bone marrow failure, or immune problems. The goal is to see if the transplant can replace the diseased cells with healthy donor cel…

This study tests a new drug called SAB-142 in people recently diagnosed with type 1 diabetes. The goal is to see if it can help the body keep making its own insulin for longer, slowing the disease. About 159 people aged 5 to 40 will receive either the drug or a placebo, and resea…

This study tests whether tirzepatide, a weekly injection already used for type 2 diabetes, can help adults with type 1 diabetes use an automated insulin pump without needing to count carbohydrates at meals. About 105 participants will be randomly assigned to receive tirzepatide o…

This study follows 1,000 people with Stage 2 Type 1 Diabetes who have received teplizumab in routine care. Researchers will track how long it takes for the disease to progress to Stage 3 and assess quality of life. The goal is to see if teplizumab delays the need for insulin ther…

This phase 2 trial tests two doses of rilzabrutinib, an oral drug, in 30 adults with Graves' disease (with or without eye problems). The main goal is to see if the drug lowers high thyroid hormone levels over 16 weeks. Researchers will also monitor safety and side effects.

This phase 2b trial tests an experimental drug called IMVT-1402 in 240 adults with Graves' disease whose thyroid is still overactive despite standard treatment. The goal is to see if the drug can help patients achieve normal thyroid hormone levels and stop taking antithyroid medi…

This early study is testing a new drug called BHV-1300 in 15 people with Graves' disease. The main goal is to see if the drug is safe and to check how it affects certain markers of the disease. This is a phase 1 trial, so it's one of the first steps in testing this treatment in h…

This study tests a new drug called tegoprubart along with other medicines to help people with type 1 diabetes and chronic kidney disease receive pancreatic islet cell transplants. The goal is to see if this approach is safe and can improve blood sugar control without needing life…

This study looks at whether automated insulin delivery (AID) systems can safely manage blood sugar during labor and delivery for pregnant people with type 1 diabetes. About 150 participants will be randomly assigned to use their usual AID system or standard intravenous insulin. T…

This early-stage study tests a new drug called MTX-101 in healthy adults and people with type 1 diabetes. The main goal is to check for side effects, see how long the drug stays in the body, and learn how it affects immune cells. About 96 participants will receive either a single…

This study looks at whether regular exercise can improve how well blood vessels work in adults with type 1 diabetes who do not yet have complications. About 34 participants will be randomly assigned to an exercise program or usual care. The main goal is to see if exercise helps b…

This study tests a 16-week behavioral program called T1DAL, designed specifically for teens with type 1 diabetes who have overweight or obesity. About 50 teens will be randomly assigned to either the program or usual care. The program includes virtual group sessions and one-on-on…

This study tests whether taking a probiotic called Desulfovibrio piger for 4 weeks can lower inflammation and help preserve the body's own insulin production in people who have had type 1 diabetes for more than 5 years. Twenty adults with remaining beta cell function will receive…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study tests a stem cell transplant for people with common variable immunodeficiency (CVID) and other immune disorders. The goal is to replace the faulty immune system with a healthy donor's stem cells. Participants are aged 5 to 40 and will receive a reduced-intensity transp…

This early-stage study is testing a new treatment called GNTI-122 for adults who were recently diagnosed with type 1 diabetes. The therapy is made from a person's own blood cells and is designed to help rebalance the immune system. Sixteen participants will receive either a low o…

This study follows 350 people with type 1 diabetes in France who use the Control-IQ insulin pump system. Researchers want to see how safe and effective the system is over 12 months, focusing on blood sugar control and quality of life. Participants must be at least 6 years old and…

This study tests whether taking a prebiotic fibre supplement for 6 months can help people with type 1 diabetes have fewer dangerous low blood sugar episodes. Researchers will also see if it improves overall blood sugar control and gut health. The study involves 144 people aged 7 …

This study tests whether the drug ZT-01 can reduce nighttime low blood sugar (hypoglycemia) in adults with type 1 diabetes. Participants will inject ZT-01 or a placebo before bed for two 4-week periods while wearing a continuous glucose monitor. The goal is to see if ZT-01 lowers…

This study looks at two ways of managing blood sugar during labor in pregnant women with type 1 diabetes. One group will follow a strict target (70-110 mg/dL), while the other will have a more relaxed target (70-140 mg/dL). The goal is to see if the relaxed approach is safe for n…

This study tests whether adding belimumab to standard therapy can better control autoimmune hepatitis, a chronic liver disease. About 48 adults with active or stable disease will receive weekly injections for 72 weeks. The goal is to reduce liver inflammation and lower the need f…

This study is testing a new continuous glucose monitoring system called ROME GS in 60 adults with type 1 or type 2 diabetes. The goal is to see if it measures blood sugar accurately and is safe to use. Participants will wear the sensor and have their glucose levels checked agains…

This study tests whether frequent, short virtual visits with diabetes educators can help adults with type 1 diabetes improve their blood sugar control. 580 participants will receive video check-ins every 1-3 weeks for 6 months, plus access to online education tools. The goal is t…

This study is testing a new glucose monitoring system called Eversense Gemini, which includes a flash glucose measurement feature. The goal is to see how accurate and safe it is for adults with type 1 or type 2 diabetes. About 80 participants will wear the device and have their g…

This study tests whether dimethyl fumarate, a drug already used for multiple sclerosis, can help preserve the body's ability to make insulin in adults with type 1 diabetes. About 96 people will either receive the drug plus standard insulin therapy or insulin alone for 24 weeks, t…

This study looks at whether changing the types of carbohydrates people with type 1 diabetes eat can improve blood sugar control. Researchers will compare a diet with more whole grains and beans to one with mostly refined grains. 80 adults will be monitored to see if the diverse c…

This study tests tirzepatide, a medication already used for obesity, in 60 adults who have both type 1 diabetes and obesity. Participants will receive either tirzepatide or standard care to see if it helps with weight loss and is safe. The goal is to understand if this drug can b…

This study tests whether a special exercise program that combines rhythm and multitasking (called RYMA) can reduce falls, fractures, and heart problems in people aged 65 and older with type 1 or type 2 diabetes. Participants will be screened for fall risk, bone health, nerve func…

This early-phase trial tests a single infusion of genetically modified immune cells (CAR-T cells) designed to target and calm the immune attack that causes type 1 diabetes. Nine adults with early-stage type 1 diabetes will receive the cells and be monitored for safety, insulin ne…

This study follows 200 people with stage 2 type 1 diabetes (early, no symptoms yet) who are taking TZIELD to delay the disease from getting worse. Researchers will watch for side effects over time, including serious infections and allergic reactions. The goal is to make sure the …

This phase 2 trial is testing a drug called MTX228 (Tolimidone) in 24 adults with type 1 diabetes who still produce some insulin. The goal is to see if the drug can help regrow the beta cells that make insulin, which could lower the amount of insulin they need to inject and impro…

This study follows 120 Israeli children and teens with type 1 diabetes who use the Medtronic 780G system, a closed-loop insulin pump that automatically adjusts insulin. Researchers will track blood sugar control, sleep, diet, and emotional well-being over two years. The goal is t…

This study tests a new drug called OPT101 in adults diagnosed with type 1 diabetes within the last 20 years. Participants receive injections three times a week for up to one year. The goal is to see if OPT101 can safely help the body keep making its own insulin, reducing the need…

This study tests whether a daily tablet called sotagliflozin can improve quality of life for people with both type 1 diabetes and heart failure. Researchers will give 320 participants either the drug or a placebo for 4 months, then compare symptoms like breathlessness and tiredne…

This study is testing a new wearable device that continuously measures both glucose (sugar) and ketone levels in adults with type 1 diabetes. The device is worn for 15 days and its readings are compared to standard lab tests. The goal is to see if it is accurate and safe enough f…

This study tests AIDANET, an automated insulin delivery algorithm, in 40 adults with type 1 diabetes. Participants will use the system in three modes: fully automatic (no meal announcements), hybrid (with meal announcements), or a mix. The goal is to see which mode keeps blood su…

This study tests whether an immunomodulatory drug (rituximab) can improve or normalize ovarian function in women aged 18-38 with autoimmune premature ovarian insufficiency (POI). Participants receive either rituximab or a placebo, and those who respond may undergo IVF. The goal i…

This study tests whether automated insulin pumps (hybrid closed loop systems) can help underserved adults with type 1 diabetes better control their blood sugar. About 140 participants will be randomly assigned to use one of three FDA-approved pump systems or continue with standar…

This early-stage study tests a new mRNA-based treatment (ABO2203) for people with autoimmune diseases that haven't improved with standard care. The therapy works by directing the body's immune cells to attack and control overactive immune cells causing the disease. The study will…

This study tests whether a daily pill called sotagliflozin can slow kidney function loss in people with type 1 diabetes who already have moderate to severe kidney disease. About 150 participants will take either the drug or a placebo for 3 years, while following a special plan to…

This phase 3 study tests VX-880, a stem-cell therapy infused into the liver, in 10 people with type 1 diabetes who have already received a kidney transplant. The main goal is to see if participants can stop using insulin entirely. The therapy is given alongside standard transplan…

This study looks at whether closely monitoring patients with mild to moderate liver inflammation from cancer immunotherapy, and only giving steroids if needed, is as safe and effective as starting high-dose steroids right away. About 56 adults with grade 2 or 3 immune-related hep…

This study follows up to 30 people with type 1 diabetes who previously received islet cell transplants. Researchers want to see how long the transplanted cells keep working to control blood sugar. Participants must continue taking immunosuppressive drugs to prevent rejection.

This study is testing a new implantable insulin pump (MIIPS 2020) in 40 adults with type 1 diabetes whose blood sugar is hard to control with standard insulin shots or external pumps. The pump is placed inside the body and delivers insulin directly, aiming to reduce dangerous hig…

This study tests whether the drug Myfortic can prevent the immune system from becoming sensitized after a failed islet transplant in people with type 1 diabetes. Participants have already lost their graft and will take Myfortic alone for two years. The goal is to see if this redu…

This study tests a program called 'Type 1 Doing Well' for youth aged 10–13 with type 1 diabetes and their parents. The program uses a smartphone app, goal-setting, and family meetings to build on the teen's diabetes strengths. Researchers want to see if it improves blood sugar co…

This study tests whether a special adhesive patch (COVER PATCH) can help keep continuous glucose monitors (CGMs) stuck to the skin for their full recommended wear time. About 194 people with type 1 or type 2 diabetes, aged 6 and older, will either use the patch or not for 4 month…

This study tests a two-step transplant for children with type 1 diabetes who also have an immune deficiency. First, they receive umbilical cord blood stem cells to rebuild their immune system. Then, if that works well, they get a transplant of insulin-producing islet cells. The g…

This early-phase trial tests HN2301, a new type of CAR-T therapy given directly into the blood, for people with refractory Graves' disease—a thyroid condition that doesn't respond well to standard treatments. The therapy reprograms the body's own immune cells to target and calm t…

This study tests whether a very-low-carbohydrate (ketogenic) diet can safely improve blood sugar control in adults with type 1 diabetes. Researchers will enroll 58 people and measure changes in blood sugar levels and insulin sensitivity. Participants will follow the diet for a pe…

This study is testing whether a high-fiber supplement called Trimtab can help preserve beta-cell function in children aged 6 to 12 who were recently diagnosed with type 1 diabetes. For 12 weeks, participants will take the supplement daily, and researchers will measure C-peptide l…

This study tests whether adding empagliflozin or semaglutide to insulin can improve blood sugar control in overweight or obese adults with type 1 diabetes. About 105 participants will take one of the two drugs or a placebo for 3 months. The goal is to see if these drugs help lowe…

This study tests whether a nutrition program that provides twice-daily meal delivery for up to 90 days after hospital discharge, plus diet education, can reduce food insecurity in people with type 1 or type 2 diabetes. About 160 hospitalized patients who screen positive for food …

This study tests whether a 15-minute brisk walk, taken right after a missed insulin dose, can prevent high blood sugar in people with type 1 diabetes. Researchers will compare blood sugar levels in 30 adults aged 18-24 who either take insulin before a meal, after a meal, or after…

This early-phase trial tests transplanting insulin-producing cells into the front chamber of the eye in legally blind people with diabetes. The goal is to see if the cells survive and work safely using only eye drops for immune suppression. Only 2 participants are enrolled, so th…

This study tests whether dimethyl fumarate, a drug already used for multiple sclerosis, can protect the pancreas's insulin-producing cells in adults recently diagnosed with type 1 diabetes. Ninety participants will take either the drug or a placebo twice daily for 24 weeks, along…

This study tests whether a lab-made antibody called Tegoprubart can safely prevent the immune system from attacking transplanted islet cells in people with type 1 diabetes who have dangerous low blood sugar. The goal is to help patients stop needing insulin without using standard…

This phase 3 trial is testing whether semaglutide, a drug already used for type 2 diabetes and weight loss, can improve heart and kidney function in adults with type 1 diabetes. The study will measure artery stiffness, insulin sensitivity, and kidney blood flow in 60 participants…

This study looks at how a new insulin pump system (mylife CamAPS FX with Dexcom G6 sensor) helps people with type 1 diabetes control their blood sugar and improve quality of life. About 125 adults and children in France will use the system for one year while doctors track their p…

This study tests whether combining automated insulin pumps (Omnipod 5 or Medtronic 780G) with specialized education can help adults with type 1 diabetes who have lost the ability to feel low blood sugar (hypoglycemia). The trial will enroll 324 participants and follow them for up…

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells enclosed in a protective capsule, for people with unstable type 1 diabetes who still experience severe low blood sugar episodes despite using an automated insulin pump and continuous glucose m…

This study enrolls 50 children and teens (ages 6 to under 18) with type 1 diabetes who have high blood sugar levels and come from low-income families. Participants will receive help from an insurance navigator to get a closed-loop insulin pump and continuous glucose monitor. The …

This study tests whether adding a natural gut hormone called gastrin to islet cell transplants can help people with hard-to-control type 1 diabetes produce their own insulin and stabilize blood sugar. About 20 adults aged 18-68 with unstable type 1 diabetes will receive donor isl…

This study tests whether an artificial pancreas system can improve blood sugar control and, in turn, reduce heart disease risk in people with type 1 diabetes. The system combines an insulin pump with a continuous glucose monitor to mimic a healthy pancreas. Researchers will measu…

This study tests whether a new drug called CIR-0602K can help people with type 1 diabetes keep their blood sugar in a healthy range and reduce their insulin needs. The trial involves 40 adults aged 18-45 who already use an automated insulin pump. Half will get the drug and half a…

This expanded access program offers a stem cell transplant using donor cells that have been specially processed to remove certain immune cells, reducing the risk of graft-versus-host disease. It is for patients with serious blood disorders, immune deficiencies, or metabolic disea…

This study tests whether the Medtronic 780G automated insulin pump can improve blood sugar control in adults with type 1 diabetes who also have gastroparesis (stomach paralysis). Participants will use the device for three months, and researchers will measure how often blood sugar…

This early-stage trial tests a single injection of a new drug called GenSci098 in 24 adults with Graves' disease, a condition where the thyroid is overactive. The main goal is to check safety and side effects over about 5 months. Researchers will also measure how the drug moves t…

This early-phase trial is testing a new treatment called CELZ-201 for people recently diagnosed with type 1 diabetes. The treatment involves a one-time infusion of cells from donated tissue into the pancreas. The main goal is to see if it is safe, but researchers will also check …

This study looks at whether using ultrasound to find fatty lumps (lipohypertrophy) caused by insulin injections can help people with diabetes improve their blood sugar levels. About 50 adults with type 1 or type 2 diabetes who use insulin and a continuous glucose monitor will get…

This study aims to see if a hybrid closed-loop insulin pump (a smart insulin pump) can help adults with poorly controlled type 1 diabetes (A1c >8.5%) from diverse backgrounds. The study will enroll 40 participants from Los Angeles who do not currently use an insulin pump. The goa…

This study tests whether a single infusion of arginine hydrochloride, a natural amino acid, can help people with type 2 diabetes recover faster from diabetic ketoacidosis (DKA), a serious complication. Sixty adults arriving at emergency rooms with DKA will receive either arginine…

This study looks at whether giving Lugol's solution before removing the thyroid gland can lower the chance of two common surgery complications: low calcium levels from damaged parathyroid glands and vocal cord weakness from nerve injury. About 182 adults with overactive thyroid f…

This Phase 3 trial is testing a drug called Neovasculgen, given as injections into the leg muscles, to see if it can help heal foot ulcers in people with diabetes. The study will include 144 adults with type 1 or type 2 diabetes who have a non-healing foot ulcer. Participants wil…

This pilot study tests whether adding high-dose vitamin D to standard methimazole therapy helps control thyroid function and antibodies in children aged 9-17 newly diagnosed with Graves' disease. The main goal is to see if a larger trial is possible by measuring recruitment, adhe…

This study tests whether using a continuous glucose monitor (CGM) helps kidney transplant recipients with type 2 diabetes keep their blood sugar in a healthy range. Eighty adults who received a kidney transplant within the past year and use insulin will wear a Dexcom G6 sensor th…

This study tests whether adding a weekly medicine called tirzepatide to usual insulin therapy helps adults with type 1 diabetes control their blood sugar better. About 42 people aged 18-65 who already use an automated insulin pump will take part. The goal is to see if the combina…

This early-stage study tests an experimental drug called LY3938577 in healthy volunteers and people with type 1 diabetes. The main goals are to see how the body processes the drug and whether it can safely lower blood sugar. The study has four parts, comparing the drug to insulin…

This study is tracking 1,875 people with type 1 diabetes (ages 6 and up) who are already using the Twiist automated insulin delivery system. Researchers are monitoring for severe low blood sugar events, diabetic ketoacidosis, and hospitalizations related to the device. The goal i…

This study tests whether an automated insulin delivery system (CamAPS FX) can help women with type 1 diabetes maintain better blood sugar control before and during pregnancy, compared to their usual insulin routine. The trial will enroll 305 women aged 18-45 who are either planni…

This study tests whether a combination of special immune cells (Tregs) and a drug (rituximab) can delay or prevent type 1 diabetes in children aged 6–16 who are at high risk but still produce insulin normally. About 150 participants will be randomly assigned to one of four groups…

This study tracks 50 children and adults with non-malignant disorders like immune deficiencies and anemias who receive a stem cell transplant after a reduced-intensity chemotherapy regimen. The goal is to see if this approach improves survival and reduces severe graft-versus-host…

This study tests a program called T1CARE, where a community health navigator helps young adults with type 1 diabetes address social needs like housing, food, and healthcare access. 100 participants will be randomly assigned to get the navigator right away or after a wait. The goa…

This study looks at whether an automated insulin delivery system (the Medtronic 780G) can help adults with diabetes and advanced kidney disease manage their blood sugar better than their usual insulin injections. Participants will use the system for 8 weeks and then switch to the…

This study is testing a mobile app called glUCModel that uses artificial intelligence to predict glucose levels and help people with type 1 diabetes decide how much insulin to take. About 34 adults aged 18 to 65 will use the app for several weeks while wearing a continuous glucos…

This study is testing a new automated insulin delivery system for adults with type 1 diabetes. The system uses a patch pump and a smart algorithm to adjust insulin automatically. Researchers will check if it improves blood sugar control and is safe to use in daily life. 200 parti…

This early-phase trial tests a single infusion of genetically modified immune cells (CAR-T cells) in 4 people with refractory Graves' disease, a thyroid condition that doesn't respond well to standard medication. The cells target two proteins (CD19 and BCMA) to reset the immune s…

This study tests a program called AHEAD that helps young people aged 16-19 with type 1 diabetes improve their blood sugar control as they move from pediatric to adult care. About 306 participants will either get usual care or the AHEAD program, which offers tailored support to bu…

This pilot study will test the safety of thyroid artery embolization (TAE) in 10 UK patients with benign thyroid nodules or goitre. TAE is a minimally invasive procedure that blocks blood flow to the thyroid gland using tiny particles, causing it to shrink. The goal is to see if …

This study tests whether colchicine, a drug used for gout, can improve how the body uses insulin in people with type 1 diabetes who have low-grade inflammation. 26 adults will receive either colchicine or a placebo for four weeks, and their insulin sensitivity will be measured us…

This study tests whether a 12-week sleep improvement program can help adults aged 18-40 with type 1 diabetes manage their blood sugar and reduce distress. Participants will receive coaching based on motivational interviewing and behavior change techniques. The study will track sl…

This study tests a weekly injection of semaglutide (a GLP-1 drug) in 76 adults with 'double diabetes' — a mix of type 1 diabetes and inherited insulin resistance. The goal is to see if the drug improves blood sugar control and helps with weight loss. Participants must be over 18,…

This study looks at whether adding a GLP-1 drug (semaglutide, sold as Rybelsus®) to the standard teplizumab treatment can help control blood sugar and improve blood vessel function in people with early stage type 1 diabetes. Researchers will give 24 participants a liquid meal tes…

This study tests whether giving teens with type 1 diabetes financial rewards for meeting blood sugar goals improves their diabetes management. About 96 teens will either get usual care or earn money for hitting targets. Researchers will compare blood sugar levels and quality of l…

This study is testing a less intense chemotherapy and radiation regimen before a stem cell transplant for children and young adults up to age 55 with non-cancerous blood disorders like immune deficiencies, anemias, and metabolic diseases. The goal is to see if this gentler prepar…

This study tests whether personalized nutrition education on a healthy Nordic diet can improve blood sugar control in adults with type 1 diabetes. 54 participants will either receive this education or standard brief dietary advice. The main goal is to see if the intervention incr…

This study tests whether transplanting insulin-producing islet cells from deceased donors can help people with brittle type 1 diabetes achieve safer blood sugar control without insulin shots. Up to 20 adults aged 18–70 with long-standing type 1 diabetes will receive the cells thr…

This phase 2 trial tests a drug called emapalumab in 10 people with APECED, a rare disease where the immune system attacks the body. The drug aims to reduce gut inflammation (enteritis) that causes severe symptoms. Participants receive 7 IV doses over 6 months, and researchers tr…

This phase 2 trial tests whether transplanting insulin-producing islet cells from deceased donors can help people with type 1 diabetes who have already received a kidney transplant. The goal is to achieve safe blood sugar levels without insulin shots. Ten participants will receiv…

This study looks at whether a community health worker (CHW) can act as a diabetes technology coach for Black children with type 1 diabetes who use an automated insulin delivery system but still have high blood sugar (HbA1c of 8% or higher). Over 6 months, families meet monthly wi…

This phase 2 trial tests whether a low dose of anti-thymocyte globulin (ATG), followed by verapamil, can help preserve the body's ability to produce insulin in adolescents and young adults recently diagnosed with type 1 diabetes. The study will enroll 60 people aged 6 to 35 who h…

This study is testing whether a flash continuous glucose monitor (CGM) can help children and young adults in Uganda with type 1 diabetes keep their blood sugar in a healthy range more often than standard finger-prick testing. Half of the 180 participants will use the CGM for the …

This early study tests whether siplizumab, given at the time of liver transplant, can safely prevent the immune system from attacking the new liver. Up to 8 adults with autoimmune hepatitis or primary sclerosing cholangitis will receive two doses. The main goal is to check for se…

This early-stage trial is testing a new long-acting insulin called GZR33 in 12 adults with type 1 diabetes. The goal is to see how well it controls blood sugar compared to an existing insulin, degludec, and to check its safety. Participants will receive both insulins at different…

This study compares having one laser treatment versus several sessions for a serious diabetic eye condition that can cause blindness. Researchers want to see which approach is safer and works better. The study will involve 40 adults with type 1 or type 2 diabetes who have this ey…

This study tests whether using a Dexcom G7 continuous glucose monitor (CGM) instead of standard fingerstick blood sugar checks leads to better blood sugar control and fewer dangerous lows in hospitalized adults with type 1 diabetes. One hundred participants will be randomly assig…

This study tests whether a sleep coaching program can help 150 teens (ages 11-17) with type 1 diabetes sleep longer and more consistently. Participants will receive either sleep coaching or standard diabetes education. Researchers will measure sleep with a Fitbit, check blood sug…

This study looks at whether wearing a continuous glucose monitor (CGM) for two weeks after leaving the hospital helps people with diabetes who are starting insulin for the first time. About 150 adults with type 1 or type 2 diabetes will be randomly assigned to use either a CGM or…

This study is testing whether verapamil, a drug used for high blood pressure, can help children aged 4 to 9 with newly diagnosed type 1 diabetes keep making some insulin. The trial has two parts: first, 6 children will take verapamil to check safety; then, 30 more children will b…

This study tests whether a very low-calorie ketogenic diet (600-800 calories per day) can help people with type 1 diabetes and obesity lose weight safely. Fourteen adults will follow the diet for 4 weeks while using an automated insulin pump. The main goal is to see how much weig…

This study tests whether an online training and support platform can help adults with type 1 diabetes better manage their blood sugar and well-being. About 322 participants across Canada will use the platform for 12 months, either as part of their usual clinic care or on their ow…

This study tests whether an online training and peer support platform (Support-t) helps teens with type 1 diabetes prepare for the move from pediatric to adult healthcare. About 200 teens aged 14-16 will either use the platform plus usual care or just usual care. The main goal is…

This study tests whether inhaled insulin (Afrezza) given with a meal is safer than a standard pump insulin bolus for preventing low blood sugar during exercise afterward. About 30 adults with type 1 diabetes who use automated insulin pumps will complete three exercise sessions in…

This early-stage trial tests a new treatment called RGB-5088 for people with type 1 diabetes. It involves transplanting insulin-making cells under a muscle layer in the abdomen. The goal is to see if it is safe and if it can help patients control blood sugar without insulin shots…

This study looks at whether low-dose prednisolone (a steroid) can safely treat liver inflammation (hepatitis) caused by immune checkpoint inhibitors in cancer patients. Researchers will enroll 63 adults with grade 2 or 3 immune-related hepatitis and give them 0.5-1 mg/kg of predn…

This study is testing whether transplanting gut bacteria from healthy donors into people with type 1 diabetes can help control blood sugar and reduce insulin needs. Fifty participants will receive three doses of washed microbiota through the gastrointestinal tract. Researchers wi…

This study is testing whether a specially designed digital game can help children aged 8-13 with type 1 diabetes improve their blood sugar control, confidence in managing their diabetes, and overall quality of life. The game is based on a health education model and will be played…

This study tests whether a comprehensive management program—including a specialized diabetes team, structured education, peer support, and modern diabetes technology like insulin pumps and continuous glucose monitors—can improve blood sugar control in people with type 1 diabetes.…

This study tests a computer model called OptiThyDose that helps doctors find the best dose of thyroid medication for children with congenital hypothyroidism or Graves' disease. The model uses past lab results to keep thyroid hormone levels in a healthy range. About 150 children w…

This study is testing an artificial intelligence tool called Tia Bete that helps people with type 1 diabetes count carbohydrates and adjust their insulin doses in real time. Researchers will enroll 50 participants (children and adults) and track their blood sugar control, quality…

This study tests whether using an AI-driven retinal camera during regular diabetes checkups can increase the number of young people screened for diabetic retinopathy, a leading cause of blindness. Researchers will enroll 500 youth with type 1, type 2, or cystic fibrosis-related d…

This study tests a software called Glandy HYPER that uses artificial intelligence to detect thyrotoxicosis—a dangerous overactive thyroid state—in people with Graves' disease. The AI analyzes resting heart rate data from wearable devices like smartwatches and compares it with sta…

This study is testing a new real-time continuous glucose monitoring (CGM) system to see how accurate and safe it is for adults with type 1 diabetes. About 82 participants will wear the device, and its readings will be compared to standard lab measurements. The goal is to improve …

This study is testing a new scoring system called OC26 to help doctors more accurately diagnose autoimmune pancreatitis, a condition where the immune system attacks the pancreas. Researchers will review medical data from 82 adults suspected of having the disease. If the OC26 crit…

This study tests whether a wearable breath sensor can detect high or low blood sugar in teens with type 1 diabetes. Participants wear the device for 72 hours and provide breath samples while checking blood sugar with a finger prick. The goal is to see if breath chemicals can repl…

This study from the University of Oxford is testing whether a finger-prick blood test, done at home, can replace the standard oral glucose tolerance test (OGTT) for diagnosing type 1 and type 2 diabetes in children and young people. The standard OGTT requires a vein drip and mult…

This study is testing how well a new continuous glucose monitor, called CareSens Air 3, measures blood sugar levels in adults with type 1 diabetes. Researchers will compare the monitor's readings to standard lab measurements. The goal is to see if the device is accurate and preci…

This study tests whether a self-administered fingerstick glucose tolerance test done at home can accurately measure blood sugar levels compared to the standard clinic-based test. Researchers will enroll 60 people at risk for or recently diagnosed with type 1 diabetes. If accurate…

This study tests a new imaging method called Al18F-NOTA-FAPI-04 PET/CT or PET/MRI to see if it can better detect and guide treatment for malignant tumors, heart problems, and autoimmune diseases like hyperthyroidism. About 600 adults will receive the imaging agent and be monitore…

This study is testing whether a combined autoantibody test on a drop of blood from a finger prick (dried on special paper) can detect type 1 diabetes as accurately as the standard blood draw from a vein. The researchers will enroll 106 children newly diagnosed with type 1 diabete…

This study aims to identify people at increased risk of developing type 1 diabetes by testing for specific markers in the blood called autoantibodies. Children and adults aged 1 to 45 who have a family member or close friend diagnosed with type 1 diabetes before age 45 can join. …

This study is translating and testing a questionnaire called PainPREDICT for Thai-speaking people with diabetes. The goal is to create a mobile app that can screen for painful diabetic neuropathy, a common complication that causes nerve pain. Researchers will check if the Thai ve…

This study tests whether the drug baricitinib can delay the onset of type 1 diabetes in children aged 1 to 36 months who are at high risk. Participants take baricitinib or a placebo daily for up to 5 years. The goal is to see if the drug can push back or prevent the need for insu…

This study tests whether intensive diet and physical activity counseling from 3 months to 2 years of age can protect the pancreas in infants with a genetic risk for Type 1 diabetes. About 1,244 babies will be randomly assigned to receive the counseling or standard care, and resea…

This study is testing whether the shingles vaccine (RZV) works and is safe for adults with autoimmune rheumatic diseases like rheumatoid arthritis or lupus who are taking immune-suppressing drugs. Two hundred participants will receive two doses of the vaccine. Researchers will me…

This study tests whether giving the COVID-19 vaccine (Comirnaty) to children starting at 6 months old can lower their chance of developing type 1 diabetes. The trial will include 2,252 children who have a high genetic risk for the disease. Half will get the vaccine, half a placeb…

This study tests whether pairing teens with type 1 diabetes with a young adult peer mentor can help them become more physically active and improve their quality of life. The 12-week program includes in-person, virtual, and text-based support. Researchers will measure how well the…

This study tests a group-based program called Supporting Teen Problem Solving (STePS) designed to reduce diabetes-specific emotional distress in teenagers with type 1 diabetes. The program is based on cognitive-behavioral and problem-solving approaches. Researchers will enroll 36…

This study compares a psychological therapy program called ACT1VATE to standard diabetes education in 250 adults with type 1 diabetes who have high emotional distress and poor blood sugar control. The therapy is delivered in five group sessions via video call. Researchers will me…

This study is testing a serious video game designed to improve emotional well-being in teenagers aged 12 to 16, both with and without chronic conditions like type 1 diabetes, asthma, and allergies. The game uses artificial intelligence to personalize activities that build coping …

This study compares a Mediterranean diet to a Western diet to see which one better reduces fatigue in people with autoimmune hepatitis. About 48 adults will try both diets in a random order. Researchers will measure changes in fatigue and quality of life using a standard question…

This study tests a group-based psychological program called ACTnow for emerging adults (ages 18-35) with type 1 diabetes who feel overwhelmed by their condition. The program includes six bi-weekly sessions led by a psychologist and nurse, focusing on mindfulness and acceptance st…

This phase 2 trial tests whether metoclopramide, a drug currently used for stomach issues, can restore the ability to feel low blood sugar symptoms in people with type 1 diabetes. About 36 participants will take either the drug or a placebo for four weeks. Researchers will measur…

This study tests whether a four-week online self-compassion course can reduce diabetes-related distress, self-criticism, and shame in adults with type 1 or type 2 diabetes. Researchers will enroll 50 participants to see if the program is feasible and acceptable. The course includ…

This study tests a program that gives people with diabetes a continuous glucose monitor (CGM) when they leave the hospital. The goal is to see if it makes patients more satisfied and improves their quality of life. About 37 adults with Type 1 or Type 2 diabetes who use insulin wi…

This early-stage study tests a new drug called LY4057996 in 124 healthy volunteers and people with type 1 or type 2 diabetes. The main goal is to see if the drug is safe and what side effects it may cause. Participants receive the drug as a shot under the skin or into a vein, and…

This study looks at whether using a continuous glucose monitor (CGM) after hospital discharge helps people with diabetes feel more in control and satisfied with their care. About 60 adults with type 1 or type 2 diabetes who need insulin will use a CGM at home and answer questionn…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help people with type 1 diabetes who also have eating disorders. Participants will be randomly assigned to ACT, supportive diabetes counseling, or a waitlist. The goal is to see if …

This study tests whether a gamified education program can improve health literacy and quality of life in children aged 8-12 with type 1 diabetes. Half of the 52 participants will receive the gamified program plus standard education, while the other half gets standard education al…

This study tests a mindfulness app called Calm Health in 10 young adults (ages 18-30) with type 1 diabetes or similar conditions. Participants use the app to track mindfulness, blood sugar, stress, and sleep, and get personalized feedback. The goal is to see if the app is easy to…

This study looks at whether watching an animated film or reading a storybook can lower fear and anxiety in children aged 7 to 12 who have just been diagnosed with type 1 diabetes. About 64 children will take part, and their anxiety levels will be measured using special child-frie…

This study tests a program called REAL-Fam, designed to help families in rural areas manage a child's type 1 diabetes. About 16 families will either receive 12 telehealth sessions focused on diabetes routines and family participation, or just 3 basic check-in meetings. The goal i…

This study tests whether cognitive behavioral therapy for insomnia (CBTi) can improve sleep, blood sugar levels, and quality of life in adults with type 1 diabetes. Fifteen participants will either receive 8 virtual CBTi sessions or health education emails and calls over 12 weeks…

This study tests a survey called Spotlight AQ that teens and young adults with type 1 diabetes fill out before their clinic visit. The survey asks about their therapy, feelings, social life, and diabetes knowledge. Doctors then use the results to guide the visit. The goal is to s…

This study tests a virtual peer support program for people with type 1 diabetes and their loved ones across Canada. Participants join small online meetings and larger webinars to share experiences and reduce diabetes distress. The program is designed by researchers who also live …

This pilot trial tests the Discovery Program, a 3-month behavioral intervention for adolescents and young adults with type 1 diabetes. The program combines patient surveys, in-clinic goal setting, and personalized text messages to help improve blood sugar control and reduce diabe…

This study tests a new NHS pathway to help adults with type 1 diabetes manage diabetes distress—the worry, frustration, and burnout that often comes with the condition. The pathway trains healthcare teams to recognize and discuss distress during routine visits, and offers an onli…

This study tests whether a person-centred care (PCC) programme, delivered by phone and online, can help people with Graves' disease feel better mentally and return to work. 220 adults with first-time Graves' disease will be randomly assigned to receive either usual care or usual …

This study tests whether a special course on mental fatigue can help people with Graves' disease who struggle with ongoing brain tiredness, trouble focusing, and memory issues. About 96 adults aged 18-72 with stable thyroid levels will either take the course plus standard care or…

This study tests a mobile app that gives personalized exercise coaching and feedback on blood sugar, sleep, and mood to help middle-aged adults with type 1 diabetes exercise more. Participants get a free Garmin smartwatch and program membership. The goal is to see if the app help…

This study tests whether a special type of talk therapy, delivered via video calls, can reduce anxiety and depression in young adults (ages 18-64) with type 1 diabetes. The therapy also includes reviewing continuous glucose monitor data to help link emotions and blood sugar level…

This study compares two virtual group programs—one focused on emotions, the other on problem-solving—to help adults with type 1 diabetes reduce diabetes distress. Participants who don't improve can get extra one-on-one sessions. The goal is to find better ways to support emotiona…

This study tests whether a structured education program, combined with regular follow-up visits, can help adults with type 1 diabetes better control their blood sugar. Researchers at Peking University First Hospital will enroll 150 participants and provide courses on diet, exerci…

This study is looking for the genes that cause certain immune system problems. Researchers want to understand why some people get sick and others don't, even in the same family. Up to 5,000 people with immune disorders and their relatives will give blood or cheek cell samples for…

This study will analyze DNA from up to 20,000 people, including those with immune disorders and their relatives, to find genetic variants linked to conditions like atopy, autoimmunity, and primary immunodeficiency. Researchers will also study how best to return genetic results to…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study looks at how improving sleep regularity might help control blood sugar and reduce heart disease risk in adults with type 1 diabetes. Researchers will monitor 100 participants' sleep, blood sugar, and heart health markers. The goal is to understand the body clock's role…

This study looks at basic blood and clotting measures in children with type 1 diabetes compared to healthy children. Researchers want to see if diabetes causes changes in red blood cells or clotting that could lead to complications. The study involves children aged 1 month to 18 …

This study at the National Institutes of Health is looking at 1,000 adults with known or suspected hormone gland (endocrine) disorders. The goal is to better understand these conditions and help train doctors. Participants may receive tests, treatments, or surgery as part of thei…

This study follows people who previously took part in type 1 diabetes trials to see how long their bodies continue to produce insulin. Researchers will also look at how immune system changes relate to insulin production. The goal is to gather information that could lead to better…

This study is measuring a protein called STIM1 on the surface of immune cells in 670 people with various autoimmune diseases. The goal is to find which diseases have high levels of this protein, which could help researchers develop new antibody-based treatments. Participants prov…

This study aims to understand why some people are more prone to fungal infections, especially from Candida yeast. Researchers will collect blood, saliva, urine, and tissue samples from people with immune disorders, their family members, and healthy volunteers. No treatment is giv…

This study is looking for biological markers (biomarkers) in blood, saliva, and urine that signal damage to insulin-producing beta cells in the pancreas. Researchers will compare samples from people with type 1 diabetes, type 2 diabetes, prediabetes, and healthy volunteers. The g…

This study is testing a new device that combines an insulin pump with a continuous glucose monitor in one unit for adults with type 1 diabetes. The goal is to see how insulin delivery near the sensor affects glucose readings and to gather data to improve the design. About 40 part…

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study from Mayo Clinic looks at how one session of exercise changes breastmilk. Researchers will measure tiny particles called exosomes that carry messages between cells. They want to see if exercise boosts these particles in breastmilk, which might help prevent childhood ob…

This trial is studying a medical device that has not been approved by the U.S. FDA. The purpose and specific details are not publicly available. It likely involves a small group of participants to gather initial safety or effectiveness data.

This study will give 100 adults with diabetes a thermal camera that attaches to their smartphone to take daily pictures of their feet. The goal is to collect temperature data and see if hot spots can predict where foot ulcers might form. Participants will use the device at home f…

This study looks for better ways to detect lung inflammation and infections early in people who have received a stem cell transplant from a donor. About 40 participants aged 5 to 70 will get regular lung scans, breathing tests, blood draws, and a procedure where a tube collects f…

This study aims to understand why some people get severe or unusual fungal infections due to immune system problems. Researchers will collect blood, tissue, and other samples from up to 1,200 participants over 25 years. No new treatments are being tested; the goal is to learn mor…

This observational study is gathering detailed metabolic data from 25 adults with insulin-dependent type 2 diabetes. After drinking a standard liquid meal, participants will have frequent blood tests to measure glucose, insulin, and other markers. They will also wear continuous g…

This study looks at how blood sugar changes day-to-day in people with ketosis-prone diabetes as they go into remission. Researchers will use this data to build a math model that describes the remission process. The study involves 12 African American adults with a BMI of 28 or hig…

This study looks at how menstrual cycles and birth control pills impact blood sugar levels and exercise in women with type 1 diabetes. Researchers will monitor 150 women for three months using continuous glucose monitors and offer personalized insulin and diet adjustments. The go…

This study looks at how accurate continuous glucose monitors (CGMs) are in children and young adults with type 1 diabetes when they have surgery. Researchers will compare CGM readings to standard blood glucose tests during the procedure. The goal is to see if these devices can be…

This study looks at whether a special nursing care model helps people with long-term health conditions like diabetes, heart disease, or Parkinson's work better with their advanced practice nurse. About 420 adults will take part. The goal is to see if this approach improves how pa…

This study is testing whether a mobile app called Fabla-diabetesMM, which lets people record audio diaries, is easy and helpful for older adults with type 1 or 2 diabetes who also have other health conditions. Thirty participants will use the app and answer questions about their …

This study looks at how social factors and health literacy affect the ability of people with diabetes to manage their own care. Researchers will survey 400 adults with type 1 or type 2 diabetes to understand these connections. The goal is to design better support programs that he…

This study looks at whether improving sleep and circadian timing can reduce heart disease risk in adolescents with type 1 diabetes who typically sleep less than 7 hours per night. Fifty teens will follow a one-month program that includes a longer sleep schedule, a low dose of mel…

This study looks at whether a genetic risk score can predict which people with newly diagnosed diabetes will eventually need insulin. Researchers will follow about 3,000 patients aged 14 to 50 for up to 3 years, tracking their C-peptide levels (a marker of insulin production) and…

This study observes 60 people with stage 2 type 1 diabetes who received teplizumab as part of managed access programs. Researchers will review medical records to describe patient characteristics, monitoring practices, and how long it takes for diabetes to progress. The goal is to…

This study is collecting blood samples from 1,160 people with and without type 1 diabetes to analyze the immune cells that mistakenly attack the pancreas. The goal is to better understand how these cells work, which could lead to improved treatments or prevention strategies in th…

This study looks at whether a substance in the blood called 1,5-anhydroglucitol can help measure how many insulin-making cells (beta cells) children with type 1 diabetes still have. Researchers will compare levels in 60 children with diabetes (newly diagnosed and long-term) to he…

This study enrolls adults with known or suspected endocrine (hormone gland) disorders, such as diabetes or thyroid disease, to help researchers learn more about these conditions. Participants will undergo medical exams, blood and imaging tests, and possibly genetic testing. The m…

This study looks at whether exercising before breakfast (fasted) or after breakfast (fed) is better for people with type 1 diabetes. Over 12 weeks, 20 participants will do combined resistance and aerobic training three times a week. Researchers will track insulin doses and blood …

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study looks at how being overweight affects insulin sensitivity and heart-lung fitness in people with type 1 diabetes. Researchers will compare participants with and without diabetes, before and after a 15-week high-intensity interval training program. The goal is to underst…

This study is for adults aged 18 to 55 who were diagnosed with type 1 diabetes within the last 6 months. Researchers want to see how many of them carry a specific gene called HLA-DRB1*04:01. Participants will provide a blood sample or cheek swab for genetic testing. The goal is t…

This study is testing a new ultrasound method that uses tiny, safe bubbles to measure blood flow in the pancreas. The goal is to see if changes in blood flow can help detect type 1 diabetes early, before symptoms appear. Researchers will compare 50 healthy adults and people recen…

This study surveys up to 900 adults with type 1 diabetes who use a closed-loop insulin system for at least 4 months. The goal is to understand how satisfied they are with the special 'physical activity mode' designed to prevent low blood sugar during exercise. Participants fill o…

This study is observing 55 adolescents with type 1 diabetes to understand the many factors that influence their physical activity, from personal motivation to school and community support. Participants will wear an activity tracker for a week and complete questionnaires about the…

This study looks at whether improving blood sugar control in people with type 1 diabetes can restore the normal function of HDL, or 'good' cholesterol. Researchers will compare 80 patients with poorly controlled diabetes who receive standard intensive therapy to 63 healthy people…

This study tests whether a machine learning program can detect lipohypertrophy—hidden lumps under the skin caused by insulin injections—using portable ultrasound. About 100 people with diabetes will first have their injection sites scanned. In a second phase, 40 people found to h…

This early-stage trial tests a new insulin formula (U-500) given directly into the belly cavity in 25 adults with type 1 diabetes. Researchers want to see if it's safe, how fast it's absorbed, and how quickly it works compared to standard insulin shots. Participants will have the…

This study is a large registry that will follow 20,000 people with type 1 diabetes across China. It aims to track changes in blood sugar, kidney function, heart health, and emotional well-being over many years. The goal is to better understand how the disease progresses and impro…

This study tests different ways to help teenagers and young adults with type 2 diabetes address social needs like food or housing. About 104 teens and their caregivers will try either tailored resource lists or a universal empowerment approach. The goal is to see which method is …

This study collects and freezes testicular tissue from boys and young men who are at risk of becoming infertile due to cancer, autoimmune disorders, or their treatments. The tissue is stored in a research bank, with the hope that future medical advances will allow it to be used t…

This study aims to better understand acute kidney injury and chronic kidney disease by analyzing kidney tissue from 1000 volunteers. Researchers will use advanced technology to identify different disease types and find new targets for therapies. The goal is to pave the way for pe…

This study explores how certain immune cells (MAIT cells) and gut bacteria work together in children who either have type 1 diabetes, are at high genetic risk, or are healthy. Researchers will collect blood and gut samples from 180 children to understand these interactions. The g…

This study is looking at how certain genes affect the immune system and may increase the risk of developing type 1 diabetes. Researchers will collect blood samples from 2,800 people to study immune cells and genetic risk factors. The goal is to better understand why some people d…

This observational study will measure oxidative stress and antioxidant levels in 75 people with type 1 diabetes and 75 with LADA (a slow-progressing form of autoimmune diabetes). Researchers will collect blood samples and compare markers like d-ROMs, BAP, and HbA1c to see if oxid…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study observes 160 cancer patients to understand why some develop liver injury from checkpoint inhibitor drugs. Researchers will track blood markers and genetic factors to identify who is at risk. No new treatment is tested; the goal is to improve diagnosis and monitoring.

This study follows people with type 1 diabetes who have had an islet transplant that later stopped working. Researchers want to learn how the body's immune system changes after the graft is lost. The goal is to gather information, not to test a new treatment.

This study looks at the gut bacteria of 3000 adults with chronic liver diseases like autoimmune hepatitis and fatty liver. Researchers want to find specific bacteria linked to each disease to better understand how the gut and liver interact. This is an observational study, not a …

This study looks at children aged 2-16 who are newly diagnosed with type 1 diabetes. It checks if those who also have diabetic ketoacidosis (a serious complication) show early signs of kidney or heart injury using special blood and urine tests. The goal is to better understand wh…

This study looks at 100 people with Graves disease to see if inflammation and thyroid antibodies are linked to changes in the eye's nerve layer and macula. Researchers will compare eye scans (OCT) and blood tests between patients with and without eye involvement, plus healthy con…

This study follows 36 people with type 1 diabetes who have received a pancreatic islet transplant. Researchers will use continuous glucose monitors to see if a measure called 'Time in Tight Range' can detect early loss of graft function. The goal is to find a simple way to spot p…

This study takes a small sample of skin, blood, or urine from people with diabetes and healthy volunteers. Scientists will turn those cells into stem cells and then into insulin-producing cells in the lab. The goal is to learn more about diabetes and pave the way for future cell-…

This study aims to understand the step-by-step process that causes type 1 diabetes by looking at genetics and environment. Researchers will follow families with a history of the disease, as well as healthy controls, for up to 10 years. Participants provide a blood sample, medical…

This study looks at how different types of exercise—walking and weight-lifting—affect blood sugar levels in post-menopausal women with type 1 diabetes. Twenty participants will wear a continuous glucose monitor and complete three sessions: one with aerobic exercise, one with resi…

This study is working to create a system that can identify people at high risk for type 1 diabetes. Researchers will follow 340 people, including patients with type 1 diabetes and their close relatives, for four years. They will collect blood, urine, and stool samples each year t…

This study aims to identify different subgroups among people with type 1 diabetes by analyzing their health data using artificial intelligence. Researchers will look at clinical records and glucose monitoring information from 800 adults. Participants do not need to do anything ex…

This study looks at how blood sugar levels change during the menstrual cycle in women with type 1 diabetes. Researchers will track 86 women in Canada using continuous glucose monitors, insulin data, ovulation kits, and activity trackers. The goal is to understand why insulin need…

This study looks at how type 1 diabetes affects the nerves that control the heart in children. Researchers will measure heart rate variability in 100 children with diabetes and compare them to healthy kids of the same age and sex. The goal is to find early signs of cardiac dysaut…

This study is testing whether it's practical to screen thousands of children for type 1 diabetes and celiac disease during their regular doctor visits. Researchers will enroll up to 33,000 children from birth to age 6 and follow them for about 5 years. The goal is to see if paren…

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This study looks at why people with diabetes have a higher risk of memory problems and dementia. Researchers will use brain scans and thinking tests to see if brain insulin resistance and damaged blood vessels play a role. About 150 adults aged 50-80 with type 1 or type 2 diabete…

This study is screening children and adolescents aged 1.5 to 18 years who have a parent or sibling with type 1 diabetes. Researchers will collect blood samples to look for early signs of the disease, such as specific autoantibodies, before symptoms appear. The goal is to identify…

This early study tests whether a natural protein called C-peptide can help the liver produce more sugar during insulin-induced low blood sugar in people with type 1 diabetes. Researchers will give C-peptide or a placebo to 38 volunteers and measure glucagon levels and liver sugar…

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases and primary immune deficiencies. Researchers will collect blood samples and health data to better understand how these treatments work and who respo…

This study looks at how changing thyroid hormone levels affect the way the body uses sugar and fat. Researchers will study people with Graves' disease (whose thyroid hormones are too high) and people with thyroid cancer (whose hormones are intentionally raised). Participants will…

This study aims to understand why people with type 1 diabetes have a higher risk of heart attacks and strokes. Researchers will compare fat and protein processing in 30 adults—some with type 1 diabetes and some healthy—using special tracer infusions and blood tests. The goal is t…

This study tests whether a virtual education program called CGM Academy helps youth (ages 8-18) with type 1 diabetes improve their blood sugar control. Participants will receive an interactive workbook and four online group sessions with diabetes educators, while a comparison gro…

This observational study will use special PET scans to measure how much oxygen the heart and kidneys use in people with type 1 diabetes. Researchers want to see if a more intensive treatment plan (multifactorial intervention) lowers oxygen demand compared to standard care. Forty …

This study looks at how sleep apnea (pauses in breathing during sleep) affects blood sugar levels in adults with type 1 diabetes. Researchers will track blood sugar patterns using continuous glucose monitors in 40 participants. The goal is to understand the link between sleep apn…

This study looks at how exercising in hot conditions (40°C) changes blood sugar levels in people with type 1 diabetes compared to a normal temperature (20°C). 38 adults who have had type 1 diabetes for over a year and exercise regularly will do 40 minutes of moderate exercise in …

This study looks at whether newer automated insulin delivery systems help people with type 1 diabetes have healthier eating behaviors. Researchers will survey over 100 youth and adults across Canada about their eating habits and blood sugar control. The goal is to understand if t…

This study looks at whether continuous glucose monitors (CGMs) can help seafarers who need insulin manage their diabetes while working at sea. Fifty insulin-dependent seafarers will wear a CGM for 12 months and track their glucose levels during work and rest. The goal is to see i…

This study looks at how reducing cholesterol levels affects blood cells and blood vessels in people with type 1 diabetes. Researchers will follow 125 participants for one to two months to measure changes in platelet activity, immune cell function, and blood vessel health. The goa…

This early-phase study looks at whether reducing high insulin levels (common in type 1 diabetes) with an SGLT2 inhibitor can improve heart and blood sugar health. Researchers will compare people with type 1 diabetes, those with a mild genetic diabetes (GCK-MODY), and healthy volu…

This study looks at how caring for a child recently diagnosed with type 1 diabetes affects caregivers' work, daily life, and well-being. About 100 Canadian caregivers will fill out online questionnaires about their productivity, healthcare use, and quality of life. No treatment i…

This study looks at babies diagnosed with type 1 diabetes before age 2, a rare and extreme form of the disease. Researchers want to understand what goes wrong in the immune system to cause such early onset. By studying these children and comparing them to others with diabetes and…

This study looks at how being overweight or having early signs of type 2 diabetes affects the brains of teenagers aged 12 to 17. Researchers will use brain scans and memory tests to see which factors—like insulin resistance or inflammation—are most linked to changes in brain stru…

This study looks at whether sexual activity raises the risk of low blood sugar (hypoglycemia) in adults with type 1 or type 2 diabetes who use insulin and continuous glucose monitors. Researchers will track 100 participants for 3 months, comparing glucose levels on days with and …

This early study tests whether two modified insulins (diluted U-200 Humalog and diluted U-500 Humulin) work faster than a current rapid insulin (Lyumjev) in 20 adults with type 1 diabetes who use insulin pumps. Participants receive each insulin after a meal, and researchers measu…

This study looks at whether the chemicals in your breath change throughout the day and if those changes are different for people with diabetes. Researchers will measure breath samples from 60 adults—some without diabetes, some with type 1, and some with type 2. The goal is to lea…

This study follows 550 people with stage 2 type 1 diabetes in the U.S. to see how teplizumab affects their quality of life, anxiety, and diabetes management. Some participants received teplizumab, others did not, and researchers compare their experiences over time. The goal is to…

This study aims to identify subgroups of people with diabetes who share similar patterns between their blood sugar levels and mental health. By using smartphone surveys and continuous glucose monitors, researchers will create 'digital twins'—virtual models that can predict how me…

This study aims to understand how insulin sensitivity and blood sugar levels change across menstrual cycles in women with type 1 diabetes. Researchers will track 350 women aged 18-40 who have regular periods and use automated insulin delivery systems. The goal is to identify patt…

This observational study at Turku University Hospital will use ultrasound radiomics to compare fetal liver texture between 60 pregnant women with type 1 diabetes and healthy controls. The goal is to see if this noninvasive method can detect signs of fetal hyperinsulinemia (high i…

This study looks at blood samples from 80 children (ages 2-17) recently diagnosed with type 1 diabetes and compares them to healthy children. Researchers want to understand how certain immune cells (called T cells) stop working properly, leading to the disease. The goal is to gat…

This study looks at how immune cells and inflammatory molecules differ in people with migraine, especially those who also have autoimmune diseases like multiple sclerosis, rheumatoid arthritis, or endometriosis. Researchers will compare blood samples from 396 women to measure reg…

This study aims to identify specific blood markers that can distinguish hepatitis caused by immune checkpoint inhibitors from other types of autoimmune hepatitis. Researchers will collect blood samples and liver tissue from 60 adults receiving immunotherapy. The goal is to improv…

This study looks at how well people with type 1 diabetes follow the Mediterranean diet after starting the Minimed 780G insulin pump, and whether that affects their blood sugar levels and insulin use. About 240 participants aged 7 and older will be observed for 12 months. The goal…

This study tests a special collar worn around the neck that measures radiation exposure in people with thyroid cancer or Graves' disease receiving radioactive iodine therapy. The goal is to see if this device gives more accurate dosing information than current methods, potentiall…

This study looks at how controlling blood sugar and using a GLP-1 drug (liraglutide) changes the way the pancreas works in people with type 1 or type 2 diabetes. Researchers will measure hormone levels before and after treatment. The goal is to understand how these treatments aff…

This study looks at how blood sugar levels change during exercise in healthy adults and those with type 1 diabetes. Participants will cycle after a standard breakfast, and their glucose will be tracked with a continuous monitor and finger-prick tests. The goal is to see if the bo…

This early-phase study is testing whether the antidepressant fluoxetine (Prozac) and/or the hormone DHEA can improve the body's ability to defend against low blood sugar in people with type 1 diabetes. About 60 adults will take the drugs or a placebo for 8 weeks, then undergo two…

This study examines whether using advanced automated insulin pumps soon after diagnosis can protect brain growth and thinking skills in children aged 5-7 with type 1 diabetes. Researchers will compare brain scans and cognitive tests over 18 months between children using standard …

This study investigates why some people with Graves' disease continue to feel mentally fatigued even after their thyroid levels return to normal. Researchers will compare blood and spinal fluid from 180 participants—60 with mental fatigue, 60 without, and 60 healthy controls—to f…

This observational study is looking at how diet, gut bacteria, and genetics influence blood sugar spikes after meals in people with type 1 diabetes. Researchers will track 200 participants using continuous glucose monitors, food diaries, and stool samples. The goal is to find pat…

This study looks at whether entering fake carbohydrates into the MiniMed 780G insulin pump improves blood sugar control in children and teens with type 1 diabetes. Forty participants aged 7-18 will try two weeks with fake carbs and two weeks without, and their glucose levels will…

This study looks at why diabetes devices like insulin pumps and continuous glucose monitors can cause skin irritation, eczema, or fatty lumps. Researchers will use non-invasive tools to measure skin health in 150 people with type 1 diabetes. The goal is to find ways to prevent th…

This study is collecting blood, urine, and stool samples from 500 children with autoimmune diseases and healthy controls. Researchers will analyze these samples to find molecular patterns that could help diagnose these conditions and guide treatment decisions. The goal is to crea…

This study looks at how the time of day (circadian rhythm) affects blood sugar levels during different types of exercise in teenagers with type 1 diabetes. Researchers will have 18 teens do continuous and intermittent exercise on a stationary bike at different times. They will tr…

This study is testing whether a continuous glucose monitor (CGM) can predict blood sugar problems in people who are at risk for type 1 diabetes but have no symptoms. Researchers will follow 75 people aged 5 to 39 who have diabetes-related autoantibodies. They will compare CGM dat…