Old drug, new trick: metoclopramide may restore low blood sugar warning signs

NCT ID NCT03970720

Recruiting now Symptom relief Sponsor: Simon Fisher Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether metoclopramide, a drug currently used for stomach issues, can restore the ability to feel low blood sugar symptoms in people with type 1 diabetes. About 36 participants will take either the drug or a placebo for four weeks. Researchers will measure changes in hormone levels and symptom recognition during controlled low blood sugar experiments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Metoclopramide
What this could lead to: If it works, this could help people with type 1 diabetes better sense when their blood sugar drops, reducing the risk of severe hypoglycemia.
What could go wrong: This is a small, early-phase trial with only 36 participants. Metoclopramide may not improve awareness or could cause side effects like drowsiness or restlessness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOGLYCEMIA UNAWARENESS

Contacts and locations

Locations

University of Kentucky
RECRUITING

Lexington, Kentucky, 40516, United States
University of Utah
COMPLETED

Salt Lake City, Utah, 84132, United States

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