Can two old drugs stop a dangerous diabetes complication?
NCT ID NCT03608163
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether two medications, naloxone (a nasal spray) and diazoxide (an oral pill), could prevent the body from losing its ability to sense low blood sugar—a condition called hypoglycemia unawareness. Only 4 healthy volunteers were enrolled before the trial was stopped early. The goal was to see if these drugs could boost the body's natural response to low blood sugar episodes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
naloxone and diazoxide
What this could lead to
If successful, this approach could help people with type 1 diabetes maintain their ability to sense low blood sugar, reducing the risk of severe hypoglycemia.
What could go wrong
The trial was terminated early with only 4 participants, so results are very limited. It also tested healthy people, not those with diabetes, so it may not apply to patients.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Albert Einstein College of Medicine
The Bronx, New York, 10461, United States