Can two old drugs stop a dangerous diabetes complication?

NCT ID NCT03608163

Terminated Knowledge-focused Sponsor: Albert Einstein College of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether two medications, naloxone (a nasal spray) and diazoxide (an oral pill), could prevent the body from losing its ability to sense low blood sugar—a condition called hypoglycemia unawareness. Only 4 healthy volunteers were enrolled before the trial was stopped early. The goal was to see if these drugs could boost the body's natural response to low blood sugar episodes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: naloxone and diazoxide
What this could lead to: If successful, this approach could help people with type 1 diabetes maintain their ability to sense low blood sugar, reducing the risk of severe hypoglycemia.
What could go wrong: The trial was terminated early with only 4 participants, so results are very limited. It also tested healthy people, not those with diabetes, so it may not apply to patients.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus hypoglycemia type 1 diabetes mellitus type 1 diabetes mellitus 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 1 HYPOGLYCEMIA HYPOGLYCEMIA UNAWARENESS

Contacts and locations

Locations

Albert Einstein College of Medicine

The Bronx, New York, 10461, United States

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