Prostate disorder

This trial compares two types of hormone injections given before prostate brachytherapy (internal radiation) for early-stage prostate cancer. One injection lasts one month, the other three months, and both are used to lower testosterone to make radiation more effective. The study…

This study tests a type of radiation called high-dose brachytherapy for men with prostate cancer that hasn't spread. Doctors place tiny radioactive sources directly into the prostate to deliver a strong dose to the tumor while sparing nearby healthy tissue. The goal is to control…

This study tests whether a secure website with educational sessions, goal-setting, and tracking tools can help survivors of several cancers (including breast, prostate, colorectal, and others) improve their diet, increase physical activity, and manage weight. Participants are age…

This trial compares three modern radiotherapy techniques—helical tomotherapy and two types of dynamic arc therapy (RapidArc and VMAT)—for treating prostate, cervical, and anal canal cancers that require pelvic lymph node irradiation. The goal is to determine which method is most …

This study tests two drugs, saruparib and darolutamide, given alone or together before prostate removal surgery in men with newly diagnosed prostate cancer. The goal is to see how these drugs affect cancer cells and check for side effects. About 120 men with localized, higher-ris…

This study tests whether adding darolutamide to standard hormone therapy (ADT) helps Chinese men with a high-risk form of prostate cancer that has not spread but is no longer responding to hormone therapy alone. Darolutamide blocks the effects of male hormones on cancer cells, po…

This trial investigates a combination of two drugs: EP0057, a chemotherapy drug wrapped in a nanoparticle to help it reach cancer cells, and olaparib, which stops cancer cells from fixing DNA damage. The study includes adults with small cell lung cancer, bladder cancer, or prosta…

This small, completed Phase 1 study tested a single injection of a radioactive drug called Lutetium-177 BQ7876 in 7 men with prostate cancer. The main goals were to see how the drug spreads in the body, how much radiation reaches tumors, and whether it is safe. Because it is very…

This phase 3 trial tested whether adding bevacizumab (Avastin) to standard chemotherapy (gemcitabine and cisplatin) helps people with advanced urinary tract cancer live longer. 506 patients with cancer that had spread or could not be removed by surgery took part. The study compar…

This phase 2 trial tested phenelzine sulfate (Nardil), an antidepressant, in 26 men with prostate cancer that returned after initial treatment but hadn't spread. The goal was to see if the drug could lower PSA levels, a marker of cancer activity. Researchers measured how many pat…

This study tested a new drug called CT7001, alone or with other cancer treatments, in 124 people with advanced solid tumors like breast and prostate cancer. The main goal was to check safety and side effects. The drug is taken by mouth and aims to control the disease, not cure it…

This study tested whether adding an experimental drug (MK-2206) to the standard hormone therapy bicalutamide can better control prostate cancer in men whose PSA levels are rising after initial treatment. About 108 men with recurrent prostate cancer took part. The goal was to see …

This study tested the safety and effectiveness of enzalutamide (Xtandi) in 52 Indian men with metastatic castration-resistant prostate cancer that had worsened after chemotherapy. Participants took enzalutamide daily while continuing hormone therapy. The main goal was to see how …

This study looked at 612 men with prostate cancer that had been removed by surgery. It compared standard treatment (hormone therapy plus radiation) against the same treatment plus the chemotherapy drug docetaxel. The goal was to see if adding chemo helps keep the cancer from comi…

This study tested whether giving a higher dose of radiation specifically to the visible tumor inside the prostate could improve cancer control in men with localized prostate cancer. Eighty-five men either received a standard radiation plan with an extra boost to the tumor or a co…

This study tested a new type of PET/MRI scan that uses a special tracer to find small spots of prostate cancer that standard scans miss. Men with a rising PSA after prostate surgery and radiation received targeted radiation to those spots. The goal was to see if this approach can…

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This study tests whether the drug olaparib can help control aggressive variant prostate cancer when given after initial chemotherapy. About 96 men will receive cabazitaxel, carboplatin, and prednisone first, then either olaparib or observation. The goal is to see if olaparib exte…

This completed phase II trial tested whether a targeted chemotherapy drug (abemaciclib) and an immunotherapy drug (atezolizumab), alone or together, can shrink or slow advanced prostate cancer that no longer responds to hormone therapy. Nineteen men with metastatic castration-res…

This early-stage study tests two oral drugs (darolutamide and abemaciclib) plus standard hormone therapy in men with high-risk prostate cancer that has spread or may come back. The first part finds the safest dose; the second checks if the combination can shrink or eliminate tumo…

This completed Phase 3 study compared the risk of major heart problems between two hormone therapies—relugolix (a pill) and leuprolide (an injection)—in 387 men with prostate cancer. The trial was stopped early by the sponsor, but enrolled patients could continue treatment for up…

This early-phase trial tested a new drug called vilastobart, alone or with another drug (atezolizumab), in 125 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the right dose. Researchers also looke…

This phase 2 trial tested the chemotherapy drug carboplatin in 16 men with metastatic castration-resistant prostate cancer that has specific gene changes in the homologous recombination pathway. The goal was to see if carboplatin could shrink tumors or lower PSA levels. The study…

This study compares two ways of injecting BOTOX into the prostate for men with benign prostatic hyperplasia (BPH) who still have bothersome urinary symptoms despite medication. One group receives BOTOX only in the prostate gland, while the other gets injections in the prostate, b…

This study tested a combination of two targeted drugs (pertuzumab and trastuzumab) plus a chemotherapy drug (enzalutamide) in 7 men with advanced prostate cancer that had stopped responding to standard treatments. The goal was to see if the combination could shrink or slow the gr…

This study tested a radioactive drug called 177Lu-PSMA-617 in 62 Chinese men with advanced prostate cancer that had spread and stopped responding to hormone therapy and chemotherapy. The drug targets a protein on cancer cells and delivers radiation directly to them. Researchers m…

This study tested a drug called ARN-509 in 127 men with advanced prostate cancer that had stopped responding to standard hormone therapy. The goal was to find a safe dose and see if the drug could lower PSA levels, a marker of cancer activity. The drug works by blocking male horm…

This study tested a device called NanoKnife to treat prostate cancer in 121 men with intermediate-risk disease. The goal was to safely destroy cancer tissue while avoiding major side effects. Researchers checked if the treated area was cancer-free after 12 months and tracked any …

This phase II trial tested a combination of three drugs—carboplatin, cabazitaxel, and abiraterone—in 61 men with high-volume metastatic prostate cancer that still responds to hormone therapy. The goal was to see how many men had no cancer growth after one year. The study also tra…

This early-phase trial tested a shorter course of radiation for men whose prostate cancer came back after their prostate was removed. Instead of the usual 6-7 weeks of daily radiation, researchers gave higher doses over just 2-4 weeks, focusing the strongest radiation on the tumo…

This phase II trial tested a shorter course of higher-dose radiation (hypofractionation) in 53 men with high-risk prostate cancer who had already had their prostate removed. The goal was to see if this approach could control cancer while reducing side effects. Participants also r…

This study tests whether adding an immunotherapy drug called lorigerlimab to standard chemotherapy (docetaxel) can help men with a tough-to-treat type of prostate cancer live longer without their disease getting worse. About 150 men with metastatic castration-resistant prostate c…

This study followed 354 men with low- to intermediate-risk prostate cancer who chose to freeze only the cancerous half of their prostate (hemi-gland cryoablation). Researchers tracked how well the treatment controlled the cancer and how it affected urinary function and quality of…

This study tested a combination of three hormone-blocking drugs (enzalutamide, abiraterone, and standard hormone therapy) given before surgery in 12 men with newly diagnosed prostate cancer that hasn't spread. Researchers also used special PET/CT scans with a new tracer to see if…

This study tested whether a shorter course of higher-dose radiation (hypofractionated) works as well as standard radiation after prostate removal in 296 men with prostate cancer. The main focus was on quality of life, especially urinary and bowel function. The goal is to find a t…

This study tested a new X-ray monitoring technique (KIM) during prostate cancer radiation therapy. The goal was to see if it helps doctors aim more precisely at the tumor while reducing harm to healthy tissue. 49 men with low- or intermediate-risk prostate cancer took part. The a…

This study tested whether adding the drug niraparib to standard radiation and hormone therapy can help prevent high-risk prostate cancer from coming back. Niraparib blocks a protein that cancer cells use to repair their DNA, which may kill them. The trial enrolled 22 men with agg…

This phase I trial tested a new type of radiation therapy for low- and intermediate-risk prostate cancer that delivers a higher dose each day, completing treatment in just 5 sessions over 2 weeks instead of the usual 45-48. The study enrolled 120 participants to check the safety …

This phase 2 trial tested the immunotherapy drug nivolumab (Opdivo) in 8 men whose prostate cancer had returned after surgery or radiation, shown by rising PSA levels. The men had specific genetic changes (MMR deficiency or CDK12 alteration) that might make their cancers more sen…

This study tested a new drug (BXCL701) combined with an immunotherapy (pembrolizumab) in 98 men with advanced prostate cancer that no longer responds to hormone therapy. The goal was to see if the combination could shrink tumors or slow the disease. This is a disease control appr…

This trial tested whether a precise type of radiation called SBRT could slow the growth of metastatic prostate cancer in men whose disease was starting to worsen despite hormone therapy. 86 men with one or two growing tumors received SBRT while continuing their current hormone dr…

This study tested a daily supplement of curcumin (from turmeric) and piperine (from black pepper) in 30 people with early-stage prostate cancer or pre-cancerous blood conditions (MGUS or low-risk smoldering multiple myeloma). The goal was to see if the supplement could lower canc…

This study tested a new way to give radiation therapy for prostate cancer. It used very precise, high-dose radiation over just five days. The goal was to control the cancer while reducing side effects on the bladder and bowel. 444 men with localized prostate cancer took part, and…

This study tested a radioactive drug called 177Lu-PSMA-617 in 94 Japanese men with advanced prostate cancer that had spread and stopped responding to hormone therapy. The drug seeks out and delivers radiation directly to cancer cells. Researchers measured how well it shrank tumor…

This early-stage trial tested the safety and best dose of adding niclosamide (a drug used for tapeworm infections) to standard hormone therapy (enzalutamide) in 6 men with advanced prostate cancer that no longer responds to hormone treatment. The goal was to see if the combinatio…

This study compares a new procedure called high-frequency irreversible electroporation (H-FIRE) to standard surgery (TURP) for treating benign prostatic hyperplasia (enlarged prostate). 118 men aged 40 and older with moderate to severe symptoms are participating. H-FIRE uses elec…

This pilot study tested a new, shorter radiation schedule (ultra-hypofractionation) in 13 men with early-stage prostate cancer. The goal was to see if this approach causes fewer urinary side effects while still controlling the cancer. Participants had low- to intermediate-risk pr…

This Phase 2 trial tested an immunotherapy drug called vudalimab, either by itself or combined with standard chemotherapy or targeted therapy, in 72 men with metastatic castration-resistant prostate cancer that had worsened after prior treatments. The main goal was to check safet…

This study tested a device that uses water vapor (steam) to destroy cancerous tissue in the prostate. 32 men with prostate cancer received the treatment just before their scheduled prostate removal surgery. Researchers checked how well the steam destroyed the targeted tissue and …

This early-stage study tested a new drug, ARV-110, combined with the standard treatment abiraterone in 45 men with metastatic prostate cancer whose PSA levels were rising despite abiraterone alone. The main goals were to check safety and find the best dose. The study is complete,…

This study tested whether adding a prostate cancer vaccine (PROSTVAC) and chemotherapy (docetaxel) to standard hormone therapy works better than hormone therapy alone for men whose prostate cancer has spread. 74 men with metastatic castration-sensitive prostate cancer took part. …

This early-phase trial tested a new drug called AZD8186 combined with the chemotherapy docetaxel in 23 patients with advanced solid tumors that have PTEN or PIK3CB gene mutations. The main goal was to find the safest dose and understand side effects. The study is complete, but re…

This study tested whether adding a radioactive drug (radium-223) to standard targeted radiation (SBRT) can delay cancer progression in men whose prostate cancer has returned in a few bone spots but hasn't yet become hormone-resistant. Twelve men participated, receiving either the…

This early-phase study tested a new drug, opevesostat (MK-5684), in 7 Japanese men with a type of advanced prostate cancer that no longer responds to standard hormone therapy. The main goals were to check the drug's safety and how the body processes it. This is a first step to se…

This large Phase 3 trial tested whether adding the immunotherapy pembrolizumab (Keytruda) to standard hormone therapy (enzalutamide plus ADT) could improve outcomes for men with metastatic hormone-sensitive prostate cancer. Over 1,200 participants were enrolled. The study was unb…

This early study tested a new laser treatment for prostate cancer that can be done in a doctor's office. Ten men with early-stage prostate cancer received focal laser ablation guided by MRI and ultrasound images. The main goal was to see if the procedure is safe and feasible, not…

This study tested whether adding apalutamide to standard hormone therapy after prostate removal surgery can keep prostate cancer from coming back in high-risk patients. 108 men who had surgery for non-spread prostate cancer took the drug combo for up to 2 years. Researchers check…

This study tested a single, high-dose radiation treatment for men with low-risk or low intermediate-risk prostate cancer. The goal was to see how well the body tolerates this one-time treatment by tracking side effects in the bladder and digestive system within the first 6 months…

This early-phase trial tested a combination of four drugs—apalutamide, abiraterone, docetaxel, and prednisone—in 16 men with metastatic castrate-resistant prostate cancer, a form of the disease that no longer responds to standard hormone therapy. The main goal was to find a safe …

This early-phase study tested a new treatment called JNJ-75229414, which uses a patient's own immune cells (T cells) engineered to attack prostate cancer cells. The study involved 15 men with metastatic castration-resistant prostate cancer that had already been treated with other…

This study tested a precise radiation implant (brachytherapy) for men with low-risk prostate cancer. Instead of treating the whole prostate, doctors placed radioactive seeds only in the tumor area. The goal was to see if this targeted approach could deliver the right radiation do…

This study compared two types of radiation therapy for men with intermediate-risk prostate cancer: standard image-guided external beam radiation (IGRT) versus IGRT plus a high-dose-rate brachytherapy boost. The goal was to see which treatment works better and what side effects oc…

This study tested a drug combination (abiraterone acetate plus prednisolone and hormone therapy) given before radiation in 45 men with high-risk localized prostate cancer. The goal was to see if the treatment could shrink tumors and lower PSA levels. The approach aims to improve …

This study tested whether giving two drugs together—Radium-223 and enzalutamide—is safe for men with advanced prostate cancer that has spread to other parts of the body and is no longer controlled by standard hormone therapy. 45 men took part. The main goal was to track serious s…

This study tested whether giving three hormone-blocking drugs along with high-dose, precisely targeted radiation could stop very high-risk prostate cancer from coming back. Sixty-four men with aggressive prostate cancer received the treatment. The main goal was to see how many me…

This study tested a new way to treat intermediate-risk prostate cancer using a 3D map to guide microwaves directly to the main tumor. 76 men across Europe received the treatment, and researchers checked if the cancer was gone after 12 months. The goal is to destroy the cancer whi…

This study tested a closed-system bladder irrigation device designed to reduce urinary tract infections after endoscopic urologic surgery. 240 patients undergoing prostate or bladder tumor surgery were randomly assigned to use the new device or standard irrigation. The device all…

This early-phase study tested a new combination of two drugs—enzalutamide and relacorilant—in 42 men with advanced prostate cancer that no longer responds to standard hormone therapy. The main goals were to check safety and see how the drugs interact in the body. Researchers also…

This study compared two radiation therapy schedules for men with intermediate- or high-risk prostate cancer. One group received fewer, higher-dose radiation sessions (hypofractionated), while the other received standard daily doses. Both groups also received hormone therapy. The …

This study looked at whether taking an oral hormone therapy called apalutamide for 6 months could slow down low-risk prostate cancer and delay the need for more aggressive treatments like surgery or radiation. 93 men on active surveillance (watching the cancer without immediate t…

This early-phase study tested a new drug called MK-5684 (opevesostat) in 14 Chinese men with a type of advanced prostate cancer that no longer responds to standard hormone therapy. The main goals were to check the drug's safety and how the body processes it. Participants took the…

This study looked at whether deep cleaning of the gums (non-surgical periodontal therapy) could reduce prostate-specific antigen (PSA) levels and urinary tract infections in men with both gum disease and chronic prostatitis or recurrent UTIs. Sixty men were split into three group…

This study tested a new way to give radiation to men with intermediate-risk prostate cancer. After standard radiation to the prostate and nearby glands, a precise, high-dose boost was added to the tumor. The goal was to improve cancer control while keeping side effects on the bla…

This early-phase trial tested whether rituximab, a drug that depletes B cells, could reduce immune cell infiltration in prostate tumors. Eight high-risk prostate cancer patients received four weekly doses before their scheduled prostate removal. The main goal was to see if B-cell…

This large phase 3 trial studied 1,538 men with intermediate-risk prostate cancer. It compared dose-escalated radiation therapy alone versus radiation plus short-term (6 months) androgen deprivation therapy (hormone therapy). The goal was to see if adding hormone therapy improves…

This study looked at 588 men with intermediate-risk prostate cancer to see if adding external beam radiation to brachytherapy (placing radioactive seeds in the prostate) works better than brachytherapy alone. The goal was to see which approach better controls the cancer over time…

This Phase 3 trial tested whether adding the drug TAK-700 to standard hormone therapy and radiation could better control high-risk prostate cancer. 239 men participated. The study compared standard treatment (GnRH agonist plus anti-androgen) with an enhanced version that also inc…

This study tested a drug called niraparib in 11 men with advanced prostate cancer that was no longer responding to hormone therapy but had recently been treated with platinum chemotherapy. The goal was to see if niraparib could keep the cancer from growing for at least 6 months. …

This study tested whether adding the drug axitinib to standard hormone therapy before surgery helps men with prostate cancer that has spread to lymph nodes. About 73 men received either hormone therapy alone or hormone therapy plus axitinib before having their prostate removed. T…

This early-phase trial tested an experimental cell therapy called INKmune in 12 men with advanced prostate cancer that no longer responds to hormone therapy. The goal was to find the safest and most effective dose by measuring immune cell activity, PSA levels, and tumor changes. …

This phase 2 trial tested a drug called Lutetium-177-PSMA-617, which delivers radiation directly to prostate cancer cells. It included 58 men with prostate cancer that had spread to a few spots in bones or lymph nodes but was still hormone-sensitive. The study compared the drug t…

This study tested whether adding darolutamide to standard hormone therapy helps men with prostate cancer that has spread to other parts of the body. 669 men participated. The goal was to see if the combination delays cancer growth or death. Results showed improvement in progressi…

This study tested a shorter course of proton radiation (5 treatments over 2 weeks) for men with localized prostate cancer, compared to the usual 8 weeks. The goal was to see if this approach maintains quality of life and controls the cancer. 150 men with low- to intermediate-risk…

This study tested a combination of abiraterone acetate and prednisone in 131 men with advanced prostate cancer that had not yet spread on scans. The goal was to see if the drugs could lower PSA levels and delay cancer progression. Participants took daily pills alongside standard …

This study tested a treatment called focused ultrasound (HIFU) that aims to destroy only the cancerous part of the prostate, avoiding common side effects like incontinence and impotence from standard treatments. It involved 174 men aged 50-80 with intermediate-risk prostate cance…

This study tested a radioactive drug called radium-223 in 921 men with advanced prostate cancer that no longer responds to hormone therapy and has spread to the bones. The goal was to see if it helps them live longer and controls the cancer. Participants received either the drug …

This early study tested a combination of heat therapy (hyperthermia) and high-dose radiation for men whose prostate cancer returned after earlier radiation. Only 3 men took part, and the main goal was to check safety and side effects. The approach aims to make cancer cells more s…

This study compared two ways of taking prostate tissue samples: the standard transrectal method (through the rectum) and a newer transperineal method (through the skin between the scrotum and anus). Over 1,000 men participated to see if the transperineal approach causes fewer inf…

This study tested a new surgical clip called VasoClip, designed to hold blood vessels closed more securely during robotic surgery for prostate, kidney, or bladder cancer. Forty patients were randomly assigned to receive either the new clip or a standard clip. The goal was to see …

This Phase 2 study tested a radiation therapy plan that gives a slightly higher dose each day over fewer sessions (16 days instead of the usual 8-9 weeks) for men with early-stage prostate cancer. The goal was to see if this shorter schedule is safe and effective, while also trac…

This early-phase study tested a new drug called JNJ-70218902 in 82 people with advanced solid tumors, including prostate cancer. The drug works by redirecting the body's immune T cells to attack cancer cells. The main goals were to find a safe dose and check for side effects, not…

This completed Phase 1/2 trial tested a combination of stereotactic body radiation therapy (5 high-dose sessions) and 4 months of hormone therapy in 45 men with intermediate-risk prostate cancer. The goal was to see how well this approach controls cancer and what side effects occ…

This study tested a combination of high-dose radiation and hormone therapy (leuprorelin) in 74 men with prostate cancer that had returned in up to 5 pelvic lymph nodes after initial treatment. The goal was to see if this approach could delay further cancer growth or relapse. Part…

This early-stage trial tested a new oral drug, MSP008-22, in 7 adults with advanced solid tumors (breast, ovarian, prostate, head and neck cancers) that had spread or could not be removed. The main goal was to find a safe dose and check for side effects. This is a first step to s…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

This study tested the immunotherapy drug nivolumab (Opdivo) combined with one of three other drugs (rucaparib, docetaxel, or enzalutamide) in 292 men with advanced prostate cancer that had spread and stopped responding to hormone therapy. The goal was to see if these combinations…

This study tested a drug called enzalutamide in 1401 men with a type of prostate cancer that has not spread to other parts of the body but is no longer controlled by standard hormone therapy. The goal was to see if enzalutamide could delay the cancer from spreading. Participants …

This study looked at whether men with advanced prostate cancer could safely stop their regular hormone injections (like leuprolide) and rely only on the pills abiraterone and prednisone to keep testosterone at very low levels. 31 men participated. The goal was to see if testoster…

This study tested whether adding a precise, high-dose radiation treatment (SBRT) to the hormone therapy apalutamide helps control prostate cancer that has stopped responding to standard hormone therapy and spread to a few spots. Twenty-six men with this type of cancer took part. …

This study tested whether adding focused radiation to standard hormone therapy or chemotherapy helps men with prostate cancer that has spread to a few spots (oligometastatic) and is no longer responding to hormone therapy alone. Fourteen participants received either standard trea…

This study tested whether a device called the Pelvic Clock® helps men recover bladder control and sexual function faster after robotic prostate cancer surgery. Sixty men aged 55 to 80 used either the device plus standard exercises or standard exercises alone. The main goal was to…

This study tested a new way to treat early-stage prostate cancer using MRI-guided ultrasound waves to destroy tumors without surgery. 25 men with low-to-intermediate risk prostate cancer received the treatment. The main goal was to see if no significant cancer remained one year l…

This pilot study tested whether a diet and exercise program could prevent or reduce metabolic side effects like insulin resistance and weight gain in 20 men with prostate cancer receiving hormone therapy and radiation. Participants followed dietary instructions and did aerobic an…

This phase 2 trial tested two immunotherapy drugs, ipilimumab and nivolumab, in 69 men with a specific type of advanced prostate cancer that no longer responds to hormone therapy. The goal was to see if the combination could shrink tumors or slow disease progression. Participants…

This study tested whether adding the drug TAK-700 to standard hormone therapy helps men with newly diagnosed prostate cancer that has spread live longer than adding the drug bicalutamide. Over 1,300 men took part. The goal was to see which combination works better for controlling…

This study compared two robot-assisted surgical techniques for removing the prostate in men with prostate cancer. One method uses a combined posterior-anterior-lateral (PAL) approach, while the other uses a traditional posterior approach. The goal was to see which technique leads…

This study tested a new antibody called ICT01 combined with low-dose interleukin-2 (IL-2) in 56 people with advanced solid tumors like colorectal, ovarian, and pancreatic cancer. The goal was to see if the combo is safe and can shrink tumors. Early results suggest it may help con…

This phase 2 trial tested whether combining two immunotherapy drugs, nivolumab and ipilimumab, could shrink tumors or slow progression in men with metastatic castration-resistant prostate cancer. 351 participants received either the combination, ipilimumab alone, or the chemother…

This early-stage trial tested a new drug called CC-94676 in 131 men with metastatic castration-resistant prostate cancer, a type that has stopped responding to standard hormone therapy. The main goal was to check safety and find the right dose, while also looking for signs that t…

This study tested a drug called niraparib in 289 men with advanced prostate cancer that no longer responds to hormone therapy and has specific DNA repair issues. The goal was to see if the drug could shrink tumors or slow the disease. Results may help identify which patients coul…

This study looked at the long-term safety of the drug degarelix in 57 men with prostate cancer. Participants received a monthly injection of degarelix for up to 5 years. The goal was to monitor side effects, such as changes in blood pressure, pulse, weight, and liver function.

This phase 3 study tested whether adding apalutamide (Erleada) to standard hormone therapy (LHRH analogues) can delay cancer progression in men whose prostate cancer has returned after surgery. 504 men with rapidly rising PSA levels took part. The goal was to see if the combinati…

This study tested whether adding a radioactive drug (Radium-223) to targeted radiation (SABR) helps men with prostate cancer that has spread to a few bones or soft tissues. 64 men participated, receiving either SABR alone or SABR plus Radium-223. The goal was to see if the combin…

This study looked at a combination of two drugs, talazoparib and temozolomide, in 16 men with advanced prostate cancer that had spread and stopped responding to hormone therapy. The goal was to find the safest dose and see if the drugs could shrink tumors. The study was completed…

This study tested a new way to treat low-risk prostate cancer using MRI-guided laser ablation. Seven men with early-stage prostate cancer received the treatment to see if it was safe and could successfully destroy tumors. The goal was to target only the cancer while avoiding side…

This large phase 3 trial tested whether adding the chemotherapy drug docetaxel to standard hormone therapy helps men with metastatic prostate cancer live longer. 790 men participated. The results showed that the combination improved overall survival compared to hormone therapy al…

This early-phase study tested a new approach for men with prostate cancer that has spread to nearby lymph nodes. The standard treatment combines radiation with 2-3 years of hormone therapy, which can cause lasting side effects. Researchers added a targeted radioactive drug (Lu-PS…

This study tested whether adding the immunotherapy drug pembrolizumab (Keytruda) — alone or with an injected immune stimulant called SD-101 — to standard radiation and short-term hormone therapy could better control prostate cancer that has spread to a few spots. Twenty-three men…

This small pilot study tested a procedure called prostatic arterial embolization in 10 men with low-risk, one-sided prostate cancer who were already on active surveillance. The idea was to block the artery feeding the tumor, starving it of blood. Researchers checked for side effe…

This study tested a new type of radiation therapy called DaRT seeds for men with prostate cancer. The goal was to see if it is safe and possible to place these tiny radioactive seeds directly into the tumor before surgery. Only one person took part, and the focus was on whether t…

This early-phase trial tested whether injecting a man's own bone marrow stem cells into the penis could help restore erections after prostate cancer surgery. The study included 18 men who had normal erections before surgery but developed erectile dysfunction due to blood vessel d…

This Phase 3 study tested whether adding darolutamide to standard hormone therapy and chemotherapy helps men with metastatic hormone-sensitive prostate cancer live longer. Over 1,300 participants received either darolutamide or a placebo, along with standard treatments. The main …

This study tested a cancer vaccine called ETBX-011 in 43 people with advanced colorectal, lung, breast, or prostate cancers that produce a protein called CEA. The vaccine uses a modified virus to teach the immune system to attack cancer cells making CEA. The main goals were to ch…

This early-phase trial tested a combination of three drugs—cabozantinib, abiraterone, and nivolumab—in 18 men with metastatic hormone-sensitive prostate cancer that had not yet been treated. The main goal was to find a safe dose and check for serious side effects. Researchers als…

This early-phase study tested a new treatment schedule for men with castration-resistant prostate cancer. The approach alternates between giving testosterone through the skin and the drug enzalutamide, aiming to control the disease. The main goals were to see if this schedule is …

This study tested whether adding the drug enzalutamide to standard radiation therapy can better control prostate cancer that has come back after surgery. Eighty-six men with rising PSA levels after prostate removal took part. The goal was to see if the combination could delay can…

This study looked at a gel called SpaceOAR that is injected between the prostate and rectum before radiation therapy for prostate cancer. The gel creates a temporary space to protect the rectum from radiation damage. Fifteen men with early-stage prostate cancer took part, and the…

This study tested an experimental drug called CPI-1205 combined with standard hormone therapies (enzalutamide or abiraterone/prednisone) in 175 men with metastatic castration-resistant prostate cancer, a form of prostate cancer that has spread and stopped responding to usual horm…

This phase 3 study tested the drug enzalutamide in 395 Asian men with metastatic prostate cancer that had stopped responding to standard hormone therapy. Participants had not yet received chemotherapy. The study compared enzalutamide to a placebo to see if it could delay rises in…

This large phase 3 trial tested whether adding enzalutamide (Xtandi) to standard hormone therapy (ADT) helps men with metastatic hormone-sensitive prostate cancer. Over 1,100 participants received either enzalutamide plus ADT or a placebo plus ADT. The main goal was to see how lo…

This study looked at whether eating a whole food plant-based diet for six months can help men with prostate cancer whose PSA levels are rising. Eleven men attended cooking classes and ate mostly plants. Researchers measured changes in PSA, cholesterol, blood sugar, and inflammati…

This study looked at whether giving chemotherapy (docetaxel) before starting hormone therapy (degarelix) helps men with prostate cancer that has spread. 52 men took part. The main goal was to see how many had very low PSA levels after 10 months. The approach aims to improve disea…

This phase 2 trial tested whether adding a radioactive drug (I-131-1095) to standard enzalutamide therapy helps men with a specific type of advanced prostate cancer that had worsened on another treatment. The study enrolled 120 men with PSMA-positive metastatic castration-resista…

This early-phase trial tested a combination of two experimental drugs, vobramitamab duocarmazine and lorigerlimab, in 31 people with advanced solid tumors like prostate, melanoma, and pancreatic cancer. The main goal was to check safety and find the right dose. Participants recei…

This early-phase study tested a highly targeted type of radiation (SBRT) in 17 men whose prostate cancer returned after prior radiation. The goal was to find the highest safe dose and see how well the body tolerated it. Participants received five focused treatments over two weeks…

This early-phase trial tested a combination of two drugs—docetaxel (a chemotherapy) and radium 223 (a radioactive drug)—in 43 men with advanced prostate cancer that no longer responds to hormone therapy and has spread to the bones. The main goal was to find the safest dose and wa…

This study tested different combinations of immunotherapy drugs in 59 adults with advanced prostate cancer that no longer responds to hormone therapy. The goal was to see if these combinations are safe and can help shrink tumors or lower PSA levels. Participants received up to fo…

This study tested whether adding the immunotherapy drug pembrolizumab to standard hormone therapy (enzalutamide plus ADT) could help men with metastatic hormone-sensitive prostate cancer live longer or delay cancer growth. The trial enrolled 186 Chinese men and was stopped early …

This completed study looked at medical records from over 10,000 men with enlarged prostate (BPH) in the UK and China. Researchers wanted to see if men taking 5-alpha reductase inhibitors (drugs like finasteride) had fewer heart problems like heart attacks and strokes. The study c…

This phase 2 trial tested a combination of testosterone and olaparib in 36 men with castration-resistant prostate cancer. The idea is that testosterone can cause DNA damage in cancer cells that have adapted to low testosterone, while olaparib blocks the cells' ability to repair t…

This study tested a two-step treatment in 15 men with metastatic castration-resistant prostate cancer. First, they took high-dose oral testosterone for three 28-day cycles. If the cancer grew, they switched to enzalutamide. The goal was to see if oral testosterone could control t…

This study looked at a small implantable spacer placed between the prostate and rectum in men receiving radiation for prostate cancer. The goal was to see if the spacer reduces the radiation dose reaching the rectum, potentially lowering side effects. A total of 175 men who alrea…

This completed study tested a hydrogel spacer placed between the prostate and rectum in 20 men undergoing radiation for prostate cancer. The goal was to see if the spacer reduces radiation reaching the rectum. Researchers compared rectal radiation exposure before and after insert…

This study tested a combination of two drugs, apalutamide and abiraterone, plus prednisone, in 93 men with advanced prostate cancer that had spread and was no longer responding to hormone therapy. The goal was to see how long the cancer stayed under control and whether the drugs …

This early-stage trial tested a drug called Tarlatamab in 41 men with a rare and aggressive form of prostate cancer called neuroendocrine prostate cancer. The main goal was to check the drug's safety and find the best dose. The drug works by helping the body's immune cells recogn…

This study compared two treatments for men with an enlarged prostate causing urinary symptoms. One group received a procedure called Rezum, which uses water vapor (steam) to shrink prostate tissue. The other group took a daily medication called tamsulosin. The trial enrolled 94 m…

This early study tested whether adding a radioactive drug (177Lu-PSMA) to standard brachytherapy is safe and feasible for men whose prostate cancer returned after initial radiation. Only 3 men took part. The goal was to see if the combination could control cancer both in the pros…

This early-phase trial tested a new drug, Karonudib, in 63 people with advanced solid tumors that had not responded to standard treatments. The main goal was to check the drug's safety and find the best dose. Researchers also looked at how the drug moves through the body and any …

This trial tested a steroid injection called triamcinolone in 55 men with castration resistant prostate cancer, a type that no longer responds to standard hormone therapy. The goal was to see if it could extend the time before chemotherapy is needed, since current steroid treatme…

This study tested a single injection of triptorelin pamoate that lasts 6 months in 195 Chinese men with advanced or metastatic prostate cancer. The goal was to lower testosterone to castrate levels, which helps slow cancer growth. Results showed the injection effectively reduced …

This study tested a new way to deliver radiation for prostate cancer. The goal was to give a higher dose to the tumor while protecting the urethra and other healthy tissue. 115 men with early-stage prostate cancer took part. The researchers looked at side effects and how well the…

This study looked at men with advanced prostate cancer that no longer responds to hormone therapy. When the standard dose of abiraterone stopped working, some patients received a double dose to see if it could stabilize the disease. The goal was to find out if this approach is sa…

This study tested a new way to treat low-risk prostate cancer using a microwave probe inserted through the rectum. The goal was to see if it could safely destroy the main tumor while protecting nearby tissues. Eleven patients were treated, and the researchers checked for complete…

This pilot study tested high dose rate brachytherapy, a type of internal radiation, in 43 patients with cervical, endometrial, esophageal, prostate, or biliary cancer. The goal was to see if the radiation implants could deliver the planned dose accurately. Participants received b…

This completed phase 1 trial tested a radioactive imaging agent called [99mTc]Tc-DB8 in 10 people with prostate or breast cancer. The goal was to see how the agent spreads in the body and whether it can help detect tumors using SPECT scans. Researchers also checked for safety and…

This completed phase 1 study tested a new radioactive imaging agent called 99mTc-RM26 in 10 people with prostate or breast cancer. The goal was to see how the agent spreads in the body and whether it can help spot tumors using SPECT scans. Researchers also checked for safety and …

This completed Phase 1 study tested a new radioactive tracer called [99mTc]Tc-BQ0413 in 10 men with prostate cancer. The tracer was injected once, and SPECT scans were taken over 24 hours to see where it goes in the body and how safe it is. The goal is to develop a better imaging…

This study tested a new blood test called EPISPOT to find prostate cancer cells in the blood of 361 men with localized prostate cancer before they received any treatment. The goal was to see if this test could predict remission better than an existing test called CellSearch. The …

This completed Phase 2 trial tested an imaging dye called Cytalux (pafolacianine) in 9 men with prostate cancer. The dye is injected before surgery and makes cancer cells glow under near-infrared light, helping surgeons see and remove all cancerous tissue during prostate removal.…

This study tested a new MRI method that measures temperature changes in the prostate. The goal is to help doctors find cancer more accurately and guide laser treatments. Researchers scanned 70 men who already needed an MRI for prostate cancer diagnosis. The focus was on checking …

This completed study tested whether combining PET/MRI scans with machine learning could better assess how aggressive prostate cancer and other solid tumors are. Researchers enrolled 50 adults with prostate cancer, liver cancer, brain tumors, or kidney cancer. The goal was to see …

This study tested an AI software called Quantib Prostate to see if it can detect prostate cancer on MRI scans as accurately as expert radiologists. Researchers looked at 200 men who had prostate MRIs and biopsies. The AI's readings were compared to the radiologist's readings, usi…

This study looked at tiny particles called extracellular vesicles (EVs) found in prostate fluid from 100 men. The goal was to find unique molecular signatures that could help tell aggressive prostate cancer from slow-growing or benign conditions. Researchers used advanced techniq…

This study tested whether specially trained dogs can identify breast, lung, prostate, or colorectal cancer by sniffing breath samples collected on masks. Over 1,300 people provided breath samples before their regular cancer screening or biopsy. The dogs' results were compared to …

This study tested two different radioactive tracers (68Ga-RM2 and 68Ga-PSMA-617) used in PET/CT scans to see which one better detects prostate cancer in men scheduled for prostate removal surgery. Twenty-two men with low, intermediate, or high-risk prostate cancer received both s…

This study compared two radioactive tracers, piflufolastat (18F) and flotufolastat (18F), used in PET scans to detect prostate cancer that has returned after surgery. The main goal was to see which tracer produces less radioactivity in the bladder, which can interfere with image …

This study tested whether an artificial intelligence (AI) system could help find prostate cancer on MRI scans. 365 men who needed a prostate biopsy had their MRI images reviewed by both the AI and by senior radiologists. Doctors then performed targeted biopsies on any suspicious …

This study looked at two methods of taking prostate tissue samples to diagnose cancer: one through the rectum and one through the skin between the scrotum and anus. Researchers wanted to see which method causes fewer infections and less bleeding. 101 men with suspected prostate c…

This study looked at 60 men who had a prostate biopsy to check for cancer. It compared two imaging methods used to guide the biopsy: the standard multiparametric MRI and a newer scan called Ga-68 PSMA PET/CT. The goal was to see which method better finds aggressive prostate cance…

This study tested a new type of PET-CT scanner that can scan a tumor right after it is removed from the body. Patients with prostate or head and neck cancer received a small amount of radioactive tracer before surgery, which sticks to cancer cells. After removal, the specimen was…

This study tested a new imaging technique called Full Field Optical Coherence Tomography (FFOCT) to see if it can detect prostate cancer in biopsy samples as well as standard microscope analysis. Researchers compared FFOCT results to the usual pathology exam in 91 men with elevat…

This study tested whether a high-resolution PET-MRI scan using a prostate-specific tracer (18F-PSMA) can find cancers that standard MRI might miss. 62 men with prostate cancer considering focal therapy or surgery received both scans, and results were checked with biopsies. The go…

This Phase 3 study tested a radioactive tracer called Copper Cu 64 PSMA I&T, given as an injection, to improve PET/CT scans in 235 men with prostate cancer that may have returned after initial treatment (surgery or radiation). The goal was to see how accurately the scan could det…

This study tested a new type of PET scan using a radioactive tracer called 89Zr-DFO-huJ591 to find prostate cancer that has spread to other parts of the body. 77 men with metastatic prostate cancer received the experimental scan, and some also had standard scans and biopsies for …

This early-phase trial tested a new radioactive imaging agent called rhPSMA-7.3 (18F) in 24 people: some healthy volunteers and some with prostate cancer. The goal was to check safety and see how the agent spreads in the body and how well it lights up cancer on PET scans. The stu…

This study tested an artificial intelligence (AI) model designed to detect whether prostate cancer has spread to nearby lymph nodes. Researchers used digital images of lymph node tissue from 225 prostate cancer patients and compared the AI's accuracy to standard pathology reports…

This completed registry study at Princess Margaret Cancer Centre tested whether a special PET scan tracer called 18F-DCFPyL (PSMA) can find prostate cancer that has spread to lymph nodes or other organs better than standard CT and bone scans. A total of 142 men with intermediate-…

This study tested a new radioactive imaging agent called 68Ga-OncoACP3 in 20 men with prostate cancer. The goal was to see if it is safe and to measure how much radiation the body receives. The agent helps doctors see where cancer has spread using a special scan.

This study collected blood and urine samples from 61 men with prostate cancer and healthy volunteers to look for cancer DNA. The goal is to develop a non-invasive way to detect and track prostate cancer without needing a biopsy. Researchers compared genetic material from cancer p…

This study compared two ways to biopsy the prostate in 275 men with suspected cancer. The standard method takes random samples from the gland, which can miss aggressive tumors or find harmless ones. The new method uses MRI images to guide the needle to suspicious spots. The goal …

This study tested whether new deep learning (AI) technology can make prostate MRI scans faster while still finding suspicious nodules. Researchers compared standard MRI sequences with faster, AI-enhanced versions in 34 adults referred for prostate MRI. The goal was to see if the …

This study tested whether using an MRI to guide prostate biopsies could detect cancer as well as the standard 12-sample systematic biopsy. Researchers enrolled 108 men aged 45-75 with elevated PSA levels and suspicious MRI findings. They compared the cancer detection rates of 3 t…

This study explored whether prostate cancer cells can be detected in blood samples instead of using a needle biopsy. Researchers collected blood from 127 men with suspected prostate cancer and used a special filter to isolate tumor cells. The goal was to see if this non-invasive …

This study tested a simple, rapid PSA blood test that gives results in minutes, comparing it to the standard lab PSA test. Researchers enrolled 94 men with prostate cancer or benign prostate disease. The goal was to see if the quick test is accurate enough for screening. If it wo…

This phase 2 study tested a new radioactive imaging agent called 64Cu-SAR-BBN in 53 men with prostate cancer that had returned after treatment but was not visible on standard PSMA PET scans. The goal was to see if this agent could safely and accurately detect where the cancer had…

This study tested whether a new, high-resolution ultrasound (micro-ultrasound) can find aggressive prostate cancers as well as MRI does during biopsy. Over 800 men with suspected prostate cancer were randomly assigned to one of three biopsy guidance methods. The goal was to see w…

This completed Phase 3 study tested a new radioactive tracer called [18F]CTT1057 for PET/CT scans in 190 men with prostate cancer whose PSA levels were rising after initial treatment. The goal was to see if the tracer could accurately locate where the cancer had returned. Partici…

This study tested a new imaging agent called [18F]CTT1057 for PET scans to see how well it can find prostate cancer tumors. 195 men with high-risk prostate cancer who were scheduled for surgery received the scan. The results were compared to tissue samples taken during surgery to…

This study tested a new imaging agent called 68Ga-NTA-476 for PET scans in 10 men with prostate cancer. The goal was to see how well it finds tumors compared to the standard scan, and to check for side effects. This was the first time this agent was used in humans, so safety and …

This phase 3 study tested a new radioactive imaging agent, rhPSMA-7.3 (18F), in 391 men with suspected prostate cancer recurrence after initial treatment. The agent is used during a PET scan to highlight cancer cells. The goal was to see how well it detects where the cancer has r…

This pilot study tested whether a special PET scan (18F-fluciclovine) can better track how advanced prostate cancer responds to treatment compared to standard CT and bone scans. Nine men with metastatic castration-resistant prostate cancer received the scan before and 12 weeks af…

This completed study collected urine and blood samples from 80 men, including those with prostate cancer, suspected cancer, or benign prostate enlargement, as well as healthy donors. The goal was to find RNA biomarkers that could lead to a simple liquid biopsy test for diagnosing…

This study tested a fluorescent dye called IS-002 that makes prostate cancer cells glow under special lights during robotic surgery. Fifty-nine men with prostate cancer received the dye before surgery, and surgeons used a special camera to see the glowing areas. The goal was to s…

This study tested whether two imaging methods—Histoscanning and multiparametric MRI—can accurately detect and locate prostate cancer that comes back after radiation therapy. Thirty men with rising PSA levels or biopsy-confirmed recurrence were enrolled. Each participant received …

This completed study tested an artificial intelligence model called BEAM that combines MRI scans with a blood test (cell-free DNA) to improve prostate cancer diagnosis. Over 1,600 men participated, including those with healthy prostates, benign enlargement, or prostate cancer. Th…

This study looked at whether an extract from banana flower stamens could help prevent benign prostatic hyperplasia (BPH), a non-cancerous enlargement of the prostate that can cause urinary problems. Fifty men aged 40 to 80 with mild to moderate symptoms took part. Researchers mea…

This study tested whether tadalafil, a drug often used for erectile dysfunction, can prevent nerve damage caused by docetaxel chemotherapy in men with metastatic prostate cancer. 90 participants were randomly assigned to receive either tadalafil plus standard care or standard car…

This study tests whether placing ice inside the rectum before a prostate biopsy can lower pain, anxiety, stress hormone levels, and complications like bleeding. About 84 men having their first prostate biopsy will either receive standard care or ice application. The goal is to se…

This pilot study tests a new way to treat urinary symptoms caused by an enlarged prostate. Using 3D ultrasound guidance, doctors insert a thin needle through the skin between the scrotum and anus to deliver microwave heat directly to the overgrown prostate tissue. The approach ai…

This study compared two surgical techniques for treating benign prostatic hyperplasia (BPH): bipolar enucleation and thulium laser enucleation. Sixty men with large prostates (80 grams or more) were randomly assigned to one of the two procedures. Researchers measured operation ti…

This study tested whether a very low dose of apalutamide, taken for 3-4 weeks before prostate removal surgery, could lower PSA levels in 34 men with early-stage prostate cancer. The goal was to see if the drug blocks testosterone's effect on cancer growth. If it works, it might o…

This study tested whether professional socio-aesthetics (specialized beauty and well-being care) can improve quality of life, reduce pain, and ease anxiety in adults undergoing chemotherapy for lung, breast, colon, or prostate cancer. 400 participants were randomly assigned to re…

This study tested whether a mobile app that teaches patients about prostate surgery can improve their experience. 68 patients were split into two groups: one used the app, the other received standard care. Researchers measured anxiety, fear, pain, and satisfaction before and afte…

This study compared two treatments for an enlarged prostate (BPH): a newer steam-based procedure called Rezum and a standard surgery called TUEP. Researchers measured how well each improved urinary symptoms, urine flow, and sexual function in 70 men over age 50. The goal was to s…

This small pilot study tested a 3-month program where men with prostate cancer on hormone therapy were encouraged to fast for 12 to 16 hours each night, supported by weekly coaching calls and text messages. The 40 participants found the program feasible and satisfying, with some …

This study looked at 110 men with an enlarged prostate to compare two minimally invasive treatments: laser surgery (HoLEP) and water vapor therapy (Rezum). The goal was to see which one better protects sexual function, especially ejaculation. Participants filled out questionnaire…

This study tested a special type of prostate surgery designed to preserve ejaculation in men with an enlarged prostate. The surgery removes extra prostate tissue while protecting the area around the ejaculatory duct. Researchers followed 108 sexually active men for 3 months to se…

This study tested whether using virtual reality hypnosis before chemotherapy infusions could lower anxiety in men with metastatic prostate cancer. Fifty-three patients were randomly assigned to either receive the VR hypnosis session or standard care before each docetaxel infusion…

This study tested a treatment called Rezūm, which uses water vapor (steam) to shrink an enlarged prostate. It included 129 men aged 45 to 96 who had trouble urinating. The goal was to see if the treatment is safe and works well when done under local anesthesia with sedation. Resu…

This study tested a program to help men prepare for and manage side effects from prostate cancer treatments like surgery or radiation. The program used daily texts and emails, plus support from other men, to encourage healthy habits before treatment. The goal was to reduce distre…

This study tested whether a supplement made from muscadine grapes could reduce fatigue and improve quality of life in 106 men with prostate cancer who were already receiving hormone therapy (androgen deprivation therapy). Participants took either the grape extract or a placebo fo…

This study tested whether a prehabilitation program—including exercise, nutrition advice, and education—before robotic prostate surgery helps men regain quality of life more quickly. One hundred men with localized prostate cancer participated. The goal was to see if preparing the…

This study looked at whether men with metastatic prostate cancer prefer cabazitaxel or docetaxel as their first chemotherapy. 195 patients tried both drugs in sequence and then stated their preference. The goal is to see if side effects like nerve damage or fatigue influence choi…

This study tested whether listening to music during radionuclide treatment helps prostate cancer patients feel less anxious and distressed. Sixty men were split into two groups: one listened to their choice of instrumental music through headphones during treatment, while the othe…

This small pilot study tested whether acupuncture could help reduce hot flashes and night sweats in men with prostate cancer who are on hormone therapy. Twelve men received acupuncture sessions, and researchers measured how well the treatment was accepted and whether symptoms imp…

This study tested whether a nerve block (injecting numbing medicine near the tailbone) can reduce pain and the need for opioid painkillers after transurethral prostate resection (TURP) surgery. Sixty men undergoing TURP were split into two groups: one received the nerve block plu…

This study tested a stepped-care telehealth program for cancer survivors living in rural areas who experience anxiety, depression, or sleep problems. Participants received either low-intensity check-ins or high-intensity phone therapy with a licensed therapist, depending on sympt…

This study looked at whether giving a lower dose of the steroid dexamethasone before the chemotherapy drug docetaxel can prevent allergic reactions with fewer side effects. The standard high dose can cause problems like high blood sugar, mood changes, and weakened immunity. Resea…

This study tested whether buffered lidocaine (lidocaine mixed with baking soda) reduces pain during prostate biopsy. 350 men undergoing a prostate biopsy received either buffered or standard lidocaine. Researchers measured pain from the numbing injection and from the biopsy itsel…

This study tested whether exercise, with or without internet-based cognitive behavior therapy, could reduce fatigue in 126 men with advanced prostate cancer. Participants were on hormone therapy and followed a 12-week exercise program. The goal was to see if these non-drug approa…

This study looked at 200 men with early-stage prostate cancer who had robotic surgery to remove the prostate. It compared two surgical methods—the standard approach and a newer 'HOOD' technique—to see which one helps men regain bladder control sooner after surgery. The goal is to…

This completed trial tested a web-based remote monitoring platform called CONTINUUM+ CONNECT in 411 adults with metastatic breast, lung, colorectal, or prostate cancer. Patients used the platform to report symptoms and receive alerts, aiming to improve their physical health and q…

This study followed 85 men with enlarged prostate who had a laser surgery called Thulium Fiber Laser Enucleation. The goal was to see how quickly a surgeon could learn the technique and how well it improved urinary symptoms and quality of life over a year. The results help doctor…

This study tested a web-based program called True North Peer Navigation for men recently treated for prostate cancer. 184 men were randomly assigned to get a trained peer navigator or usual care. The program aimed to help men take a more active role in their health and improve qu…

This study tested whether a TENS device, which uses mild electrical pulses, can reduce pain during a prostate biopsy. 84 men were randomly assigned to receive TENS plus local anesthetic, a sham TENS device plus local anesthetic, or local anesthetic alone. Participants reported th…

This study tested a special type of prostate surgery (TURP) designed to preserve the ability to ejaculate. 90 men with an enlarged prostate who had not responded to medication took part. The goal was to see if the surgery could improve urination while maintaining sexual function.

This study tested whether an online program combining nutrition counseling and resistance training could improve physical function in older adults (65+) who finished treatment for breast, colorectal, or prostate cancer. 75 participants received virtual sessions with dietitians an…

This study tested whether adding a drug called Longidaze to the standard treatment tamsulosin helps reduce urinary symptoms in men with an enlarged prostate. 229 men aged 40 and older took part. The combination was given as injections and rectal suppositories over several months,…

This study tested a special mask that uses lights and sounds to help patients relax during a prostate biopsy. The goal was to see if it reduces pain and anxiety compared to standard care. 88 men took part, and researchers measured their pain levels and satisfaction after the proc…

This study tested a drug called Tanzânia in 295 men who have both erectile dysfunction and an enlarged prostate (benign prostatic hyperplasia). The goal was to see if the drug improves erectile function better than a placebo. Participants took the drug or a dummy pill for a perio…

This small study tested a wrist-worn cooling device to see if it reduces the severity of hot flashes in women and men. Twenty-seven participants wore both an active cooling device and a placebo device (identical but without cooling) for two weeks each. They recorded their hot fla…

This study tested whether wearing a white noise sleep mask after prostate surgery (TUR-P) improves sleep quality and comfort. 70 adults who had elective surgery used the mask or standard care. The goal was to see if blocking hospital noise could help patients rest better and feel…

This study looked at 50 elderly men with an enlarged prostate who needed a urinary catheter. Doctors compared blocking blood flow to one side of the prostate versus both sides. The goal was to see if the simpler one-sided procedure could help patients stop using catheters just as…

This study tested a new device called Optilume BPH, which is a balloon coated with medicine that is inflated inside the prostate to open the urinary passage. The goal was to see if it safely improves moderate-to-severe urinary symptoms in men with an enlarged prostate. Eighty men…

This study tested a 3D imaging navigation system to help guide HoLEP surgery for benign prostate enlargement. 150 men were split into two groups: one with the navigation system and one without. The goal was to see if the system reduces complications like urine leakage and urethra…

This study tested whether listening to relaxing instrumental music during prostate surgery helps reduce anxiety and pain afterward. 135 men having a specific type of prostate surgery were randomly assigned to either listen to music or receive standard care. Researchers measured a…

This study tested a special laser to treat an enlarged prostate (BPH) in 20 men who needed surgery. The laser was used to vaporize extra prostate tissue, and the men were followed for 3 months to see how well it worked and if there were side effects. The goal was to find out if t…

This study looked at whether acupuncture can reduce pain and anxiety in men undergoing a prostate biopsy. 72 men were randomly assigned to receive either real acupuncture or a sham (fake) version before the procedure, in addition to standard numbing medicine. The main goal was to…

This study tested whether adding spinal anesthesia to standard general anesthesia helps men recover faster and feel less pain after robotic prostate cancer surgery. Thirty men took part in this double-blind, placebo-controlled trial. The main goal was to see how quickly they coul…

This completed Phase I safety trial tested whether using the UroLift system—a device that lifts and holds enlarged prostate tissue out of the way—before stereotactic ablative body radiotherapy (SABR) is safe for men with both prostate cancer and benign prostatic hyperplasia (BPH)…

This study tested a remote exercise program for 27 men with prostate cancer who were receiving hormone therapy (androgen deprivation therapy). The program included walking or cycling, strength training, and counseling sessions over 8 weeks. The main goal was to see if the program…

This pilot study tested whether vitamin B6 supplements can reduce hot flashes in 43 men with prostate cancer who were receiving hormone therapy (ADT). Hot flashes are a common side effect of this treatment. The study measured how bothersome hot flashes were before and after 8 and…

This study looked at whether a 12-week home exercise program using mobile technology could reduce fatigue in cancer survivors. 110 adults who had finished cancer treatment or were on immunotherapy took part. Some also tried acupressure or brief mindfulness exercises. The goal was…

This completed Phase 2 trial tested whether formal hypnosis, alongside standard care, could reduce anxiety and pain in 68 cancer patients undergoing brachytherapy. Patients received either standard care with Kalinox or standard care plus formal hypnosis. The study measured anxiet…

This study tested whether watching 360° virtual reality movies can reduce fear and anxiety in cancer patients about to start radiation therapy. 292 adults with breast, lung, prostate, head and neck cancer, or brain tumors participated. Patients watched a VR movie and then filled …

This pilot study tested a behavioral program called PROWESS for Black and Hispanic men with prostate cancer who are on hormone therapy (ADT). The program included video or in-person sessions with a psychologist or social worker and a FitBit to track activity. The goal was to see …

This study tested a new, less invasive laser treatment (TU-FLAP) against standard surgery (TURP) for men with an enlarged prostate causing bothersome symptoms. 56 men were randomly assigned to one of the two procedures and monitored for a year. The goal was to see if the new lase…

This completed Phase 3 trial tested whether pregabalin, a drug used for nerve pain, can reduce symptoms in men with chronic prostatitis/chronic pelvic pain syndrome. 324 participants received either pregabalin or a placebo for 6 weeks. The main goal was to see if pain scores impr…

This phase 2 trial tested whether testosterone replacement therapy could safely improve symptoms like low sex drive and fatigue in 136 men who had their prostate removed for low-risk prostate cancer. Participants received weekly testosterone injections or a placebo for 12 weeks. …

This early-phase trial tested a dye called Illuminare-1 that makes nerves glow during prostate cancer surgery. The goal was to find a safe dose that helps surgeons avoid damaging nerves, which can cause side effects like incontinence. The study involved 41 men undergoing standard…

This pilot trial tested a behavioral program called ActiveHeal EST in 30 adults recently diagnosed with breast or prostate cancer. The program includes group sessions and home activities to help survivors persist in daily tasks despite challenges. Researchers measured changes in …

This study tested a 10-week stress management group program for Spanish-speaking Hispanic men who had treatment for prostate cancer. The program taught relaxation, coping skills, and ways to handle stress. Researchers measured changes in quality of life, mood, and physical sympto…

This study tested two drugs used to reverse muscle relaxants after surgery: sugammadex and a combination of neostigmine and glycopyrrolate. The goal was to see which one better prevents urinary retention in 124 patients having ear, nose, or throat surgery who were at high risk du…

This completed phase 3 trial tested whether taking psyllium husk fiber capsules during pelvic radiation therapy could reduce gut inflammation and urgency symptoms. 354 adults with pelvic cancers (like rectal, prostate, or gynecological) took either fiber or placebo capsules daily…

This study looked at whether showing patients a dynamic video before a prostate biopsy could lower their pain and anxiety compared to just verbal instructions or static images. 223 men aged 50-80 with elevated PSA levels participated. Pain was measured with a Visual Analog Scale …

This study tested two types of nerve blocks—Quadratus Lumborum (QL) and Erector Spinae (ESP)—to see which provides better pain relief after abdominal surgery. 100 adults having surgery for colorectal, prostate, or kidney cancer, or gallbladder removal, received one of the blocks …

This completed study tested whether wearing an InBody Band 3 fitness tracker for 6 weeks could help Black prostate cancer survivors become more active and improve their quality of life. Thirteen participants wore the tracker and had regular check-in discussions. The main goals we…

This study looked at whether having a special consultation with a radiotherapy technician (called a manipulator) helps cancer patients feel more informed about their treatment. Researchers enrolled 308 adults with various cancers who were getting radiation therapy. They compared …

This study tested whether Pluvicto, a radioactive drug for prostate cancer, can be safely given through a permanently implanted port (TIVAP) instead of a standard IV. Researchers measured if any drug got stuck in the port in 107 patients. The goal was to see if using the port is …

This study looked at whether it is safe to skip antibiotics before a prostate biopsy. Researchers followed 1753 men who had a biopsy through the perineum (the area between the scrotum and anus). They compared infection rates in those who did not get antibiotics to existing data f…

This completed study looked at 80 patients with advanced prostate cancer that had stopped responding to chemotherapy. All patients received a radioactive drug called 177Lu-PSMA-617. Researchers compared two types of scans—PET and SPECT—to see which better tracks changes in tumor …

This early-phase trial tested a precise, high-dose radiation technique called stereotactic body radiotherapy (SBRT) in 42 patients with breast, lung, or prostate cancer that had spread to several places in the body. The main goal was to find the safest dose and check for side eff…

This study looks at how prostate cancer and its treatment affect quality of life three years after diagnosis. Researchers compared 900 men with prostate cancer to cancer-free men of the same age. The goal is to understand what life is like after treatment and whether patients ret…

This study looks at whether a special type of PET scan, using two different tracers, can help predict how aggressive a person's prostate cancer is before surgery. Researchers will use computer models to analyze the scan images and compare the results with standard biopsy and surg…

This study looked at how two prostate cancer drugs, darolutamide and enzalutamide, affect thinking and memory in men with advanced prostate cancer. About 111 men took one of the two drugs and completed computer-based cognitive tests over time. The goal was to see if one drug caus…

This study created a massive, secure database of over 14,000 prostate MRI scans from men with or suspected of having prostate cancer. Researchers used this data to train artificial intelligence (AI) models to better tell apart slow-growing from aggressive cancers, predict if canc…

This study looked at how an experimental drug called SHR3680 affects the way the body processes three other common drugs: digoxin, rosuvastatin, and metformin. Thirty-six men with prostate cancer took SHR3680 along with these drugs to see if there were any interactions. The goal …

This early-stage study tested the safety of a single dose of an Angelica herbal supplement (AGN-Cogni.Q) in 12 men aged 40 and older with prostate cancer. Researchers checked heart health and blood tests for any side effects, and measured how the supplement's compounds move throu…

This early-phase trial tested a fluorescent antibody that attaches to prostate cancer cells. Seven men with moderate- to high-risk prostate cancer received the antibody before robotic prostate removal surgery. The goal was to see if the glowing antibody could help surgeons identi…

This study looked at two ways of giving anesthesia during robotic prostate removal surgery. One method used a low flow of gas (1 liter per minute) and the other used a normal flow (3 liters per minute). The goal was to see which one is better for breathing, heart function, and co…

Researchers at Stanford University tested a new micro-ultrasound device to see if it can more accurately find and outline prostate cancer. The study involved 95 men scheduled for biopsy or prostate removal. The ultrasound images were compared with standard pathology results to he…

This study looked at genetic changes in prostate cancer samples from 84 men who had surgery. The goal was to find DNA markers that could predict if the cancer would come back or spread. By identifying these markers, doctors may one day better tailor follow-up care and treatment f…

This completed study looked at ways to increase diversity in cancer clinical trials, focusing on breast, liver, and prostate cancers. Researchers worked with communities, doctors, and scientists in New York City to find better ways to include people of color and underserved group…

This early-phase trial studied how compounds from black raspberries are absorbed and processed in 60 men with prostate cancer who were scheduled for surgery. Participants ate a black raspberry confection and followed a special diet before surgery. The goal was not to treat cancer…

This study looked at 30 men with prostate cancer to understand why MRI and PSMA-PET scans sometimes spot different tumors. Researchers used stored tissue samples to analyze the genes and molecules of these mismatched lesions. The goal was to find out if these differences mean the…

This study aimed to improve how doctors predict whether prostate cancer has spread to nearby lymph nodes. Researchers combined patient information, MRI scans, and genetic data from 367 men who had their prostate removed. The goal was to create a more accurate tool to help decide …

This study looked at 185 men with low-risk prostate cancer who chose active surveillance (monitoring instead of immediate treatment). Researchers used a genetic test called a polygenic risk score to see if it could predict which men would have their cancer get worse over time. Th…

This study tested whether implanting tiny gold markers near spinal tumors helps deliver radiation more accurately. Researchers also checked if giving slightly more radiation to the nearby esophagus is safe, which might improve tumor control. The study involved 41 adults with vari…

This study compared penile length in 200 adult men undergoing cystoscopy under spinal anesthesia versus general anesthesia. Researchers measured length and asked surgeons to rate satisfaction with access. The goal was to see if anesthesia choice affects penile size during the pro…

This study looked at a new device called AE05ML that helps surgeons place clips on blood vessels and other tissues during keyhole surgery. The goal was to see if the device is safe and works well. A total of 161 adults took part in the study.

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study tested whether an AI tool can help health providers write medical summaries that are easier for patients to understand. 120 providers were split into two groups: one used the AI tool, the other did not. The goal was to see if AI could improve readability and save time,…

This pilot study tested whether a special 2D antiscatter grid can improve the quality of cone-beam CT (CBCT) images used during radiation therapy for prostate, head and neck, and upper abdomen cancers. 43 participants received one extra CBCT scan with the grid, and researchers co…

This study looked at 120 men who had HoLEP surgery for an enlarged prostate. Researchers wanted to see if bowel problems before surgery made recovery harder. Patients filled out questionnaires about bowel and urinary symptoms before and after surgery. The goal was to learn how bo…

This completed study from the University of Aberdeen looked at how dietary fiber supplements might influence prostate cancer. Researchers gave mice different fibers (inulin, pectin, hemp hull) along with stool samples from healthy men over 60. They then measured changes in gut ba…

This study looked at how prostate and colorectal cancer affect mitochondria—the energy factories in cells—and whether a 4-week home exercise program could improve them. Fifteen men awaiting surgery did either resistance or high-intensity interval training at home. Researchers mea…

This study tested whether taking dasatinib alone or with darolutamide for 14 days can increase PSMA levels on PET scans in men with metastatic prostate cancer. Only 4 men participated, all with low PSMA uptake on their initial scan. The goal was to learn more about how PSMA expre…

This study tested an online decision aid called 'Talk to Nathan About Prostate Cancer Screening' in 88 men aged 55-69. The goal was to see if it improved knowledge and helped men make clearer decisions about screening compared to standard materials. Participants used the tool or …

This study tested a tool built into electronic health records that prompts doctors to discuss heart health with cancer survivors during routine visits. Researchers enrolled 645 survivors of breast, prostate, colorectal, endometrial, and lymphoma cancers across 12 clinics. The goa…

This study analyzed blood, urine, and tissue samples from 273 adults with brain or lung cancer who were receiving radiation therapy. The goal was to find biological markers that could predict which patients are more likely to develop serious side effects from radiation, such as l…

This study looked at 30 men taking alpha-blocker drugs for urinary symptoms who were scheduled for cataract surgery. Researchers used a special eye scan to measure the thickness of iris muscles and pupil size. The goal was to see if these measurements could predict intraoperative…

This study looked at whether cancer survivors living in rural areas can create their own survivorship care plans and learn from telehealth education. 261 survivors of breast, colorectal, lung, lymphoma, or prostate cancer took part. The goal was to see if this approach improves t…

This study looked at how often a specific gene change (called HOXB13 c.853delT) occurs in men with prostate cancer in Martinique. Researchers tested 465 men of African descent who had prostate cancer. The goal was to find out how common this gene change is, which may help underst…

This study looked at how closely 200 adults with advanced breast or prostate cancer follow their prescribed oral cancer treatments. Participants filled out questionnaires about their medication use and gave blood samples to check certain health markers. The goal was to understand…

This study looked at whether an educational session about orchiectomy (surgery to remove the testicles) would make more men with prostate cancer choose it over lifelong hormone therapy. 101 men who were already on hormone therapy for at least a year took part. The goal was to see…

This completed study surveyed 51 men with localized prostate cancer and their healthcare providers in Belgium, Italy, and Spain. The goal was to understand how acceptable artificial intelligence (AI) is as a tool to help diagnose prostate cancer, and whether people are willing to…

This study looked at nearly 1,000 cancer survivors to find out which follow-up care model works best for their quality of life and satisfaction. Participants were breast, prostate, or colorectal cancer survivors who had finished active treatment. Researchers compared different ca…

This study tested whether a neighborhood-based educational program could increase knowledge about prostate cancer and screening among 239 men living in high-risk areas. Participants learned about the pros and cons of screening, and researchers measured changes in decision-making …

This study looked at 50 men having robot-assisted prostate surgery to compare two ways of using a breathing machine: flow-controlled and volume-controlled ventilation. The goal was to see which method keeps oxygen levels better and helps the lungs work more smoothly. Researchers …

This study looked at 168 men with metastatic hormone-sensitive prostate cancer to see if a model using PSMA-PET scans and routine medical information could predict how well they would respond to standard first-line treatment. The goal was to help doctors better understand which p…

This study looked at over 1,200 men with advanced prostate cancer who received a radioactive drug called Lutetium-177 vipivotide tetraxetan in real-world clinics. Researchers tracked patient characteristics, treatment patterns, and PSA level reductions. The goal was to see how th…

This study looked at 132 men aged 55-80 who had surgery for an enlarged prostate. Researchers compared two common procedures—HoLEP and TURP—to see if one affects memory and thinking more than the other. Participants took thinking tests before surgery and three months after. The g…

This study looked at whether a special website or coaching phone calls could help more people with a personal or family history of certain cancers get genetic testing. Over 800 participants were randomly assigned to one of these two methods or to standard care. The goal was to se…

This study tested whether breathing in humidified wood or fragrant oils could mimic the immune-boosting effects of a forest walk. 28 adults who finished chemotherapy or radiation for early-stage breast or prostate cancer took part. The goal was to see if this approach is practica…

This study examined medical records of over 6,400 prostate cancer patients who received a treatment called 177Lu-PSMA-617. Researchers wanted to understand the patients' characteristics, treatment patterns, and survival outcomes. The study did not test a new treatment but instead…

This study looked at men whose prostate cancer came back after surgery, shown by a small rise in PSA. It compared giving radiation right away versus waiting and doing another special scan when PSA rose higher. Only 4 men took part, so the main goal was to see if such a study is e…

This study translated and tested a Turkish version of the UCLA Prostate Cancer Index, a survey that measures how prostate cancer and its treatment affect daily life. Researchers worked with 115 Turkish-speaking men diagnosed with prostate cancer to check if the new version is rel…

This study looked at oxygen levels inside prostate tumors in 186 men with early-stage prostate cancer. Researchers wanted to see if low oxygen (hypoxia) makes standard treatments like radiation less effective and increases the risk of cancer spreading. Participants had a special …

This study tested a special PET scan tracer called 18F-FAZA to find low oxygen areas (hypoxia) in prostate tumors. Hypoxia can make cancer harder to treat with radiation or chemo. The study involved 18 men with intermediate to high-risk or metastatic prostate cancer. The goal was…

This pilot study tested a web-based tool called MAP (Management of Active surveillance in Prostate Cancer) in 39 men aged 55+ with low-risk prostate cancer who were already on active surveillance. The tool provides education, helps coordinate care with primary care doctors, and o…

This study tested a digital chatbot (called CATALYST) to help cancer survivors learn about genetic testing for inherited cancer risk. Fifty adults who had certain cancers (like breast, ovarian, or prostate) used the chatbot or received usual care. The goal was to see if the chatb…

This study looked at 10 men to understand why androgen deprivation therapy (ADT) for prostate cancer can lead to high blood pressure. Researchers checked if problems with the nervous system or kidneys were to blame. The goal is to find ways to prevent heart disease in prostate ca…

This study looked at medical records from over 2,700 men with advanced prostate cancer that no longer responds to hormone therapy. Researchers compared two common treatments, enzalutamide and abiraterone, to see which one helped men live longer. The goal was to understand how the…

This study followed 25 men who carry BRCA1 or BRCA2 gene mutations (and a control group of non-carriers) to see if they developed prostate cancer. Researchers called participants to update their medical history and check for new diagnoses. The goal is to learn how to better scree…

This study tested a new education program for men with metastatic prostate cancer who are taking next-generation hormone therapy. The program aimed to help patients better understand their disease, stick to their medication, and improve their quality of life. 18 patients took par…

This study analyzed blood samples from 33 men with advanced prostate cancer that no longer responds to hormone therapy. Researchers looked for tiny molecules called microRNAs that might predict whether a patient will resist chemotherapy or newer hormone drugs. The goal is to help…

This completed study at Yale University enrolled 600 men with prostate cancer to test a new biopsy method that combines MRI and ultrasound images. The goal was to collect extra tissue samples for detailed single-cell analysis, looking at proteins and other markers to better predi…

This study looked at whether a blood test measuring how certain immune cells die after radiation can predict long-term side effects in breast and prostate cancer patients. Researchers enrolled 885 participants and tracked late complications. The goal is to personalize treatment t…

This completed study involved 100 men aged 40 and older, with no personal history of prostate cancer, to understand their beliefs about genetic risk for the disease. Participants filled out a questionnaire and were asked to provide a saliva sample for genetic testing. The goal wa…

This completed study tracked 1000 men with localized prostate cancer who had their prostate removed. Researchers measured a heart protein called troponin before and after surgery to see if the operation caused hidden heart injury. The goal was to learn how often heart problems ha…

This study measured how often muscle loss (sarcopenia) happens in men aged 70 and older with prostate cancer who are treated with radiation and hormone therapy. Researchers screened 112 patients using a simple questionnaire and body scans. The goal was to understand risk factors …

This completed study collected blood and tumor tissue from 64 patients with advanced cancers (like melanoma, breast, lung, and kidney cancer) to study genetic changes and treatment resistance. The samples are stored for future research, including genomic analysis. No new treatmen…

This study tested whether a peer-led health education program could help African American men better understand genetic testing for prostate cancer. 149 men with or without a personal or family history of prostate cancer took part. The program aimed to reduce confusion and improv…

This completed study looked at over 1,000 men with metastatic prostate cancer in the Pirkanmaa region of Finland. Researchers analyzed patient characteristics, treatments used, and outcomes to better understand the disease burden. The goal was to fill gaps in knowledge about how …

This study followed 831 men aged 60 and older with prostate cancer who were starting GnRH agonist therapy (a type of hormone therapy). Researchers measured how their quality of life changed over 6 months, comparing different age groups. The goal was to understand how age affects …

This study tested new guidelines for PSA screening to help doctors decide when to start and stop screening, how often to repeat it, and when to refer for biopsy. Researchers also provided patient navigation for men with elevated PSA levels. The goal was to see if these steps coul…

This early-stage study tested a new drug called CKD-846 in 31 healthy men to see how the body processes it and if it is safe. The goal was to gather information, not to treat the condition. Participants were healthy men aged 19 to 55 who agreed to use contraception.

This study tested a program called KanSurvive, which uses virtual education sessions and practice support to help rural primary care clinics improve follow-up care for cancer survivors. Researchers worked with 15 rural practices to see if they could better follow guidelines for m…

This pilot study tested whether a brief educational session with a trained educator could increase the number of men with prostate cancer who agree to germline (inherited) genetic testing. The study enrolled 50 men who met national guidelines for testing but had not yet been test…

This study looked at gene activity in prostate tissue from 867 men to learn how genes relate to prostate cancer development and growth. Researchers collected tissue samples from men having prostate biopsies or surgery. The goal was to link genetic patterns with patient outcomes, …

This study gathered information and samples from 382 men with low-grade prostate cancer to create a tool that can better predict if the cancer is actually more aggressive than it appears. The goal is to help doctors and patients make more informed decisions about treatment. Parti…

This study tested whether combining PET-CT and MRI scans (called trimodality imaging) can better define the target area for radiotherapy in high-risk prostate cancer. Twenty patients received both standard scans and the new combined scan before treatment. Researchers compared the…

This completed study examined how long men with metastatic castration-sensitive prostate cancer take newer hormonal therapies like abiraterone, apalutamide, and enzalutamide. Researchers analyzed Medicare claims data from over 3,000 men aged 65 and older. The goal was to describe…

This study looked at 130 men aged 50+ with enlarged prostate (BPH) causing urinary symptoms. Researchers used an ultrasound to measure how far the prostate bulges into the bladder, then tracked symptom changes over 6 months of standard medication. The goal was to see if this simp…

This study tested whether a multimedia educational program helps African American men and their doctors make better decisions about PSA screening for prostate cancer. 161 African American men aged 40-69 took part. Half received the program, half got usual care. The goal was to se…

This study surveyed 109 men with prostate cancer and women with breast cancer who were starting radiation therapy. Researchers asked about their use of complementary and alternative medicines (CAM), such as nutritional supplements, at three different times to see if their habits …

This study looked at 12 men with benign enlarged prostate who had Greenlight laser surgery. Researchers used MRI and special ultrasound scans to measure the area of dead tissue created by the laser and tracked urinary symptoms for a year. The goal was to better understand how the…

This study looked at whether a special 3D camera can accurately measure radiation from a prostate cancer drug called lutetium. Researchers used data from 20 patients who had already received the treatment. The goal was to see if images taken at different energy levels give the sa…

This study tested a special barbed suture (Symmcora Longterm) used to reconnect the bladder after robotic prostate removal for prostate cancer. Researchers measured how long the stitching took and checked for leaks or other problems up to 6 months after surgery. The goal was to s…

This study tested whether using 3D reconstructed images of the pelvis can help doctors perform more precise prostate biopsies. A total of 436 men with suspicious prostate lesions took part. Researchers compared standard biopsy methods with a 3D imaging-assisted approach to see if…

This study compared two common methods for taking a prostate biopsy: one through the rectal wall and one through the skin between the scrotum and anus. 840 men who needed a biopsy for suspected prostate cancer were randomly assigned to one of the two methods. The goal was to see …

This completed study collected MRI and 3D ultrasound images from 2 men with prostate cancer who had their prostate removed. The goal was to create a database that could later be used to train a computer system to detect cancer without needing a biopsy. This is a very early step i…

This study looked at a newer way to take prostate tissue samples using MRI guidance through the perineum (the area between the scrotum and anus) instead of the standard method through the rectum. The goal was to see if this approach causes fewer complications and hospital readmis…

This study looked at whether a simple smiley-face tool (HappyOrNot) or a visual scale (VAS) can effectively measure urinary symptoms in men with an enlarged prostate. One hundred men from two hospitals filled out these quick tests, and the results were compared to standard sympto…

This completed registry study followed nearly 1,000 Japanese men with high-risk metastatic hormone-naïve prostate cancer to see how well standard treatments work in everyday medical practice. Researchers tracked PSA levels, cancer progression, survival, and quality of life. No ne…

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This study asked 167 people with cancer (and their caregivers) what they value most during pharmacy consultations for oral cancer drugs. Using a survey method, researchers identified key preferences to help hospitals design better support services. The goal was to improve patient…

This study looked at the total cost of two types of prostate cancer surgery over 5 years: robot-assisted surgery using the da Vinci system and traditional open surgery. Researchers tracked medical expenses and patient outcomes in 90 men with localized prostate cancer. The goal wa…

This study analyzed medical records of 507 U.S. veterans with prostate cancer who started taking the drug relugolix between 2020 and 2023. Researchers wanted to understand the patients' backgrounds, previous treatments, and health conditions. The study did not test a new treatmen…

This study tested whether a special gel spacer placed near the rectum can help doctors aim radiation more accurately for prostate cancer. Seventeen men who already had the spacer and small metal markers (fiducials) were included. Doctors compared how well the gel spacer worked fo…

This study reviewed medical records from over 1,300 men with metastatic prostate cancer that still responds to hormone therapy. Researchers wanted to see how long patients actually take the pills apalutamide or enzalutamide when prescribed by their own doctors in routine care. Th…

This study tested whether using at-home monitoring devices (like a wristband pedometer, scale, and blood pressure cuff) can help improve care for cancer patients after they leave the hospital following surgery. 22 patients with various cancers participated. The goal was to see if…

This study tested a program for adults aged 65-90 who had breast, colorectal, or prostate cancer. A community health worker assessed their health and provided coaching to address issues often missed after cancer treatment. The goal was to see if the program was feasible and could…

This study tested a mobile-friendly web tool that educates men with prostate cancer about genetic testing. Researchers compared traditional genetic counseling with the online tool to see if it helps patients decide whether to get tested. The study involved 346 men with advanced o…

This completed study created a biobank of saliva, tumor tissue, and questionnaire data from 592 African American men with prostate cancer in Florida. Researchers want to see if smoking is linked to more aggressive prostate cancer. Participants filled out surveys and provided samp…

This study looked at how DNA from tumors changes in the blood before, during, and after surgery for breast, prostate, or colon cancer. Thirty adults having curative surgery provided blood samples to measure these DNA levels. The goal was to understand the natural pattern of DNA c…

This early trial tested a less invasive treatment for prostate cancer called microwave ablation, which uses heat to kill tumor cells. One man with prostate cancer received the ablation before his scheduled prostate removal surgery. The goal was to see if the procedure is safe and…

This study watched 50 men having prostate surgery to see if the special positions used in robotic surgery increase pressure on the breathing tube and cause more sore throats or hoarseness. Half had robotic surgery, half had open surgery. The goal was to learn how to prevent throa…

This study looked at whether a blood test could predict how prostate cancer responds to the drug abiraterone. Instead of taking a tissue sample (biopsy), researchers measured tumor cells circulating in the blood of 40 men with advanced prostate cancer. The goal was to see if chan…

This study tested whether an automated system can grow cancer cells from patient samples (blood, fluid, or tumor tissue) inside chicken eggs. Researchers aimed to see if at least half of the samples would successfully grow. The goal is to create a better, cheaper way to study can…

This study tested a new classification system called BICEP to better identify and categorize bladder injuries that can happen during prostate surgery. Researchers studied 250 patients undergoing common prostate procedures to see how often injuries occur and how severe they are. T…

This pilot study tested a patient navigator program for African-American adults with breast or prostate cancer. The goal was to see if having a navigator helps patients understand their treatment options and complete radiation therapy as planned. The study enrolled 30 people and …

This study looked at whether giving prostate cancer survivors more detailed survivorship care plans helps them get better follow-up care for heart health. The study involved 550 men who had radiation and hormone therapy, which can increase risks for diabetes and heart problems. R…

This early-phase study looked at whether giving a single, short course of the drug flutamide can create DNA breaks in prostate cancer cells. The 25 participants were already receiving standard hormone therapy and brachytherapy (internal radiation). The goal was to see if this app…

This study followed over 1,400 men with metastatic castration-resistant prostate cancer who were already receiving Radium-223 as part of their routine care. Researchers tracked serious side effects and the development of new cancers over several years. The goal was to better unde…

This study observed over 1,000 Chinese patients with ovarian or prostate cancer who were already taking or starting the drug olaparib. Researchers tracked side effects and how doctors managed them in everyday practice. The goal was to better understand the drug's safety in this s…

This study looked at over 257,000 Swedish men aged 75-79 to see if PSA blood tests for prostate cancer reduce deaths. Since no clinical trials have tested this age group, researchers used existing health records to compare screened and unscreened men. The goal is to find out if s…

This study followed 30 men aged 45-70 who had their prostate removed due to cancer. Researchers measured urine leakage by weighing pads over 24 hours and during a 1-hour activity test. The goal was to better understand how long and how severe incontinence lasts after surgery.

This completed study looked at whether special PET scans can predict how aggressive a person's prostate cancer is. Researchers compared scan features with tumor samples from 70 patients who had surgery. The goal was to see if imaging could replace or reduce the need for invasive …

This study looked at how the drug radium-223 spreads in the bones of men with prostate cancer that has spread to bones. Researchers gave the drug intravenously every 4 weeks for up to 6 doses and used imaging scans to measure its distribution in both tumor and healthy bone. The g…

This completed study looked at 261 French cancer patients to understand why many do not exercise, despite evidence that physical activity improves survival and well-being. Researchers surveyed patients about their personality, motivation, anxiety, and social background. The goal …

This study created a registry of 149 cancer patients who received a precise type of radiation called SBRT. The goal was to track how doctors use this treatment in four different situations: for cancer that has spread to a few spots, after chemotherapy, before starting chemotherap…

This completed Phase 1 study tested how the antibiotic rifampicin changes the way the body processes HRS-5041, an experimental drug for prostate cancer. Sixteen healthy men took HRS-5041 with and without rifampicin to measure drug levels and safety. The goal was to understand pot…

This completed registry study collected real-world data on 99 patients receiving HydroPearl microspheres to block blood flow to conditions like uterine fibroids, arteriovenous malformations, hypervascular tumors, and benign prostatic hyperplasia. The procedure was done through th…

This study gave 20 men with enlarged prostates a single dose of the antibiotic ertapenem before their scheduled prostate surgery. Researchers then measured how much of the drug actually reached the prostate tissue. The goal was to see if a pre-surgery dose could provide enough an…

This study looked at whether androgen deprivation therapy (ADT), a common hormone treatment for prostate cancer, affects how well the heart pumps. Researchers compared heart function in 18 men: some who had ADT, some who didn't, and some without cancer. They used ultrasound and e…

This small study looked at whether special MRI scans can help doctors adjust radiation treatment for high-risk prostate cancer. Only 5 men took part, all with aggressive cancer. The goal was to see if the MRI method was reliable enough to guide changes in radiation doses. Because…