New combo therapy may reduce need for long-term hormone drugs in prostate cancer

NCT ID NCT05162573

First seen Jan 11, 2026 · Last updated May 15, 2026 · Updated 18 times

Summary

This early-phase study tested a new approach for men with prostate cancer that has spread to nearby lymph nodes. The standard treatment includes radiation plus 2-3 years of hormone therapy, which can cause lasting side effects. Researchers added a targeted radioactive drug (Lu-PSMA) to the radiation, hoping to better control the cancer and possibly shorten or avoid hormone therapy. The study involved 14 participants and focused on finding the safest dose of the added drug.

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Contacts and locations

Locations

  • Netherlands Cancer Institute

    Amsterdam, 1066 CX, Netherlands

  • UMC Utrecht

    Utrecht, 3508 GA, Netherlands

Conditions

Explore the condition pages connected to this study.