Diet and exercise may tame hormone Therapy's metabolic side effects in prostate cancer

NCT ID NCT04870515

Completed Disease control Sponsor: Fred Hutchinson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested whether a diet and exercise program could prevent or reduce metabolic side effects like insulin resistance and weight gain in 20 men with prostate cancer receiving hormone therapy and radiation. Participants followed dietary instructions and did aerobic and strength exercises. The study measured changes in insulin resistance, body weight, waist size, and body composition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dietary and exercise intervention
What this could lead to: If successful, this approach could help manage weight and insulin resistance caused by hormone therapy, improving quality of life for prostate cancer patients.
What could go wrong: This is a very small pilot study with only 20 participants, so results may not apply to everyone. The intervention requires significant lifestyle changes, which may be hard to maintain.

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Conditions

The condition(s) this trial relates to.

prostate adenocarcinoma prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALIZED PROSTATE CARCINOMA PROSTATE ADENOCARCINOMA

Contacts and locations

Locations

Fred Hutch/University of Washington Cancer Consortium

Seattle, Washington, 98109, United States

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