Neoplasm

This phase II trial is testing whether adding the immunotherapy drug tislelizumab to a chemotherapy regimen (pegaspargase, gemcitabine, and oxaliplatin) plus radiation can improve outcomes for people with early-stage, intermediate- or high-risk extranodal NK/T-cell lymphoma. The …

This phase 2 trial tests whether giving patients their own tumor-specific immune cells, along with a dendritic cell vaccine, can help fight recurrent medulloblastoma or primitive neuroectodermal tumors. Participants receive these treatments after high-dose chemotherapy and a stem…

This trial is testing a new type of immune cell therapy called CD123 CAR-NK cells in people with relapsed or refractory acute myeloid leukemia (AML) or blastic plasmacytoid dendritic cell neoplasm (BPDCN). The cells are designed to find and attack cancer cells that carry a protei…

This trial is for adults with relapsed or refractory acute myeloid leukemia (AML) who have no standard curative options. Researchers are testing whether giving the drug gemtuzumab ozogamicin followed by an infusion of donor white blood cells can stimulate the immune system to att…

This phase 2 trial tests a two-step approach to stem cell transplantation for people with blood cancers. The method separates the infusion of donor lymphocytes from stem cells, aiming to better control the dose and reduce the risk of graft-versus-host disease, a serious complicat…

This phase 1 trial is testing an experimental therapeutic cancer vaccine called AST-021p in people with advanced solid tumors that no longer respond to standard treatments. The goal is to see if the vaccine is safe and can trigger an immune response against the cancer. Participan…

This phase 2 trial tests whether a vaccine made from immune cell-derived exosomes can slow cancer growth in people with advanced non-small cell lung cancer who have responded to initial chemotherapy. Participants receive low-dose cyclophosphamide followed by weekly injections of …

This trial investigates how well routine childhood vaccines work in children who have recently finished chemotherapy for cancer. The goal is to see if revaccination can restore protective immunity against diseases like measles, mumps, and whooping cough. Participants receive a se…

This phase 2 trial is testing whether adding venetoclax, a pill taken daily for 12 months, can reduce the number of leukemia stem cells that remain in the bone marrow of people with chronic myeloid leukemia (CML) who are already in deep molecular remission on standard TKI therapy…

This study tests whether adding intermittent or water-only fasting to standard chemotherapy can improve outcomes for breast cancer patients. Sixty women will be split into four groups: chemo alone, chemo plus intermittent fasting, chemo plus intermittent fasting with a ketogenic …

This trial investigates an experimental oral drug, LY3143921 hydrate, which blocks a protein called Cdc7 that cancer cells need to divide. It is being tested in adults with advanced solid tumours, including colorectal, ovarian, lung, and pancreatic cancers, that have not responde…

This early-stage trial is testing an experimental drug called BEBT-209 in women with advanced HR+/HER2- breast cancer. The study aims to find the safest dose and see how well the drug works, both on its own and when combined with standard hormone therapies like letrozole or fulve…

This study looks at the long-term safety of imatinib, a daily pill for certain cancers like GIST and CML. It includes 250 patients who were already benefiting from imatinib in a previous Novartis trial and continue taking it. The main goal is to track side effects over time, with…

This phase 2 study tested a personalized cell therapy called KTE-X19 (brexucabtagene autoleucel) in 95 adults with mantle cell lymphoma that had returned or stopped responding to prior treatments. Participants received a single infusion of their own genetically modified immune ce…

This phase II trial is testing whether adding an experimental drug called BEBT-209 to standard chemotherapy (carboplatin and gemcitabine) can help people with advanced triple-negative breast cancer. The study will enroll about 65 women whose cancer has returned or spread and is n…

This study tests an HPV vaccine (PRGN-2009) alone or with a drug called M7824 in people with HPV-positive cancers like cervical, anal, and throat cancers. The goal is to find a safe dose and see if the combination boosts the immune system's attack on tumors. The trial includes 39…

This trial is testing whether combining a procedure that blocks blood flow to tumors (TACE) with two drugs—sintilimab, which boosts the immune system, and bevacizumab, which cuts off tumor blood supply—can safely and effectively treat liver cancer that cannot be surgically remove…

This trial is investigating whether adding an experimental antibody called CS1001 to standard chemotherapy can help people with stage IV non-small cell lung cancer. The study compares the combination against chemotherapy alone in patients who have not yet received treatment for a…

This trial compares two oral medications for adults with chronic myeloid leukemia (CML) in its chronic phase who have already been treated with at least two other targeted therapies. Participants receive either the experimental drug asciminib or the existing drug bosutinib. The g…

This phase II trial tests whether combining the immunotherapy drug nivolumab with the chemotherapy drug temozolomide can shrink tumors in people with small-cell lung cancer that has returned or not responded to treatment, or advanced neuroendocrine tumors. About 55 participants w…

This phase II trial is testing an experimental drug called BEBT-908 in adults with diffuse large B-cell lymphoma that has come back or not responded to at least two prior treatments. The study aims to see how well BEBT-908 shrinks tumors and controls the disease, as well as how s…

This study tested a combination of three immunotherapy drugs (INCMGA00012, INCAGN02385, and INCAGN02390) in 61 people with advanced melanoma or other solid tumors that had stopped responding to standard treatments. The goal was to find the safest dose and see if the drugs could s…

This early-phase trial tested the drug everolimus (RAD001) alongside radiation therapy in 26 people with advanced non-small cell lung cancer that could not be surgically removed. The goal was to find a safe dose and check for side effects. Participants received everolimus weekly …

This trial asks men with advanced prostate cancer which of two oral medications they prefer: the experimental drug ODM-201 or the approved drug enzalutamide. Both work by blocking male hormones that fuel cancer growth. Participants will take each drug for a period and then answer…

This trial is testing whether adding anakinra, a drug used for arthritis, to standard chemoradiotherapy is safe for people with rectal cancer. The study will include about 12 patients and will use a dose-escalation design to find the highest tolerable dose of capecitabine when co…

This trial is testing whether choosing chemotherapy based on the genetic profile of a patient's breast tumor can improve treatment response compared to standard chemotherapy. Women with HER2-negative breast cancer that is not eligible for conservative surgery will be randomly ass…

This trial tests whether radiofrequency ablation—a procedure that uses heat to destroy cancer cells—can effectively treat lung tumors that cannot be removed with surgery. The study includes people with primary lung cancer or lung metastases, with up to five tumors each no larger …

This study tested a combination of two drugs, ramucirumab and pembrolizumab, in 43 people with head and neck cancer that had spread or come back. The goal was to first find a safe dose and then see if the combination could shrink tumors. The approach aims to block blood vessel gr…

This trial is testing whether giving the immunotherapy drug atezolizumab before surgery can help people with early-stage non-small cell lung cancer. The study includes adults with stage IB to IIIA (non-N2) disease who are eligible for surgery. Participants receive one dose of ate…

This pilot trial is investigating whether giving two immunotherapy drugs, nivolumab and ipilimumab, along with radiation therapy before surgery can safely help treat soft tissue sarcoma. The study enrolls adults with resectable, intermediate-to-high grade sarcomas larger than 5 c…

This phase 2 trial is testing whether combining two chemotherapy drugs, gemcitabine and oxaliplatin, can shrink tumors in children and adolescents with certain solid cancers that have come back or not responded to standard treatment. The study includes patients with medulloblasto…

This trial is testing several different targeted drug combinations in people with mesothelioma that has returned after initial treatment. The goal is to see which therapies can control the disease and potentially improve survival. Participants are assigned to a treatment based on…

This early-phase trial tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, a drug that blocks blood vessel growth in tumors, in 18 adults with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the …

This early-phase study tests whether Mozobil, a drug already used to boost stem cells for transplants, can safely raise white blood cell counts in people with WHIMS. WHIMS is a rare genetic condition that traps infection-fighting cells in the bone marrow, leading to frequent infe…

This trial tests whether using 3D on-board imaging before each radiation session improves accuracy and outcomes for men with prostate cancer compared to standard imaging. The study tracks disease-free survival, side effects, and costs over 2 to 5 years. It aims to find the best i…

This trial is testing two different ways of delivering a second course of radiation to people whose head or neck cancer has come back after prior radiation. One approach uses a single daily dose of radiation combined with two chemotherapy drugs given every other week over 11 week…

This trial compares two surgical techniques for removing a pterygium, a fleshy growth on the eye's surface that can distort vision. Researchers are testing whether using a piece of the patient's own conjunctiva (the clear tissue covering the eye) or a preserved amniotic membrane …

This early-phase trial tested whether adding nilotinib (a pill) to paclitaxel (a chemotherapy) is safe and tolerable for people with advanced solid tumors that no longer respond to standard treatments. The study included 47 adults and children aged 12 and older. Researchers aimed…

This early-phase trial tested whether giving patients their own natural killer (NK) cells, boosted by the drug bortezomib, is safe for treating advanced cancers like leukemia, lung, and pancreatic cancer. Thirty-five adults whose cancers had not responded to standard treatments r…

This phase III trial is testing whether taking oral azacitidine as a maintenance therapy after an allogeneic stem cell transplant can help prevent relapse in people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Participants are randomly assigned to receive…

This trial is testing whether a radioactive tracer, technetium Tc 99m sulfur colloid, can accurately locate sentinel lymph nodes in women with early-stage breast cancer. The sentinel node is the first lymph node cancer is likely to spread to, and finding it helps guide surgery. T…

This trial tests whether Masgutova Neurosensorimotor Reflex Integration (MNRI) therapy can improve fine motor skills in children aged 2-6 with developmental delays. Participants receive either MNRI sessions or standard care for four weeks. The study measures changes in hand funct…

This phase 2 study tested a combination of three drugs in 46 people with a specific type of lung cancer (EGFR-mutated) that had spread to the lining of the brain and spinal cord (meningeal metastasis). The treatment included a high-dose targeted pill (furmonertinib), an intraveno…

This study tested a new way of giving radiation therapy combined with immunotherapy for people with advanced non-small cell lung cancer that does not have certain genetic mutations. The goal was to see if mixing high-dose and low-dose radiation could help the immune system fight …

This phase II trial is testing whether argon plasma coagulation (APC) can safely and effectively treat high-grade anal lesions (AIN 2/3) in HIV-positive men who have sex with men. APC uses ionized argon gas to deliver a controlled electrical current that destroys abnormal cells. …

This phase II trial is testing whether the immunotherapy drug tislelizumab can help control locally advanced non-small cell lung cancer when given after radiation therapy or sequential chemoradiation. The study enrolls people with stage III lung cancer who cannot tolerate the sta…

This phase 3 trial is testing an investigational drug called DKF-MA102 (leuprorelin acetate) in men with advanced prostate cancer. The goal is to see if two injections, given 12 weeks apart, can safely lower testosterone levels to a target range, which may help control the cancer…

This phase II trial tested the drug Minnelide in 16 adults with a rare and aggressive form of pancreatic cancer called adenosquamous carcinoma of the pancreas (ASCP) that had not responded to prior treatments. Participants took Minnelide by mouth daily for 21 days of each 28-day …

This early-phase study tests a new oral drug, furmonertinib, in 30 people with advanced non-small cell lung cancer that has a specific EGFR exon 20 insertion mutation. Some participants have already tried other treatments, while others are newly diagnosed. The goal is to see if t…

This trial is testing whether adding targeted radiation (SBRT) to two immunotherapy drugs, durvalumab and tremelimumab, can better control metastatic head and neck cancer. The study includes adults with this cancer that has spread, and the radiation is given between cycles of the…

This early-phase trial is testing whether adding the immunotherapy drug pembrolizumab to standard chemoradiotherapy can help control gastroesophageal cancer that cannot be removed by surgery. The study includes 16 participants and primarily looks at safety and whether the cancer …

This early-phase trial tested an experimental drug called BMS-986408, alone or combined with the immunotherapy drugs nivolumab (Opdivo) and ipilimumab (Yervoy), in 68 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to chec…

This trial tests a new way to personalize the dose of levothyroxine, a thyroid hormone medication, for people who have had surgery for thyroid cancer. Using mathematical and statistical models, the approach aims to predict the best dose for each individual, potentially reducing s…

This phase 1 trial is testing an investigational drug called AEB1102 in adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has returned or stopped responding to standard treatments. AEB1102 is a modified human enzyme that breaks down arginine, an amin…

This trial tests whether giving radiation to the nipple and areola after a nipple-sparing mastectomy is safe and feasible for women with early-stage breast cancer. The goal is to see if this extra radiation can reduce the risk of cancer returning in the preserved nipple area, all…

This phase II trial is testing whether combining brentuximab vedotin, a targeted antibody-drug conjugate, with lenalidomide, a chemotherapy drug, can shrink tumors in people with T-cell lymphoma that has relapsed or not responded to earlier treatment. The study enrolls adults wit…

This study tested a new combination of drugs for people with Hodgkin lymphoma that either returned after treatment or didn't respond. The goal was to find the safest dose of a targeted drug (brentuximab vedotin) when added to standard chemotherapy. 45 adults took part, and the st…

This trial is testing a procedure called HIPEC, where a heated chemotherapy drug (cisplatin) is delivered directly into the abdomen after surgery to remove visible cancer. The goal is to find the safest dose that can be used in patients with advanced ovarian, fallopian tube, or p…

This early-stage trial is testing an experimental drug called APX005M in 32 children with brain tumors that have come back or are hard to treat, including a type of brain stem glioma. The drug works by activating the immune system to attack cancer cells. The main goals are to fin…

This phase II trial is investigating whether giving the drug bevacizumab directly into the liver's main artery, alongside standard chemotherapy, can shrink liver tumors in people with colorectal cancer that has spread only to the liver. The study enrolls patients whose cancer pro…

This phase 2 trial tests a treatment called Lete-Cel, which uses a patient's own immune cells that have been specially trained to attack cancer cells. It is for people with advanced synovial sarcoma or myxoid/round cell liposarcoma whose tumors have a specific marker (NY-ESO-1) a…

This phase 2 trial tests whether adding experimental drugs (MK-4830, boserolimab, or lenvatinib) to the standard combination of pembrolizumab and chemotherapy can improve outcomes for people with extensive-stage small cell lung cancer. Participants receive one of these new combin…

This trial tests whether giving a fluorescent dye called indocyanine green during endoscopic surgery helps surgeons remove non-functioning pituitary macroadenomas more completely. About 34 adults with these tumors will be randomly assigned to receive the dye or not during surgery…

This study looked at whether people with chronic myeloid leukemia (CML) who have done very well on the drug nilotinib can safely stop taking it. 215 patients who had been on nilotinib for at least two years and had very low levels of cancer cells were enrolled. The main goal was …

This early-phase trial tested a combination of four drugs (romidepsin, CC-486, dexamethasone, and lenalidomide) in 26 adults with T-cell cancers that had returned or stopped responding to prior treatments. The main goal was to find a safe dose and check for side effects. While th…

This trial is testing whether combining the immunotherapy drug pembrolizumab with other experimental agents can help people with advanced melanoma whose cancer has stopped responding to standard anti-PD-1 treatment. The study includes several treatment arms, each pairing pembroli…

This phase 1 trial is testing whether adding the antiviral drug Vistide (cidofovir) to the standard combination of radiation and chemotherapy can improve outcomes for people with HPV-positive cervical cancer. The idea is that Vistide may make cancer cells more sensitive to radiat…

This study tested a combination of the targeted drug brentuximab vedotin (ADCETRIS) plus standard CHP chemotherapy in 82 people with newly diagnosed peripheral T-cell lymphoma (PTCL) that has low CD30 levels. The goal was to see how many patients' tumors shrank or disappeared. Re…

This study tests whether gabapentin, an FDA-approved medication, can help restore the balance of key brain chemicals (GABA and glutamate) in people with bipolar disorder who also use cannabis. Participants are randomly assigned to receive either gabapentin or a placebo for 17 day…

This trial tests whether a dye called indocyanine green, viewed with near-infrared imaging, can help surgeons spot pelvic lymph nodes during robot-assisted prostate removal in men with stage II prostate cancer. The dye is injected into the prostate, and the imaging system is used…

This trial is testing whether a chemotherapy drug called treosulfan, given in different doses along with fludarabine, can safely prepare patients with advanced blood cancers for a stem cell transplant. The study focuses on patients who are not eligible for the standard, more inte…

This study tests whether a gel containing a human growth factor (rhPDGF-BB) can help wounds heal faster after skin cancer removal on the head or neck. About 40 adults whose surgical wounds are too large to stitch closed will receive either the gel or a placebo. The goal is to see…

This phase II study tests the targeted therapy regorafenib (Stivarga) in 8 people with metastatic medullary thyroid cancer that has progressed after prior treatment. The drug aims to block cancer growth by targeting specific proteins. Researchers are measuring how long participan…

This phase I trial is testing a combination of drugs—avelumab, utomilumab, rituximab, ibrutinib, and chemotherapy—in people with diffuse large B-cell lymphoma or mantle cell lymphoma that has returned or not responded to treatment. The goal is to find the safest dose and see how …

This Phase 2 trial tests whether adding chemotherapy (carboplatin and pemetrexed) to the targeted drug osimertinib works better than osimertinib alone for people with a specific type of advanced lung cancer (EGFR-mutant non-small cell lung cancer). The study enrolls 80 patients w…

This trial is testing whether an experimental drug called JS015, when combined with standard chemotherapy or immunotherapy, is safe and effective for people with advanced solid tumors that have not responded to prior treatment. The study includes patients with certain cancers lik…

This phase II trial is testing an oral drug called RAD001 (everolimus) in people with advanced thyroid cancer that no longer responds to radioactive iodine treatment. The drug works by blocking a key growth pathway (mTOR) in cancer cells. The study aims to see if RAD001 can slow …

This early-phase study tested an experimental drug called COM902, alone or with other drugs, in 94 people with advanced cancers like ovarian, lung, and colon cancer. The main goal was to check safety and find the right dose. Researchers also looked for early signs that the drug m…

This study compares a new treatment called TheraSphere (tiny radioactive beads) to standard chemoembolization for people with liver cancer that cannot be removed by surgery. About 92 Chinese adults with early-to-mid stage liver cancer will be randomly assigned to one of the two t…

This study looked at whether people with chronic myeloid leukemia (CML) who had very low levels of cancer cells could safely stop taking the drug nilotinib (Tasigna). Participants had already been treated with imatinib (Gleevec) and then nilotinib for at least 3 years. The main g…

This early-stage trial tests a combination of two drugs, venetoclax and azacitidine, in people with a serious type of myelodysplastic syndromes (MDS) who have not had treatment before. The goal is to find the safest dose and see how well the drugs work together to control the dis…

This early-stage trial is testing whether an immunotherapy drug called tislelizumab can be given as a simple injection under the skin instead of through an IV drip for people with advanced non-small cell lung cancer. The study will compare how well the body absorbs the drug in bo…

This phase III trial is investigating whether adding lapatinib to the standard combination of paclitaxel and trastuzumab before surgery can improve outcomes for patients with HER2-positive stage II or III breast cancer. The study aims to see if the three-drug regimen leads to a h…

This pilot trial asks whether removing a wider margin of brain tissue around a high-grade glioma—beyond the standard visible tumor boundary—can improve survival without causing more neurological harm. It enrolls adults with a first-time diagnosis of high-grade glioma in a surgica…

This early-stage trial is testing an experimental drug called AMG 355, given alone or together with the immunotherapy Keytruda, in 77 adults with advanced solid tumors (like lung, colon, stomach, or melanoma) that have not responded to standard treatments. The main goals are to c…

This study looks at whether giving less radiation after surgery for HPV-positive throat cancer can still prevent the cancer from coming back while causing fewer long-term side effects. About 83 adults with HPV-positive oropharyngeal cancer will receive either a standard or reduce…

This early-phase study tested a new drug called BAY 2862789 in 45 people with advanced solid tumors, including non-small cell lung cancer. The drug works by activating immune cells to fight cancer. The main goals were to check safety, find the best dose, and see how the drug move…

This early-phase trial is testing whether adding an experimental drug called alisertib to the standard treatment osimertinib can help people with stage IV EGFR-mutant lung cancer. The study aims to find the safest dose of alisertib when given with osimertinib and to see how the c…

This phase 2 trial is testing the drug ibrutinib in 18 people with stage IV melanoma that has not responded to previous treatments. Ibrutinib works by blocking certain enzymes that help cancer cells grow. The study aims to see if the drug can shrink tumors and how long it keeps t…

This trial tests whether giving goserelin, a hormone-blocking drug, alongside chemotherapy can help preserve ovarian function and fertility in premenopausal women with breast cancer. Participants receive either chemotherapy plus goserelin or chemotherapy alone. Researchers will m…

This phase II trial is testing whether combining the targeted drug ixazomib with two chemotherapy drugs (gemcitabine and doxorubicin) can shrink tumors or stop them from growing in patients with a rare and aggressive kidney cancer called renal medullary carcinoma. The study enrol…

This trial is testing an experimental drug called BST-236 in adults with acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes (MDS) that have come back or not improved after initial treatment. Participants receive BST-236 as a one-hour intravenous infusion for six …

This trial tests whether adding the immunotherapy drug toripalimab to a standard chemotherapy regimen (FLOT) before surgery can improve outcomes for people with locally advanced gastric cancer. Participants receive four cycles of the combination, then undergo surgery, and are fol…

This early-stage trial is testing whether combining two experimental immunotherapy drugs, zalifrelimab and balstilimab, can help shrink or control advanced solid tumors, including cervical cancer. The drugs are designed to block different 'brakes' on the immune system, potentiall…

This Phase 2 trial tests whether drinking three cups of ArtemiCoffee (made from the Artemisia annua plant) daily for 24 weeks can lower PSA levels in 20 men whose prostate cancer has returned after initial treatment. The goal is to see if at least half of the men experience a 50%…

This trial tests whether a simple clip-and-floss traction device can speed up the removal of large colon polyps using a technique called endoscopic submucosal dissection (ESD). About 280 people scheduled for ESD will be randomly assigned to receive either the traction device or s…

This phase II trial is testing whether adding the experimental drug xevinapant to the standard post-surgery chemoradiation treatment can improve outcomes for people with high-risk head and neck cancer. The study enrolls adults with certain types of head and neck cancer who have h…

This phase III trial is testing whether adding selinexor to a standard two-drug regimen (bortezomib and dexamethasone) can help people with relapsed or refractory multiple myeloma—a blood cancer that has returned or stopped responding to treatment. About 154 adults with measurabl…

This early-phase study tested an experimental drug called NT-I7 (efineptakin alfa) in 17 people with relapsed or refractory large B-cell lymphoma who had already received CAR-T cell therapy. The goal was to see if giving NT-I7 after CAR-T is safe and tolerable, and to look for ea…

This study tested two new treatments for people with small cell lung cancer that came back after initial chemotherapy. The experimental drugs, lurbinectedin alone or with irinotecan, were compared to standard treatments (topotecan or irinotecan). The goal was to see if the new op…

This study is testing whether giving a PD-1 inhibitor (a type of immunotherapy) after microwave ablation can help prevent early-stage liver cancer from coming back. About 200 adults with early liver cancer will receive the drug every three weeks for nine cycles. The main goal is …

This phase II trial tests whether adding pembrolizumab (Keytruda) and trastuzumab (Ontruzant) to standard FLOT chemotherapy, given before and after surgery, can improve outcomes for people with HER2-positive esophagogastric adenocarcinoma. Participants receive the drug combinatio…

This study looked at whether giving heated chemotherapy directly into the abdomen during a second-look surgery is possible for people with ovarian, fallopian tube, or peritoneal cancer. Ten participants who had already received standard treatment were enrolled. The goal was to se…

This pilot trial is testing whether adding NP-101, a compound from black seed oil, to two immunotherapy drugs (nivolumab and ipilimumab) can help control advanced or metastatic extra-pulmonary neuroendocrine carcinoma (EP-NECA) that has progressed after initial treatment. About 1…

This early-phase trial tested whether giving activated natural killer (NK) cells, with or without a protein called rhIL15, is safe and feasible for children and young adults with solid tumors that didn't respond to other treatments. Sixteen participants received chemotherapy to l…

This trial tests a personalized approach to radiation therapy for people with HPV-related oropharynx cancer. Doctors use PET-CT scans taken before and during treatment to see how well the tumor is responding. If the response is good, the radiation dose is reduced, which may lesse…

This early-phase trial tests a new type of immunotherapy for people who develop a rare blood cancer called post-transplant lymphoproliferative disease (PTLD) after a solid organ transplant. The treatment uses the patient's own immune cells (T-cells) that are engineered to resist …

This trial tests whether stem cells grown in the lab before being returned to the body can help blood counts recover faster after a stem cell transplant for multiple myeloma. Adults aged 18 to 65 with myeloma in first response will receive their own amplified stem cells. The main…

This phase II trial investigates whether eltrombopag, a drug that stimulates platelet production, can help older adults with acute myeloid leukemia (AML) recover their platelet counts faster after initial chemotherapy. Older patients often experience slow platelet recovery, which…

This phase III trial compares two treatment strategies for people whose glioblastoma, an aggressive brain cancer, has returned or progressed after initial therapy. One group receives bevacizumab alone, while the other receives dose-dense temozolomide followed by bevacizumab if th…

This early-phase study tested a new approach for people whose B-cell cancers (like lymphoma or leukemia) came back after a donor stem cell transplant. Researchers took white blood cells from the original donor, genetically modified them to recognize and attack cancer cells, and g…

This trial asks whether adding the antibody drugs bevacizumab and/or cetuximab to standard chemotherapy can help people with metastatic colorectal cancer live longer. Participants receive one of several treatment combinations, and researchers compare overall survival and progress…

This phase 2 trial compares three hormone therapies—fulvestrant, anastrozole, and tamoxifen—in women with invasive lobular breast cancer, a subtype that is often treated the same as more common breast cancers despite limited evidence. Participants take one of the drugs for about …

This phase 1 trial tested the combination of dasatinib (a pill) and bevacizumab (an infusion) in 50 adults with advanced solid tumors that no longer respond to standard treatments. The goal was to find the safest dose and see how well the two drugs work together to slow cancer gr…

This phase 2 trial is testing whether a combination of two drugs, venetoclax and azacitidine, can effectively treat adults aged 18 to 59 who have been newly diagnosed with acute myeloid leukemia (AML) and have not yet received any treatment. Participants take both drugs in cycles…

This phase II trial is testing whether a cancer vaccine called PolyPEPI1018, when combined with the immunotherapy drug atezolizumab, can help people with a specific type of metastatic colorectal cancer that has not responded to previous treatments. The study enrolls adults with m…

This study tested a drug called ramucirumab, given with standard chemotherapy, for children and young adults with a rare cancer called desmoplastic small round cell tumor (DSRCT) that had come back or not responded to treatment. The goal was to see if the combination could slow t…

This early-stage study tests the safety of combining the chemotherapy drug TAS-102 with radiation therapy for people with stage II or III rectal cancer that hasn't been treated yet. The goal is to find the safest dose of TAS-102 to use with radiation before surgery to remove the …

This early-stage trial is testing an investigational therapy called OH2, a modified herpes simplex virus designed to infect and destroy cancer cells while also stimulating the immune system. The study will evaluate OH2 alone or in combination with the immunotherapy drug pembroliz…

This phase III trial is testing whether a combination of docetaxel and cyclophosphamide works as well as or better than anthracycline-based chemotherapy (like doxorubicin) for women with HER2-negative breast cancer that has spread to lymph nodes or is high-risk. The study aims to…

This study compares two bowel cleansing solutions, Golytely and SUPREP, for colon cancer screening in people with diabetes. Researchers want to see which one cleans the colon better and is easier to tolerate. About 80 participants will be randomly assigned to one of the two preps…

This early-stage trial is testing an experimental drug called AEB1102 in people with advanced solid tumors that have not responded to standard treatments or for which no standard treatment exists. The main goal is to find the highest dose that is safe and to understand the drug's…

This phase II trial is testing whether the chemotherapy drug eribulin, given alone or combined with the immunotherapy pembrolizumab, can help people with ovarian or uterine carcinosarcoma that has returned or progressed. The study aims to see if these treatments can shrink tumors…

This trial is testing a new radiation technique called CT-STAR for people with early-stage non-small cell lung cancer located near the center of the chest, where treatment is tricky. The approach uses a machine that takes CT images during each session and adapts the radiation pla…

This study tested whether adding a metabolic therapy program (fasting and a ketogenic diet) to standard treatment (chemoradiation and chemotherapy) is safe and feasible for people with glioblastoma, an aggressive brain cancer. The approach aims to starve cancer cells by lowering …

This trial asks whether it is safe to shorten the total treatment time for people with newly diagnosed high-grade gliomas, a type of aggressive brain tumor. The usual plan is laser surgery followed by radiation and chemotherapy, taking about 10 weeks. The study tests starting rad…

This trial is testing whether adding the immunotherapy drug toripalimab to standard chemotherapy can help people with advanced non-small cell lung cancer whose tumors have a specific EGFR mutation and have stopped responding to TKI targeted therapy. About 440 participants will be…

This trial tests an experimental virus-based therapy called JX-594 (Pexa-Vec) in people with advanced colorectal cancer that has not responded to standard treatments. The virus is designed to infect and kill cancer cells while also stimulating the immune system. It is given alone…

This phase 2 trial is testing whether adding hydroxychloroquine to standard radiation and chemotherapy before surgery can better control pancreatic cancer. About 50 people with resectable pancreatic cancer will receive either proton or photon radiation along with capecitabine and…

This study looks at how a shorter tuberculosis (TB) treatment regimen works for children and adolescents with non-severe TB in Zambia. It involves children, caregivers, health workers, and policymakers to understand how well the regimen is accepted, followed, and feasible in real…

This trial is testing whether adding the traditional herbal remedy Bojungikki-tang to the immunotherapy drug pembrolizumab can help people with advanced non-small cell lung cancer. The study includes adults with stage IV disease whose tumors are PD-L1 positive and who have no EGF…

This phase II trial tested two immunotherapy drugs, durvalumab and tremelimumab, in 100 women with ovarian, fallopian tube, or peritoneal cancer that had come back or stopped responding to platinum-based chemotherapy. The study compared giving the drugs together versus one after …

This study tests a combination of an immunotherapy drug (pembrolizumab) and low-dose radiation for people with non-Hodgkin lymphoma that has come back or not responded to prior treatments. Six participants will receive the drug plus radiation to one or more tumor sites. The goal …

This study tests a new fluorescent clip that glows under special light to help surgeons locate colon tumors during minimally invasive surgery. About 110 adults with colon cancer will be randomly assigned to receive either the clip or a standard dye injection before surgery. The g…

This phase 2 trial tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard surgery, radiation, and chemotherapy could help prevent head and neck cancer from coming back. The study enrolled 67 adults with advanced, surgically removable head and neck squam…

This study tests whether a combination of ribociclib (a targeted pill) and hormone therapy can shrink tumors faster and more effectively than chemotherapy in women with a fast-growing type of advanced breast cancer (HR-positive, HER2-negative). Participants receive ribociclib plu…

This trial tests two different mouthwashes—benzydamine hydrochloride and super saturated calcium phosphate—to see which better prevents and manages oral mucositis, a painful inflammation of the mouth lining, in head and neck cancer patients receiving radiation therapy. Participan…

This trial is testing an experimental treatment called OH2, a modified herpes simplex virus, for people with recurrent central nervous system tumors, including glioblastoma. The virus is injected into the tumor cavity after surgery to see if it can safely attack cancer cells and …

This trial tests a vaccine designed to help the immune system recognize and attack neuroblastoma, a type of childhood cancer. The vaccine contains two antigens found on neuroblastoma cells, plus an adjuvant to boost the immune response. Participants also take an oral supplement c…

This trial is testing a new abdominal compression technique to reduce breathing-related movement of liver tumors during radiation therapy. The study will compare this novel method with current compression devices and traditional thermoplastic masks in 120 adults receiving radiati…

This trial is testing whether combining two drugs—toripalimab, an immunotherapy, and cetuximab, a targeted therapy—can shrink tumors in people with advanced head and neck squamous cell cancer. The study includes patients whose cancer has returned or spread after initial treatment…

This phase 2 trial tests an experimental drug called DZD8586 in 59 adults with diffuse large B-cell lymphoma that has come back or not responded to previous treatment. The study aims to see if the drug can shrink tumors and to understand its side effects and how the body processe…

This early-phase study tests whether combining the immune-boosting drug nivolumab with a procedure that delivers chemotherapy directly to liver tumors (called deb-TACE) is safe for people with advanced liver cancer. Twenty participants will receive the combination, and researcher…

This study tested a drug called trametinib in 260 people with low-grade ovarian or peritoneal cancer that returned or worsened. Trametinib works by blocking certain enzymes that help cancer cells grow. The goal was to see if it works better than standard treatments like hormone t…

This early-phase trial is testing an oral drug called ATRN-119 in 132 people with advanced solid tumors that have specific DNA repair mutations. The main goals are to check safety, how the drug moves through the body, and whether it can shrink tumors. Participants must be able to…

This trial is testing whether adding an experimental antibody called XB2001 to a standard chemotherapy regimen can help people with advanced pancreatic cancer. The study has two parts: first, it finds the safest dose of XB2001, then it compares the antibody plus chemo against a p…

This early-stage study tests a new drug called SKB410 in about 54 adults with advanced solid tumors who have no standard treatment options left. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. Participants receive multiple doses…

This study looked at the safety and effectiveness of continuing sitravatinib, a targeted cancer drug, either alone or combined with other therapies like nivolumab or pembrolizumab, in people with advanced or metastatic solid tumors. It enrolled 52 patients who were already benefi…

This trial is testing an experimental oral drug called PXS-5505 (amsulostat) in people with myelofibrosis, a type of bone marrow cancer. The study focuses on patients who are not eligible for a stem cell transplant. The main goal is to see if the drug is safe and tolerable, and t…

This study tested three ways to treat warts: a topical acid solution, injections of candida antigen (a yeast extract), and a combination of both. 126 people with warts took part. The goal was to see which approach cleared warts best, including warts not directly treated, and how …

This phase 2 trial tests a powerful mix of short-course radiation, chemotherapy (mFOLFOX6), an immunotherapy (PD-1 antibody), and a targeted drug (cetuximab or bevacizumab, depending on genetic markers) in people with high-risk rectal cancer that is mismatch repair proficient (pM…

This trial tests whether injecting platelet-rich plasma (PRP) — a concentrate made from a person's own blood — into the penile plaque can reduce curvature and ease symptoms in men with Peyronie's disease. Half the participants receive PRP injections and half receive a placebo (sa…

This trial tests whether a single dose of risedronate, a bone-strengthening drug, given before stereotactic body radiation therapy (SBRT) for peripheral lung tumors can prevent the rapid bone loss that radiation can cause in nearby ribs. Adults with lung tumors within 2 cm of the…

This early-phase trial is testing whether combining two immunotherapy drugs, nivolumab and ipilimumab, can safely treat advanced melanoma that cannot be removed by surgery. The study includes adults with stage III or IV melanoma and focuses on the safety and tolerability of the d…

This phase 2 trial is testing whether a combination of three drugs—sintilimab, pegaspargase, and anlotinib—can effectively treat stage IV extranodal NK/T-cell lymphoma in patients who are not healthy enough for high-intensity chemotherapy. The study enrolls adults with newly diag…

This study tests whether adding thymosin alpha 1 to standard chemoradiation and immunotherapy helps patients with advanced non-small cell lung cancer complete a full year of immunotherapy. About 114 adults will participate. The goal is to see if this approach improves survival an…

This study tested whether giving the immunotherapy drug durvalumab alongside radiation works better than the standard cetuximab plus radiation for people with advanced head and neck cancer who cannot take the usual chemotherapy drug cisplatin. A total of 196 adults took part. The…

This trial is testing whether combining three drugs—camrelizumab, apatinib, and pegaspargase—with radiation therapy can improve outcomes for people with early-stage natural killer/T-cell lymphoma, a rare type of cancer. The study includes about 61 patients with stage IE or IIE di…

This study tested a shorter course of a chemotherapy combination called EPOCH-R in 68 people with HIV and a type of lymphoma. The goal was to see if reducing the amount of chemotherapy could still control the cancer while causing less damage to the immune system. Participants rec…

This phase 2 trial tests whether adding the drug apatinib to standard chemotherapy and radiation helps people with advanced esophageal cancer that cannot be removed by surgery. About 170 participants will receive either the standard treatment or the standard treatment plus apatin…

This trial tests whether giving the sedative dexmedetomidine during and after reconstructive microsurgery can help transplanted tissue (flaps) survive better in cancer patients. The study will compare flap health at 48 hours after surgery in patients receiving dexmedetomidine ver…

This trial is testing whether adding an experimental drug called HBI-8000 to the immunotherapy nivolumab can safely control advanced melanoma, kidney cancer, and non-small cell lung cancer. The study enrolls adults whose cancers have not responded to prior treatments. Researchers…

This trial is investigating whether a targeted drug called CMC-544 (inotuzumab ozogamicin), given alone or later combined with rituximab, can control acute lymphoblastic leukemia (ALL) that has returned or not responded to standard treatment. The study enrolls adults and older ch…

This early-phase trial is testing an experimental drug called SPYK04 in people with advanced solid tumors that have stopped responding to standard treatments. The main goal is to check the drug's safety and find the right dose. Researchers will also look for early signs that SPYK…

This phase 2 trial is testing whether a combination of three FDA-approved drugs—oxaliplatin, capecitabine (Xeloda), and cetuximab—can slow tumor growth in people with advanced or metastatic gastric or gastroesophageal cancer that has not been treated with chemotherapy before. The…

This phase 2 trial is investigating whether adding the targeted drug copanlisib to the standard R-CHOP chemoimmunotherapy regimen can help people with previously untreated diffuse large B-cell lymphoma (DLBCL) live longer without their cancer progressing. The study enrolls adults…

This trial is testing a personalized treatment for people with inoperable perihilar cholangiocarcinoma, a type of bile duct cancer. The approach combines radiofrequency ablation — using heat to destroy tumor tissue — with complete drainage of bile ducts, guided by both endoscopy …

This pilot study is testing whether a rapid, timed sequence of different drugs can improve outcomes for people with advanced or inoperable clear cell kidney cancer. Participants first receive cabozantinib, then a combination of two immunotherapies (ipilimumab and nivolumab), foll…

This trial tests whether a lower-strength light-activated gel (8% vs. 16%) and a shorter wait time before red light treatment (1 hour vs. 3 hours) can effectively clear actinic keratoses—rough, precancerous spots caused by sun damage—on the face. Participants will receive one of …

This study tracks adults with relapsed or refractory multiple myeloma who are already receiving isatuximab as part of their routine care. Researchers will measure how many patients respond to treatment, how long the response lasts, and how the drug affects quality of life and sid…

This study tests whether adding a targeted drug called brentuximab vedotin to standard chemotherapy can help people with adult T-cell leukemia/lymphoma (ATLL), a rare and aggressive blood cancer. The combination, known as BV-CHEP, aims to improve response rates by targeting a mar…

This phase 2 trial tests whether adding lenvatinib to a standard chemotherapy-plus-immunotherapy regimen can shrink tumors in people with advanced non-squamous non-small cell lung cancer that has a specific EGFR mutation. Participants will receive lenvatinib capsules daily along …

This phase 1 trial is testing an experimental drug called STP707 in people with advanced or metastatic solid tumors that have not responded to standard treatments. The study aims to find a safe dose and see whether the drug can slow or shrink tumors. Participants receive STP707 b…

This study looks at whether giving a drug called terlipressin continuously during keyhole (laparoscopic) liver surgery can lower the chance of severe complications afterward. Terlipressin helps keep blood pressure stable, which may protect organs during surgery. Researchers will …

This phase 2 trial is testing whether the chemotherapy drug temozolomide can shrink tumors in people with a rare type of gastrointestinal stromal tumor (GIST) that has a mutation in the SDH gene. Standard GIST treatments do not work for this subtype. Participants take temozolomid…

This trial tests whether starting oral feeding within 24 hours after ileostomy reversal surgery is safer than waiting 48 to 72 hours for bowel function to return. The main question is whether early feeding reduces the chance of anastomotic leakage, a serious complication where in…

This trial compares two common methods for placing a totally implantable vascular access device (TIVAD), a port used for chemotherapy and other treatments in cancer patients. Researchers are randomly assigning patients to have the port inserted via either the internal jugular vei…

This trial is testing whether a modified virus called JX-594 (Pexa-Vec) can safely and effectively shrink tumors in people with advanced melanoma that cannot be surgically removed. The virus is injected directly into the tumor and is designed to infect and kill cancer cells while…

This phase II trial tests whether the experimental drug BKM120 can slow or stop the growth of recurrent glioblastoma, an aggressive brain cancer, in patients whose tumors have an activated PI3K pathway. Some participants take the drug before surgery to see if it reaches the brain…

This trial compares two ways to make the first incision for laparoscopic surgery in women with endometrial cancer: the standard umbilical entry versus entry through the Lee-Huang point, a spot on the upper left abdomen. The goal is to see which approach leads to fewer complicatio…

This trial investigates whether injecting bleomycin directly into low-flow vascular malformations (abnormal clusters of blood or lymph vessels) in the head and neck can shrink them. Twenty participants will receive up to four sessions of the drug under local anesthesia. The main …

This trial tests whether a personalized ventilation strategy, guided by electrical impedance tomography (EIT), can reduce lung complications in men undergoing robot-assisted prostate removal. During this surgery, the abdomen is inflated with gas and the patient is tilted head-dow…

This phase II trial is testing whether adding two HER2-targeted drugs (trastuzumab and pertuzumab) to the chemotherapy gemcitabine can help people with metastatic HER2-positive breast cancer who have already received similar treatments. The study aims to see how long the cancer s…

This trial tests an experimental drug, RSO-021, given directly into the chest cavity of people with malignant pleural effusion—a buildup of fluid around the lungs caused by advanced solid tumors or mesothelioma. The study aims to find a safe dose and check for early signs that th…

This trial tests whether a personalized diet and exercise program, delivered by phone and online, can help adult survivors of childhood leukemia who are overweight or obese lose weight. Participants are randomly assigned to either the active coaching program or a self-directed ap…

This phase 3 trial tests whether a web-based physical activity program, including a wearable tracker and interactive app, can improve fitness and long-term health in children and adolescents who have completed cancer treatment. Participants are randomly assigned to receive either…

This phase 3 trial tests whether adding the immunotherapy drug toripalimab to standard chemotherapy before surgery can improve outcomes for people with stage II-III non-small cell lung cancer. Participants receive either toripalimab plus chemotherapy or a placebo plus chemotherap…

This trial is testing whether adding high-dose vitamin C (ascorbic acid) to a standard three-drug chemotherapy cocktail can safely and effectively control metastatic pancreatic cancer in people who have not yet received any treatment. The study enrolls adults with stage IV pancre…

This trial tests whether giving the chemotherapy drugs raltitrexed and oxaliplatin every two weeks is as effective and less toxic than the standard every-three-week schedule in people with metastatic colorectal cancer who have not had prior chemotherapy. Some participants also re…

This phase II trial tests whether adding high-dose vitamin C (ascorbate) to standard chemotherapy (gemcitabine and nab-paclitaxel) can help people with metastatic pancreatic cancer live longer. About 40 participants are randomly assigned to receive either standard chemo alone or …

This study follows about 269 people with chronic lymphocytic leukemia (CLL) who are starting venetoclax, a targeted pill. Researchers will track how well the drug shrinks or controls the cancer over the first year, and how long it takes before patients need another treatment. The…

This study monitors the safety and effectiveness of the drug olaparib (Lynparza) in people with ovarian, breast, prostate, or pancreatic cancer who are prescribed it as part of routine care in South Korea. Researchers will track side effects and how long the cancer stays under co…

This early-phase trial is testing an experimental drug called SM3321 in people with advanced solid tumors that have stopped responding to standard treatments. The main goal is to see if the drug is safe and tolerable, and to find the best dose. Participants receive SM3321 as a we…

This trial tests a modified surgical approach for removing bladder tumors that are 3 centimeters or larger. The technique first removes the outer part of the tumor in pieces, then removes the base in one piece. The goal is to see if this method leads to complete tumor removal and…

This phase 2 trial tests a personalized approach for people with newly diagnosed, advanced classical Hodgkin lymphoma. After two cycles of standard chemotherapy, patients are grouped based on a PET scan. Those with a moderate response receive the immunotherapy drug sintilimab plu…

This study follows women who received a REGENERA implant after having a non-cancerous breast lump removed. The goal is to see if the implant remains safe and performs well up to five years after the initial surgery. Researchers are tracking any side effects or complications linke…

This phase II trial is testing whether adding the immunotherapy drug atezolizumab to standard chemotherapy and radiation can help people with stage III non-small cell lung cancer that cannot be surgically removed. About 50 participants will receive the combination treatment, and …

This trial tests whether a device called VitaSmart, which pumps cold, oxygenated preservation fluid through a donor liver before transplant, can reduce early organ dysfunction and improve survival compared with the usual method of simply storing the liver on ice. About 228 adults…

This phase 2 trial is testing whether combining bevacizumab (a blood-vessel growth blocker) with nab-paclitaxel and an oral chemotherapy called S-1 can shrink tumors in people with advanced biliary tract adenocarcinoma that has worsened after initial treatment. About 32 participa…

This trial is testing whether a special PET/CT scan, typically used for prostate cancer, can better detect hepatocellular carcinoma (the most common type of liver cancer) compared to standard CT or MRI scans. The study will enroll about 30 adults with liver lesions suspicious for…

This trial is testing whether a new radioactive tracer, [18F]AlF-NOTA-pentixather, can accurately identify aldosterone-producing adenomas (benign adrenal tumors) in people with primary aldosteronism—a condition where the adrenal glands make too much aldosterone, leading to high b…

This study tests a new scanner that uses light-based imaging to quickly check whether small lung tissue samples taken during a bronchoscopy are adequate for diagnosis. The goal is to see if the scanner can accurately tell apart samples that are usable from those that aren't, comp…

This trial tests whether a vaginal self-sampling device can accurately detect high-risk human papillomavirus (HPV) compared to samples collected by a clinician. About 1,000 women aged 30-64, either regular screening attendees or those who haven't been screened in 3+ years, will p…

This study evaluates Thyroscan, a genomic test that analyzes genetic material from thyroid nodule samples, to see if it can accurately distinguish benign from malignant nodules. The trial involves 250 adults with suspicious thyroid nodules who are scheduled for surgery or have st…

This trial tests whether a new PET/CT tracer, 64Cu-SAR-bisPSMA, can find more sites of prostate cancer recurrence than the standard 68Ga PSMA-11 scan in men whose PSA rises after prostate removal. Fifty men will receive both scans, and researchers will compare how many lesions ea…

This study investigates whether a liquid biopsy taken from the airways during a bronchoscopy can help diagnose lung cancer and identify genetic mutations. The approach aims to be less invasive and faster than traditional tissue biopsies. Researchers will compare the accuracy of t…

This study tests a special dye that makes prostate cancer cells glow during surgery. About 22 men with aggressive prostate cancer will receive the dye before their prostate removal surgery. Surgeons will use a special camera to see the glowing cancer, helping them remove more of …

This study tested a special PET/MRI scan that uses a radioactive tracer to find liver cancer cells. The goal was to see if this scan can detect liver cancer earlier and more accurately than standard scans. 52 adults with liver cancer took part, and researchers compared the new sc…

This study tested an artificial intelligence (AI) system called Vision-LSTM to see if it could accurately diagnose a specific type of thyroid nodule (TI-RADS 4b) from ultrasound images. Researchers used images from 401 patients and compared the AI's performance to that of junior …

This trial explores whether specially trained dogs can identify high-risk prostate cancer by smelling urine samples. Men with suspected prostate cancer will provide urine samples, which six dogs will sniff. The study will compare the dogs' accuracy against MRI results and biopsy …

This study looks at which tests work best to find early signs of HPV-related cancer in the cervix or anus of people living with HIV. About 1,586 participants from Mexico and Puerto Rico will be tested using different methods, including HPV tests and cell samples. The goal is to c…

This study is testing a new way to detect motor delays in infants using a special play mat with sensors and a smart toy. Researchers will watch how babies move and interact with the toy, then use AI to spot early signs of disability. The goal is to create an easy, objective tool …

This trial tests whether a new CT image-reconstruction algorithm called Veo can detect asbestos-related lung and pleural changes as accurately as the standard method, while delivering a much lower radiation dose. The study involves 90 workers previously exposed to asbestos, who w…

This trial is testing whether an AI-assisted ultrasound system can help surgeons plan thyroid cancer surgery. People scheduled for thyroid surgery will receive a standard ultrasound followed by an AI-assisted repeat exam. The AI identifies and scores thyroid nodules, and the stud…

This trial evaluates an AI-based software tool designed to assist doctors in interpreting colonoscopy images. Using previously collected images and biopsy results from over a thousand patients, the study checks how accurately the AI classifies colorectal lesions as cancerous, pre…

This study looks at whether ten specific substances in the blood can help tell apart patients with gallbladder cancer from those with only gallstone disease. Researchers will measure these markers in a new group of Chilean patients to confirm earlier findings. If the markers prov…

This trial is testing whether an artificial intelligence (AI) model can accurately diagnose and grade several types of solid tumors that affect children, including neuroblastoma, medulloblastoma, Wilms tumor, hepatoblastoma, and rhabdomyosarcoma. The AI is trained on thousands of…

This study tests a new, ultra-sensitive blood test (NGS) to detect EGFR gene mutations in patients with advanced lung cancer. Researchers will compare it to the current standard test using stored blood samples from 130 patients. The goal is to see if the new method finds more mut…

This completed study tested whether a special type of MRI (multiparametric MRI) can accurately tell the difference between benign and malignant small kidney tumors. About 387 adults with small solid kidney masses (1.5-4 cm) were scanned before surgery or biopsy. The goal was to s…

This study investigates whether a protein called FGF19, normally found in the intestine and gallbladder, appears at higher levels in the blood of people with breast or colorectal cancer compared to healthy individuals. Researchers will measure FGF19 and related markers in fasting…

This study tests whether a combination of serial C-reactive protein blood tests and targeted CT scans can safely identify which rectal cancer patients can skip a temporary ileostomy after laparoscopic low anterior resection. Anastomotic leakage is a serious complication, and a pr…

This trial tests whether a new hybrid tracer, ICG-99mTc-nanoscan, can replace the standard tracer for sentinel node biopsy in people with penile cancer, melanoma, or oral cancer. The hybrid tracer combines a fluorescent dye with a radioactive marker, potentially allowing surgeons…

This trial tests a workplace program designed to encourage local government organizations to adopt sun protection policies for outdoor workers. The program provides education and resources to managers and employees, aiming to increase the use of sun-safe practices. Researchers wi…

This trial tests whether using a technique called hybrid argon plasma coagulation (h-APC) on the edges of the removal site can prevent colon polyps from growing back after endoscopic mucosal resection (EMR). EMR is a standard procedure for removing large polyps, but when polyps a…

This trial tests a cancer prevention program delivered by trained Chinese American community health workers to Chinese American adults in Texas. The program uses family health history to provide personalized education on breast, colorectal, gastric, liver, and lung cancers, along…

This study followed 40 women at high genetic risk for ovarian cancer due to BRCA mutations or strong family history. One group chose to have their ovaries and fallopian tubes removed to prevent cancer, while the other group opted for regular CA-125 blood tests every 3 months to c…

This clinical trial investigates whether two existing medications, allopurinol and atorvastatin, can help prevent serious complications in people with stable liver cirrhosis. The study will compare these drugs against a placebo to see if they reduce the number of acute decompensa…

This pilot study tests a peer-led program designed to help Black Veterans at high risk for lung cancer get screened. Veterans who have not yet had lung cancer screening will receive group orientations and one-on-one support from a peer to navigate the process. The study aims to s…

This trial tests whether giving azithromycin—a common antibiotic—twice a year to young children in Niger can reduce deaths. It compares giving the drug to all children aged 1-59 months versus only to infants 1-11 months, who are at highest risk. The study also checks how these ap…

This trial tests whether memantine, a drug used for Alzheimer's disease, can prevent the chronic nerve pain that sometimes develops after breast cancer surgery. Half of the participants receive memantine for four weeks, starting two weeks before their operation, while the other h…

This trial tests whether motivational interviewing—a type of counseling that helps people find their own motivation to change—can help women overcome procrastination and get screened for cervical cancer. The study will include women aged 30-65 who have never had a Pap smear. Half…

This study follows people at high risk for diabetes who previously took part in a program testing intensive lifestyle changes or the drug metformin. The goal is to see if these approaches can prevent or delay diabetes and reduce long-term health problems like heart disease and ca…

This study tests whether limiting daily eating to an 8–10 hour window can improve metabolic health and potentially lower the risk of endometrial cancer. Overweight or obese Native Hawaiian/Pacific Islander women at elevated risk will follow a time-restricted eating schedule for s…

After endoscopic removal of large, early-stage esophageal tumors, the esophagus can narrow and make swallowing difficult. This trial tests whether injecting a steroid directly into the surgical site works better than taking oral steroids to prevent that narrowing. About 30 people…

This trial tests whether a combined nerve block can provide better pain relief than standard local anesthesia for cancer patients undergoing chemoport implantation. The study will compare the two approaches in 80 adults, measuring the need for extra pain medication during the pro…

This study looked at whether acupuncture can reduce pain and anxiety in men undergoing a prostate biopsy. 72 men were randomly assigned to receive either real acupuncture or a sham (fake) version before the procedure, in addition to standard numbing medicine. The main goal was to…

This study tests whether a mobile app can teach family caregivers safe massage techniques to help cancer survivors with long-term nerve pain and numbness caused by chemotherapy. About 300 participants (survivors and their caregivers) will use the app at home. The goal is to reduc…

This study tested a new way to help cancer patients quit smoking before their surgery. 282 adults with cancer or suspected cancer who smoked daily took part. Half received standard counseling and nicotine patches, while the other half also got extra rewards for staying smoke-free…

This study looked at how satisfied people were with three different types of mouthguards (occlusal splints) for jaw joint and muscle pain (TMD). 27 adults who had jaw pain for at least 3 months and had never been treated for it tried one of the splints. The main goal was to see w…

This early-stage trial is testing whether a topical solution containing calcitriol, a form of vitamin D, can safely reduce hair loss in adults receiving taxane-based chemotherapy for breast, gynecologic, or other solid tumors. Participants apply the solution to their scalp twice …

This phase 2 trial tests whether inhaling a blend of peppermint and lemon essential oils can reduce nausea and vomiting in people receiving their first chemotherapy for a solid tumor. Participants will inhale the oils four times daily and whenever nausea strikes, with symptoms tr…

This study tests whether training the muscles you use to breathe can improve how long obese breast cancer survivors can exercise. Researchers will compare breathing exercises plus aerobic exercise to aerobic exercise alone in 78 women who finished treatment. The goal is to see if…

This study tested a structured physiotherapy program for 60 people who had lung cancer surgery. The program included breathing exercises, early walking, and posture training during their hospital stay. Researchers measured how long people stayed in the hospital and checked vital …

This study looks at whether cooling the mouth with popsicles during chemotherapy can reduce taste changes in prostate cancer patients. About 60 people starting a type of chemo called taxane will be asked to suck on popsicles during their infusion. The goal is to see if this simpl…

This trial tests a nurse-assisted eHealth program for patients with heart failure or colorectal cancer. After leaving the hospital, participants use a tablet with the MyDignio app to track vital signs and symptoms, and communicate with a nurse navigator. The goal is to see if thi…

This trial compares two ultrasound-guided pain-relief techniques for children aged 1 to 12 undergoing surgery on the front or side of the thigh. One group receives a fascia iliaca nerve block, while the other gets caudal analgesia, both given after general anesthesia. The goal is…

This trial tests whether an ultrasound-guided injection of alcohol and a numbing agent around the celiac ganglia can relieve pain in people newly diagnosed with inoperable pancreatic cancer. Participants receive either the nerve block or a sham procedure, alongside standard pain …

This study explores whether engaging in positive activities can improve emotional well-being and quality of life for Asian American cancer patients and their caregivers. Participants, who are within a year of a cancer diagnosis and undergoing treatment, along with their caregiver…

This study tested short, digital exercises (called micro-interventions) designed to reduce distress and improve well-being in breast cancer survivors. 120 women who had been diagnosed with early-stage breast cancer in the past 5 years and had mild-to-moderate anxiety or depressio…

This study tests whether a low dose of oral ketamine can safely help with anxiety in people with pancreatic cancer. Twenty participants will receive both ketamine and a placebo at different times to compare effects. The main goal is to see if such a study is even possible, not to…

This study tests four different vaginal treatments (estrogen, DHEA, estrogen with probiotics, and a moisturizer) in 160 breast cancer patients who have vaginal atrophy due to hormone therapy. The goal is to see which treatment best relieves symptoms like dryness and pain, and imp…

This trial tests whether a mouthwash containing lithium can prevent or reduce oral mucositis (painful mouth sores) and dysgeusia (taste changes) in people receiving radiation for head and neck tumors. Participants will rinse with either a lithium mouthwash or a placebo during the…

This study tests whether placing ice inside the rectum before a prostate biopsy can lower pain, anxiety, stress hormone levels, and complications like bleeding. About 84 men having their first prostate biopsy will either receive standard care or ice application. The goal is to se…

This study tests whether a CT-guided nerve block called celiac plexus neurolysis can relieve severe abdominal pain in people with upper gastrointestinal cancer better than standard pain medication. About 110 adults with biopsy-proven upper GI cancer and severe pain will be random…

This study tests an electronic program that combines mindfulness and music therapy for people undergoing stem cell transplants for blood cancers. The goal is to see if it improves quality of life and reduces symptoms like pain. About 60 adults will participate, and the program in…

This study looks at a breast reconstruction method that uses only a small part of a back muscle, aiming to reduce shoulder pain and stiffness. Researchers will compare this technique to standard implant reconstruction in about 190 women. The goal is to see which approach gives be…

This pilot study tests whether a daily herbal supplement made from Lindera obtusiloba can improve quality of life for people with non-small cell lung cancer who are receiving PD-1 or PD-L1 inhibitor immunotherapy. About 20 adults will take the supplement for 8 weeks alongside the…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This study tests whether a heavy lifting strength training program is safe and helpful for people who have finished treatment for head and neck cancer at least one year ago. Researchers want to see if it improves muscle strength, physical function, fatigue, and quality of life co…

This study tests if progressive resistance exercise can improve arm swelling and function in people who developed lymphedema after breast cancer treatment. Fifty adults aged 18-60 who are at least 3 months past surgery will be enrolled. Participants will do supervised exercises a…

This trial tests whether a phone-based positive psychology program can improve mood, quality of life, and daily functioning in adults who have just undergone a stem cell transplant for blood cancer. Participants receive weekly calls and complete exercises focused on gratitude, pe…

This study tests whether a home-based telerehabilitation program can improve functional capacity and quality of life for patients recovering from colorectal cancer surgery. Fifty-four participants will either follow the digital program or receive a standard booklet. The goal is t…

This trial tests whether combining pranayama breathing exercises with music listening can help manage fatigue and improve quality of life in cancer patients receiving immunotherapy. Sixty participants are split into two groups: one receives the integrative therapy alongside their…

This trial tests whether a cream made with mushroom extracts can help protect the skin of women undergoing radiation therapy for breast cancer. Participants use the cream or a standard moisturizer on the treated breast twice daily, starting before radiation and continuing for a m…

This study tests a self-help rehabilitation model for people with head and neck cancer who are feeling anxious or depressed. Participants are randomly assigned to either the self-help program or standard care. The program includes three therapy sessions over eight weeks, led by a…

This trial tests whether a new care approach, called PediQUEST Response, can improve quality of life for children, adolescents, and young adults with advanced cancer. Participants use an app to regularly report symptoms and quality of life, and a palliative care team receives the…

This study tests whether a music-assisted mandala coloring activity can improve psychological well-being and quality of life in adults receiving their first chemotherapy treatment for cancer. Participants will color mandalas weekly for 8 weeks, guided by an instructional video, a…

This study tests whether using virtual reality glasses or doing breathing exercises during chemotherapy can help reduce anxiety in breast cancer patients. Participants will be divided into three groups: one using VR glasses, one doing guided breathing exercises, and one receiving…

This study tests whether teaching family caregivers about lung cancer care—through a handbook and personalized guidance—can reduce stress and improve quality of life for patients undergoing lung cancer surgery. The trial involves 160 patients and their caregivers, with some recei…

This study tests a psychosocial program called Conquer Fear Support (CFS) for people with stage III or IV lung or gynecologic cancer who are experiencing fear of cancer progression. The program includes psychoeducation, attention training, worry management, and detached mindfulne…

This study looks at whether a program called prehabilitation—which helps patients get stronger and healthier before surgery—can lower the chance of problems after surgery for advanced ovarian cancer. About 146 women having surgery for ovarian cancer will take part. The goal is to…

This study tests whether a short, personalized music listening session with a therapist can lower anxiety, stress, and pain in cancer patients starting radiation therapy. 72 adults will be randomly assigned to receive music therapy during their first radiation session or standard…

This trial compares two types of nerve blocks for pain relief after open gastric cancer surgery. The blocks are injected near the abdominal wall to numb the area, potentially reducing the need for opioid painkillers, which can cause side effects like drowsiness and constipation. …

This study tested whether a mobile app that teaches patients about prostate surgery can improve their experience. 68 patients were split into two groups: one used the app, the other received standard care. Researchers measured anxiety, fear, pain, and satisfaction before and afte…

This study tests whether using a virtual reality headset during PICC line placement can reduce anxiety and pain in cancer patients. About 120 adults will be randomly assigned to either receive VR plus standard care or standard care alone. The goal is to see if this non-drug appro…

This study tests a program called UPLYFT designed to help lymphoma survivors who have finished treatment cope with the fear that their cancer might return. The program provides information and tools to improve quality of life and reduce worry. Researchers will first gather feedba…

This trial tests whether myofascial chain release techniques—gentle manual therapy targeting the connective tissue around muscles—can improve shoulder range of motion in women who have had a mastectomy for breast cancer. Participants will receive either standard physiotherapy or …

This trial tests whether an augmented reality (AR) app-based cognitive behavioral therapy (CBT) program can help children aged 6 to 12 who are undergoing chemotherapy for cancer cope with treatment-related distress and improve their quality of life. Participants are randomly assi…

This early-stage study looked at whether giving two standard chemotherapy drugs (cytarabine and daunorubicin) in a different way could be safer for the heart in adults newly diagnosed with acute myeloid leukemia (AML). Researchers used heart MRI scans to monitor for damage. The g…

This study looks at whether giving a local anesthetic to the abdominal wall at the start of robotic prostate surgery, rather than at the end, can reduce the amount of strong painkillers (opioids) needed during the operation. About 50 adults with prostate cancer or benign prostate…

This study tests a new type of radiotherapy that uses daily MRI scans to precisely target head and neck cancer while avoiding the saliva glands. The goal is to reduce severe dry mouth, a common and lasting side effect. Forty-nine patients will receive this adaptive treatment and …

This trial tests whether adding nebulized ketamine to lidocaine before a fiberoptic bronchoscopy reduces coughing and discomfort compared to lidocaine alone or standard spray. About 134 adults scheduled for bronchoscopy will receive one of three premedication approaches. The stud…

This trial tests whether a special liquid nutrition formula, enriched with arginine, omega-3 fatty acids, and nucleotides, can reduce the frequency and severity of mouth sores (mucositis) in patients with head and neck or esophageal cancer undergoing chemoradiotherapy. Participan…

This study looks at two ways of delivering palliative care—specialized support to ease symptoms and stress—for people recently diagnosed with advanced lung cancer. One approach starts with basic palliative care and adds more if needed, while the other provides full palliative car…

This trial tests whether immersive virtual reality or relaxing nature videos can reduce symptom severity, distress, and improve quality of life in people with lung cancer who are starting chemotherapy. Participants will be randomly assigned to one of three groups: virtual reality…

This trial investigates whether removing a urinary catheter within 6 hours after laparoscopic liver surgery, as part of an enhanced recovery program, improves urinary function and reduces complications. About 212 adults aged 18 to 75 with benign or malignant liver tumors schedule…

This trial tests whether sucking lemon candy and using honey mouthwash can reduce salivary gland damage caused by radioiodine therapy for thyroid cancer. About 120 adults who have had their thyroid removed and are about to receive radioiodine will be randomly assigned to the cand…

This trial compares two bowel-cleansing agents—lactulose and polyethylene glycol (PEG)—to see which provides a cleaner colon for colonoscopy. About 450 adults aged 18–79 scheduled for a screening colonoscopy will be randomly assigned to one of the two preparations. The study meas…

This trial tests whether adding two surgical steps—suspending the urethra and rebuilding pelvic fascia—during robot-assisted prostate removal can help men regain urinary continence sooner. About 60 prostate cancer patients will receive the modified procedure and be followed for t…

This trial tests whether applying a hyaluronic acid gel (Endotra Gel) to the breathing tube before general anesthesia can reduce sore throat, hoarseness, and coughing after breast cancer surgery. About 132 adults undergoing breast cancer surgery will be randomly assigned to recei…

This trial tests two types of nerve blocks for pain after breast cancer surgery. One method targets a deeper layer of muscle, while the other combines both superficial and deep layers. The goal is to see which approach better reduces pain, cuts down on opioid use, and improves co…

This study looks back at medical records of adults with head and neck cancer who developed painful mouth sores from radiation or chemotherapy. Researchers will compare how well laser therapy and ozone therapy eased those sores and reduced pain. The goal is to see if one approach …

This trial tests whether a web-based education program can improve body image, self-esteem, and quality of life in women with breast cancer who lose their hair during chemotherapy. The program provides information on hair loss, scalp care, wigs, and emotional coping strategies. R…

This trial tests whether a telemedicine follow-up — a simple online survey with photos and a vision check — can safely replace the first in-person visit after low-risk eyelid procedures like droopy eyelid repair or skin cancer removal. Adults undergoing these surgeries will eithe…

This phase 2 trial tests whether giving the sedative dexmedetomidine during pituitary tumor surgery can dampen the body's stress response and improve early recovery. About 64 adults with non-functioning pituitary adenomas undergoing endoscopic transsphenoidal surgery will be rand…

This study tests whether a hospital-at-home care model can help people with advanced blood cancers receive end-of-life care at home instead of in the hospital. Participants use remote monitoring and home-based supportive care, with researchers tracking how many enroll and complet…

This study gathered information from 326 adults with rare central nervous system tumors, such as medulloblastoma and ependymoma. Participants completed surveys about their symptoms, treatments, and lifestyle, and provided a saliva sample for genetic analysis. The goal was to lear…

This study follows up on over 32,900 people from Linxian, China, who took part in a nutritional trial between 1985 and 1991. Researchers are tracking cancer cases and deaths to see if earlier vitamin and mineral supplements had lasting effects. They are also collecting blood samp…

This study is testing whether a special type of ultrasound, called endoscopic ultrasound elastography, can predict the texture of the pancreas and the risk of a pancreatic fistula after a major surgery called pancreaticoduodenectomy. The study will enroll 100 adults scheduled for…

This study looked at whether a special website or coaching phone calls could help more people with a personal or family history of certain cancers get genetic testing. Over 800 participants were randomly assigned to one of these two methods or to standard care. The goal was to se…

This study looked at why some women have dense breasts on mammograms and why that increases their risk of breast cancer. Researchers collected tissue samples, medical records, and health updates from 466 women aged 40-65 who were having a breast biopsy. The goal was to understand…

This study followed 17 adults with neurofibromatosis type 1 (NF1) over two years to learn how their skin tumors (dermal neurofibromas) grow and change. Researchers used special cameras and skin biopsies to measure tumor growth and look for genes that might influence it. The goal …

This completed study analyzed genetic material from 1,340 patients with lymphoma, leukemia, or multiple myeloma. Researchers used DNA microarrays and other tools to find new molecular subtypes that could explain why some patients respond better to treatment than others. The goal …

This study looks at how skin conditions related to cancer or cancer treatments affect the well-being of cancer patients and survivors. About 1,025 participants will fill out questionnaires about their skin condition. The goal is to better understand these effects and improve trea…

This study collected information from 733 people with a personal or family history of hereditary stomach cancer. The goal was to better understand how these cancers develop and what genes are involved. Participants provided medical history, blood samples, and genetic testing. The…

This study looked at adrenal gland tumors to understand why they form, why some release extra hormones, and why some are cancerous. Researchers studied 690 people with known or suspected adrenal tumors. Participants underwent tests like blood draws, imaging scans, and urine colle…

This study looks at whether a short risk-assessment tool, called the CARG score, can predict severe side effects from chemotherapy in cancer patients aged 70 and older. Participants will answer questions about their health and daily function before starting a new chemotherapy reg…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study analyzed health records of over 200,000 adults with obesity and type 2 diabetes to see if taking GLP-1 drugs (like Ozempic) before a cancer diagnosis is linked to better survival and fewer complications after cancer. The researchers compared GLP-1 users to those on oth…

This study is testing whether certain markers in the blood can predict how well the drug trastuzumab shrinks tumors in women with early HER2-positive breast cancer. Participants receive trastuzumab before breast-conserving surgery, and researchers compare blood marker levels with…

This study is watching nearly 3,000 people newly diagnosed with breast cancer in Latin America. It does not test a new treatment but instead collects information on how the cancer is diagnosed, what treatments are used, and how patients do over time. The goal is to better underst…

This study looked at whether standard radiation treatment for cancer that has spread to the brain causes changes in thinking skills like memory and attention. 35 adults with brain metastases received radiation and took tests and surveys before and after treatment. The goal was to…

This completed study enrolled over 50,000 adults aged 40-75 in Iran's Golestan Province to understand why esophageal cancer is so common there. Participants filled out lifestyle and diet questionnaires and provided blood, urine, hair, and nail samples. Researchers are analyzing f…

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This study looks at whether natural variations in immune-related genes affect how well children with a rare type of lymphoma (ALCL) respond to treatment. By analyzing blood samples from 185 patients, researchers hope to find genetic markers linked to longer periods without the di…

This trial is testing whether using whole-body PET/CT scans and liquid biopsies (blood tests that detect cancer DNA) can improve the follow-up care of people who have completed treatment for early-stage non-small cell lung cancer. The goal is to see if these advanced tools can fi…

This study will analyze the genetic makeup of tumors from 100 people with relapsed multiple myeloma. Researchers will use advanced DNA and RNA sequencing to find genetic changes and understand how the cancer works. The goal is to gather information that could guide more personali…

This pilot study tested whether PET-CT scans can detect leukemia that has spread outside the bone marrow in patients with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia (ALL). Ten participants received a PET scan before and after CAR T-cell therapy. The goal was to…

This study looked at people with three rare genetic conditions—xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD)—that affect the body's ability to repair DNA. Researchers examined 709 participants to understand how these defects relate to cancer ri…

This trial explores whether a blood test measuring reticulocyte hemoglobin content (RET-He) can predict how well cancer patients with anemia will respond to intravenous iron treatment. The study involves adults with solid tumors who have functional iron deficiency. By checking RE…

This study looked at nearly 1,400 people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. The goal was to find the genetic causes and link them to specific symptoms. Researchers used clinical exams and genetic testing to better understand how these dis…

This study explores whether a virtual robot assistant can help Black men recently diagnosed with prostate cancer get the support and information they need. Researchers will ask about 50 participants to use the app and give feedback on how easy and helpful it is. The goal is to se…

This study looks at how often women develop intrauterine adhesions (scar tissue inside the uterus) after having fibroids removed through laparoscopic or open surgery. Researchers will check for adhesions using a small camera inserted into the uterus three months after surgery. Th…

This study looks back at medical records to see how ribociclib, a CDK4/6 inhibitor used for hormone receptor-positive, HER2-negative metastatic breast cancer, is prescribed and tolerated in older adults (65 and over) and Black/African American patients. These groups are often und…

This study looks at whether having a patient navigator—a person who helps guide you through the healthcare system—can help women get timely follow-up care after an abnormal mammogram. The COVID-19 pandemic caused many delays in cancer diagnosis, especially for at-risk groups. Res…

This research program aims to deepen understanding of severe asthma by closely studying its clinical and biological features over time. Researchers will follow more than a thousand people with asthma, aged 6 and older, measuring lung function and tracking how often severe asthma …

This study looked at 460 people with HIV to see what types of cancer they have and why some choose to join cancer clinical trials. Researchers tracked cancers like Kaposi sarcoma, lymphoma, and HPV-related tumors. They also used surveys to learn how HIV and cancer treatments affe…

This study looks at whether a web-based virtual genetics board helps doctors discuss and manage prostate cancer genetics. About 118 healthcare providers, including oncologists and genetic counselors, will use the board and then give feedback through surveys and interviews. The go…

This study looks at genes in men with advanced prostate cancer that has spread and is no longer responding to hormone therapy. Researchers will analyze tissue, blood, and urine samples from 92 patients receiving a drug called abiraterone. The goal is to find genetic changes that …

This study looks at how a simple monitor called the Pleth Variability Index (PVI) changes during laparoscopic-assisted vaginal hysterectomy. Researchers will track PVI at six key moments when the patient's body position changes, such as tilting the head down or raising the legs. …

This early-stage study looks at how a drug called Flonoltinib maleate (being developed for a bone marrow condition) is processed and removed from the body. Six healthy adult men will take a single dose, and researchers will measure the drug and its breakdown products in blood, ur…

This study looks at whether a simple score calculated from routine blood tests—measuring hemoglobin, albumin, lymphocytes, and platelets (the HALP score)—can help predict complications after surgery to remove esophageal cancer. Researchers will track how this score changes before…

This study looks at long-term hormone and metabolic problems in people who survived a childhood brain tumor. Researchers will check survivors for issues like growth, thyroid, and blood sugar problems, and see how these relate to the tumor and its treatment. The goal is to help do…

This study tested new screening methods like MRI, duct lavage, and PET scans in 200 women with BRCA gene mutations who are at high risk for breast cancer. The goal was to see if these tools can find cancer earlier than standard mammograms. Participants were followed for three yea…

This study investigates whether proteins from the Hippo signaling pathway—known to control cell growth and bone health—are present at different levels in the gum fluid of people with healthy gums, gingivitis, or periodontitis. Researchers will collect fluid samples from 75 partic…

This study observed over 2,400 women in Russia with advanced HR+/HER2- breast cancer to see how well different treatments work in everyday medical practice. Researchers tracked how long patients stayed on their therapy before it stopped working or caused side effects. The goal wa…

This study follows over 2,700 people with bladder, lung, or liver cancer who are receiving the drug atezolizumab as part of their normal treatment. Researchers are tracking how long patients live and how well the drug controls their cancer outside of a controlled clinical trial. …

This study examines national data from Switzerland to understand trends in early-onset colorectal cancer, which affects people under 50. By analyzing surgical cases from 2003 to 2022, researchers aim to see how common this cancer is, where it occurs, and what short-term outcomes …

This study follows 1,200 people in China newly diagnosed with advanced non-small-cell lung cancer (stage IIIB/IV) that cannot be removed by surgery. Researchers will collect information from medical records and follow patients over time to see what treatments they receive, how lo…

This study aims to understand why testicular cancer sometimes runs in families. Researchers will collect DNA samples and medical information from about 750 people in families with multiple cases of testicular cancer. No treatment is given; the goal is to find genes that increase …

This study analyzed data from 414 esophageal cancer patients who received chemoimmunotherapy before surgery. Researchers developed a new 'bio-anatomical' staging system that combines tumor characteristics and immune response to better predict survival and guide post-surgery treat…

This study tested a new imaging technique using a special substance (hyperpolarized carbon-13 alpha-ketoglutarate) to see how active brain tumors are in people with IDH mutant glioma. Twelve adults with this type of brain tumor received an injection and then had an MRI scan. The …

This study will test whether 3D-printed or milled occlusal splints are more comfortable and stable for healthy adults. Twenty-four participants will try both types and report how they feel. Dentists will also evaluate the fit. The goal is to learn which method works best for futu…

This observational study looks at whether muscle loss, measured on routine CT scans, is linked to 28-day survival in adults with cancer who are admitted to the intensive care unit (ICU). Researchers will compare muscle quality and nutritional scores between patients who survive a…

This study looked at whether offering genetic counseling by phone or video could help more childhood cancer survivors get genetic testing. About 391 survivors took part, comparing remote counseling to usual care. The goal was to see if remote services increase testing uptake and …

This study tests whether sending text message reminders to patients and alerts to doctors can increase the number of women who get their recommended mammograms. About 8,490 women aged 40-74 who are overdue for screening will take part. The goal is to see if these simple 'nudges' …

This pilot trial explores whether using a tumor's molecular profile—its gene expression and DNA sequencing—can help doctors choose a personalized treatment plan for children and young adults with high-grade glioma (a type of brain cancer). Participants receive a recommendation fr…

This study compares two breathing techniques used during robotic bronchoscopy, a procedure to biopsy lung nodules. The goal is to see which method better prevents atelectasis (lung collapse) during the procedure. About 62 adults with suspicious lung nodules will be randomly assig…

This study tests whether analyzing a patient's tumor alongside a sample of their normal tissue can help doctors select a more effective treatment for advanced cancer. The approach aims to provide a personalized therapy choice for every participant, even those without known geneti…

This study reviews medical records of 360 Japanese patients with advanced bladder cancer who received avelumab as a maintenance treatment after initial chemotherapy. The goal is to understand patient characteristics, treatment patterns, and outcomes like survival and tumor respon…

This pilot study tested whether a mindfulness program could help reduce colorectal cancer risk factors in Black women aged 45-65 who live in high-crime Chicago neighborhoods and have had a colon polyp. Twenty-four women participated to see if the program was feasible and acceptab…

This completed study from Minia University looked at 200 patients with autoimmune thyroiditis (an inflamed thyroid) who had thyroid surgery. The goal was to see how often thyroid cancer is found by accident when examining the removed tissue. Researchers checked for cancer in pati…

This trial tests whether an online training course, called MelaMEd, can improve primary care doctors' ability to detect and manage melanoma, the most serious form of skin cancer. Participants—general practitioners, trainees, and pediatricians—answer questions and review skin lesi…

This study looks at whether obesity, measured by body mass index (BMI), affects the chances of a 'textbook outcome' after minimally invasive surgery for colorectal cancer. A textbook outcome means the surgery went smoothly with no major complications, a short hospital stay, and n…

This study looks at whether special MRI scans can be used safely during surgery to remove brain tumors called gliomas. Researchers will try two advanced imaging techniques before and during the operation. The goal is to see if these scans are possible and to track any complicatio…

This study examines whether patients who have a thyroid nodule found on a PET scan can safely skip a follow-up ultrasound without affecting their survival. Researchers will compare death rates over 7 years between those who had an ultrasound within 3 months and those who did not.…

This completed study examined 217 Hispanic people living with HIV in California, Mexico, and Puerto Rico to see if the types of bacteria in the anus are linked to high-risk HPV infection and pre-cancerous lesions. Researchers collected anal swabs and questionnaires to compare mic…

This study looks at proteins in the blood of women with ovarian, peritoneal, or fallopian tube cancer who are in remission. The goal is to find a protein pattern, or 'fingerprint,' that signals when the cancer might come back. Researchers followed 119 women with stage III or IV c…

This study is testing a new smartphone app designed to help cancer patients remember to take their oral anticancer medications and report any side effects. The app also helps patients communicate with their care team and find support for financial or social needs. Researchers wil…

This study looked at whether a lung rehab program done over video calls can help people recover after lung cancer surgery. 36 patients aged 55-75 who had part or all of a lung removed took part. They did exercises and tests like the 6-minute walk and breathing tests, all guided b…

This study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…

This study uses an online questionnaire to explore how people with past or active cancer in France use self-medication, including non-prescription drugs, herbal remedies, and supplements. It aims to understand what products they take, why, and where they get them. The findings co…

This study tested a document called Voicing My CHOiCES, designed to help young adults (ages 18-39) with serious illnesses like cancer or HIV discuss their care preferences. Participants filled out questionnaires about anxiety, social support, and communication, then reviewed the …

This study looks at a nerve in the neck called the ansa cervicalis, which controls muscles that help keep the airway open. Researchers will measure the nerve's size and shape in 50 adults having neck surgery for head and neck cancer. They will also test how stimulating the nerve …

This study investigates whether lymph nodes in the lower abdomen, called the inferior epigastric lymph node basin, might be an early stop for ovarian cancer spreading from the peritoneum. Researchers will biopsy these nodes in 20 patients undergoing surgery for ovarian peritoneal…

This study looks at whether a person's genetic makeup can help predict which head and neck cancer patients will experience side effects from radiation therapy, such as difficulty swallowing, dry mouth, and other complications. Researchers will collect blood samples from about 200…

This study is testing whether a specific gene variant (MC4R rs17782313) and metabolic health status influence how men with obesity respond to a 12-week exercise and diet program. Forty men aged 18 to 59 with obesity will be classified as having metabolically healthy or unhealthy …

This large observational study is investigating whether nitrate, nitrite, and phosphate—compounds found naturally in food and water and used as additives—are linked to chronic diseases like gastrointestinal cancers, heart disease, and respiratory conditions. Researchers will foll…

This study looks at whether having certain E. coli bacteria in the colon after colorectal cancer surgery is linked to anxiety or depression. Researchers will compare psychiatric symptoms and diagnoses between patients who carry the bacteria and those who do not. The goal is to be…

This study tested a school program called SocLaLola that uses a comic book to teach children aged 8-11 about pain. The goal was to see if it improves kids' understanding of pain and reduces their fear of moving. Eighty-two students from two primary schools took part. The program …

This study looks at why some people get infections after surgery for oral cancer. Researchers will track 40 patients undergoing standard reconstructive surgery to see where infection-causing bacteria come from and how well antibiotics work. The goal is to find better ways to prev…

This study looks back at medical records of people who had an allogeneic stem cell transplant to see whether romiplostim helped their platelets recover faster. Platelets are blood cells that help clotting, and low counts are common after transplant. The researchers will compare p…

This study measures the carbon dioxide emissions produced during colonoscopy for colorectal cancer screening, including energy use, equipment, medications, and waste. Researchers will also compare different polypectomy techniques to see which are more eco-friendly. The goal is to…

This 100% remote study surveys 250 people diagnosed with non-small cell lung cancer before age 50. Participants answer questions about their environment, lifestyle, and family history, and may donate blood. The goal is to uncover factors linked to genetic changes that drive young…

This study interviews 55 patients with resectable non-small cell lung cancer and their doctors in the US, Germany, and Japan. The goal is to understand what treatment features they value most, such as effectiveness or side effects. Results may help align care with patient priorit…

This study is testing whether a CT-free electromagnetic navigation system can accurately locate small lung nodules before surgery, compared to the standard CT-guided method. The goal is to see if the new approach can mark nodules within 10 millimeters of their center, which is cr…

This study looked at people with neurofibromatosis type 1 (NF1) to better understand how harmless tumors (plexiform neurofibromas) turn into a rare cancer called MPNST. Ten participants had MRI, PET scans, and tumor biopsies. Researchers tested whether a special PET scan (FLT PET…

This study followed 76 children with brain tumors to learn how radiation therapy affects their quality of life, thinking, and body functions over time. Researchers collected blood, urine, and MRI scans before and after treatment, along with tests of memory, behavior, vision, and …

This study looks at whether the virus that causes COVID-19 can be found in the semen of men with cancer who are storing sperm before treatment. Researchers will test both the fluid and the sperm cells for the virus and compare results with nasal swabs and blood tests. The goal is…

This completed study looked at why some women reject personalized breast cancer risk estimates. Researchers gave 781 Black or African American women aged 39-74 a personal risk score based on the Gail Model and asked if they agreed with it. The goal was to understand risk rejectio…

This completed study surveyed 100 adults with brain tumors (gliomas) to understand how social factors like income, education, housing, and community support affect their health. Participants answered questionnaires about their neighborhoods, access to food and transportation, and…

This study looks back at tissue samples from patients with nasopharyngeal carcinoma who took part in an earlier treatment trial. Researchers are using advanced genetic testing and protein analysis to look for markers linked to how long patients survive. The goal is to better unde…

This study looks at whether getting a yearly LDL cholesterol test could help cancer survivors avoid serious heart problems like heart attacks and strokes. Researchers will analyze health records from over a million cancer survivors in Korea, comparing those who had the test with …

This study looks back at medical records of 150 adults with active cancer who had a confirmed case of shingles (herpes zoster). The goal is to understand the clinical features of shingles in these patients, such as how it spreads and complications like long-term nerve pain, and t…

This study tests a small, wearable ECG patch that uses artificial intelligence to monitor heart rhythms in patients recovering from cardiac surgery. Participants wear the patch for up to a week after leaving the intensive care unit. The goal is to see if the device can reliably t…

This study looks at how a surgeon's growing experience with single-incision laparoscopic surgery—a minimally invasive technique using a single small cut—affects short- and long-term results for people with rectal or sigmoid colon cancer. By analyzing past cases from one surgical …

This study tests whether a direct meeting between breast cancer patients and a pathologist—where the pathologist reviews the patient's own pathology slides—can improve the patient's understanding of their disease and sense of empowerment. Participants complete questionnaires befo…

This study analyzes DNA and RNA from stored tumor samples of 401 people with head and neck squamous cell carcinoma. The goal is to classify each tumor by its genetic mutations and immune activity, potentially pointing toward which treatments—such as immunotherapy—might work best.…

This trial investigates how a single injection of degarelix, a drug that lowers testosterone, affects prostate cancer cells when given just days before prostate removal surgery. Researchers aim to measure changes in cell growth (Ki-67 levels) by comparing biopsy and surgical tiss…

This study explores the experiences of women who saw their GP with a breast health concern and were referred to a specialist. Through interviews and focus groups, researchers aim to uncover what helped or hindered the referral process. The goal is to inform medical education and …

This pilot study tests whether a multi-ingredient whey supplement can reduce fructose malabsorption in healthy adults after hiking under heat stress. Eight participants will consume fructose and have their breath hydrogen measured as a marker of malabsorption, both before and aft…

This study looks at people who develop a leak after colorectal cancer surgery. Researchers will track which patients need emergency surgery, die within 90 days, or end up with a permanent stoma. The goal is to find factors that predict these outcomes and help guide future care.

Multiple myeloma, a common blood cancer, often causes bone lesions that lead to pain, fractures, and other serious events. This study reviews medical records of patients diagnosed between 2019 and 2021 to describe how often these bone complications occur and what rehabilitation s…

This study reviews the medical records of 20 people treated for eyelid carcinomas at a hospital in eastern Morocco. Researchers are examining patient characteristics, tumor types, and surgical approaches to better understand how these cancers present and are managed in this regio…

This study examines 300 esophageal cancer tissue and blood samples to classify tumors based on p53 gene mutations, protein expression, and immune response. Researchers will link these molecular subtypes to patient survival and treatment patterns. The goal is to see whether p53 fe…

This study looks at how anti-tumor T-cell responses change in people with lung or head-and-neck cancer who are receiving radiochemotherapy. Researchers will collect blood and tumor samples to track immune markers. The goal is to understand whether this standard treatment can boos…

This study looks back at 21 children and teens diagnosed with a rare type of lymphoma that starts in the bone. Researchers are collecting medical records to describe how the disease presents, how it was treated, and how well patients did over time. The goal is to learn more about…

This large Italian study investigates whether a composite measure called 'Textbook Outcome' can serve as a reliable indicator of quality in colorectal cancer surgery. Researchers will analyze data from over 6,000 patients to see if meeting six key criteria—including survival, com…

This study looks at how two heat-based procedures — radiofrequency ablation and microwave ablation — affect the immune system in people with small liver cancers. Researchers will take blood samples and tissue biopsies before and after treatment to track changes in immune cells. T…