Immune booster after CAR-T shows promise in early lymphoma trial
NCT ID NCT05075603
First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 3 times
Summary
This early-phase study tested an experimental drug called NT-I7 (efineptakin alfa) in 17 people with relapsed or refractory large B-cell lymphoma who had already received CAR-T cell therapy. The goal was to see if giving NT-I7 after CAR-T is safe and tolerable, and to look for early signs that it might help fight the cancer. The trial focused on finding the right dose and checking for side effects, not yet on proving the treatment works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Efineptakin alfa (NT-I7)
- What this could lead to
- If it works, this could point toward a way to boost the immune system after CAR-T therapy, potentially improving outcomes for people with hard-to-treat lymphoma.
- What could go wrong
- This is a very early, small phase 1 trial with only 17 participants, so results may not apply broadly. The main goal is safety, not yet proof of effectiveness, and there is a risk of side effects from the drug.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
City of Hope
Duarte, California, 91010, United States
-
Duke Cancer Institute
Durham, North Carolina, 27710, United States
-
Washington University in St. Louis
St Louis, Missouri, 63110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a single shot build a cancer army inside the body?