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A dab of gel on the breathing tube might spare surgery patients a sore throat — a trial puts it to the test.

NCT ID NCT07040631

Symptom relief Sponsor: Pusan National University Yangsan Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial tests whether applying a hyaluronic acid gel (Endotra Gel) to the breathing tube before general anesthesia can reduce sore throat, hoarseness, and coughing after breast cancer surgery. About 132 adults undergoing breast cancer surgery will be randomly assigned to receive the gel or standard care. Researchers will track symptoms right after surgery and the next day to see if the gel improves comfort and recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a hyaluronic acid-based gel (Endotra Gel) applied to the endotracheal tube cuff before intubation
What this could lead to
If it works, this simple gel application could become a routine way to prevent throat discomfort after surgery under general anesthesia.
What could go wrong
This is a small, early-stage trial. The gel may not reduce symptoms more than standard care, and individual results may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

132 people

The number who actually took part.

Started

Aug 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 19 to 80 years * Scheduled to undergo breast cancer surgery under general anesthesia with endotracheal intubation * American Society of Anesthesiologists (ASA) physical status I to III Exclusion Criteria: * Mallampati classification of III or higher * Recent upper respiratory infection or symptoms of upper airway infection * Pre-existing laryngeal disease or chronic respiratory conditions (e.g., asthma, chronic bronchitis) * Current use of systemic steroids * Refusal to provide informed consent * Determined to be unsuitable for study participation by the investigator

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Cough Hoarseness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breast cancer Endotracheal intubation General anesthesia Postoperative sore throat, cough, hoarseness

Contacts and locations

Locations

  • Pusan national university yangsan hospital

    Yangsan, Gyeongsangnam-do, 50612, South Korea

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