Engineered immune cells show promise against tough lymphoma

NCT ID NCT04880434

Completed Disease control Sponsor: Kite, A Gilead Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 study tested a personalized cell therapy called KTE-X19 (brexucabtagene autoleucel) in 95 adults with mantle cell lymphoma that had returned or stopped responding to prior treatments. Participants received a single infusion of their own genetically modified immune cells designed to attack the cancer. The main goal was to see how many patients had their tumors shrink or disappear.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Brexucabtagene autoleucel (KTE-X19), a CAR T-cell therapy made from the patient's own immune cells
What this could lead to: If successful, this could provide a powerful treatment option for people with mantle cell lymphoma that has stopped responding to other therapies.
What could go wrong: This is a phase 2 trial with 95 participants, so results are not yet confirmed in larger groups. CAR T-cell therapy can cause serious side effects like cytokine release syndrome and neurological problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

mantle cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSED/REFRACTORY MANTLE CELL LYMPHOMA

Contacts and locations

Locations

Academisch Medisch Centrum

Amsterdam, 1100, Netherlands
Advocate Aurora Health - Advocate Lutheran General Hospital

Park Ridge, Illinois, 60068, United States
Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234, United States
Baylor Cancer Hospital

Dallas, Texas, 75246, United States
CHU de Montpellier

Montpellier, 34295, France
CHU de Rennes

Rennes, 35033, France
Centre Hospitalier Lyon Sud

Pierre-Bénite, 69495, France
Cleveland Clinic - Taussig Cancer Institute

Cleveland, Ohio, 44195, United States
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Duke University

Durham, North Carolina, 27710, United States
Emory University

Atlanta, Georgia, 30322, United States
Erasmus MC

Rotterdam, 3015 CE, Netherlands
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Hopital Haut-Leveque

Pessac, 44035, France
Hospital Clinic Barcelona

Barcelona, Spain
Hospital Saint Louis

Paris, 75010, France
Hospital Universitari Vall D'Hebron

Barcelona, 08035, Spain
Hospital Universitario de Salamanca

Salamanca, 37007, Spain
Johannes Gutenberg University Hospital-University Mainz

Mainz, 55101, Germany
Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Kings College Hospital

London, SE5 9RS, United Kingdom
Loyola University Medical Center

Maywood, Illinois, 60153, United States
MD Anderson Cancer Center

Houston, Texas, 77030, United States
Manchester Royal Infirmary

Manchester, M13 9WL, United Kingdom
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Munich University of Technology-Medical Faculty- Ethics Committee

München, 81377, Germany
Ohio State University

Columbus, Ohio, 43220, United States
Queen Elizabeth University Hospital

Glasgow, G51 4TF, United Kingdom
Sarah Cannon - Tenessee

Nashville, Tennessee, 37203, United States
Sarah Cannon- Denver

Denver, Colorado, 80218, United States
Stanford University

Palo Alto, California, 94305, United States
Swedish Cancer Institute

Seattle, Washington, 98104, United States
Universitaetsklinikum Wuerzburg

Würzburg, 97080, Germany
University California Los Angeles (UCLA)

Santa Monica, California, 90404, United States
University Medical Center Groningen

Groningen, 9700 RB, Netherlands
University of Chicago

Chicago, Illinois, 60637, United States
University of Miami

Miami, Florida, 33136, United States
University of Rochester

Rochester, New York, 14642, United States
Vanderbilt University

Nashville, Tennessee, 37232, United States

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