Can a modified virus shrink Hard-to-Treat melanoma tumors?
NCT ID NCT00429312
First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time
Summary
This trial is testing whether a modified virus called JX-594 (Pexa-Vec) can safely and effectively shrink tumors in people with advanced melanoma that cannot be surgically removed. The virus is injected directly into the tumor and is designed to infect and kill cancer cells while also stimulating the immune system. The study includes about 10 adults with stage 3 or 4 melanoma who have at least one injectable tumor.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a modified vaccinia virus (JX-594, also called Pexa-Vec) that is injected directly into tumors
- What this could lead to
- If it works, this could offer a new treatment option for people with advanced melanoma that cannot be removed by surgery.
- What could go wrong
- This is an early-phase trial with only 10 participants, so the results may not apply to everyone. The virus may cause side effects or fail to shrink tumors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Billings Clinic
Billings, Montana, 59101, United States
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Cancer Centers of the Carolinas
Greenville, South Carolina, 29605, United States
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University of California, Los Angeles
Los Angeles, California, 90024, United States
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