Disease by body system or component

This early-stage trial is testing an experimental therapy called LCAR-BCDR, which uses a patient's own immune cells that have been engineered to recognize and attack a protein called BCMA found on myeloma cells. The study aims to see if this treatment is safe and tolerable, and w…

This trial tests a gene therapy called FLT180a in adults with hemophilia B, a condition where the body lacks a clotting protein. The therapy delivers a working gene to help the body produce its own clotting factor. A small group of participants will receive a single dose and be f…

This trial tests whether a single injection of a gene-editing tool can safely correct a specific mutation in the CHD3 gene that causes Snijders Blok-Campeau syndrome, a condition marked by developmental delay and intellectual disability. The gene editor is delivered directly into…

This phase II trial is testing whether adding the targeted antibody-drug inotuzumab ozogamicin to a standard chemotherapy regimen (Hyper-CVAD) improves outcomes for adults with B-cell acute lymphoblastic leukemia. The study enrolls people with newly diagnosed or recently remitted…

This phase 1 trial tests a gene therapy that helps prostate cancer cells absorb more radioactive iodine, potentially killing them while sparing healthy tissue. The study enrolls men whose prostate cancer returned after prior radiation therapy. Researchers aim to find the safest d…

This early-stage trial is testing a new malaria vaccine candidate, called Pfs48/45, in healthy adults aged 18 to 45 in the UK. The vaccine is designed to block the malaria parasite from spreading, and it's given with an adjuvant called Matrix-M to boost the immune response. The s…

This trial tests an experimental mRNA vaccine, mRNA-1468, to see if it can safely prevent shingles in healthy adults aged 50 and older. Participants receive either the new vaccine, a placebo, or an existing shingles vaccine (Shingrix) to compare safety and immune response. The st…

This study tested a nasal spray RSV vaccine in nearly 1,000 healthy infants and toddlers aged 6 to 22 months. The goal was to see if a lower dose works as well as the standard dose and to check safety across different doses. The trial was ended early, so final results are not ava…

This early-stage trial tests an experimental RSV vaccine called CodaVax-RSV, given as nose drops, in healthy children aged 6 months to 5 years. The study evaluates the vaccine's safety and the immune response it triggers. Some children receive the vaccine at different doses, whil…

This study looked at how well the drug iptacopan works for people with paroxysmal nocturnal hemoglobinuria (PNH) when used in everyday medical practice in Russia. Only 6 adults took part, and the study was terminated early. Researchers measured whether patients' hemoglobin levels…

This study tested a drug called REC-2282 in people aged 12 and older with progressive meningiomas (brain tumors) linked to NF2 gene mutations. Participants took the drug or a placebo three times a week in cycles. The goal was to see if the drug could slow tumor growth. The trial …

This pilot study tests whether shining near-infrared light on the eye can reduce macular edema—swelling in the central retina—caused by a retinal vein occlusion. Six participants with this condition will receive 12 light treatments over about five weeks. The main goal is to see i…

This study tests whether a supervised treadmill walking program can improve memory, attention, and other thinking skills in adults with type 2 diabetes. Participants will follow a personalized exercise plan, and researchers will measure changes in cognitive function and blood mar…

This trial tests whether an experimental oral medication, deucrictibant, can reduce the number of swelling attacks in people with hereditary angioedema (HAE) types I and II. Participants take either a low or high dose of the drug or a placebo for 12 weeks, and then may continue o…

This study tests the long-term safety of a nasal spray called carbetocin for people with Prader-Willi syndrome who experience severe, constant hunger (hyperphagia). About 160 participants who completed a previous study will receive the spray three times daily. The goal is to see …

This study tests an experimental drug called REGN7041 in 72 people with active noninfectious uveitis, a condition causing inflammation inside the eye. The drug is an antibody designed to calm the immune system. Since this is the first time it's tested in humans, the main goal is …

This trial tested an experimental drug called ASP1570 in adults with advanced solid tumors that had spread or could not be removed by surgery. The drug aims to help the body's immune T-cells attack tumors that have become resistant. The study was in two parts: first to find a saf…

This phase 2 trial tested the drug olaparib (Lynparza) in people with advanced pancreatic acinar cell carcinoma, a rare pancreatic cancer. Participants took olaparib pills twice daily for up to 2 years. The study was terminated early after enrolling only 5 people, so it is not kn…

This early-stage trial tested an experimental drug called SAR442257 in 47 adults with relapsed or refractory multiple myeloma or non-Hodgkin lymphoma. The main goals were to find a safe dose and check for side effects. Researchers also looked for signs that the drug might fight t…

This phase 2 trial tests whether a once-daily topical ointment called PF-07038124 can ease moderate-to-severe seborrheic dermatitis and papulopustular rosacea. Adults with either condition will apply the ointment or a placebo for 8 weeks, with follow-up visits to check skin impro…

This trial is testing whether an experimental drug called NC410, when combined with the immunotherapy drug pembrolizumab, can safely and effectively treat people with advanced solid tumors that have not responded to standard immunotherapy or that are unlikely to respond. The stud…

This trial investigates a combination of two drugs: EP0057, a chemotherapy drug wrapped in a nanoparticle to help it reach cancer cells, and olaparib, which stops cancer cells from fixing DNA damage. The study includes adults with small cell lung cancer, bladder cancer, or prosta…

This study tested a device called the Amplatzer Amulet, which is implanted to close a part of the heart and reduce stroke risk in people with non-valvular atrial fibrillation who cannot take blood thinners. The study enrolled 50 participants in China and tracked safety and effect…

This trial tests whether a liquid called silver diamine fluoride (SDF) can stop cavities in baby teeth. About 830 children aged 12 months to 5 years with active cavities will receive either SDF or a placebo applied to their teeth twice, six months apart. Researchers will check if…

This study tests whether inhaling alpha-1 antitrypsin (AAT) daily can slow lung function loss in people with Alpha-1 deficiency and moderate-to-severe lung disease. 220 adults will receive either the drug or a placebo for two years, then all will receive the drug for two more yea…

This trial is testing whether combining two drugs—pembrolizumab and lenvatinib—can help people with metastatic uveal melanoma, a rare eye cancer that has spread to other parts of the body. Participants receive both drugs for up to two years. The study measures how long people liv…

This trial tests whether a combination of plasma exchange, rituximab, and intravenous immunoglobulins can improve survival in people hospitalized in intensive care with a severe acute exacerbation of idiopathic pulmonary fibrosis (IPF). IPF is a progressive lung disease, and thes…

This phase 3 trial is testing an experimental oral drug, SAR302503, in people with a rare bone marrow disorder called myelofibrosis who have an enlarged spleen. Participants are randomly assigned to receive one of two doses of the drug or a placebo. The main goal is to see if the…

This study tested an experimental drug called PF-06823859 for adults with lupus that affects the skin. The goal was to see if the drug could reduce skin inflammation and improve symptoms. The trial was stopped early and only enrolled 8 people instead of the planned 48, so results…

This study tested a new type of artificial lens (TECNIS DEN00V) for people having cataract surgery. It compared the new lens to a standard lens in 243 adults with cataracts. The goal was to see if the new lens improves vision at arm's length (66 cm) while keeping good distance vi…

This trial tests whether an experimental stem cell therapy called MultiStem can help people with moderate to severe acute respiratory distress syndrome (ARDS) caused by infections like COVID-19. ARDS is a serious lung condition that often requires a breathing tube and ventilator.…

This study checks the long-term safety of a drug called batoclimab for adults with chronic inflammatory demyelinating polyneuropathy (CIDP), a nerve disorder that causes weakness and numbness. About 108 people who finished an earlier batoclimab study will get weekly injections fo…

This phase 3 trial is testing whether a single infusion of MultiStem, an experimental stem cell product, can improve recovery in adults who have had a moderate-to-severe ischemic stroke within the past 18 to 36 hours. The study compares the stem cell treatment against a placebo t…

This early-phase trial tests whether ExoFlo, a product made from extracellular vesicles derived from donor bone marrow stem cells, can safely treat perianal fistulas in people with Crohn's disease. The study enrolls adults aged 18-75 who have had Crohn's for at least six months a…

This trial is testing whether an experimental drug called batoclimab can help adults with active chronic inflammatory demyelinating polyneuropathy (CIDP), a condition where the immune system damages nerves, causing weakness and disability. Participants receive either batoclimab o…

This early-stage trial is testing whether genetically modified T-cells can safely control viral infections in cancer patients with weakened immune systems. The T-cells are designed to target specific viruses like CMV, BK virus, or COVID-19. The study involves 30 participants and …

This study tests an experimental drug called rocatinlimab in adults with moderate-to-severe asthma. The goal is to see if it can reduce the number of asthma attacks. Participants continue their usual asthma medications while receiving the drug or a placebo. The study involves abo…

This trial is testing whether the targeted drug pemigatinib can slow or shrink a specific type of bile duct cancer (cholangiocarcinoma) that has a genetic change called FGFR2 rearrangement and cannot be removed by surgery. Participants will receive either pemigatinib as a daily p…

This early-stage study tests the safety of an experimental drug called RO7669330, given as an injection into the eye, for people with geographic atrophy (GA) due to age-related macular degeneration (AMD). The study involves 27 participants and will monitor side effects and eye he…

This study tested a drug called amlitelimab in 166 adults with severe alopecia areata, a condition causing significant hair loss. Participants received either the drug or a placebo by injection. The main goal was to see if the drug could reduce hair loss scores after 36 weeks. Th…

This trial tests whether adding augmented reality (AR) to treadmill training can help people with Parkinson's disease who have trouble walking and are at risk of falling. Participants will be randomly assigned to one of three groups: treadmill training with AR, treadmill training…

This trial is testing whether an experimental biologic called MK-6194 can reduce disease activity in adults with systemic lupus erythematosus (SLE), an autoimmune condition that causes inflammation and organ damage. Participants receive either MK-6194 or a placebo as an injection…

This study tests whether a daily supplement called nicotinamide riboside (a form of vitamin B3) can help children with mild to moderate ulcerative colitis. About 40 kids will take either the supplement or a placebo for 6 to 12 months, alongside their usual treatment. The main goa…

This study follows about 300 people who receive a hip replacement using the GTS cementless stem, a type of implant that anchors to bone without cement. The goal is to see how well the implant performs over up to 10 years, measuring pain, function, and joint stability. Participant…

This phase 2 trial is testing whether a topical gel containing ZL-1102, an antibody fragment that blocks IL-17A, can safely and effectively reduce the severity of chronic plaque psoriasis. The study enrolls adults with psoriasis for at least six months and compares different dose…

This phase 2 trial tests whether adding ALXN2420 (a growth hormone blocker) to standard acromegaly treatment can lower IGF-1 levels more than placebo. About 60 adults with acromegaly who are already on a stable dose of somatostatin analogs will receive either ALXN2420 or placebo …

This phase 2 trial aimed to see if infliximab and intravenous immunoglobulin (IVIG) could help cancer patients with severe lung inflammation that didn't respond to steroids. Only one patient was enrolled before the study was terminated, so no meaningful results were obtained. The…

This study tests whether a single injection of Axolotl Ambient, a fluid rich in growth factors derived from human amniotic cells, can reduce pain and improve function in people with ankle osteoarthritis. Participants will be randomly assigned to receive either the investigational…

This trial explores whether adding counseling, cognitive behavioural therapy, or hypnotherapy to nicotine replacement therapy can help cancer patients quit smoking before their surgery. The study includes adults with breast, digestive, gynecologic cancer, or melanoma who smoke da…

This pilot study tests whether simvastatin (a cholesterol-lowering drug) and ursodeoxycholic acid (a bile acid medication), taken alone or together for six months, can improve markers of liver fibrosis in adults with advanced liver scarring after viral hepatitis has been controll…

This early-stage trial is testing an experimental oral drug called NXP800 in people with advanced solid tumors that have not responded to standard treatments. The study has two parts: first, to find the safest dose and schedule, and then to see if the drug shows promise in specif…

This study tested two drugs, encorafenib and binimetinib, given before surgery to people with stage IIIB-D melanoma that had spread to lymph nodes. The goal was to see if the drugs could shrink or eliminate the cancer before removal. The trial was stopped early after enrolling on…

This study is testing the long-term safety and effectiveness of a drug called briquilimab for people with chronic hives. It includes 67 participants who have already completed a previous trial with the same drug. The goal is to see if briquilimab remains safe and helps control hi…

This trial asks whether adding an oral statin to the usual steroid treatment can improve recovery from sudden sensorineural hearing loss, a condition where hearing drops rapidly in one ear. Adults diagnosed within 30 days of symptom onset will receive either a statin or a placebo…

This study tested whether adding hydroxychloroquine (a malaria drug) to standard targeted therapy (dabrafenib and trametinib) could help control advanced melanoma that had spread or could not be removed by surgery. It was designed for people with a specific gene mutation (BRAF V6…

This phase II trial tests two different chemotherapy combinations (treosulfan-based vs. clofarabine-based) given before a donor stem cell transplant in adults with myelodysplastic syndromes or acute myeloid leukemia. The goal is to see which regimen leads to better relapse-free s…

This phase 2 trial tests whether combining high-dose IL-2 with nivolumab can shrink tumors in people with advanced melanoma or kidney cancer that has progressed despite prior anti-PD-1 therapy. Participants receive nivolumab and high-dose IL-2 in repeated cycles, and researchers …

This phase 3 trial tests whether an inhaled combination of budesonide (a corticosteroid) and formoterol (a bronchodilator) can prevent acute respiratory failure in hospitalized adults with pneumonia and low blood oxygen levels. Participants receive either the active treatment or …

This phase 2 trial tests a personalized vaccine made from a patient's own immune cells fused with their tumor cells, given alongside GM-CSF injections and imiquimod cream. The goal is to see if this combination can trigger a stronger immune response against ovarian, fallopian tub…

This clinical trial is testing an investigational drug called bexotegrast (PLN-74809) in people with idiopathic pulmonary fibrosis (IPF), a disease that causes progressive lung scarring and breathing difficulties. The study will compare different doses of bexotegrast against a pl…

This study tests a remote, app-enabled exercise program designed for people aged 10 to 50 with congenital heart disease. Participants use a smartphone app with exercise modules and wearable devices to track heart rate and progress. The goal is to see if this approach can safely i…

This study tested whether two immunotherapy drugs, nivolumab and ipilimumab, could shrink tumors in people with advanced liver cancer that had already been treated with another drug combination. The trial enrolled 15 adults whose cancer had spread or could not be removed by surge…

This trial is testing an experimental oral drug, GSK1278863, in people on dialysis who have anemia due to chronic kidney disease and who don't respond well to standard erythropoietin (EPO) injections. The goal is to see if the drug can raise or maintain hemoglobin levels within a…

This study collects real-world data from people with PSMA-positive metastatic castration-resistant prostate cancer who receive PSMA radionuclide therapy. The goal is to track patient characteristics, treatment responses, and survival outcomes. By gathering this information, resea…

This early-stage study tested a new drug called BI 765049, alone or combined with another drug (ezabenlimab), in 21 Asian adults with advanced solid tumors (stomach, colorectal, pancreatic, liver, head and neck, or lung cancer) that have a specific marker called B7-H6. The main g…

This early-stage study tests a new oral drug, BBI-940, in people with advanced or metastatic breast cancer that has not responded to standard treatments. The drug works by breaking down a protein that helps cancer cells grow. The study aims to find the safest dose and check for s…

This study tested the drug alemtuzumab in children aged 10 to 18 with relapsing-remitting multiple sclerosis (MS) whose disease was still active despite other treatments. The goal was to see if the drug could reduce new brain lesions and improve quality of life. However, the tria…

This phase II pilot trial is asking whether combining the chemotherapy drug gemcitabine with the immunotherapy drug nivolumab can shrink tumors in people with advanced small cell lung cancer that has spread and no longer responds to initial treatment. The study enrolls about 14 a…

This phase 2 trial tests an injection called TQH2929, a lab-made antibody that blocks inflammation, in 36 adults having a sudden, severe flare of generalized pustular psoriasis (GPP). Half get the drug, half get a placebo. The main goal is to see if the drug clears pustules withi…

This study is testing whether fecal microbiota transplantation (FMT) can help children with functional gastrointestinal disorders (FGIDs) – chronic gut issues without a clear physical cause. Researchers will give 100 children either FMT or standard drugs and track changes in symp…

This pilot trial asks whether propranolol, a drug that blocks stress signals, can influence how prostate cancer cells survive or die. Men with prostate cancer scheduled for surgery will take propranolol before their operation. Researchers will then examine the removed prostate ti…

This study tested several immunotherapy-based drug combinations in 214 people with advanced stomach, gastroesophageal junction, or esophageal cancer that could not be removed by surgery or had spread. Participants received either standard chemotherapy or chemotherapy plus the imm…

This study tested several immunotherapy-based drug combinations in 272 people with advanced bladder cancer that had worsened after platinum chemotherapy. The goal was to see which combinations were safest and most effective at shrinking tumors or slowing the disease. Participants…

This trial is investigating whether adding an experimental drug called defactinib to standard chemotherapy (paclitaxel and carboplatin) can help treat ovarian cancer that has become resistant to platinum-based chemotherapy. The study includes people with recurrent ovarian, fallop…

This trial tests whether a medication called eptacog beta can safely prevent excessive bleeding in people with hemophilia A or B who have inhibitors and need major surgery. Participants receive the drug during and after their operation, and doctors measure how well bleeding is co…

This trial tests whether a short vocational advice program helps people on sick leave return to work sooner. Adults who have been off work for at least two weeks due to health issues receive support from a trained worker to identify barriers and plan their return. The study compa…

This trial tests whether adding an experimental immunotherapy called eftilagimod alpha to standard chemotherapy (paclitaxel) can help people with HER2-negative metastatic breast cancer live longer. The study first finds the best dose of eftilagimod alpha, then compares the combin…

This trial tests whether a 6-month telehealth program can reduce stroke risk factors, especially high blood pressure, in people already at elevated risk. Participants receive personalized remote care including blood pressure monitoring, wearable tracking, and virtual visits with …

This phase 3 trial tests whether metformin, a standard diabetes medication, can prevent or reverse metabolic syndrome in men with prostate cancer who are starting androgen deprivation therapy (ADT). Metabolic syndrome—a cluster of conditions like high blood sugar, high blood pres…

This early-stage trial is testing an experimental drug called ONO-7018 in people with relapsed or refractory Non-Hodgkin lymphoma. The drug works by blocking a protein called MALT1 that may help lymphoma cells grow. The study aims to see if the drug is safe and tolerable, and how…

This trial is testing whether combining an experimental IDO1 inhibitor (BMS-986205) with the immunotherapy drug nivolumab can shrink tumors or slow disease progression in people with advanced liver cancer that cannot be surgically removed. The study enrolls adults whose cancer ha…

This trial tests whether a single intravenous iron infusion can improve exercise capacity in people with heart failure and iron deficiency. Participants are randomly assigned to receive the infusion or no treatment, then undergo cardiopulmonary exercise testing to measure peak ox…

This phase 2 trial compares a new combination of camrelizumab (an immunotherapy) plus apatinib (a targeted therapy) against the standard chemotherapy plus bevacizumab as a first treatment for women with stage IVB, recurrent, or persistent cervical cancer. The study aims to see if…

This trial is testing whether combining two drugs—glumetinib and toripalimab—can help people with advanced non-small cell lung cancer that has not responded to or is no longer controlled by standard treatments. The study is enrolling adults whose cancer has a specific marker (PD-…

This pilot trial investigates whether potassium citrate can improve bone quality and strength in adults and children with chronic kidney disease. Participants take either potassium citrate or a placebo for six months, along with blood and urine tests and advanced bone scans. The …

This phase 2 trial is testing whether toripalimab, an immunotherapy drug, can shrink tumors in people with advanced stomach or gastroesophageal junction cancer that has worsened after at least two prior treatments. Participants receive toripalimab every three weeks. The main goal…

This trial offers continued treatment with poziotinib for people with non-small cell lung cancer or breast cancer who have already benefited from the drug in a previous study. The goal is to monitor safety and see how long the cancer remains controlled with extended use. Only pat…

This phase 2 trial tests whether a modified Chinese herbal formula, Shenling Baizhu San, can reduce swelling in the retina (macular edema) and improve vision. Adults diagnosed with macular edema take either the herbal granules or a placebo twice daily for 12 weeks. The study meas…

This study investigates whether a spinal cord stimulator (SCS) alters the sympathetic nervous system — the body's fight-or-flight response — in people with Complex Regional Pain Syndrome (CRPS). Ten adults with CRPS will have their nerve activity, heart rate, and blood pressure m…

People with chronic kidney disease (CKD) often have an overactive sympathetic nervous system, which raises their risk of heart problems and death. This phase 4 trial tests whether pioglitazone, a drug usually used for diabetes, can reduce that nerve overactivity and improve blood…

This trial tests whether a weekly IV antibiotic called oritavancin, given alongside medication for opioid use disorder, can help people finish treatment for serious infections like bloodstream or bone infections without needing to stay in a nursing facility. The study enrolls adu…

This trial tests the safety of a single intravenous dose of an experimental drug called NTS-104 tris in healthy adults aged 18 to 65. The drug is being developed as a potential treatment for acute ischemic stroke. Researchers will monitor participants for side effects and measure…

This trial is testing whether giving chemotherapy before the standard combination of chemo and radiation for rectal cancer could allow some patients to have a minor surgical procedure instead of a major one. The study enrolls adults with stage T2-T3 rectal cancer. The goal is to …

This trial tests whether an experimental drug called XNW5004, which blocks a protein that helps cancer grow, can boost the effects of the immunotherapy pembrolizumab (Keytruda) in people with advanced solid tumors that have stopped responding to standard treatments. The study inc…

This trial is testing an experimental drug called NUC-3373, a nucleotide analogue, in combination with standard cancer drugs for people with advanced solid tumors. The study has two parts: one combining NUC-3373 with pembrolizumab, and the other combining it with docetaxel. The g…

This early-stage trial is testing an experimental drug called CycloSam (153-Sm-DOTMP), a radioactive compound that delivers radiation directly to bone tumors when injected. The study aims to find the safest dose in people aged 15 to 75 with solid tumors that have spread to the bo…

This trial is testing whether a 'watchful waiting' approach after chemotherapy and radiation can safely avoid radical surgery in people with a certain type of rectal cancer. Participants receive chemotherapy (FOLFOX) followed by chemo-radiation, and those whose tumors completely …

This phase 2 trial is testing whether adding an oral chemotherapy drug (CC-486, a form of azacitidine) to the immunotherapy pembrolizumab can help people with advanced non-small cell lung cancer who have already received one round of platinum-based chemotherapy. About 100 partici…

This trial tests whether a small implanted device that electrically stimulates the lower esophageal sphincter can reduce acid reflux in people with GERD. Participants receive either active stimulation or a sham (inactive) device for six months, then all receive stimulation. The s…

This phase 2 trial is testing whether adding an experimental drug called evorpacept to two existing cancer drugs (cetuximab and pembrolizumab) can shrink tumors in people with a specific type of advanced colorectal cancer that has not responded to prior treatments. The study enro…

This phase II trial tests whether alectinib, a drug typically used for ALK-positive lung cancer, can shrink tumors or control disease in people with advanced non-small cell lung cancer that has a RET gene rearrangement and has progressed after prior treatment. Participants take a…

This phase 2 trial tests whether sintilimab, an immunotherapy drug, can help control angiosarcoma—a rare cancer of the blood vessels—that is advanced, has spread, or has returned. Participants receive sintilimab intravenously, and the study measures how many have no cancer growth…

This trial tests a combination of two drugs, elacestrant and onapristone, in people with a specific type of advanced or metastatic breast cancer that is fueled by the hormones estrogen and progesterone. The goal is to see if blocking both hormone signals at once is safe and can s…

This trial tests a gel called patidegib applied to the face twice daily for 9 months in people who develop many basal cell carcinomas (a common skin cancer) but do not have Gorlin syndrome. The goal is to see if the gel reduces the number of new skin cancers that would normally r…

This trial tests whether a new type of spectacle lens can slow the progression of myopia (nearsightedness) in children aged 8 to 13. Over 12 months, researchers measure changes in eye length and prescription, comparing results to a historical group that wore standard lenses. The …

This phase 2 trial tests an experimental drug called JS005 in Chinese adults with active non-radiographic axial spondyloarthritis, a form of inflammatory back pain that does not yet show damage on X-rays. Participants receive either a low, medium, or high dose of JS005 or a place…

This trial tests whether intravenous (IV) iron or oral iron pills work better for adults with congestive heart failure who also have low iron levels. Participants are randomly assigned to receive either a one-time IV infusion of ferric carboxymaltose (with a possible repeat dose)…

This study tests whether a short questionnaire can identify hospitalized patients who were incorrectly labeled as allergic to penicillin. Those deemed low-risk receive a supervised dose of amoxicillin to confirm they can tolerate it. If they do, the allergy label is removed from …

This study tests the safety and best dose of loncastuximab tesirine, a targeted antibody-drug conjugate, in people with relapsed or refractory diffuse large B-cell lymphoma or high-grade B-cell lymphoma who also have moderate or severe liver impairment. The goal is to find a dosi…

This phase 2 trial tests whether adding metformin — a common diabetes medication — to high-dose dexamethasone can improve outcomes for people with multiple myeloma that has returned or stopped responding to prior treatments. The study enrolls adults over 18 who have failed at lea…

This study investigates whether a 10-week behavioral intervention called JASPER can improve early communication skills and alter brain activity in toddlers and preschoolers with autism. Participants aged 18 to 59 months receive twice-weekly sessions focused on joint attention and…

This phase 2 trial tests an experimental drug called SAR302503 in people with myelofibrosis who have already been treated with ruxolitinib. The main goal is to see if the drug can shrink the spleen by at least 35% after six months of daily oral capsules. The study also tracks whe…

This pilot study tests whether a special PET scan tracer called 18F florbetapir can detect changes in amyloid protein deposits in the heart of people with AL cardiac amyloidosis who are receiving chemotherapy. Four participants will have a PET/CT scan before starting chemotherapy…

This phase 3 trial tests whether a fixed-dose combination inhaler containing tiotropium and salmeterol works better than either drug alone or placebo for people with chronic obstructive pulmonary disease (COPD). The study measures improvements in lung function, shortness of breat…

This study investigates whether adding the immunotherapy drug durvalumab to stereotactic body radiation therapy (SABR) improves outcomes for people with early-stage non-small cell lung cancer who cannot have surgery. Participants are randomly assigned to receive either SABR alone…

This study tests an experimental drug called ATG-031 in people with advanced solid tumors or B-cell non-Hodgkin lymphomas that have not responded to standard treatments. The main goals are to check the drug's safety and find the best dose. Participants receive ATG-031 by infusion…

This study tested whether a 14-day course of hydrochlorothiazide (a water pill) could prevent high blood pressure from returning after delivery in women with preeclampsia or gestational hypertension. Over 450 women were planned, but the trial was stopped early. The main goals wer…

This trial tests a new cell therapy called TC-510 for people with advanced cancers that have a protein called mesothelin on their surface, including mesothelioma, ovarian cancer, and pancreatic cancer. TC-510 uses a patient's own immune cells, which are genetically modified to be…

This phase 1 trial is testing whether a combination of two drugs (venetoclax and azacitidine) followed by donor immune cell infusions can prevent relapse in people with very high-risk acute myeloid leukemia (AML) who have already received a stem cell transplant. The study enrolls…

This trial tests whether a light-activated cream (Levulan Kerastick) followed by red light therapy can slow the growth of benign skin tumors called neurofibromas in people with neurofibromatosis type 1 (NF1). About 30 participants aged 14 and older with superficial tumors on the …

This study looks at genetic changes in postmenopausal women with a common type of advanced breast cancer (HR+ HER2-). Participants first receive ribociclib plus letrozole; those with a specific mutation (PIK3CA) may later switch to alpelisib plus fulvestrant. The goal is to track…

This trial tests a new therapy called CART123 for adults with acute myeloid leukemia (AML) that has not responded to standard treatments or has returned after treatment. The therapy uses a patient's own immune cells, which are modified in a lab to recognize and attack cancer cell…

This trial tests whether a telehealth-based family navigation program helps Black toddlers under age 4 start autism-specific intervention faster after diagnosis. Families in the program receive up to four virtual sessions with a trained navigator who helps them find and enroll in…

This early-stage trial tests a new drug, [177Lu]Lu-EVS459, that delivers radiation directly to cancer cells in people with advanced ovarian or lung cancers. The study aims to see if the treatment is safe and tolerable, and to get an early look at whether it can shrink tumors. Par…

This trial investigates whether adding a device that removes carbon dioxide from the blood (ECCO2R) to standard care improves survival in people with very severe flare-ups of chronic obstructive pulmonary disease (COPD). The study includes patients at high risk of needing a breat…

This trial investigates whether adding intravenous iron to standard oral iron supplements can help heal intestinal damage in people with celiac disease who have iron deficiency and gut atrophy. Participants receive either intravenous iron infusions plus oral iron, or oral iron al…

This phase 2 trial tests a new approach called UPPROACH for people with loco-regionally advanced endometrial cancer who have had surgery. The treatment combines intensity-modulated proton beam therapy (IMPT) with standard chemotherapy (carboplatin and paclitaxel) given at the sam…

This clinical trial investigates whether a 3-month combination of clofazimine and rifapentine can effectively treat drug-susceptible tuberculosis (TB) compared to the standard 6-month regimen. The study includes adults with pulmonary TB, some of whom also have HIV. Researchers ar…

This study observes children aged 3 to 18 with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas and are starting treatment with selumetinib. Researchers will track how well the drug shrinks or stabilizes tumors, how long patients stay on tre…

This trial tests whether adding a precise, internal radiation treatment (166Holmium microspheres) to standard immunotherapy (atezolizumab and bevacizumab) can shrink liver tumors that cannot be surgically removed. About 10 adults with unresectable hepatocellular carcinoma will re…

This phase 2 trial tests whether combining two drugs—erlotinib and everolimus—can slow the growth of advanced pancreatic cancer in patients who have already received at least one prior treatment. The study enrolls people with unresectable or metastatic pancreatic adenocarcinoma a…

This phase 3 trial tests whether ralinepag, an oral medication, can improve exercise capacity in people with pulmonary arterial hypertension (PAH) who have recently started PAH therapy. Participants take ralinepag or a placebo for 28 weeks, and their peak oxygen consumption durin…

This study tests whether a drug called amobarbital, injected into the ankle joint during fracture repair surgery, can prevent post-traumatic osteoarthritis. The trial involves 5 adults aged 18–60 with severe ankle fractures. The main goal is to check safety, but researchers will …

This early-phase trial tests whether a single dose of donor stem cells (OmniMSC-AMI) given directly into the heart arteries is safe for people who have just had a major heart attack. The study enrolls adults aged 20–80 with a specific type of heart attack (anterior STEMI) who are…

This early-phase trial tests a personalized cell therapy for people with metastatic pancreatic cancer. A patient's own T-cells are genetically modified to recognize and attack mesothelin, a protein found on many pancreatic cancer cells. Before receiving the modified cells, patien…

This trial investigates whether screening for gestational diabetes earlier in pregnancy (at 18-20 weeks instead of the usual 24-28 weeks) and providing prompt lifestyle advice and medication if needed can reduce complications such as large babies, C-sections, and high blood press…

This phase 3 trial compares two oral vitamin D therapies—Hectorol (doxercalciferol) and Rocaltrol (calcitriol)—in children aged 5 to 18 with chronic kidney disease stages 3 or 4 who have high parathyroid hormone levels but are not yet on dialysis. The main goal is to see if Hecto…

This study tests whether taking propranolol, a beta blocker, before and after surgery can reduce complications like delirium, kidney problems, and pain in people with post-traumatic stress disorder (PTSD). Participants are veterans scheduled for certain surgeries and will take th…

This trial investigates whether giving a combination of bevacizumab (a drug that blocks blood vessel growth to tumors) and chemotherapy before surgery can eliminate all signs of cancer in people with stage II or III rectal cancer. Participants receive the treatment before their p…

This trial investigates whether an oral medication called etrasimod can help people with moderate to severe Crohn's disease who have not responded well to other treatments. Participants take either etrasimod or a placebo daily for up to several years. The study measures improveme…

This study tests whether adding a three-drug combination (ixazomib, lenalidomide, and dexamethasone) to zoledronic acid after radiation therapy can prevent solitary plasmacytoma of bone from turning into multiple myeloma. Participants receive either the drug combo plus zoledronic…

This study investigates whether giving a repeat course of betamethasone, a steroid, to pregnant women with preterm premature rupture of membranes (PPROM) can improve health outcomes for their premature babies. The main goal is to see if it shortens the baby's stay in the neonatal…

This phase 2 study tests whether combining magrolimab and pembrolizumab can shrink or eliminate tumors in people with classic Hodgkin lymphoma that has come back or not responded to at least two prior treatments. Magrolimab targets a 'don't eat me' signal on cancer cells, while p…

This trial compares two approaches to antibiotic use after appendix removal surgery: a restrictive course (none or up to 24 hours) versus a liberal course (24 hours to 4 days). The goal is to see if the shorter course is just as safe and effective, while reducing side effects and…

This study tests whether a wearable bioimpedance wristband (like a fitness tracker) helps people with severe obesity and knee osteoarthritis improve their body composition—gaining muscle and losing fat—before joint replacement surgery. All participants receive coaching on body co…

This study tests an experimental drug called lebrikizumab in teenagers aged 12 to 17 whose asthma is not well controlled even with daily inhalers and a second medication. Participants receive either lebrikizumab or a placebo as a shot every 4 weeks for a year, while continuing th…

This phase 2 study tests whether an oral antiviral pill called obeldesivir can safely shorten RSV symptoms in adults who are not hospitalized but are at higher risk for severe disease (e.g., those aged 60+ or with chronic lung conditions). Participants take the pill or a placebo,…

This trial investigates whether combining two drugs, niraparib and dostarlimab, with a short course of radiation before surgery can help treat locally advanced rectal cancer. The study first finds a safe dose of niraparib, then checks how well the combination shrinks the tumor. P…

This phase 2 trial tests whether a low dose of radiation (12 Gy in 3 fractions) combined with one dose of the immunotherapy drug durvalumab can boost the immune system's attack on lung cancer cells before surgery. The study enrolls people with stage 2 or 3 non-small cell lung can…

This study tests whether adding peer-based counseling to standard HIV and opioid treatment helps people who inject drugs stay on their medications and achieve viral suppression. Participants receive either enhanced usual care or extra support from a peer counselor. The goal is to…

This early-phase trial tested a new therapy called CYNK-001, which uses natural killer cells from the placenta to fight COVID-19. It enrolled only 7 adults with moderate COVID-19. The study was terminated early, so we have limited information on safety and effectiveness.

This study tested a drug called deupirfenidone (LYT-100) in 185 adults who had breathing problems after a serious COVID-19 infection. Participants took either the drug or a placebo for several weeks to see if it improved their ability to walk. The trial was stopped early, so the …

This study tested brazikumab, an experimental biologic drug, in 89 adults with moderate-to-severe Crohn's disease. Participants received either brazikumab, a placebo, or an active comparator (Humira) to see if the drug could improve symptoms and heal the gut lining. The trial was…

This study looks at the long-term safety of brazikumab, a drug given as a shot every 4 weeks, for people with moderate to severe ulcerative colitis. Participants had already taken part in an earlier study of brazikumab. The goal is to see if the drug remains safe over a longer pe…

This phase 2 trial tested the immunotherapy drug nivolumab (Opdivo) given before and after a procedure called electroporation for people with advanced hepatocellular carcinoma (liver cancer) that could still be treated with curative intent. The study aimed to see if adding nivolu…

This study compared a device called Aquadex, which filters excess fluid from the blood, to standard IV diuretics in 167 hospitalized heart failure patients with fluid overload. The goal was to see which method better prevented heart failure events like rehospitalization. However,…

This early-stage trial tested a combination of two targeted drugs—tagraxofusp-erzs and gemtuzumab ozogamicin—in 7 patients with acute myeloid leukemia that had come back or not responded to treatment. The goal was to find a safe dose and see if the combination could control the d…

This phase 3 trial tested whether adding bevacizumab (Avastin) to standard chemotherapy (docetaxel and gemcitabine) helps people with advanced or recurrent uterine leiomyosarcoma. The study enrolled 107 participants but was terminated early. Researchers measured how long patients…

This study tested an intravenous antiplatelet drug called PRT060128 in 70 people having a severe heart attack (STEMI). The goal was to see if giving the drug before emergency artery-opening treatment improved blood flow and was safe. The trial was terminated early, so the full re…

This trial tests whether high-flow nasal cannula oxygen or noninvasive ventilation works better than standard oxygen therapy for ICU patients with acute respiratory failure. About 1,470 adults will be randomly assigned to one of the three methods. The main goal is to see which ap…

This trial investigates whether adding bevacizumab (Avastin) to standard first-line chemotherapy plus trastuzumab (Herceptin) helps people with HER2-positive metastatic breast cancer. Participants receive either bevacizumab or a placebo alongside their regular treatment. The main…

This phase 3 trial aimed to compare two drugs, ribociclib and palbociclib, in people with a specific type of advanced breast cancer (HR+/HER2- with HER2-enriched features). Participants received one of the drugs combined with hormone therapy. The goal was to see which combination…

This early-phase trial tested a two-step chemotherapy approach for people with a type of liver cancer (intrahepatic cholangiocarcinoma) that cannot be surgically removed. First, patients received a standard chemo mix (mFOLFIRINOX) through the veins. Then, they got a second chemo …

This study investigates whether a 5-day course of oral azithromycin can reduce wheezing severity in preschool children (18 months to under 5 years) who come to the emergency department with a severe wheezing episode. Children are randomly assigned to receive either azithromycin o…

This study tested an experimental drug called SAR442501 in children with achondroplasia, a common form of dwarfism. The goal was to see if the drug was safe and could improve growth. However, the trial was stopped early after enrolling only 16 children, so we have very little inf…

This phase 2 trial tested brazikumab in 242 adults with moderate-to-severe ulcerative colitis. Participants received either brazikumab or a placebo intravenously and then as injections over 54 weeks. The goal was to see if the drug could improve symptoms and heal the colon lining…

This early study tested a new device called the Cardiovalve Transfemoral Mitral Valve System in just one person with severe mitral regurgitation who was too high-risk for surgery. The device is inserted through a vein in the leg to replace the faulty mitral valve without open-hea…

This study tested whether a 6-month program of nurse-led phone calls could help women with uncontrolled high blood pressure take their medication as prescribed. The program included 7 phone calls to address barriers to medication adherence. Only 14 women enrolled before the study…

This phase 2 trial investigates whether polyethylene glycol (a laxative) can reduce intestinal inflammation in children with cystic fibrosis. The study includes children aged 4 to 17 with cystic fibrosis and pancreatic insufficiency who have elevated fecal calprotectin (a marker …

This study tested whether a robotic exoskeleton could help children aged 6 to 12 with severe cerebral palsy improve their walking and motor skills. Participants used the robot for 45-minute sessions three times a week over six months. The trial aimed to measure changes in movemen…

This study tests an oral drug called AK0529 (Ziresovir) in adults aged 18 to 75 with respiratory syncytial virus (RSV) infection. Participants receive either the drug or a placebo, and researchers measure how well symptoms improve and track any side effects. The goal is to see if…

This study looks at people with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who are in deep remission. It compares two methods for gradually increasing the time between infliximab infusions: one based on symptoms and one based on drug levels in the blood. T…

This study tested whether adding timolol gel to pulsed dye laser treatment could improve results for port wine stains on children's faces. Twenty-five children aged 6 months to 18 years were enrolled, but the study was stopped early. The goal was to see if the combination led to …

This study looked at whether giving pregnant people oral antibiotics at home could delay delivery after their water broke very early (between 18 and 23 weeks). The goal was to see if more people would stay pregnant for at least 28 days after the water broke. The study was stopped…

This trial tests a special pacemaker called the Moderato System in people who need a pacemaker and have high blood pressure that is hard to control with medication. The device is implanted like a regular pacemaker and may help lower blood pressure by adjusting the heart's pacing.…

This study tested a new drug, CRLX101, combined with standard chemotherapy (paclitaxel) in 30 women with ovarian cancer that came back or didn't go away. The goal was to find the safest dose and see if the combination helped shrink tumors. The trial was terminated early, so resul…

This phase 2 trial investigates whether a personalized course of peginterferon alfa-2a can control membranous nephropathy, an autoimmune kidney disease. The treatment targets the Th17 inflammatory pathway, which is linked to a higher risk of relapse. Participants receive injectio…

This was an early-phase study testing a new drug called XMT-2056 in people with advanced solid tumors that have a protein called HER2. The trial aimed to find a safe dose and check for side effects. It was terminated early, so the full results are not available.

This early-stage study tested the safety and best dose of combining the drugs RAD001 and docetaxel in 15 people with metastatic breast cancer. The goal was to find a dose that is tolerable while potentially controlling the disease. The study was terminated early, so results are l…

This study tested whether an extra dose of bezlotoxumab, a drug that blocks the harmful toxin made by C. diff bacteria, could help very sick patients recover after emergency colon surgery. Only 5 people took part before the study was stopped early. The goal was to see if the drug…

This Phase 3 trial tests whether tezepelumab, an injectable biologic, can help adults with severe asthma reduce their daily dose of oral corticosteroids while still keeping their asthma under control. Participants receive either tezepelumab or a placebo for 28 weeks, and doctors …

This study looked at whether using antibiotic ear drops during and after ear tube surgery reduces the chance of tube blockage or ear drainage in children. Only 9 children took part, and each child received drops in one ear but not the other. The study was stopped early, so the fi…

This study tested a special bone graft material (MatriBONE mixed with the patient's own bone marrow) for spinal fusion surgery in people with painful degenerative back problems. The goal was to see how well the bones fused together after 12 months. However, the trial was stopped …

This trial tests a special pacemaker-like device, the Moderato System, designed to lower blood pressure in people who have resistant hypertension and already need a dual-chamber pacemaker. Participants are randomly assigned to have the device's blood-pressure-lowering feature tur…

This early-stage trial tested a two-step radioimmunotherapy combining GD2-SADA and 177Lu-DOTA in patients with recurrent or metastatic solid tumors, including small cell lung cancer, high-risk neuroblastoma, sarcoma, and melanoma. The goal was to assess safety and find the right …

This study looked at whether people with type 2 diabetes should continue taking their usual metformin medication while hospitalized. The goal was to see if it helped control blood sugar, caused stomach issues, or affected how long patients stayed. Only 22 people took part before …

This study tested a low dose of the drug bevacizumab (Avastin) against standard laser treatment for retinopathy of prematurity, an eye disease that can blind premature infants. Sixteen babies with severe disease were enrolled. The goal was to see if the drug could control the dis…

This early-stage study tested a new type of cell therapy called LUCAR-B68 in 8 adults with multiple myeloma that had come back or stopped responding to treatment. The therapy targets a protein called BCMA on cancer cells and is designed to be used without needing to match the pat…

This study aimed to see if liver transplantation is possible and safe for people infected with both HIV and hepatitis C. Fifteen patients were enrolled to track survival, virus behavior, and drug interactions after transplant. The goal was to understand how these two viruses inte…

This study tested an oral medication, NX-13, in 81 adults with moderate to severe ulcerative colitis. Participants received either NX-13 or a placebo for 12 weeks, with a long-term follow-up option. The trial was terminated early, so the full results are not available, but the da…

This study tested whether using a Freestyle Libre 2 continuous glucose monitor for 28 days, along with standard therapeutic education, helps people recently diagnosed with type 2 diabetes improve their blood sugar control. The trial enrolled 27 adults diagnosed within the past ye…

This study compared two surgical repairs for pelvic organ prolapse (when organs like the bladder or uterus drop into the vagina). One method uses a robot to place mesh inside the abdomen; the other uses stitches through the vagina to tighten natural ligaments. The trial enrolled …

This study tests an automated insulin delivery system for adults with type 1 diabetes. The system uses a smartphone connected to a continuous glucose monitor and insulin pump to help keep blood sugar levels in a healthy range, especially overnight. Ten participants compare the au…

This study looked at whether treating the dental cause of chronic maxillary sinusitis with dental procedures and medication could resolve symptoms. Only 16 patients were enrolled before the study was terminated. The main goal was to see if symptoms disappeared and pus cleared fro…

This trial tests whether performing balloon aortic valvuloplasty without the blood thinner heparin reduces serious bleeding and blood vessel complications. About 94 adults with severe, symptomatic aortic stenosis will be randomly assigned to receive either heparin or a placebo du…

This study tested a drug called poziotinib in 648 people with advanced non-small cell lung cancer that has specific genetic changes (EGFR or HER2 exon 20 mutations). The goal was to see if the drug could shrink tumors. The study was stopped early, but results showed some patients…

This study tests whether injections of cells from donated human placentas can help heal foot ulcers in people with diabetes. The trial includes patients with and without peripheral artery disease, a common complication that slows healing. Participants receive either the cell trea…

This study tested two different proton therapy schedules for people with large choroidal melanomas (eye cancer) that would normally require removal of the eye. The goal was to see if a gentler radiation schedule could control the tumor and avoid severe side effects, allowing pati…

This study tested whether a synthetic gum graft (Mucogain matrix) could be a good alternative to the standard connective tissue graft for treating receding gums. The goal was to see if the synthetic option covers the exposed tooth root just as well, but with less pain and fewer c…

This study tests whether using a special tube (EZ-Blocker) to collapse one lung during heart bypass surgery can reduce fluid buildup and the need for chest drains. The trial includes adults having planned coronary artery bypass surgery that uses the internal thoracic artery. The …

This study tested an oral drug called epetraborole for people with a tough-to-treat lung infection called MAC lung disease. The trial aimed to see if adding epetraborole to standard treatment could improve symptoms and clear the infection. However, the study was terminated early,…

This study tested whether the drug surufatinib could help prevent pancreatic neuroendocrine tumors from coming back after surgery. The trial was planned for many participants but was stopped early with only 6 people enrolled. Because it ended early, we don't have clear answers on…

This phase 2 trial tested a combination of two drugs, venetoclax and rituximab, as a first treatment for people over 60 with mantle cell lymphoma. The goal was to see if this chemo-free approach could shrink or control the cancer. However, the study was stopped early after enroll…

This study tests whether an additional dose of a COVID-19 vaccine can improve immune protection in adults and children with autoimmune diseases like rheumatoid arthritis, lupus, multiple sclerosis, and others who are taking immunosuppressive medications. Participants who had a we…

This phase 2 trial tested a combination of two drugs—NT-I7 and atezolizumab—in people with advanced non-small cell lung cancer that had not been treated before. The goal was to see if the combo could shrink tumors. However, the study was stopped early and only enrolled 33 out of …

This study tested whether repeatedly inflating and deflating a blood pressure cuff on the arm (remote ischemic conditioning) could improve recovery in 458 people who had a severe stroke caused by a blocked artery in the brain. The goal was to see if this simple, non-drug treatmen…

This study tested an experimental drug called APX-115 in hospitalized patients with mild to moderate COVID-19. The goal was to see if it was safe and could help people recover faster. However, the trial was stopped early and only 16 people took part, so we don't have enough infor…

This study tested whether a daily tablet called MEMOPTIC (containing citicoline, magnesium, and Ginkgo biloba) could help preserve vision in people with open-angle glaucoma when added to their usual eye-pressure-lowering treatments. The trial planned to follow 15 patients for two…

This study tested whether applying 0.25% timolol gel (a beta-blocker eye drop used for glaucoma) to skin grafts could improve healing and appearance after skin cancer surgery. Researchers planned to enroll 82 patients but stopped early with only 10 participants. The goal was to s…

This study tested a drug called selinexor in 17 people with a rare bone marrow cancer (myelofibrosis) that did not respond to or could not tolerate standard JAK inhibitor treatments. The main goal was to see if the drug could shrink an enlarged spleen by at least 35%. The trial w…

This pilot study tested a new drug called sEphB4-HSA combined with standard chemotherapy (azacitidine or decitabine) in 7 patients with myelodysplastic syndrome, chronic myelomonocytic leukemia, or acute myeloid leukemia that had returned or not responded to prior treatment. The …

This phase 3 trial tests whether adding the chemotherapy drug carboplatin to standard palliative radiotherapy helps control tumor growth and reduce pain better than radiotherapy alone. The study includes adults with advanced lung or head and neck cancer who need palliative radiat…

This study compared two HIV treatment approaches in people who had never taken HIV drugs before. One group started with a three-drug combo for 16 weeks, then switched to a two-drug combo. The other group took a two-drug combo from the start. The goal was to see if the first appro…

This Phase 2 trial tested a two-step treatment for patients with relapsed or refractory B-cell non-Hodgkin's lymphoma. First, patients received a stem cell transplant using their own cells, followed by an infusion of CAR-T cells (a type of immune cell therapy). The goal was to se…

This early-stage study tested a new drug called PF-07265807 in people with advanced or metastatic solid tumors that had spread. The main goals were to find a safe dose and check for side effects. The trial was terminated early, so results are limited.

This phase II trial tested the drug everolimus in 11 people with classic or endemic Kaposi's sarcoma, a rare skin cancer linked to a virus. The goal was to see if the drug could shrink tumors after 6 months. The study was terminated early, so the full results are not available.

This study tested whether combining weight management (diet and exercise guidance) with a daily hormone pill (megestrol acetate) could help obese patients with early-stage endometrial cancer who want to preserve their fertility. The goal was to see if the cancer would completely …

This study tested whether adding a HER2-targeting vaccine (VRP-HER2) to the immunotherapy drug pembrolizumab could boost the immune system's attack on advanced HER2-positive breast cancer. Eight participants were randomly assigned to receive the vaccine alone, pembrolizumab alone…

This study tested a new drug (INCB099280) combined with a standard cancer drug (axitinib) in adults with advanced solid tumors that had stopped responding to other treatments. The main goals were to check safety and see if the combination could shrink tumors. The trial was termin…

This phase 2 trial tested whether the immunotherapy drug atezolizumab could shrink head and neck skin cancers that had spread to lymph nodes before surgery. Only 1 person enrolled before the study was terminated early. The goal was to see if the drug could eliminate all cancer ce…

This early-stage study tested a new drug called PF-07284892, alone or with other medicines, in people with advanced solid tumors that had specific genetic changes. The goal was to find the safest dose and check for side effects. The study was stopped early, so results are limited…

This study tested whether giving the heart medication metoprolol through a vein could help people with severe lung failure (ARDS) in the ICU. The goal was to see if it helped them breathe without a machine for more days. However, the trial was stopped early and only 14 people too…

This study tested a medicine called ADV7103 in children and adults with distal renal tubular acidosis (dRTA), a rare kidney condition that causes too much acid in the blood. The goal was to see if ADV7103 could prevent dangerous acid buildup better than a placebo. Only 3 people e…

This study aimed to see if combining surgical and catheter ablation (hybrid therapy) works better than standard catheter ablation alone for people with persistent atrial fibrillation. The trial was terminated after enrolling only 7 participants, so no meaningful conclusions can b…

This early-stage trial tested a new gene therapy called quaratusugene ozeplasmid (Reqorsa) combined with the immunotherapy pembrolizumab (Keytruda) in people with advanced non-small cell lung cancer who had already received treatment. The goal was to see if the combination was sa…

This study looked at two ways to manage older patients (80+) who had a mild type of heart attack (NSTEMI). One group got routine angiography (an invasive look at the heart's arteries), while the other group first had a non-invasive imaging test (SPECT or stress echo) and only got…

This study tested two drugs, niraparib and bevacizumab, alone or together, in people with recurrent endometrial or ovarian cancer that has a specific gene change called ARID1A. The goal was to see if the drugs could shrink tumors. However, the trial was stopped early after enroll…

This study tested whether adding aspirin or ibuprofen to standard tuberculosis (TB) treatment helps patients recover more quickly. It included 426 adults with drug-sensitive or drug-resistant TB. The trial was terminated early, so the results are not conclusive.

This trial tested a light-activated drug called PD L 506 (5-aminolevulinic acid) in 17 adults with a type of aggressive brain tumor called glioblastoma that could not be fully removed by surgery. The drug is given by mouth and then activated by a laser inserted into the brain to …

This study tested an experimental drug called MYK-224 in 18 adults with a type of heart disease that makes the heart muscle too thick and blocks blood flow. The goal was to see if the drug is safe and helps reduce symptoms. The trial was stopped early, so results are limited.

This early-phase trial tested whether adding the targeted drug ivosidenib to standard FLAG chemotherapy could help people with a specific genetic form of acute myeloid leukemia (IDH1-mutant AML). The study aimed to find the best dose and check for side effects in patients whose c…

This early-stage study tested a new drug called ONO-7018 in 9 adults with non-Hodgkin lymphoma or chronic lymphocytic leukemia that had returned or stopped responding to other treatments. The main goal was to find a safe dose and check for side effects. The study was stopped earl…

This phase 3 trial tested whether adding asciminib to the standard drug imatinib could help people with chronic myeloid leukemia (CML) achieve a deep remission and safely stop all medication. Only 8 patients were enrolled before the study was terminated early, making it too small…

This pilot study tested the drug deucravacitinib against a placebo in people with moderate-to-severe hidradenitis suppurativa, a chronic skin condition causing painful lumps. Only 7 people enrolled before the study was stopped early. The goal was to see if the drug could reduce i…

This study tested an early speech therapy program for children born very prematurely or with severe growth restriction. The program involved 10 to 20 sessions with a trained speech therapist from 6 to 24 months of age. The goal was to see if it could reduce language and communica…

This early-stage study tested a new drug called SAR445514, which helps the body's natural killer (NK) cells attack cancer cells in people with multiple myeloma or light-chain amyloidosis that had returned or stopped responding to other treatments. The study was terminated early, …

This study tested a reduced-intensity bone marrow transplant, or 'mini transplant,' for people with blood cancers like lymphoma and leukemia. The transplant used marrow from a relative and was combined with chemotherapy drugs to help the donor cells take hold. Only 15 people took…

This study tested whether injections of MYOBLOC (botulinum toxin type B) can safely reduce muscle tightness in the arm and hand of adults with spasticity caused by stroke, brain injury, multiple sclerosis, or other conditions. The trial planned to enroll about 300 participants bu…

This trial tests whether a special imaging scan using a small amount of radioactive iodine (iodine-123) can tell the difference between benign and cancerous thyroid nodules before surgery. Currently, biopsy alone can't always make that call, so many people undergo surgery just to…

This study looks at whether a special ECG and a blood test can find early signs of heart weakness in adult cancer survivors who had certain chemotherapy. Researchers will check how well these tests work compared to standard heart imaging. The goal is to gather information needed …

This study explores whether chemicals in a person's breath, called volatile organic compounds, can serve as early warning signs of pleural mesothelioma in people who have been exposed to asbestos. Researchers will also check if a blood marker, SMRP, adds to the breath test's accu…

This study tests whether a new tool, the VISIODOL® scale, can help people with visual impairment communicate pain. Researchers will compare pain ratings from this scale with those from a standard numerical scale during heat-induced pain. The study includes healthy volunteers with…

This study tests whether a blood test called TruGraf can help doctors fine-tune immunosuppression medications in liver transplant recipients with autoimmune liver diseases like autoimmune hepatitis, primary sclerosing cholangitis, or primary biliary cirrhosis. The test measures g…

This study tests whether a 10-minute video of a sleeping child, recorded by parents on a smartphone, can help identify obstructive sleep apnea. The video analysis will be compared with standard sleep monitoring and a clinical questionnaire in children aged 3 to 10 who snore. If t…

This study tests two AI models that analyze endoscopy and CT images to diagnose esophageal cancer and predict how deep the tumor has grown. The goal is to help doctors decide if a patient can be treated with a less invasive endoscopic procedure or needs more aggressive therapy. T…

This study tests whether a portable goggle system that tracks eye movements can help diagnose mild traumatic brain injury (mTBI). The goggles measure how well the eyes work together when following a specific pattern of visual cues. Researchers will compare results from people wit…

This study tests a new digital tool that uses information already in a child's electronic health records to estimate their risk of developing asthma. The tool is designed for pediatricians to use during checkups for preschool-aged children, where asthma is often missed. Researche…

This study tests a new type of MRI scan that uses a special contrast agent called hyperpolarized pyruvate to see how prostate cells use energy. The goal is to safely distinguish cancerous from normal tissue in men with suspected or known prostate cancer. Participants receive the …

This study tests whether an artificial intelligence program called NeoRetina can accurately detect diabetic retinopathy and diabetic macular edema from simple eye photographs. Researchers will compare the AI's analysis to standard exams by eye doctors. The goal is to see if this …

This study tests a new blood test called EPIDROP that looks for live circulating tumor cells in men with metastatic prostate cancer. The test uses a special technique to isolate single cells and measure their activity. Researchers want to see if EPIDROP is as good as or better th…

This trial investigates whether a new, ultra-high-frequency ultrasound device can accurately measure the depth of skin melanomas before surgery. Currently, doctors must remove the tumor, measure its depth under a microscope, and then often perform a second surgery to remove more …

This study looked at whether measuring oxygen levels in the brain and gut using a light-based device (NIRS) could help doctors diagnose necrotizing enterocolitis (NEC) earlier in newborns with symptoms like bloody stool or a swollen belly. The study planned to include 45 newborns…

This study tested a new way to guide prostate biopsies by combining three imaging methods: a PET scan using a special tracer (fluorocholine), multiparametric MRI, and 3D ultrasound. The goal was to see if this triple approach could more accurately target suspicious areas in the p…

This study tests whether a tear sample can diagnose primary progressive multiple sclerosis (MS) as accurately as a spinal tap. Currently, doctors need to collect spinal fluid to confirm this type of MS, which is invasive and uncomfortable. Researchers will compare proteins in tea…

This study tests new methods to measure pressure, blood flow, and blockage size in heart arteries. Researchers want to see if these measurements can better identify which blockages are serious enough to cause heart damage. The study involves people with known or suspected coronar…

This study tested whether a cone beam CT scan, done right after a stroke procedure called thrombectomy, could tell the difference between a brain hemorrhage and harmless contrast dye buildup. Only 5 adults were enrolled before the study was stopped early. The goal was to see if t…

This study tested a special PET/CT scan using a radioactive tracer called FES to see estrogen receptor activity in women with advanced, hormone-resistant breast cancer. The goal was to see if the scan could predict how well a new hormone therapy would work. Only 6 people were enr…

This study looked at whether taking fewer systematic biopsy cores (6 instead of 20) during an MRI-targeted prostate biopsy could still detect dangerous prostate cancers while reducing risks like infection and overdiagnosis. The trial involved 126 men with suspicious MRI results. …

This study tested whether offering a home urine test for human papillomavirus (HPV) could encourage more women to get screened for cervical cancer. The trial targeted women aged 30–65 in Brittany, France, who had not responded to an initial invitation for a Pap smear. Participant…

This early-phase trial tested a radioactive imaging agent called 68GaNOTA-Anti-MMR-VHH2 to see if it could safely highlight tumors on PET scans. It involved 13 adults with advanced solid tumors, breast cancer, or melanoma. The study was terminated early, so we have limited inform…

This study tested whether a virtual reality headset combined with machine learning can measure pupil reactions more reliably than the standard flashlight test for Relative Afferent Pupillary Defect (RAPD). About 71 adults with and without known RAPD took part. Researchers compare…

This study tested a special radioactive tracer (68GaNOTA-Anti-HER2 VHH1) to see if it can find HER2-positive brain metastases on PET/CT scans. Seven adult cancer patients with at least one brain lesion were enrolled. The goal was to compare tracer uptake in HER2-positive versus H…

This Phase II study tested a radioactive tracer called 68GaNOTA-Anti-MMR-VHH2 to see if it can light up certain immune cells (macrophages) on PET scans. The trial included 29 people with head and neck cancer, lymphoma, atherosclerosis, or sarcoidosis. The goal was to see if the t…

This study looked at whether chest ultrasound could be as good as chest X-ray for finding lung complications in infants under 2 years old with bronchiolitis. Only 19 babies were enrolled before the study was stopped early. The goal was to see if ultrasound, which uses no radiatio…

This study looked at whether analyzing sputum (phlegm) with automated cytometry, combined with low-dose CT scans and blood tests, could better detect lung cancer in workers heavily exposed to asbestos. The goal was to reduce false positives and improve early diagnosis. The trial …

This trial tests whether sodium valproate, a drug used for epilepsy, can reduce damage to the heart and kidneys in adults undergoing heart surgery with a heart-lung machine. Participants receive the drug for one to six weeks before their operation, and researchers measure organ i…

This trial tests whether giving a low dose of the hormone ACTH to infants with early warning signs on their brain wave test (EEG) can prevent West syndrome, a severe form of epilepsy. Infants between 2 and 12 months old who show a specific pre-seizure brain pattern are treated wi…

This trial tests whether applying a microbial sealant called Integuseal to the skin before leg bypass surgery can reduce postoperative wound infections. About 450 people scheduled for lower-limb arterial bypass procedures will be randomly assigned to receive the sealant or standa…

This trial tests whether giving mothers a DHA-rich omega-3 supplement after delivering very preterm (before 29 weeks) could improve their babies' chances of surviving without bronchopulmonary dysplasia, a chronic lung condition. Half the mothers receive DHA capsules, and half rec…

This trial tests whether a single low dose of droperidol, given just before the end of surgery, can prevent postoperative delirium—a state of confusion and disorientation—in adults aged 65 and older undergoing non-cardiac surgery. About 800 participants will receive either droper…

This trial tests whether giving older adults a high dose of vitamin D before their flu shot can strengthen their immune response. Participants are 65 or older with low vitamin D levels. The study measures changes in infection-fighting proteins and antibody levels after vaccinatio…

This study looked at women with pelvic organ prolapse who also had hidden (occult) stress urinary incontinence — leakage that doesn't show up on standard tests. The goal was to see if placing a TOT sling during prolapse surgery could prevent incontinence from appearing later. The…

This study tests whether a headband with special semiconductors can help with memory and thinking problems (often called 'chemo brain') in people who have had breast or gynecologic cancer. About 50 participants will wear either the active headband or a placebo version for 18 hour…

This study tested whether the sleep medication suvorexant (20 mg) could help breast cancer survivors who have trouble sleeping. Participants were postmenopausal women taking hormone-blocking drugs. The study was stopped early after enrolling only 5 people, so results are limited.

This phase II trial tests whether three low-dose ketamine infusions, given over consecutive days, can reduce depressive symptoms in patients who have been in the intensive care unit (ICU) for at least a week and show signs of clinical depression. Participants receive either ketam…

This study tested a fast-dissolving film (BXCL501) placed under the tongue to quickly reduce severe agitation in older adults with dementia. The trial aimed to enroll many participants but was stopped early after only 5 people joined. Because it ended so soon, we cannot draw reli…

This study tested a program called PRIME for older women with chronic pain and depression who also have physical disabilities. Nine women took part in nurse-led goal-setting visits and group therapy sessions focused on acceptance and commitment. The goal was to see if this combin…

This study tests whether a breathing-based meditation practice called SKY can reduce symptoms of depression and anxiety in adolescents aged 16 to 24. Participants with mild-to-moderate depression will practice the breathing techniques for 8 weeks, while researchers track mood, st…

This study tested whether a 4-month exercise program done at home could help Hispanic/Latino adults with multiple sclerosis (MS) improve their physical function, manage symptoms, and feel better overall. Participants worked with coaches via video calls and compared results to a c…

This study is testing whether giving women with early-stage breast cancer two easy-to-read booklets can help lower their anxiety after diagnosis. The booklets explain the disease and treatments in a gentle, clear way. About 60 women will take part, and researchers will measure ho…

This study tests whether a wearable device that sends tiny electrical pulses to the ear — a method called transcutaneous auricular neurostimulation (tAN) — can help people going through alcohol withdrawal. The device targets the vagus and trigeminal nerves, which may influence wi…

This study tested a drug called solriamfetol to see if it could safely help people with brain tumors (gliomas) feel more awake, think clearer, and have a better quality of life. Only 2 people enrolled before the study was stopped early. The main goal was to check for serious side…

This trial tests whether OCS-01, a dexamethasone eye drop, can reduce inflammation and pain after cataract surgery. About 117 adults scheduled for cataract removal will receive either the active drop or a placebo once daily. The study measures how well the drop clears eye inflamm…

This trial tests whether a combination of virtual reality and psychotherapy can help people undergoing colonoscopy without sedation feel less anxious and experience less pain. Participants will be randomly assigned to receive the VR-enhanced psychotherapy, a sham VR distraction, …

This study tests whether placebo pills taken knowingly — called open-label placebo — can reduce depression symptoms in unmedicated teens aged 13–18 with mild to moderate depression. Participants take placebo pills for two weeks while researchers use brain scans to see if the trea…

This phase 2 trial tests whether nabilone, a synthetic cannabinoid, can reduce agitation in people with frontotemporal dementia (FTD). Participants receive both nabilone and a placebo in random order to compare effects. The study includes adults with behavioral variant FTD or pri…

This pilot study tests whether a short-term group therapy called Emotional Awareness and Expression Therapy (EAET) can help people with persistent physical symptoms like pain or fatigue that have no clear medical cause. The therapy focuses on helping participants identify and exp…

This study tests whether a mindful walking program can help people with knee osteoarthritis walk better and more often. Participants are randomly assigned to either a mindful walking group or a self-care education group, both meeting over 11 sessions in 6 months. The study focuse…

This study tests whether virtual reality (VR) can help young adults with public speaking anxiety. Participants receive either one or three sessions of VR exposure therapy, followed by a 4-week online program. The goal is to see if a single VR session works as well as multiple ses…

This trial compares two types of stomach bypass surgery for people whose stomach is blocked by cancer. The goal is to see which surgery allows patients to eat solid food better within the first 30 days. Participants are randomly assigned to one of the two procedures, and their st…

This trial tests whether adding lidocaine ear drops to standard painkillers provides better ear pain relief for children aged 1–6 with acute otitis media. Half the children receive the ear drops plus usual care (oral painkillers, with or without antibiotics), while the other half…

This study compared a new, minimally invasive ultrasound-guided procedure to standard surgery for carpal tunnel syndrome. The goal was to see if the new technique could provide similar relief with a smaller incision and faster recovery. Only 7 people were enrolled before the stud…

This pilot trial investigates whether low-dose naltrexone (LDN) can reduce pain and urinary symptoms in people with bladder pain syndrome or interstitial cystitis. Participants receive either LDN or a placebo nightly for 8 weeks. The study measures pain scores, urinary frequency,…

This study tests whether a massage percussion device can help people pass tiny kidney stone fragments left behind after a common stone-removal surgery. After surgery, small fragments often remain in the kidney and may not pass on their own, sometimes requiring another procedure. …

This study investigates whether osteopathic manipulative treatment (OMT) — a form of hands-on manual therapy — can reduce symptoms like heartburn and regurgitation in people with gastro-oesophageal reflux disease (GERD). The trial includes 26 adults who have had symptoms for at l…

This study tests a new sedative called remimazolam for people in the ICU who need a breathing tube after oral or facial surgery. It compares remimazolam to two standard sedatives, propofol and midazolam, to see if it works just as well and helps patients wake up faster. The trial…

This trial investigates whether removing the chest tube during thoracoscopic lung surgery, instead of leaving it in place afterward, leads to less pain and faster recovery. Participants undergoing elective wedge resection are randomly assigned to have the tube removed during surg…

This study looked at whether blowing a fan with aromatherapy on the face can help reduce breathlessness in people with terminal illness. The trial planned to enroll 26 adults who were near the end of life and had trouble breathing. Participants were randomly assigned to receive a…

This study tested whether osteopathic care (hands-on manipulation) can help reduce pain in people with fibromyalgia. 32 participants received osteopathic treatments over 8 months, with a follow-up 3 months later. The goal was to see if this approach could improve pain and quality…

This study compares two treatments for transformed migraine (chronic daily headache): a sphenopalatine ganglion nerve block using lidocaine gel applied inside the nose, versus daily oral amitriptyline (Elavil), an antidepressant often used for migraine prevention. Ten adults aged…

This study tested whether a non-invasive brain stimulation technique called TMS could help reduce negative symptoms of schizophrenia, like low motivation and reduced facial expression. The trial enrolled 47 adults with schizophrenia or schizoaffective disorder and compared active…

This study looked at whether practicing walking while doing other tasks (multitasking) helps people recovering from a stroke walk faster than just walking practice alone. It included 26 adults who had a stroke within the past 6 months and had trouble walking. The trial was stoppe…

This study compared a newer, less invasive procedure called balloon sinuplasty to standard surgery for people with frontal sinusitis that did not improve with medication. The balloon procedure uses a small catheter to open blocked sinus passages, aiming to reduce pain, bleeding, …

This study tested whether injecting botulinum toxin A (Dysport) into the groin muscles could relieve chronic pain from adductor tendinopathy (pubalgia) in people who didn't get better with rest, anti-inflammatories, or physical therapy. Only 4 participants were enrolled before th…

This study investigates whether giving patients personalized, secure access to a web platform with an explanatory video about their upcoming breast cancer surgery can lower their anxiety. Participants are women with breast cancer scheduled for lumpectomy, oncoplasty, or mastectom…

This study tested a nasal spray containing a strong painkiller (sufentanil) for adults with sickle cell disease experiencing a painful crisis. The goal was to see if it could provide faster relief than the standard gas mixture (EMONO) before giving morphine through an IV. The tri…

This study tests whether the drug pregabalin, alone or with a rehabilitation program, can reduce chronic fatigue in people with post-COVID syndrome. Participants are adults aged 18 to 65 who had COVID-19 at least six months ago and still feel very tired. The trial compares four g…

This study tested whether taking a low dose of the antibiotic metronidazole for 14 days after endometriosis surgery could lower pain. It included 78 women aged 18-50 scheduled for surgery. The trial was terminated early, so the results are not conclusive.

This study tested whether a digital platform (m-Rehab) could help people with ALS who use non-invasive ventilation. The platform included educational content, remote monitoring, and video consultations. The goal was to see if it could slow the loss of physical function and improv…

This study tested a short course of targeted radiation (IMRT) given over one week before surgery for rectal cancer. The goal was to see if this approach could reduce side effects like bowel problems and improve quality of life compared to standard longer treatments. Only 2 people…

This study tested whether adding pregabalin (Lyrica) to standard treatment could reduce pain and improve function in people with complex regional pain syndrome (CRPS) of the upper limb. Only 14 adults were enrolled before the trial was stopped early. The goal was to see if the dr…

This study tested whether a motorized orthosis (Innowalk) that mimics walking is better tolerated by children with cerebral palsy than standard standing devices. The trial included 25 children aged 6-16 who had never walked. Researchers measured pain, muscle stiffness, and joint …

This study tested whether N-acetylcysteine (NAC), an antioxidant, could help reduce impulse control disorders caused by Parkinson's medications. Only 14 people with mild-to-moderate symptoms were enrolled before the trial was stopped early. The goal was to see if 10 weeks of NAC …

This study tested whether smelling lavender essential oil before and during an office hysteroscopy (a procedure to look inside the uterus) could lower women's anxiety and pain. Twenty-two women were randomly assigned to inhale either lavender oil or distilled water (placebo). The…

This study tested a smartphone app called 'Bouge' to see if it could help women with non-metastatic breast cancer increase their daily steps while on weekly Taxol chemotherapy. The goal was to add 3,000 steps per day over 90 days. Only 23 people enrolled, and the trial was stoppe…

This study looked at whether a drug called K0706 is safe and tolerable for people with Dementia with Lewy Bodies (DLB). Researchers planned to give 45 participants either a low dose, high dose, or placebo for 12 weeks, then check for side effects and measure changes in brain and …

This study tested whether a six-week course of yoga, mindfulness, and breathing exercises could help people with chronic pain feel better and manage stress. Only 5 patients took part before the trial was stopped early. Because it was so small, we cannot say whether these techniqu…

This study tested whether closing a small hole in the heart (called a PFO) with a device could reduce migraine headaches. It planned to compare the real procedure to a sham (fake) procedure in adults aged 18-55 with frequent migraines. However, the study was stopped early after e…

This study tested an oral antiviral drug called obeldesivir in children from birth to under 5 years old who had RSV infection. The goal was to see if the drug is safe and helps reduce symptoms faster. However, the trial was stopped early and only enrolled 4 participants, so the r…

This study looked at whether adding an ultrasound-guided ESP nerve block to standard pain medicine could reduce opioid use and improve pain control after laparoscopic kidney removal for cancer. Ten adults having keyhole kidney surgery were enrolled. The study was stopped early, s…

This study compared two pain medications—Ultracet (tramadol/acetaminophen) and Voltaren (diclofenac)—in people with ankylosing spondylitis who were already taking disease-modifying anti-rheumatic drugs (DMARDs). The goal was to see which one worked better for pain relief over 8 w…

This study looked at whether adding high-dose steroid pulses to the usual oral steroid course could help people with moderate ulcerative colitis flares achieve remission without needing other treatments. The trial was terminated early and enrolled 75 adults with left-sided or ext…

This study observed 18 chronic stroke patients who received botulinum toxin injections into their elbow muscles as part of routine care. The goal was to see if the injections reduced muscle tightness (spasticity) and improved active arm extension. Researchers measured muscle acti…

This study looked at whether adding an iPACK nerve block to standard pain treatments (adductor canal block and local injections) helps people feel less pain and recover faster after total knee replacement. Only 10 people were enrolled before the study was stopped early. The goal …

This study tested whether a fractional carbon dioxide laser can improve moderate to severe acne in adults aged 18 to 40. Participants received up to 3 laser treatments and were followed for changes in blemish count and skin severity. The trial was terminated early and only enroll…

This early-phase trial tested whether brivaracetam, a seizure medication, is safe for people with diffuse gliomas (a type of brain tumor). Only 3 participants were enrolled before the study was terminated. The main goal was to track side effects, not to measure tumor shrinkage or…

This study tested whether injecting a long-acting numbing drug (liposomal bupivacaine) during leg artery surgery could lower the amount of narcotics patients need during and after the procedure. The trial planned to enroll adults having elective lower extremity revascularization,…

This study tested a procedure called G-POEM, which uses a scope to cut the pylorus muscle, against a sham surgery in people with severe gastroparesis (stomach paralysis) that did not improve with medication. Only 3 patients enrolled before the study ended early. The goal was to s…

This study looks at how adults with bladder problems decide which Coloplast catheter (SpeediCath or Luja) works best for them when they start self-catheterization. Researchers will track satisfaction and challenges over six months. The goal is to help healthcare providers recomme…

This study checks on people who previously received gene editing for hemophilia B or mucopolysaccharidosis (MPS) I or II. No new treatment is given; instead, participants are monitored for up to 10 years to see if any new health problems or worsening of existing conditions appear…

This pilot study tests a new approach to supporting people after a stay in the intensive care unit (ICU). Many ICU survivors face ongoing psychological and physical challenges, such as depression, anxiety, and disability. The intervention involves a case manager who coordinates a…

This study is testing whether a special PET scan called 18F-FSPG can help doctors see how well chemotherapy and radiation are working in people with esophageal cancer. Nine adults with untreated, locally advanced esophageal cancer will get the scan before and during treatment. Th…

This study looks at rare genetic disorders where the body can't make cholesterol properly, which can cause birth defects and learning problems. Researchers collect blood, urine, and tissue samples from affected people and their families to learn more about these conditions. The g…

This study investigates whether levels of certain blood proteins—VEGF, soluble HER2, and VCAM-1—change over time in women with hormone-insensitive breast cancer. It compares women who receive maintenance chemotherapy with those who do not, and also looks at whether these protein …

This study investigates whether MRI can detect early signs of pancreatic damage linked to obesity and metabolic syndrome, which are risk factors for pancreatic cancer. Researchers will compare MRI images with tissue samples from patients undergoing pancreatic surgery, as well as …

This study aims to create a tool to assess how well people understand tone of voice (prosody) after a right-sided stroke. Over half of right-stroke patients have trouble with prosody, which can affect social interactions and quality of life. Researchers will test 150 participants…

This study aims to understand how much insulin the body actually needs to keep blood sugar normal. Ten adults with obesity and high insulin levels will take a drug called diazoxide, which stops the pancreas from making insulin. Researchers will then measure their fasting blood su…

This study investigates how the location of fat tissue in the body—under the skin versus around the organs—affects the function of mitochondria, the energy-producing parts of cells. Researchers will collect small samples of fat tissue from patients undergoing certain abdominal su…

This study is looking at whether tumor biopsies can help predict which patients with melanoma, non-small cell lung cancer, or head and neck cancer will respond to immunotherapy drugs called PD-1 or PD-L1 inhibitors. Researchers will collect tissue samples from about 152 adults be…

This study looks at whether levels of histamine, a chemical in the blood, are linked to bone pain in people with breast cancer that has spread to the bones. Researchers will collect blood samples from participants and compare histamine levels with pain scores, including in those …

This registry tracks people with severe functional mitral regurgitation and heart failure who undergo a minimally invasive mitral valve repair called M-TEER. The goal is to see whether the repair allows patients to tolerate higher, guideline-recommended doses of heart failure med…

This study measures levels of a protein called NT-3 in the blood of people with peripheral neuropathy or Charcot-Marie-Tooth disease. Researchers will compare these levels with measures of muscle strength, mobility, and daily function. The goal is to see whether NT-3 levels corre…

This study investigates how chest wall movement and lung function change in people who had open surgery for esophageal cancer more than a year ago, compared to healthy volunteers. Researchers use a 3D motion capture system and wearable sensors to track chest movement during breat…

This study is measuring how often a specific genetic marker (HLA-A*02:01) and a cancer-related protein (NY-ESO-1) appear in Taiwanese patients with solid tumors like head and neck, liver, lung, breast, and esophageal cancers. By understanding these frequencies, researchers hope t…

This trial investigates whether using 3D image fusion during iliac angioplasty reduces the amount of radiation patients receive compared to standard practice. The study involves 37 adults with iliac artery narrowing who need angioplasty. Researchers will measure radiation exposur…

This study investigates whether recording brain electrical activity during awake surgery can help identify networks involved in thinking and language. In people with glial brain tumors located in critical functional areas, surgeons place electrode grids on the brain before waking…

This study looked at why some people who have a heart attack develop extra fluid around the heart (pericardial effusion). Researchers planned to use MRI scans to see if the amount of fluid was linked to other health factors and to survival one year later. Only 3 people took part …

This study compares a new imaging tracer, 68Ga-NODAGA-RGD, with standard methods (FDG-PET, MRI, ultrasound) to detect inflamed plaques in the carotid arteries. Twenty people scheduled for plaque-removal surgery will receive the tracer and undergo scans. The goal is to see which t…

This study looks at whether dopamine can improve lymph flow in people who developed protein-losing enteropathy (PLE) after Fontan surgery for single-ventricle heart disease. PLE is a serious complication where proteins leak into the gut, possibly due to poor lymphatic function. R…

This study investigates how Alzheimer's disease and frontotemporal dementia alter a person's sense of self and ability to understand others. Researchers will compare patients with healthy older adults using questionnaires and brain imaging. The goal is to link changes in self-awa…

This study looks at whether heart cells that age rapidly after a heart attack release harmful proteins that make heart disease worse. Researchers will collect blood and heart tissue samples from people undergoing coronary artery bypass surgery after a recent heart attack or for s…

This study looks at people who had a stroke or mini-stroke with no known cause (cryptogenic stroke). Researchers want to see if a small device implanted under the skin, called an implantable loop recorder, can detect hidden atrial fibrillation — an irregular heart rhythm that can…

This study looks at how the drug luspatercept is used in real-world clinics for patients with lower-risk myelodysplastic syndromes (MDS) or beta-thalassemia. Researchers will track patient characteristics, treatments, and outcomes like reduced need for blood transfusions. The goa…

This study looks at how high blood sugar combined with a medication called moxifloxacin (an antibiotic known to affect heart rhythm) impacts the heart's electrical activity in people with insulin-resistant type 2 diabetes. Researchers will measure changes in heart tracings (ECGs)…

This study investigates why people with advanced chronic kidney disease (stages 3b to 5) often feel tired and weak. Researchers measure handgrip strength and muscle electrical signals in patients aged 60 and older, comparing them to healthy individuals of the same age and sex. Th…

This study surveys colorectal cancer patients about their use of complementary and alternative medicines (CAM), such as acupuncture, homeopathy, or dietary supplements. Researchers aim to understand which patients use CAM, why, and how it might affect their quality of life and ca…

This study observes people who have already been treated with the Pipeline Embolization Device for brain aneurysms. Researchers track neurological complications like stroke or bleeding to better understand the device's safety in everyday use. The goal is to expand knowledge on ho…

This study aimed to understand how well patients tolerate biopsies for autoimmune diseases and whether they feel properly informed. It planned to enroll 505 people but was terminated early. The results may help improve patient experience with these common procedures.

This pilot study looked at how the sleep drug zolpidem (Ambien) is processed in men with prostate cancer before and after they start hormone therapy that lowers testosterone. Researchers compared these results to healthy women, since women are known to have higher drug levels. Th…

This study used a special MRI technique to look at tiny brain changes in people who recently had a first episode of symptoms that could lead to multiple sclerosis (MS). Researchers compared 84 participants (patients and healthy controls) to see if early memory problems are linked…

This study tried to create a score that doctors could use before birth to predict whether a newborn would die after the mother's water broke very early (between 22 and 28 weeks of pregnancy). The researchers looked back at medical records of 34 women to find factors that might pr…

This study aimed to find out how often liver fibrosis and cirrhosis occur in people with head and neck cancer, since tobacco and alcohol are risk factors for both. Researchers planned to check liver health using exams and imaging. However, the study was stopped early after only 2…

This study aimed to see if a short test called BEARNI could detect alcohol-related cognitive impairments (like memory and thinking problems) in people with alcoholic cirrhosis. The researchers planned to enroll patients with cirrhosis, but the study was stopped early after only o…

This study compared signs of aging in 123 HIV-infected adults to the general population. Researchers measured bone density, muscle strength, skin changes, and thinking abilities. The goal was to understand if HIV speeds up aging in these areas. No new treatment was tested; it was…

This study looked at how diuretics (water pills) affect kidney and heart function in people who just had heart surgery. The goal was to see if removing extra fluid changes how well the kidneys and right side of the heart work. Only 9 people took part, and the study was stopped ea…

This study explores whether the community of bacteria living on the skin (the skin microbiome) plays a role in vitiligo—a condition that causes white patches—and in side effects from anti-PD-1 immunotherapy for advanced melanoma. Researchers will collect skin swabs from people wi…

This study looked at how patients with hemophilia A or those on blood thinners feel about monitoring their blood clotting at home. Researchers interviewed 19 people to understand their needs and hopes for a new device that could measure clotting factors. The goal was to gather in…

This trial tested a new way of using a breathing machine (flow-controlled ventilation) against the standard method (pressure-controlled ventilation) in 15 ICU patients with moderate to severe acute respiratory distress syndrome (ARDS). The goal was to see if the new method uses l…

This study aimed to see if certain substances in stool and blood can predict whether the gut lining has healed in people with moderate to severe ulcerative colitis. Researchers planned to measure these markers in 62 adults before and after treatment. The study was terminated earl…

This study aimed to compare how often women could go home the same day after a hysterectomy using three different minimally invasive techniques: vNOTES (through the vagina), conventional laparoscopy, and robot-assisted laparoscopy. The trial was terminated early after enrolling o…

This study tested whether real-time fMRI neurofeedback could help young adults with major depression reduce repetitive negative thinking. Participants received either real or fake feedback while their brain activity was monitored. The trial was terminated early, so the findings a…

This study aimed to understand why some people develop heart failure after a heart attack. Researchers used special PET scans and blood tests to measure blood vessel function and scarring in the heart muscle of 30 patients who had a first heart attack. The goal was to see if thes…

This study looked back at 20 young people who came to the hospital with nerve problems after using nitrous oxide (laughing gas) for fun. Researchers measured muscle strength, balance, and disability to understand how the gas harms the nervous system. The goal was to learn more ab…

This study aimed to find genetic mutations in people with idiopathic cytopenia of undetermined significance (ICUS), a condition of unexplained low blood cell counts. Researchers wanted to see if these mutations are similar to those found in myelodysplastic syndrome (MDS), a type …

This study aimed to identify brain areas outside the main motor region that help arm recovery after a severe stroke. Researchers followed 28 patients over time, using MRI and movement tracking to see which brain areas became active as arm function improved. The goal was to find n…

This study tested whether a small implanted device that stimulates the vagus nerve could improve arm and hand function in people who had a stroke at least a year ago. Four participants received either real or sham stimulation paired with physical therapy. The goal was to see how …

This study investigated whether polyomaviruses (a type of common virus) are found more often in people with autoimmune thyroiditis or goiters. Researchers compared virus presence in blood, urine, and thyroid tissue from 49 patients undergoing thyroid surgery. The goal was to see …

This pilot study aimed to see if a blood test called thromboelastography (TEG) and platelet mapping could predict clotting or bleeding complications after non-cardiac surgery. The study included 200 patients who were taking aspirin or clopidogrel for at least 10 days before elect…

This study aimed to understand why people with autism or schizophrenia sometimes struggle to recognize emotions on faces. Researchers used brain wave recordings (EEG) and eye-tracking to see how participants processed facial expressions. The study included people with autism, sch…

This study looked at how noninvasive brain stimulation techniques like rTMS, tDCS, and ECT change BDNF levels in people with depression or schizophrenia. Researchers took blood samples before and after stimulation to measure BDNF, a protein linked to brain health. The study was t…

This study looked at how a man's smoking habits might affect a couple's ability to have a baby. Researchers compared fertile and infertile couples, measuring smoking markers like carbon monoxide and cotinine in blood, semen, and hair. The goal was to understand if smoking damages…

This study looks at the tiny hair-like structures (cilia) inside the fallopian tubes of women who have had surgery to remove a tube or uterus. Researchers want to see if differences in these cilia help explain why some women have ectopic pregnancies (when a fertilized egg grows o…

This study reviewed medical records of 42 people with familial adenomatous polyposis (FAP) who had previously taken the drug erlotinib. Researchers wanted to see how quickly the disease progressed after the drug was stopped. The goal was to better understand what happens when tre…

This study looked at how anesthesia changes brain activity in people with Parkinson's disease or essential tremor who were already scheduled for deep brain stimulation (DBS) surgery. Researchers recorded brain signals during a short period of anesthesia to understand which circui…

This study aimed to see how total hip replacement changes the way the pelvic bone moves during daily activities like sitting and standing. Researchers used an ultrasound device to measure pelvic tilt in 15 people with hip arthritis before and after surgery. The study was terminat…

This study collects small skin samples from children aged 2 to 17 with Costello syndrome or a related condition. Researchers will analyze the cells to understand how a mutation in the HRAS gene affects energy use and mitochondria. The goal is to learn more about the disease's und…

This study aimed to measure how eye volume changes (a sign of pressure fluctuation) before and after cataract surgery in patients with exfoliative glaucoma, a type of glaucoma common in Brittany. Only 6 adults were enrolled before the study was terminated. The goal was to see if …

This study tested a radiofrequency-based treatment on the skin of healthy volunteers and people with hidradenitis suppurativa (a painful skin condition). The main goal was to see if the treatment is safe and tolerable. The study was stopped early, but it aimed to understand how t…

This study tested whether special insoles with pressure sensors (FEETME®) can accurately measure walking speed in people with CIDP, a nerve condition that causes walking difficulties. Researchers compared the insoles to a standard walkway system in 18 adults aged 18-75 with CIDP.…

This study aimed to see if skipping a type of muscle relaxant during general anesthesia could lower the risk of serious lung complications in high-risk surgery patients. The trial was terminated early after enrolling only 3 participants, so no meaningful conclusions can be drawn.…

This study looked at whether using Ringer's lactate instead of normal saline during emergency treatment for heat stroke could reduce the risk of acute kidney injury. Researchers planned to enroll 104 adults diagnosed with heat stroke, giving one group standard saline and the othe…

This study aimed to find out how common antibiotic resistance is in multiple myeloma patients receiving a stem cell transplant. Researchers planned to collect data from 124 adults to help design future studies on preventing infections. The study was stopped early, so results are …

This small Phase 2 study aimed to test the safety and dosing of an intravenous drug called allopregnanolone (also known as brexanolone) in 11 people with chronic PTSD. The trial was terminated before completion, so results are limited. The main goal was to monitor sedation levels…

This study looked at whether measuring a natural clot-busting substance (t-PA) released from heart arteries could predict future heart attacks or death in people with mild to moderate coronary artery disease. Researchers gave a small dose of bradykinin into the heart artery durin…

This study tested whether placing a temporary metal stent in the stomach outlet could predict if a patient with severe gastroparesis would later benefit from a permanent procedure called GPOEM. Only 8 adults with gastroparesis that didn't improve with standard treatments took par…

This study looked at whether a robotic navigation device can help doctors take brain biopsies accurately. The goal was to see if the robot could achieve a 90% success rate in getting a clear tissue sample. Only 4 people with brain tumors took part before the study was stopped. Th…

This early-phase study tested whether two optical imaging agents could be used during a bronchoscopy to visualize activated neutrophils and a cancer-related protein called c-MET in lung tumors. Five participants with lung cancer received the agents through a special catheter whil…

This pilot study tested whether a small wearable sensor called the Spire Health Tag could reliably track heart rate, activity, sleep, and stress in heart failure patients after they leave the hospital. The goal was to see if the device could capture useful data for at least 80% o…

This study looked at how the heart's pumping function recovers after a short, controlled blockage of a coronary artery using a balloon. Six adults with stable coronary artery disease undergoing angioplasty had a balloon inflated in their artery for 90 seconds. Researchers measure…

This study aimed to understand how oxygen delivery changes during heart surgery when a heart-lung machine is used. Researchers wanted to create a computer model to help doctors personalize oxygen levels for each patient, potentially reducing complications like kidney injury. Only…