Could a treadmill routine sharpen the diabetic brain?

NCT ID NCT04590833

NEW Terminated Disease control Sponsor: Florida State University Source: ClinicalTrials.gov ↗

First seen Aug 17, 2026 · Last updated Aug 17, 2026

Summary

This study tests whether a supervised treadmill walking program can improve memory, attention, and other thinking skills in adults with type 2 diabetes. Participants will follow a personalized exercise plan, and researchers will measure changes in cognitive function and blood markers like BDNF, a protein linked to brain health. The trial also looks at how genetics might influence who benefits most. It is a small feasibility study, so the main goal is to see if a larger trial is possible.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Supervised treadmill walking exercise program
What this could lead to: If successful, this could pave the way for a personalized exercise program to help protect memory and thinking in people with type 2 diabetes.
What could go wrong: This is a very small feasibility study, so results may not apply broadly. It is testing whether the approach works, not yet proving it helps cognition.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction Motor Activity type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS TYPE 2

Contacts and locations

Locations

University of Arkansas

Fayetteville, Arkansas, 72701, United States

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