Could less be more? shorter antibiotic course after appendix surgery put to the test
NCT ID NCT05966454
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This trial compares two approaches to antibiotic use after appendix removal surgery: a restrictive course (none or up to 24 hours) versus a liberal course (24 hours to 4 days). The goal is to see if the shorter course is just as safe and effective, while reducing side effects and antibiotic resistance. The study includes adults aged 18 and older who are scheduled for an appendectomy and can be reached after discharge.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
standard-of-care antibiotics (e.g., cefoxitin, piperacillin-tazobactam)
What this could lead to
If successful, this could show that a short course of antibiotics after appendectomy is safe and effective, reducing unnecessary drug exposure and side effects.
What could go wrong
This is a small early-phase trial with only 40 participants, so results may not apply broadly. There is a risk that restricting antibiotics could lead to more infections or complications.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Zuckerberg San Francisco General Hospital
San Francisco, California, 94110, United States