Could less be more? shorter antibiotic course after appendix surgery put to the test
NCT ID NCT05966454
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This trial compares two approaches to antibiotic use after appendix removal surgery: a restrictive course (none or up to 24 hours) versus a liberal course (24 hours to 4 days). The goal is to see if the shorter course is just as safe and effective, while reducing side effects and antibiotic resistance. The study includes adults aged 18 and older who are scheduled for an appendectomy and can be reached after discharge.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- standard-of-care antibiotics (e.g., cefoxitin, piperacillin-tazobactam)
- What this could lead to
- If successful, this could show that a short course of antibiotics after appendectomy is safe and effective, reducing unnecessary drug exposure and side effects.
- What could go wrong
- This is a small early-phase trial with only 40 participants, so results may not apply broadly. There is a risk that restricting antibiotics could lead to more infections or complications.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for APPENDICITIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Zuckerberg San Francisco General Hospital
San Francisco, California, 94110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Smartphone Follow-Up could replace hospital stays after common surgeries
- New Wound-Cleaning method may let surgeons close incisions right away after severe appendicitis
- Appendicitis dilemma: survey reveals patient regret over treatment choice
- Scientists create detailed map of appendix cells
- Cartoons and games beat Pre-Surgery jitters in kids
- Which pain block works best for kids after appendix removal?