Can mRNA technology outsmart shingles? a new vaccine trial aims to find out
NCT ID NCT05701800
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This trial tests an experimental mRNA vaccine, mRNA-1468, to see if it can safely prevent shingles in healthy adults aged 50 and older. Participants receive either the new vaccine, a placebo, or an existing shingles vaccine (Shingrix) to compare safety and immune response. The study aims to find the right dose and assess how well the vaccine triggers the body's defenses against the virus that causes shingles.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- mRNA-1468, an experimental mRNA-based vaccine designed to prevent herpes zoster (shingles)
- What this could lead to
- If successful, this could lead to a new mRNA-based vaccine option for preventing shingles, potentially offering better protection or convenience compared to existing vaccines.
- What could go wrong
- This is an early-phase trial, so the vaccine may not prove safe or effective. Possible side effects include injection-site reactions and systemic symptoms like fever or fatigue.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centricity Research
Columbus, Georgia, 31904, United States
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Clinical Trials of Florida, LLC
Miami, Florida, 33186, United States
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DM Clinical Research
Tomball, Texas, 77375, United States
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DM Clinical Research - Philadelphia
Philadelphia, Pennsylvania, 19107, United States
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DM Clinical Research- River Forest
River Forest, Illinois, 60305, United States
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Florida Pulmonary Research Institute, LLC
Winter Park, Florida, 32789, United States
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Floridian Clinical Research
Miami Lakes, Florida, 33016, United States
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Gadolin Research
Beaumont, Texas, 77702, United States
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Great Lakes
Chicago, Illinois, 60640, United States
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Johnson County Clin-Trials (JCCT)
Lenexa, Kansas, 66219, United States
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LinQ Research, LLC
Houston, Texas, 77087, United States
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Meridian Clinical Research - Dakota Dunes
Sioux City, Iowa, 51106, United States
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Meridien Research
Lakeland, Florida, 33805, United States
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NOLA Research Works
New Orleans, Louisiana, 70115, United States
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Research Works San Juan
San Juan, 00907, Puerto Rico
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Tekton Research
Austin, Texas, 78745, United States
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Tekton Research, Inc - Longmont Center
Longmont, Colorado, 80501, United States
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Velocity Clinical Research - Medford
Medford, Oregon, 97504, United States
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Velocity Clinical Research - Westlake
Los Angeles, California, 90057, United States
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WR-ClinSearch, LLC
Chattanooga, Tennessee, 37421, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New mRNA shingles shot shows promise in early trial