HERPES ZOSTER

This study is testing a shingles vaccine in children aged 1 to 17 who have had a kidney transplant and have a weakened immune system. The goal is to see if the vaccine is safe and helps their bodies fight the virus that causes shingles. About 184 children will take part, receivin…

This study looks at how well the Shingrix vaccine works in people with HIV compared to healthy adults. Shingrix is already approved to prevent shingles, but researchers want to see if it triggers a strong immune response in people with different CD4 counts. About 225 adults aged …

This study tests a new shingles vaccine called Z-1018 in about 764 healthy adults aged 50 and older. Researchers want to see if it is safe and triggers a strong immune response compared to the current vaccine, Shingrix. The trial has two parts and involves two doses given several…

This study is testing a new mRNA vaccine designed to prevent shingles (herpes zoster) in adults aged 40 and older. The vaccine is given as a shot and aims to teach the body to fight the virus that causes shingles. Researchers will check how safe the vaccine is and how well it tri…

This study tests whether the oral medication venlafaxine can prevent postherpetic neuralgia, a chronic pain condition that often follows shingles. Researchers will enroll 832 adults with active shingles and moderate to severe pain. The goal is to see if early treatment with venla…

This large study in Finland is testing whether the Shingrix vaccine, which prevents shingles, can also reduce the risk of developing dementia in adults aged 76 and older. About 33,600 participants will receive either the vaccine or a placebo and be monitored for new dementia diag…

This study tests whether the antidepressant desvenlafaxine can safely reduce pain in people with shingles. Researchers will enroll 750 adults who have had a shingles rash for less than 90 days and are experiencing moderate to severe pain. The goal is to see if this medication off…

This study tests whether adding a newer pain medication called mirogabalin to standard shingles treatment provides better pain relief than standard treatment alone. The trial will enroll 750 adults with shingles rash for less than 30 days and moderate to severe pain. Mirogabalin …

This study tests whether a medicated patch (loxoprofen sodium) can safely reduce pain from shingles. About 750 adults with moderate to severe shingles pain will use the patch and report their pain levels. The goal is to find a topical option that works well with fewer side effect…

This study tests whether the muscle relaxant baclofen can safely reduce pain from shingles (herpes zoster). Researchers will enroll 750 adults with moderate to severe pain who have had a shingles rash for less than 90 days. Participants will take baclofen or a placebo, and pain l…

This study compares two antiviral drugs, brivudine and famciclovir, to see which is better at reducing pain from shingles and preventing long-term nerve pain. About 140 adults with shingles will take one of the two medicines. Researchers will track pain levels over 90 days and ch…

This study compares two treatments for long-lasting nerve pain after shingles (postherpetic neuralgia). Researchers will test an ultrasound-guided nerve block and a radiofrequency treatment to see which provides better pain relief. The study involves 50 adults aged 18 to 80 who s…

This study tests whether adding crisugabalin, a newer pain medicine, to usual treatment provides better pain relief for people with shingles. About 750 adults with moderate to severe shingles pain will receive either standard care alone or standard care plus crisugabalin. The goa…

This study tests whether an oral medication called tulodsesvenlafaxine can safely reduce pain in people with shingles (herpes zoster). Shingles causes a painful rash and can lead to long-term nerve pain. The drug works by affecting brain chemicals that control pain. The trial wil…

This study tests whether a flurbiprofen patch can safely reduce pain from shingles (herpes zoster). The patch delivers pain relief directly to the skin, aiming to avoid side effects from oral painkillers. Researchers will enroll 750 adults with moderate to severe shingles pain to…

This study looks at how electroacupuncture (a type of acupuncture with mild electric pulses) affects immune cells in people with shingles. Researchers will compare patients who get standard medication alone versus medication plus electroacupuncture. The goal is to understand if e…